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At least 577 records · Page 32Linked to original sources
PubMed2003

Alpha1-adrenergic signaling mechanisms in contraction of resistance arteries.

Our goal in this review is to provide a comprehensive, integrated view of the numerous signaling pathways that are activated by alpha(1)-adrenoceptors and control actin-myosin interactions (i.e., crossbridge cycling and force generation) in mammalian arterial smooth muscle. These signaling pathways may be categorized broadly as leading either to thick (myosin) filament regulation or to thin (actin) filament regulation. Thick filament regulation encompasses both "Ca(2+) activation" and "Ca(2+)-sensitization" as it involves both activation of myosin light chain kinase (MLCK) by Ca(2+)-calmodulin and regulation of myosin light chain phosphatase (MLCP) activity. With respect to Ca(2+) activation, adrenergically induced Ca(2+) transients in individual smooth muscle cells of intact arteries are now being shown by high resolution imaging to be sarcoplasmic reticulum-dependent asynchronous propagating Ca(2+) waves. These waves differ from the spatially uniform increases in [Ca(2+)] previously assumed. Similarly, imaging during adrenergic activation has revealed the dynamic translocation, to membranes and other subcellular sites, of protein kinases (e.g., Ca(2+)-activated protein kinases, PKCs) that are involved in regulation of MLCP and thus in "Ca(2+) sensitization" of contraction. Thin filament regulation includes the possible disinhibition of actin-myosin interactions by phosphorylation of CaD, possibly by mitogen-activated protein (MAP) kinases that are also translocated during adrenergic activation. An hypothesis for the mechanisms of adrenergic activation of small arteries is advanced. This involves asynchronous Ca(2+) waves in individual SMC, synchronous Ca(2+) oscillations (at high levels of adrenergic activation), Ca(2+) sparks, "Ca(2+)-sensitization" by PKC and Rho-associated kinase (ROK), and thin filament mechanisms.

Actins↗
PubMed2005

Three-dimensional representation of complex muscle architectures and geometries.

Almost all computer models of the musculoskeletal system represent muscle geometry using a series of line segments. This simplification (i) limits the ability of models to accurately represent the paths of muscles with complex geometry and (ii) assumes that moment arms are equivalent for all fibers within a muscle (or muscle compartment). The goal of this work was to develop and evaluate a new method for creating three-dimensional (3D) finite-element models that represent complex muscle geometry and the variation in moment arms across fibers within a muscle. We created 3D models of the psoas, iliacus, gluteus maximus, and gluteus medius muscles from magnetic resonance (MR) images. Peak fiber moment arms varied substantially among fibers within each muscle (e.g., for the psoas the peak fiber hip flexion moment arms varied from 2 to 3 cm, and for the gluteus maximus the peak fiber hip extension moment arms varied from 1 to 7 cm). Moment arms from the literature were generally within the range of fiber moment arms predicted by the 3D models. The models accurately predicted changes in muscle surface geometry over a 55 degrees range of hip flexion, as compared to changes in shape predicted from MR images (average errors between the model and measured surfaces were between 1.7 and 5.2 mm). This new framework for representing muscle will enhance the accuracy of computer models of the musculoskeletal system.

Adult↗
PubMed2005

Comparison of CFD and MRI flow and velocities in an in vitro large artery bypass graft model.

Bypass graft failures have been attributed to various hemodynamic factors, including flow stasis and low shear stress. Ideally, surgeries would minimize the occurrence of these detrimental flow conditions, but surgeons cannot currently assess this. Numerical simulation techniques have been proposed as one method for predicting changes in flow distributions and patterns from surgical bypass procedures, but comparisons against experimental results are needed to assess their usefulness. Previous in vitro studies compared simulated results against experimentally obtained measurements, but they focused on peripheral arteries, which have lower Reynolds numbers than those found in the larger arteries. In this study, we compared simulation results against measurements obtained using magnetic resonance imaging (MRI) techniques for a phantom model of a stenotic vessel with a bypass graft under conditions suitable for surgical planning purposes and with inlet Reynolds numbers closer to those found inthe larger arteries. Comparisons of flow rate and velocity profiles were performed at maximum and minimum flows at four locations and used simulation results that were temporally and spatially averaged, key postprocessing when comparing against phase contrast MRI measurements. The maximum error in the computed volumetric flow rates was 6% of the measured values, and excellent qualitative agreement was obtained for the through-plane velocity profiles in both magnitude and shape. The in-plane velocities also agreed reasonably well at most locations.

Blood Flow Velocity↗
PubMed2006

Spatial correlation analysis of isotropic microvessels: methodology and application to thyroid capillaries.

The study of relations between structural organization and functions of microcirculatory networks is a major aim of modern microangiology. Such a structural aspect of microvessels (MVs) as their spatial arrangement has substantial influence on their transport and other functional properties. This paper describes a methodology of spatial correlation analysis for isotropic blood and lymphatic MVs which is based on a stereological estimator of the pair correlation function [g3D(r)] created recently by the authors for systems of elongated objects. The following main features of the methodology are presented: (i) interpretation of the shape of g3D(r) curves, (ii) their quantitative description by numerical parameters, and (iii) limitations of the method arising from statistical requirements to MVs under investigation. The methodology is considered in the light of multilevel sampling designs, which are typical for biomedical morphology. The estimator with its methodological framework is applied to perifollicular blood capillaries in the adult rat thyroid. Related methods for studying the spatial arrangement of MVs are thoroughly discussed in the paper.

Albinism↗
PubMed2006

Proper orientation of the graft artery is important to ensure physiological flow direction.

Arterial grafts such as right internal mammary artery (RIMA), radial artery (RA) or epigastric artery are being used with increasing frequency as free grafts or as composite grafts with left internal mammary artery (LIMA). Currently, there is no consideration of the orientation of the free artery graft to mimic the in vivo state. Hence, some grafts may be oriented such that the direction of blood flow exerted on the endothelium is reversed relative to the in vivo condition. Previous studies have shown that transient flow reversal lead to atherogenesis. A recent study demonstrated that nitric oxide is significantly reduced during reverse flow and the reduction is mediated through an increase in superoxide production. In light of these data, we suggest that the flow direction is important and recommend the assurance of proper orientation of the free arterial graft. Furthermore, we propose a new surgical procedure to modify the composite LIMA-RA or LIMA-RIMA configuration as a horseshoe or K composite graft to ensure proper orientation of the flow direction relative to the endothelium.

Animals↗
PubMed2006

Visualization of three-dimensional cardiac electrical excitation using standard heart model and anterior and posterior magnetocardiogram.

Our aim in this study is to obtain novel three-dimensional (3-D) images of cardiac electrical excitation that include morphological information on the whole heart. We obtain these 3-D images by projecting anterior and posterior two-dimensional (2-D) current-arrow maps (CAMs) onto a 3-D standard heart model. This standard heart model is adjusted to the individual subject's heart position by using the coordinates of the sinus node, which are obtained from magnetocardiogram (MCG) signals. The anterior and posterior CAMs are calculated by taking the orthogonal partial derivatives of the normal component of the anterior and posterior MCGs. After adjusting the base current values of the anterior and posterior CAMs, the adjusted CAMs are projected onto the standard heart model. We generated the projected CAMs (PCAMs) of the six phases (atrial, and ventricular, excitation) for seven healthy subjects. The validity of PCAM was evaluated by extracting the maximal current directions and positions from the PCAMs. The maximal current directions and positions during each excitation phase were almost in the same in the seven healthy subjects. Therefore, the PCAMs give us a clear view of the anterior and posterior myocardial excitation for the respective electrophysiological phases.

Adult↗
PubMed1994

Comparing clinician-applied loads for routine, difficult, and shoulder dystocia deliveries.

OBJECTIVE: Our goal was to examine and compare clinician-applied loads during simulated vaginal delivery. STUDY DESIGN: We developed a birthing model and a microcomputer data acquisition system and used them to measure clinician-applied extraction forces, moment, and rates for three perceived categories of delivery. In 39 experiments, clinicians simulated delivery of the fetal shoulders during vaginal delivery for routine, difficult, and shoulder dystocia deliveries. RESULTS: Clinicians averaged 84 N combined force and 473 N-cm neck-bending moment for routine deliveries, 122 N and 697 N-cm for difficult deliveries, and 163 N and 700 N-cm for shoulder dystocia deliveries (p < 0.002). No force or moment parameter was associated with clinician gender or experience. Force levels exceeding 100 N are reached for many clinicians (74% and 82%) for difficult and shoulder dystocia deliveries and for some clinicians (31%) for routine deliveries (p < 0.0001). CONCLUSION: We conclude that simulating shoulder dystocia in the laboratory may be useful in measuring extraction forces and neck-bending moment and that birthing models can be used to train clinicians in force, moment, and rate perception.

Delivery, Obstetric↗
PubMed1977

Measurement of edgewise torque force in vitro.

The construction of a model for the measurement of palatal root torque is described. It was demonstrated that: 1. Halfway between the apex of a tooth and the arch wire the force was double that which was delivered at the apex. 2. The lateral incisors were subjected to appreciably more force than the central incisors. 3. The smaller the number of teeth acted upon, the greater the force they received.

Humans↗
PubMed1979

A key to the understanding of extraoral forces.

By following certain basic principles, the effects, advantages, and disadvantages of the wide assortment of extraoral assemblies marketed are easily understood. The key to this understanding is the appreciation of the relationship of the line of action of the force application to the center of resistance of the tooth. These principles are discussed in three planes of space: sagittal, coronal, and transverse. Because of the many variables and complexity of mathematically computing the force effects of unilateral or asymmetric extraoral assemblies on molar teeth, a mechanical testing apparatus was designed to accommodate the various face-bows. Not all the designs proved effective, and many of the clinical side effects of the respective face-bow designs became manifest on mechanical testing.

Cephalometry↗
PubMed1980

Holographic determination of centers of rotation produced by orthodontic forces.

A new tool for measuring tooth movement--laser holography--offers an accurate, noninvasive approach for determining movement in three dimensions. This in vitro study is designed to establish the required force system applied on the crown of a maxillary incisor that would produce different centers of rotation, as in lingual tipping, translation, and root movement. The relationship between moment-to-force ratios and centers of rotation is shown. The experimental data are compared to theoretic approaches. With respect to the location of the center of resistance and centers of rotation, force systems needed to produce different centers of rotation are given for a central incisor of average root length.

Biomechanical Phenomena↗
PubMed1984

Analysis of simulated upper airway breathing.

There is substantial disagreement among clinicians concerning the etiologic significance of impaired nasal respiration. Conflicting views concerning the effects of breathing on facial growth suggest the need for a more quantitative approach to this important question. This investigation is the first in a series of studies representing a new direction for objectively assessing airway breathing. A model of the upper airway was used to study air movement under controlled conditions. The specific objectives were to determine the effects of airway size and shape on the aerodynamics of simulated breathing and develop a theoretical basis for predicting when breathing mode will change from nasal to predominantly oral. The following theoretical predictions are made on the basis of data generated from the model: A nasal airway cross-sectional area of less than 0.4 cm2 may represent an inadequate airway in adults and some mouth breathing would be expected. The amount of adenoid obstruction must be very large to affect airway resistance. However, if airway resistance in the nose is high, large adenoids would present a serious airway problem and cause predominantly mouth breathing. When nasal airway resistance is high, the mouth will open approximately 0.4 to 0.6 cm2. This shifts a significant amount of air orally and reduces airway resistance to a normal level. If morphologic changes are caused by airway impairment, other factors such as a large tongue, large tonsils, or a long, draping velum are probably significant contributing factors.

Airway Resistance↗
PubMed1986

Upper airway pressures during breathing: a comparison of normal and nasally incompetent subjects with modeling studies.

Although there has been considerable interest in the effects of nasal airway impairment on facial growth, the relationship is still unclear. This study examined the effect of nasal airway size on upper airway pressures during breathing. Three phases of data collection were involved. The first phase used a model to describe pressures during simulated normal and impaired respirations. The second phase involved subjects with normal airways, and the third used persons who were judged by an otolaryngologist to be nasally impaired. Aerodynamic assessment techniques were used to measure airway pressures during breathing and to assess nasal airway size. Results of the modeling study suggest that when nasal cross-sectional area is greater than 0.1 cm2, pressures associated with breathing are not excessive. These findings also suggest that slight lip opening (2 to 3 mm) would significantly reduce airway pressures. In addition, pressure magnitudes of the normal and nasally impaired groups were similar to the modeling data, and no significant difference in pressures was observed between the two groups. Accordingly, the assumptions that nasally impaired persons generate abnormal breathing pressures and that these pressures directly influence facial growth are questionable.

Air Pressure↗
PubMed1986

Localized, transverse, flexural stiffnesses of continuous arch wires.

Elastic bending (flexure) theory, although apparently extendable to the arch wire, incorporates assumptions that are violated in orthodontic application, and neglects several influences confined to the clinical arena. The standard elastic-bending test for orthodontic wires uses a passively straight segment of wire, and a rotational bending stiffness rather than the force-deflection ratio akin to the transverse deformation of a leveling wire is determined. In this study the transverse flexural stiffnesses of five preformed arch wires were quantified in each of three activation directions at five separate sites on simulated dental arches to which appliances were affixed. The influences of elastic moduli, numbers of strands, and interbracket distances were found to be less substantial than theory suggests. Other parameters, including wire curvature at the activation site, malalignment direction relative to that curvature, bracket-wire friction, and preactivation fit of the preformed arch to the dentition, also affected the localized, transverse, flexural stiffnesses.

Alloys↗
PubMed1996

Air movement around a worker in a low-speed flow field.

A knowledge of the air movement around a worker in a low-speed airflow is important in a number of areas: containment testing of fume cupboards; testing of personal dust samplers; testing of LEV effectiveness; and measurement of worker exposure. Measurements of velocity vectors around the upper torsos of manikins and a human in low-speed airflows have been made using a laser Doppler anemometer. Both heated and unheated manikins, as well as a 'breathing' manikin were used. The results show that quite distinctive flow patterns develop with heated and unheated bodies. Comparison of the flows around two- and three-dimensional manikins with that around a human shows that only a three-dimensional heated manikin gives good results. The unheated breathing manikin gave results which were unrepresentative of the real situation. A suitable manikin for use in sampling or testing in low-speed airflows would have a heated, rounded, three-dimensional body of reasonably human dimensions and would be non-breathing and clothed.

Air Movements↗