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Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant.

In several ancient systems of medicine including Ayurveda, Greek, Roman, Siddha and Unani, Ocimum sanctum has vast number of therapeutic applications such as in cardiopathy, haemopathy, leucoderma, asthma, bronchitis, catarrhal fever, otalgia, hepatopathy, vomiting, lumbago, hiccups, ophthalmia, gastropathy, genitourinary disorders, ringworm, verminosis and skin diseases etc. The present review incorporates the description of O. sanctum plant, its chemical constituents, and various pharmacological activities.

Animals↗

Newer drug treatment in dermatology.

This article deals with a number of newer drugs now being employed in dermatology. The great beneficial role of corticoids both topically and systematically for various inflammatory dermatoses is now amply proved. The addition of a corticoid to a conventional acne lotion renders it much more effective. Nystatin for monilial infections is especially effective in a powder form. For systemic use Griseovulvin, now becoming available, is the most interesting current development in dermatology. Presumably, it is highly effective against ringworm of the hair, nails and skin. The role of synthetic antimalarials in treating chronic discoid lupus erythematosus and light sensitivity eruptions also is firmly established.

Acne Vulgaris↗

Griseofulvin in the mass treatment of tinea capitis.

The prevalence of ringworm of the scalp in many countries, and the fact that many of the current measures to control it are inconvenient for mass use, lend particular interest to the account given in this paper of mass treatment of tinea capitis in an Arab village in Israel. A total of 446 cases were treated, on an ambulatory basis, with a single daily dose (25-30 mg/kg) of griseofulvin, and it was found that clinical cure, confirmed by microscopy, was achieved in 3-6 weeks in the majority. All cases were cured after 10 weeks' treatment.A preliminary study on 25 hospitalized children had previously shown the drug to be effective and apparently safe, the only side-effects encountered in these children and in the Arab village being nausea, furunculosis and drug eruption. No relapses were seen in the 25 children, who were followed up for from two to six months.

Disease↗

A controlled field trial in Yugoslavia of the efficacy of griseofulvin in the mass treatment of tinea capitis.

The introduction of the orally administered antibiotic griseofulvin has wrought a dramatic change in the prospects for controlling ringworm of the scalp. With the assistance of the World Health Organization, a field trial was carried out in Yugoslavia to determine the most suitable schedule of dosage with this drug for mass treatment and to ascertain what measures are necessary to reduce the reservoir of infection to a level where the disease ceases to be a public health problem. The value of supplementing griseofulvin administration by local treatment of the scalp was also investigated.In the endemic area selected for the trial, 495 cases of tinea capitis due to infection with Trichophyton violaceum were detected and treated among a total population of 4106. It was found that a relatively low dose (25 mg of griseofulvin per kg of body-weight, given once a week for 4 weeks) was sufficient to produce clinical cure, confirmed by microscopy, in some 95% of cases, as determined at a resurvey 6 months after the end of the treatment period. Treatment of household contacts of infected persons had no significant influence on the rate of cure. Local treatment of the scalp, on the other hand, did significantly enhance the recovery rate.An unexpected finding was that patients treated in the field trial showed consistently better recovery rates than patients given similar treatment in hospital. A controlled trial to test this finding is planned.

Griseofulvin↗

Appropriate medical care for persons in detention.

The people who are in detention are screened by the Medical Officer of the Prison and if they are found to be unwell, these prisoners will be accommodated in the sickbay and medical treatment will be provided. If their sickness needs further investigations and management, they will be sent to the Government Hospital. If the prisoners are found to have infectious or contagious diseases, steps will be taken to prevent the spread of these diseases to other prisoners in the prison. Prisoners are given time to exercise to maintain good health and their clothing are regularly washed to make sure that they will not contract skin diseases, e.g. scabies, ringworm, etc. The Prison Department since 1989 has increasing numbers of HIV positive prisoners. The Department complies with this problem by sending staff for courses, lectures and seminars so that they will be able to handle these prisoners more efficiently in the prison. When these HIV/AIDS prisoners' condition turns bad, they are usually transferred to a Government Hospital. Another of the Prison Department's prominent medical problem among the prisoners is drug addiction. Staff trained with skill and techniques are counselors for the drug related prisoners. Realizing and in anticipation that the sickbays in the prisons are going to be full of HIV/AIDS prisoners and drug related prisoners, special attention will be given to more allocation to upgrade the sickbays in the prison. White attires will be provided to the sick prisoners in the sickbays so that they will look neat and clean. More doctors, medical assistants and nurses will be employed so that appropriate medical care or rather more appropriate medical care can be provided to the sick prisoners in the prisons. The Prison Department is in the process of privatizing medical care for prisoners in the prison and the Department is also trying to convert some prisons to be medical prisons so that adequate medical care can be given to the sick prisoners.

Delivery of Health Care↗

Trichophyton tonsurans infection of the scalp.

Of 484 cases of ringworm of the scalp observed in a period of two and a half years at a clinic in Los Angeles, 57 (11.78 per cent) were caused by Trichophyton tonsurans, an organism previously considered an infrequent cause of tinea capitis in the United States. The hairs at the site of infection with this organism are distinctively fluorescent when viewed under a Wood light-glowing white rather than green as do hairs infected with microsporum. Endothrix spore formation may be noted in microscopic examination of infected hairs. Material planted on Sabouraud's media grows as a typical crateriform colony. Occasionally variant growths on cultures are obtained. Trichophyton tonsurans may cause either dry, scaly lesions or inflammatory reaction. In the present series the incidence of cure was higher and the period of treatment shorter for patients with the inflammatory variety. Various antifungal preparations were employed for topical application and although the results were extremely variable, it was felt that some benefit was derived from their use. For lesions of the dry, non-inflammatory type, roentgen ray epilation appeared to be the treatment of choice.

Ambulatory Care Facilities↗

Compendium of measures to prevent disease associated with animals in public settings, 2005.

Multiple venues encourage or permit the public to come in contact with animals, resulting in millions of human-animal contacts each year. These settings include county or state fairs, petting zoos, animal swap meets, pet stores, zoologic institutions, circuses, carnivals, farm tours, livestock-birthing exhibits, educational exhibits at schools, and wildlife photo opportunities. Although multiple benefits of human-animal contact exist, infectious diseases, rabies exposures, injuries, and other human health problems associated with these settings are of concern. Rabid or potentially rabid animals in public settings can result in extensive public health investigation and action. Infectious disease outbreaks reported during the previous decade have been attributed to multiple organisms, including Escherichia coli O157:H7, Salmonella, Coxiella burnetti, Mycobacterium tuberculosis, and ringworm. Such incidents have substantial medical, public health, legal, and economic effects. This report provides standardized recommendations for public health officials, veterinarians, animal venue operators, animal exhibitors, visitors to animal venues and exhibits, and others concerned with disease-control and with minimizing risks associated with animals in public settings. The recommendation to wash hands is the single most important prevention step for reducing the risk for disease transmission. Other critical recommendations are that venues include transition areas between animal areas and nonanimal areas (where food is sold) and that animals are properly cared for and managed in public settings. In addition, this report recommends educating venue operators, staff, exhibitors, and visitors regarding the risk for disease transmission where animal contact is possible.

Animal Husbandry↗

Nutritional status and morbidity pattern among governmental primary school children in the Eastern Nepal.

OBJECTIVE: To assess the nutritional status and morbidity pattern of primary school children. METHODS: Descriptive, cross sectional study was administered in the five governmental schools located in Dhankuta town (Dhankuta district) and Ineruwa town (Sunsari district). The schools were selected using simple random sampling technique. From these selected schools, a total number of 818 students studying from Grade I to V were enumerated in the study using census survey method. RESULTS: Among 818 students, 61% of the students were found to be malnourished. The students were more stunted (21.5%) than wasted (10.4%). Only 5.4 % of the students were found to be both wasted and stunted. The collected blood and stool samples from the students revealed parasitic infestation of 65.8% and anaemia of 58%. The most common diseases in those schools were: skin diseases (20%), dental caries (19.8%), and lymphodenopathy (10.5%). Among skin diseases, pediculosis was more common among girls while ringworms and scabies were common among boys. CONCLUSION: The study revealed that high percentage of primary school students was malnourished. It was found that there was a high prevalence of parasitic infestation and anaemia. The study result revealed the urgent need for initiation of school health program with specific emphasis on prevention of diseases, improvement of personal hygiene and nutritional status with the collaboration of governmental and non governmental institutions.

Child↗

Prevention of tinea corporis in collegiate wrestlers.

OBJECTIVE: To examine the role of a comprehensive skin disease prevention protocol in conjunction with the use of a barrier cream to prevent tinea corporis (ringworm) in collegiate wrestlers. DESIGN AND SETTING: We studied a college wrestling team for 16 weeks during 1 season. During the first 8 weeks, no preventive measures were taken. For the remaining 8 weeks, wrestlers were randomized into 2 groups and used either a barrier or a placebo. SUBJECTS: Twenty-two male college wrestlers with a mean age of 20.4 years (range, 18.1 to 23.2), a mean weight of 68.4 kg (range, 55.8 to 130.2), and a mean height of 177.8 cm (range, 168.7 to 186.9). MEASUREMENTS: We performed skin checks daily. All new or exacerbated lesions were clinically diagnosed by the same team physician and recorded. RESULTS: Cases of tinea corporis declined from 10 diagnosed before initiation of the protocol to 1 after the protocol was initiated. One athlete in the placebo group was found to have tinea corporis versus none in the barrier cream group. CONCLUSIONS: Strict adherence to the prevention protocol for skin infections significantly decreased the number of cases of tinea corporis. The use of the barrier cream in conjunction with the prevention protocol did not result in any further statistical reduction in the number of wrestlers who contracted tinea corporis.

Journal Article↗

Favus in a backyard flock of game chickens.

Favus, or avian ringworm, was diagnosed in a backyard flock of game chickens from which Microsporum gallinae was isolated. Infected birds had white crusts on the comb and on the skin of the head and neck. Histopathological lesions included hyperkeratosis of the skin epithelium with invasion of the stratum corneum by fungal mycelia, acanthosis, acantholysis, and hydropic degeneration of cells in the stratum spinosum. The underlying dermis was infiltrated by mononuclear cells and contained lymphoid foci. Daily topical treatment with miconazole was applied in the field and in the laboratory, with apparent success.

Administration, Topical↗

Radiation-induced skin carcinomas of the head and neck.

Radiation exposures to the scalp during childhood for tinea capitis were associated with a fourfold increase in skin cancer, primarily basal cell carcinomas, and a threefold increase in benign skin tumors. Malignant melanoma, however, was not significantly elevated. Overall, 80 neoplasms were identified from an extensive search of the pathology logs of all major hospitals in Israel and computer linkage with the national cancer registry. Radiation dose to the scalp was computed for over 10,000 persons irradiated for ringworm (mean 7 Gy), and incidence rates were contrasted with those observed in 16,000 matched comparison subjects. The relative risk of radiogenic skin cancer did not differ significantly between men or women or by time since exposure; however, risk was greatest following exposures in early childhood. After adjusting for sex, ethnic origin, and attained age, the estimated excess relative risk was 0.7 per Gy and the average excess risk over the current follow-up was 0.31/10(4) PY-Gy. The risk per Gy of radiation-induced skin cancer was intermediate between the high risk found among whites and no risk found among blacks in a similar study conducted in New York City (Shore et al., Radiat. Res. 100, 192-204, 1984). This finding suggests the role that subsequent exposure to uv radiation likely plays in the expression of a potential radiation-induced skin malignancy.

Adolescent↗

Universal ichthyosiform trichophyton violaceum in myxoedema.

In a man aged 29 following thyroidectomy complicated by myxoedema an onychomycotic infection of long duration spread suddenly and fast onto the skin. A serious traffic accident coincided with the insidious onset of myxoedema. The patient was very irregular in taking medicines and continuously on sick pay. Myxoedema worsened and the ringworm progressed into a generalized ichthyosiform--universal mycotic--condition.

Adult↗

Fungi causing dermatophytosis in Lagos, Nigeria.

Dermatophytes of the genera Trichophyton, Microsporum and Epidermophyton were isolated from 162 (41%) of 395 patients with clinical manifestations of ringworm infection reporting at the Lagos University Teaching Hospital, Lagos, Nigeria between January 1986 and December 1987. Of the 162 strains of fungi isolated, 120 (74.1%) were Microsporum species and 7 (4.3%) were Epidermophyton floccosum. Superficial mycosis was most prevalent on the skin (59.3%), followed by that of the hairs (27.2%). Infection of the nails (13.6%) was the least common. Infection occurred in all the age groups with the age group (20 years old and above) having the highest rate of isolation (68.5%) while the age group (5 years and below) had the lowest isolation rate (3.7%).

Adolescent↗

An in vitro human skin model for assaying topical drugs against dermatophytic fungi.

A shortened modification of Dittmar's in vitro human skin assay reliably predicts the efficacy of topical antifungals against ringworm fungi. Cadaver skin was treated with the test agents for 4 or 24 h. After heat separation of the epidermis for one minute at 60 degrees C, the undersurface was point inoculated with a spore suspension of T. mentagrophytes. In untreated skin fluffy, 3 mm colonies develop after 4 to 5 days of incubation. Effective fungistats produce complete inhibition of growth. Commercial formulations of the imidazoles, tolnaftate and ciclopirox were highly effective. Haloprogin, undecylenate, and hydroxyquinoline in proprietary form were inactive. There was a high correspondence between in vitro and in vivo effectiveness. The method should be useful for screening new antifungals and for optimal selection of vehicles.

Administration, Cutaneous↗

Thyroid neoplasia following low-dose radiation in childhood.

The thyroid gland is highly sensitive to the carcinogenic effects of ionizing radiation. Previously, we reported a significant increase of thyroid cancer and adenomas among 10,834 persons in Israel who received radiotherapy to the scalp for ringworm. These findings have now been extended with further follow-up and revised dosimetry. Overall, 98 thyroid tumors were identified among the exposed and 57 among 10,834 nonexposed matched population and 5392 sibling comparison subjects. An estimated thyroid dose of 9 cGy was linked to a fourfold (95% Cl = 2.3-7.9) increase of malignant tumors and a twofold (95% Cl = 1.3-3.0) increase of benign tumors. The dose-response relationship was consistent with linearity. Age was an important modifier of risk with those exposed under 5 years being significantly more prone to develop thyroid tumors than older children. The pattern of radiation risk over time could be described on the basis of a constant multiplication of the background rate, and an absolute risk model was not compatible with the observed data. Overall, the excess relative risk per cGy for thyroid cancer development after childhood exposure is estimated as 0.3, and the absolute excess risk as 13 per 10(6) PY-cGy. For benign tumors the estimated excess relative risk was 0.1 per cGy and the absolute risk was 15 per 10(6) PY-cGy.

Adolescent↗

Tinea capitis caused by Microsporum praecox in a patient with sickle cell anaemia.

Microsporum praecox Rivalier ex Padhye, Ajello et McGinnis is the validated name for the taxon originally published as Sabouraudites praecox Rivalier. We describe here the first case of small-conidial, ectothrix type hair invasion caused by M. praecox in an adult woman from Oklahoma, U.S.A., suffering from sickle cell anaemia. This fungus is now being encountered with greater frequency as an etiologic agent of ringworm infection.

Adult↗