SEARCH · PubMed Health

Results for “Neoplasm Recurrence, Local”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 577 records · Page 32Linked to original sources

PubMed1981

[Breast cancer treatment methods taking into account patient tumor and body characteristics].

On the basis of clinical evaluation of 1,007 case histories of breast cancer supplied from the Kazakh Republican Oncological Dispensary, Research Institute of Oncology and Radiation and Municipal Oncological Dispensary (Alma-Ata, 1960-1977), individually-tailored methods of therapy were developed. The procedures are based on such criteria as age, stage, localization, anatomical and histological characteristics of tumor.

Breast Neoplasms↗

PubMed1991

Gastric leiomyosarcoma. Prognostic factors and surgical management.

Information on gastric leiomyosarcoma, such as important prognostic factors, patterns of disease recurrence, and optimal methods of treatment, are derived from limited patient experience. We address these questions, with specific focus on whether an advantage could be demonstrated for radical resection compared with wide local excision, by retrospectively investigating 53 patients who underwent surgical treatment at Mayo Clinic, Rochester, Minn. Abdominal pain and/or gastrointestinal bleeding associated with an intramural or exogastric mass were typical features of this disease. Only tumor size and histologic grade were statistically significant prognostic factors. With analysis of survival curves and patterns of recurrence, neither the addition of lymphadenectomy nor the wider tumor-free margins of a radical gastrectomy seemed superior to the more conservative local excision. Therefore, wide local excision remains the preferred treatment when technically feasible.

Adolescent↗

PubMed2007

A review on follow-up strategies for renal cell carcinoma after nephrectomy.

OBJECTIVES: To provide a comprehensive review of the evidence supporting the necessity for follow-up after nephrectomy for renal cell carcinoma. METHODS: We searched the Medline, MeSH, EMBASE, and Cochrane databases using the terms "renal cell cancer," "kidney neoplasm," "follow-up," "surveillance," "prognosis," and "staging" to look for human/English language/Randomized Controlled Trials/Clinical trials/Review articles/Meta-analysis/Practiced Guidelines, and Editorials. RESULTS: No consensus currently exists on surveillance guidelines after radical or partial nephrectomy for renal cell carcinoma. The rationale for follow-up strategies is to detect local recurrence or metastatic disease and to allow appropriate treatment. Most of the surveillance protocols recommend various follow-up strategies for all tumour stages. The emphasis on follow-up should be during the first 3-5 yr after nephrectomy. There is no consensus about which investigations should be performed and at what intervals. Most surgeons rely on symptom enquiry, physical examination, chest x-ray, and computed tomography scanning. A protocol based on the stage of the initial tumour is adapted by the majority of the investigators. Patients should be followed similarly after radical or partial nephrectomy on the basis of stage-oriented protocols. The combination of various prognostic factors requires further validation over stage-based protocols. There is a paucity of guidelines in the literature regarding follow-up for patients with hereditary forms of renal cell carcinoma. CONCLUSIONS: Current guidelines for follow-up are based on observational and case studies. While this fact precludes a high level of evidence-based guidelines, we have to conclude that this is the best available evidence to date.

Carcinoma, Renal Cell↗

PubMed1988

Radiation-induced sarcoma of the breast in a female adolescent. Case report with histologic and therapeutic considerations.

A 14-year-old girl developed a radiation-induced sarcoma of the left breast after successful combined surgical and radiation therapy of a left adrenal carcinoma when she was 9 months old. The breast lesion was histologically described as a stromal sarcoma with fibrosarcomatous and myxosarcomatous areas. The second primary lesion and local recurrence of this was treated with surgery. At each recurrence the tumor became more aggressive both clinically and histologically, and eventually proved fatal.

Adolescent↗

PubMed1996

Increased morbidity following the introduction of remote afterloading, with increased dose rate, for cancer of the cervix.

A retrospective review of the treatment of cancer of the cervix compared the 3-year period before and after the introduction of remote afterloading using a "low dose rate' Selectron. Data was collected on 270 patients. Compared to manually loaded caesium the dose rate to point A was doubled with Selectron and a dose reduction of 20% was adopted to compensate for the expected increased effectiveness. The combined grade 2 and 3 complication rates were 12% with manually loaded caesium and 32% with Selectron at the higher dose rate. Survival and local control rates were similar.

Adenocarcinoma↗

PubMed2006

[Treatments of prostate carcinoma and imaging follow up].

Multiple treatments are proposed to cure prostate carcinoma. Radical prostatectomy is the classical option for localized tumor. However radiotherapy can be proposed in such circumstances with the argument of a less invasive procedure with similar results. High Intensity Focalised Ultrasound (HIFU) is a new technique available for similar staging of the carcinoma with good results. Follow up is based on biological evaluation of PSA. Imaging studies are required only in cases of abnormal level. Endorectal Ultrasonography with biopsies is useful after radical surgery. Indications for MRI study is mainly to differentiate a localized from a general recurrence.

Aged↗

PubMed2003

Local excision of rectal tumors.

Local excision is increasingly being used to treat rectal cancer. It appears to be an attractive option because of low morbidity and excellent functional results. Controversies remain regarding available techniques, selection criteria and results with or without adjuvant therapy. Role of salvage therapy remains uncertain. This review examines available evidence in an attempt to clarify the role of local excision in the management of rectal cancer.

Adenocarcinoma↗

PubMed2003

Extraorbital sebaceous carcinoma with rapidly developing visceral metastases.

BACKGROUND: Extraorbital sebaceous carcinoma (SC) is a rare carcinoma of the skin but is known to have a good prognosis in terms of metastasis and survival. OBJECTIVE: To discuss and emphasize through the clinical and histopathologic findings and the aggressive potential of extraorbital SC and to review the corresponding literature. METHODS: We present an unusual form of extraorbital SC that has followed an aggressive course and that has metastasized rapidly. RESULTS: Local excision of the primary cutaneous tumor with negative margins did not prevent the rapid and fatal internal organ metastases. The patient did not benefit from the docetaxel chemotherapy regimen applied after the distant metastases were developed. CONCLUSION: Extraorbital SC may show a poor prognosis. Both the dermatologic surgeon and the dermatologist should be cautious of the risk of local recurrence and distant metastasis when dealing with extraorbital SC.

Aged↗

PubMed1998

The role of monoclonal antibody in the management of prostate adenocarcinoma.

PURPOSE: A study using monoclonal antibody ProstaScint was conducted to determine the role of radioscintigraphy for evaluation of patients with adenocarcinoma of the prostate. Previous evaluations determining sensitivity and toxicity for this agent were conducted in a multicenter study. MATERIALS AND METHODS: ProstaScint scans were used for preoperative staging in patients presumed to be candidates for total prostatectomy and a subsequent study was performed for the detection and localization of recurrent prostate cancer following definitive therapy. RESULTS: The monoclonal antibody scan detected localized recurrent cancer in 43 patients who were possible candidates for external beam radiation therapy. CONCLUSIONS: The monoclonal antibody conjugate ProstaScint provides additional information in detection and localization of recurrent prostate cancer and would be helpful in the selection of patients for subsequent external beam radiation therapy.

Adenocarcinoma↗

PubMed1990

Local recurrence and intracerebral spread of squamous cell carcinoma of the scalp.

This case of squamous cell carcinoma of the scalp and malar region highlights the possibilities of therapeutic failure at the excisional, reconstructive, or histopathologic stage despite the performance of the appropriate, clinically indicated procedures and customary close examination of carcinoma patients and specimens. The extent of local recurrence and rapid intracerebral spread emphasize the occasionally aggressive nature of squamous cell carcinoma of the scalp and the need for early excision.

Aged↗

PubMed2005

A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer.

OBJECTIVE: Pancreatic cancer recurrence after initially "curative" resection is an unresolved clinical problem in the management of patients with this disease. Perineural invasion correlates with and might be partially responsible for tumor recurrence and poor survival. However, no adequate preclinical animal model is yet available to study this aspect of pancreatic cancer biology. METHODS: We modified our orthotopic xenograft model of pancreatic cancer in nude mice to develop a model for pancreatic cancer perineural invasion and recurrence. RESULTS: After initial orthotopic transplantation, complete surgical resection of MIA PaCa-2 (undifferentiated) and Capan-2 (well-differentiated) tumors at 4, 6, and 8 weeks was attempted. All animals that had undergone tumor resection survived the operation. Animals that had the MIA PaCa-2 tumor resected after 6 weeks developed recurrent pancreatic cancer with local invasion and distant metastasis. Histological evaluation revealed extensive invasion of retroperitoneal nerves by the cancer cells. CONCLUSION: Complete resection of orthotopically transplanted pancreatic cancer in nude mice leads to local tumor recurrence. This model may eventually prove valuable for studying the mechanisms of pancreatic cancer perineural invasion and recurrence.

Animals↗

PubMed2004

Quantitative DNA measurement in oropharyngeal squamous cell carcinoma and surrounding mucosa.

OBJECTIVE: The appearance of local recurrences, distant metastases and second primary tumors limit the survival rate of patients with head and neck squamous cell carcinomas. The presence of genetic alterations at the resection margins is an indicator of inadequate excision and a predictor of local failure. DESIGN: To receive insight into the genetic abnormalities in the mucosa surrounding oropharyngeal cancers, we performed a quantitative DNA measurement in the primary tumor and the surrounding areas. RESULTS: We found a high level of DNA irregularity in primary tumors. The DNA irregularity decreased in specimens taken at a distance of 1 and 2 cm from the tumor margin. CONCLUSIONS: The genetically altered field is thought to determine the risk for recurrence of a second tumor. We therefore believe that the genetic analysis of tissue surrounding the tumor could become a feasible diagnostic procedure to determine the individual risk for local recurrence or second primary tumors.

Adult↗

PubMed1991

Colorectal cancer: cross-sectional imaging for staging of primary tumor and detection of local recurrence.

This review describes the use of cross-sectional imaging in the staging of colorectal carcinoma and detection of local recurrence. The contributions of CT, MR imaging, and sonography are discussed and illustrated. Colorectal carcinoma is the second most common tumor in the United States and the most common cancer in the gastrointestinal tract. The prognosis for patients with this neoplasm is closely related to the extent of tumor at the time of diagnosis. Accurate noninvasive preoperative assessment of tumor stage by one or a combination of radiologic techniques would enable appropriate treatment to be planned in each case. Also, determination of possible tumor recurrence would permit effective monitoring of success of therapy and surgical intervention for recurrent disease before widespread metastasis occurs.

Colonic Neoplasms↗

PubMedDate not supplied

Diagnostic guided surgical therapy of gastrointestinal cancer.

Stage adapted treatment of gastrointestinal cancer including extended preoperative work-up, multimodal therapeutic options as well as complete tumor resection becomes more important in the last years. Besides conventional tumor staging, the performance of endosonography or surgical laparoscopy seems to be mandatory in planning limited surgical or endoscopic procedures with curative intent as well as preoperative therapy in locally advanced tumors or locoregional recurrences and metastases. Therefore, in modern surgical oncology, diagnostic guided treatment of the individual tumor situation represents the optimal therapy nowadays.

Endosonography↗

PubMed2006

[The long-term prognosis of locally recurrent breast cancer after breast conserving treatment].

OBJECTIVE: To study the long-term prognosis of patients with locally recurrent breast cancer following breast-conserving treatment. DESIGN: Descriptive. METHOD: Data were collected on 266 patients in 11 Dutch centres; in these patients, an isolated local recurrence of an infiltrating mammary carcinoma for which they had received breast-conserving treatment was diagnosed before January 1st, 1994. The median age was 45 years (range 16-81) at the time of treatment of the primary tumour and 49 years (range 17-82) at the time of diagnosis of the local recurrence. The patients were followed through December 2002. The median follow-up after local recurrence of those patients who were still alive was 11.2 years. RESULTS: Of the 226 patients with an infiltrating local recurrence, 148 (65%) had died and 145 (64%) had developed distant metastases. Of the metastases, 61% appeared within 2.5 years and 87% within 5 years after treatment of the local recurrence. 10 years after treatment of the local recurrence, the overall survival rate was 39% (95% CI: 32-46) and the distant metastasis-free survival rate was 36% (95% CI: 29-42). The prognosis of patients with a local recurrence occurring at a different site in the breast was the same as that of patients with a local recurrence < or = 1 cm in diameter occurring at or near the original tumour site. Both of these groups had a better prognosis than patients with a recurrence larger than 1 cm at the site of the original tumour or patients with a diffuse recurrence. CONCLUSION: Almost two-thirds of the patients with an invasive local recurrence following breast-conserving surgery for invasive breast cancer developed distant metastases. Both the exact location in the breast and the size of the local recurrence appeared to be predictors of the risk of subsequent metastatic disease.

Adolescent↗

PubMed1990

[The efficacy of economic operations in breast cancer].

The five- and ten-year results of sparing surgery in 85 cases of T1-2N0,1 breast cancer with tumors less than 3 cm in diameter is discussed. End results were calculated using life table-based dynamic method. The majority of patients with T1-2N0 cancer underwent radical resection alone. In the latter group, five- and ten-year survival rates were 93.4 and 86.1% whereas the rates of relapse-free survival--88.4 and 79.8%, respectively. Local recurrence did not affect survival; median survival in patients with distant metastases was 8 years. Cases of T1-2N1 cancer had worse prognosis.

Adult↗

PubMed1980

Treatment of superficial bladder cancer.

Most patients with bladder cancer initially present with localized, potentially curable tumours. Endoscopic surgery offers the best opportunity to eliminate these early lesions, but the rate of tumour recurrence after adequate resection is high (around 70%). Conventional methods of treatment have a place in the management of early bladder neoplasms, but their success rate is still unsatisfactory and they frequently fail to decrease the risk of recurrence. New drugs and more effective forms of administration have enhanced the use of chemotherapeutic agents. Fundamentally different approaches, such as specific immunotherapy, the use of laser energy and photodynamic therapy, are emerging as valuable approaches in the treatment of superficial bladder cancer and the prevention of recurrence. Randomized trials to assess their value and a concerted multidisciplinary effort with combined treatment give hope for effective control of early bladder cancer.

Aged↗

PubMed1996

Indications for and results of irradiation +/- chemotherapy for rectal cancer.

With mobile rectal cancers, surgery alone is insufficient treatment for most patients with high-risk factors of tumour extension beyond the rectal wall, node involvement, or both in conjunction. While single modality adjuvant treatment with pre- or postoperative irradiation can reduce the incidence of local relapse, a statistically significant impact on survival has not been achieved. Combined modality postoperative chemoirradiation has resulted in both improved disease control (local and distant) and improved survival (disease free and overall). Randomized trials are underway in high-risk patients to determine the most optimal combinations of postoperative chemoirradiation and to compare preoperative versus postoperative chemoirradiation. Standard therapy with surgery, external irradiation, and chemotherapy is often unsuccessful for patients with locally advanced primary cancers that are unresectable for cure or locally recurrent cancers. When intraoperative electron irradiation is combined with standard treatment, encouraging trends are seen with regard to improvements in local control and survival in separate analyses from the Mayo Clinic and the Massachusetts General Hospital. More standard use of systemic therapy is needed as a component of treatment, however, in view of high rates of systemic failure in spite of the locally aggressive treatment regimens.

Antineoplastic Agents↗