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[Effect of thymus hormones on the capacity of lymphocytes for contact interaction with mast cells].

A study was made of the effect of thymostimulin, a medicine of thymus principles, on immature cells including also mastocyte-affined lymphocytes possessing membranous affinity to mast cells--the influence which may result in contact interaction of the above cell types with the formation of mastocyte-lymphocyte rosettes. The results obtained indicated that under certain conditions thymus principles influenced lymphocyte ability for contact interaction with mast cells.

Adjuvants, Immunologic↗
PubMed1986

Localization of thymostimulin in mouse and rat thymuses.

Anti-bovine thymostimulin serum reacts with reticulo-epithelial cells in the cortex and in the medulla of rat and mouse thymuses. The immuno-reaction is present in a smaller number of cells which have more pallid color than those found in calf thymus. Comparative examination as to the distribution of other thymic factors and as to species-specificity was conducted.

Animals↗
PubMed1985

[Cell proliferation in mouse tissues after thymectomy and the administration of T-activin].

The epithelium of mouse cornea and lymph nodes was examined for DNA-synthetic and mitotic activity at different times after thymectomy and administration of T-activin, an active factor of the thymus. Thymectomy entails retardation of the rate of corneal epithelium regeneration, diminution in both tissues under study of the amplitude of oscillations in cell proliferation throughout the day. Administration to the animals of the immunoactive thymic factor T-activin makes the circadian rhythm of cell proliferation return to normal. It is assumed that T-activin raises the capacity of lymphocytes to interact with epithelial cells, which manifests itself in the enhancement of their mitotic activity.

Animals↗
PubMed1985

[Differentiation characteristics of circulating and bone marrow hematopoietic stem cells and the effect of thymus factors].

Circulating hemopoietic stem cells (HSC) considerably differ from bone marrow HSC in active erythroid differentiation. After thymectomy of adult animals the number and differentiation of blood HSC remain unchanged, whereas during the cloning of bone marrow cells, a decrease in the number of granulocytic colonies is revealed. In in-vitro experiments, thymalin does not influence the number or differentiation of circulating HSC. On the contrary, in experiments made in vivo, it dramatically lowers erythroid specialization of blood HSC in thymectomized and sham-operated mice, which is followed by the diminution of the total number of circulating HSC. Differentiation of thymectomized mice bone marrow stem cells is completely normalized after thymalin injection. Sham-operated and thymectomized animals' HSC stimulated by thymalin injection become similar to bone marrow cells of normal mice as regards the trend of differentiation. Thymalin injection is likely to change the bone marrow HSC differentiation profile, thereby preventing the release of the cells with erythroid-oriented differentiation from the bone marrow to blood. The influence of thymalin on HSC is mediated by the environmental component which is present in the bone marrow and absent from the peripheral blood.

Adjuvants, Immunologic↗