PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Tibia”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 577 records · Page 32Linked to original sources

[Upper metaphyseal lengthening of the tibia. Report of 57 cases in children and adolescents].

INTRODUCTION: The authors reviewed 57 upper metaphyseal lengthenings of the tibia. They especially studied complications in order to evaluate this method. MATERIAL AND METHODS: Fifty seven tibial lengthenings in 47 children and adolescents were reviewed. All lengthenings were performed according to the callotasis technique, using Judet's lengthener in the first 15 cases, the, OF-Garches Orthofix in 42 cases. All the callotasis principles were applied: delayed elongation, 1 mm per day distraction, one month neutralization after elongation period, then dynamization before removing the apparatus. Particularities were: a) metaphyseal osteotomy of the upper tibia, b) screw fixation and osteotomy of the fibula, c) classical dynamization according to De Bastiani and Aldegheri in 29 cases, dynamization by a silastic collar (OF-Dyna-Ring) in 28 cases. METHODS: Severity of complications was classified according to Caton: none, benign, serious (needed reoperation or reanesthesia) and severe (sequel). Complications and rate of lengthenings without complication or with benign complications were studied relative to etiology, age, amount of lengthening and the stage of program in which they occurred. A table summarizes data of all the lengthenings. RESULTS: Lengthening was 52.3 mm in average. Healing time (number of days to lengthen and to fuse the bone divided by the number of lengthened centimeter) was 40 in average (range: 20-105): it was 45.6 days per cm when using classical dynamization and only 34.3 with silastic collar dynamization (p = 0.002). Total of complications was 59 out of 57 lengthenings. 21 complications were benign, 37 serious and 1 severe (partial motor palsy of the foot). Thirty two (56 per cent) lengthenings were performed without unforeseen procedure or anesthesia. There were 4 intra-operative complications: 1 vascular lesion, 1 incomplete osteotomy and 2 malpositioned half screws. Complications of elongation period were the most numerous, 4 transient palsies, 6 knee contractures (2 led to a supracondylar fracture), 6 equinism (4 needed an Achilles tendon lengthening), 12 valgus deviations in which 9 were realigned using OF-Garches fixator without reoperation, 1 serious depression occurred in a bilateral lengthening. Consolidation was achieved without complication in 52 cases. Complications were: 1 refracture (fourth lengthening of the same tibia), 1 delayed union, 1 non-union, 2 late deviations. DISCUSSION: Rate of nervous and joint complications is close to that of other series. However, a high osteotomy decreases the consequences on the foot without increasing knee contracture in flexion. The ability to realign during the elongation period appears to be a prevention of valgus deformity compared to Wagner's technique. The authors's distractor is better tolerated than Ilizarov's. Problems with consolidation are rare, less than 9 per cent of the cases. CONCLUSION: A modular distractor improves the results of tibial lengthening; realignment is possible before, during or after the elongation. OF-Orthofix is easy to apply and well-tolerated by the patient, especially in bilateral lengthenings. Performing a high osteotomy, the callus is thick and the consolidation is quickly achieved and safe. A well-thought dynamization using Orthofix Dyna-Ring decreases the treatment time which is 35 days per centimeter in average.

Adolescent↗

Haemodynamic changes in the rat femur and tibia following femoral vein ligation.

Interference with venous outflow from a limb to stimulate fracture repair and bone growth has a long history, and its beneficial effects have been confirmed by many experimental and clinical studies. With the development of fracture fixation systems, the therapeutic use of circulatory intervention became redundant. Recently, a venous tourniquet effect has been cited to explain the enhancement of bone healing observed after fracture fixation with the Aircast system. As bone appears to be altered by venous stasis, it is important to characterise the vascular perturbations leading to these changes. Previous studies have often given conflicting results. This study investigated the short and long term haemodynamic effects of femoral vein ligation. Changes in blood flow rate and blood volume in the distal femur and proximal tibia of the rat were examined at 6 h and 1, 3 and 7 d following unilateral femoral vein ligation, and at 8 and 16 wk. Blood flows and volumes were generally reduced in the ligated limb 6 h after femoral vein ligation. This initial depression was followed by a relative increase (comparing the ligated limb with the contralateral unoperated bone) in blood volume during the 1st week. A significant relative reduction in epiphyseal vascular space was observed after 16 wk. A sustained reduction of arterial input to whole femora and tibiae was present in the ligated limb throughout the investigation although, for the cancellous knee joint epiphysis of the tibia, a localised relative increase in flow was apparent during the 1st week, again comparing the ligated limb with the nonligated contralateral bone.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Relationships between local circulatory changes in the tibia and kidney of male and female rats after castration and administration of estradiol or testosterone.

The effects of castration and of the four weeks' administration of estradiol or testosterone on the blood circulation in the tibia and the kidney (expressed as the 85Sr-microsphere uptake values, which are not influenced by simultaneous changes in cardiac output) were studied in four experiments on a total of 147 rats (68 females, 79 males), relative weights being noted at the same time. 85Sr-microsphere uptake in the tibia rose markedly after castration in both males and females, fell after estradiol benzoate in intact females and intact and orchidectomized males and also fell after testosterone in intact and oophorectomized females and orchidectomized males. 85Sr-microsphere uptake in the kidney rose after castration only in males in experiments B; it fell after estradiol in orchidectomized males and fell after testosterone in intact females and males and in orchidectomized males. Relative tibial weight fell in castrated females, but in castrated males only in experiment D; after estradiol it rose only in males (intact and orchidectomized) and rose after testosterone in intact and oophorectomized females and orchidectomized males. Relative kidney weight fell after castration in both males and females, rose after estradiol in intact females and intact and orchidectomized males and rose after testosterone in intact and castrated males and females. In all four experiments there was a demonstrable statistically significant correlation between the 85Sr-microsphere uptake values in the tibia and the kidney. The relative weights displayed a similar correlation.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Effect of PEMF on fresh fracture-healing in rat tibia.

The present experiment was designed to find out whether PEMF can act as a healing agent on induced fracture of rat tibia. Eighty rats were taken for this experiment. Under general anaesthesia mid-shaft of tibia and fibula of all rats were osteotomied, Intramedullary nailing was done for proper alignment of the fractured fragments. The animals were then divided into two groups: group-1 and Group-II. Each group contained forty animals. Out of these forty animals twenty were treated as experimental and twenty as control. From the third day of osteotomy, PEMF was applied to experimental rats around the osteotomy sites for a period of nine hours a day. PEMF was not applied to the control rats. The animals of group-1 and group-II were sacrificed after applied one week and three weeks of PEMF, respectively. Radiological and microscopical examination of the callus were performed. Gross and microscopic measurements of the callus were statistically analysed. The growth of callus was taken as a criterion of fracture healing. The results of the present experiment revealed significant enhancement of fracture healing in group-I. The results of the radiological evaluation of group-II experimental animals were also consistent with the morphological analysis. It was concluded that healing of fractured rat tibia was enhanced by the application of PEMF and this effect of PEMF was more pronounced at the end of third week.

Animals↗

[The change of intraosseous pressure in the femur and tibia near knee and knee pain].

The intraosseous pressure (IP) in the femur and tibia near knee of 21 patients with pain of knee region was measured and the arthroscopic examination of their knee joints was performed in past 3 years. The IP of femoral and tibial condyles in these 21 patients were averaged 0.143 +/- 0.011 kPa and 0.180 +/- 0.022 kPa, respectively. There were 16 patients (76.19%) whose IP of femoral condyle was higher than normal value (0.130 +/- 0.024 kPa, P < 0.01) and 18 patients (85.7%) whose IP of tibial condyle was higher than normal (0.105 +/- 0.25 kPa, P < 0.01). The average intracapsular pressure of the knee of 21 patients was 0.135 +/- 0.35 kPa and in 18 of them (85.7%) it was higher than the normal value (0.120 +/- 0.020 kPa, P < 0.01). The results show that increase of IP of the femur and tibia is the cause of pain and pathologic changes of the knee joint. The effect of the change of IP on physiology and pathology of the femur and tibia, the idiopathic intraosseous hypertension at the knee region, the different change of IP in various conditions of the knee, and the treatment and its improvement were discussed.

Adult↗

Stress-protecting effects of semi-rigid titanium alloy plates on osteotomized rabbit tibiae.

We have examined the stress-protecting effects of titanium alloy (Ti-6A1-4V) plates of various thicknesses on osteotomized rabbit tibiae. We used three kinds of plates: One had a load-deflection rate close to that of intact rabbit tibiae (Group A), the other two had rates of one-fourth (Group B) and one-eighth (Group C) that of intact rabbit tibiae. No mechanical failure in the plates was observed, and bone healing occurred by eight weeks after operation in every group. Bone mass at 24 weeks after operation showed significantly less reduction in Groups B and C than in Group A. In biomechanical tests at 24 weeks, maximum energy stored to the maximum load in Group C had recovered significantly more than that of Group A. These findings suggested that it is possible to make a semi-rigid metal plate without using composite materials.

Alloys↗

Cell and matrix reactions at titanium implants in surgically prepared rat tibiae.

The tissue response of rat tibiae to the surgical placement of commercially pure titanium implants was examined at 2, 6, 10, and 28 days. The transcortical placement of 1.5-mm x 2-mm implants resulted in the apposition of threaded implant surfaces within cortical and cancellous regions of the tibia. In all regions, evidence of bone formation was obtained through pre-embedding fracture of the implant from the bone tissue interface. Scanning electron microscopy examination of early responses revealed a fibrin clot and rapid formation of a loosely organized collagenous matrix. Many extravasated blood cells contacted the implant surface. At day 6, a more organized matrix containing many blood vessels opposed the implant surfaces, and few extravasated blood cells remained in contact with the implant surface. By day 10, the surgical wound was filled with woven bone that approximated the contours of the threaded implant. Later, few cells were attached to the retrieved implants. The consolidation of the forming matrix was clearly evident at 28 days. The tissue interface was an amorphous matrix that revealed the surface characteristics of the machined implant. Light microscopic analysis of ground sections indicated that, from day 6 onward, cells morphologically consistent with the osteoblastic phenotype were predominant within the gap between the surgical margin and implant surface. Osteoblastic cells had achieved the formation of an osteoid seam upon which bone formation progressed. The matrix that had formed represented woven bone containing many osteocytes. At day 6, evidence of remodeling was observed at sites distant from the surgical site, and by day 28 osteoclastic activity was observed at trabecular sites adjacent to the implant surface. The rat tibia model provides evidence of rapid formation of bone at implant surfaces.

Animals↗

Leiomyosarcoma of the tibia. Report of a case.

A 48-year-old man with an unremarkable medical history was admitted for a painful swelling over the anteromedial aspect of his right leg. Radiographs disclosed heterogeneity of the proximal tibia, with increased uptake on the bone scan. Computed tomography findings consisted of heterogeneity of the proximal tibial metaphysis and diaphysis with subtle cortical osteolysis, periosteal appositions and soft tissue involvement. Magnetic resonance images showed low signal from the metaphysis, diaphysis and soft tissues on T1 sections that enhanced after gadolinium and converted to high signal on T2 images. Lung metastases were also found. Histologic features were consistent with leiomyosarcoma, which was considered to have originated in the tibia since no other primary localization was found. Combination chemotherapy was successful in eliminating the clinical manifestations and clearing the lung metastases. Six months later, the same chemotherapy regimen failed to improve a local and pulmonary recurrence and the patient died a few months later. Primary leiomyosarcoma of bone is a rare tumor, of which one of the most characteristic locations is the proximal third of the tibia. Magnetic resonance imaging with both T1- and T2-weighted sequences is essential to evaluate intramedullary and soft tissue tumor spread. To our knowledge, there are no characteristic signal patterns allowing to differentiate leiomyosarcoma from other primary malignancies of bone. Immunohistochemical and electron microscope studies are useful diagnostic tools.

Basement Membrane↗

Ultrasound of the tibia--precision error, left versus right sides and correlation with bone mineral density.

Ultrasound of the tibia measures the speed of sound through cortical bone and is a measure of bone density and strength. Ten subjects were measured twice each on the same side by a single operator using the Myriad Soundscan 2000. Intra-operator precision error expressed as CV% was 0.3%. Inter-operator precision error was also found to be 0.3% when results on the same ten subjects by two operators were analysed. Seventy-four subjects had their speed of sound (SOS) measured on both the left and right tibiae by a single operator. The Pearson correlation co-efficient was 0.83. Fifty subjects had their SOS measured as well as their bone mineral density (BMD) determined by dual energy X-ray absorptiometry (DEXA) using the Hologic QDR 2000. BMD measurements were made at the lumbar spine AP view, neck of femur, trochanter, Ward's triangle and total hip. Pearson correlations between these various sites and SOS were as follows: SOS versus BMD AP spine r = 0.61, P < 0.0001; SOS versus neck of femur r = 0.68, P < 0.0001; SOS versus trochanter r = 0.71, P < 0.0001; SOS versus Ward's triangle r = 0.7, P < 0.0001; SOS versus total hip r = 0.67, P < 0.0001. In conclusion, ultrasound of the tibia is a precise and promising tool in the assessment of osteoporosis. Further studies are needed to document its clinical usefulness.

Absorptiometry, Photon↗

Statistical analysis of axial deformity during distraction osteogenesis of the tibia.

In this study, we documented the prevalence of coronal axis malalignment in a series of 93 tibias (from 54 patients) lengthened with monolateral fixation. The average length obtained by distraction osteogenesis was 8.9 cm (range, 3.5-15.6) or 38% of the original bone length (range, 11-78%). Fifty (54%) of 93 tibias had documented valgus angulation of > or = 10 degrees or had fixator manipulation during the lengthening process for undesirable or progressive angulation; no cases of varus angulation were noted. Thirteen (14%) segments had later corrective osteotomy for unsatisfactory valgus malalignment. Statistical analysis revealed two factors to have a significant effect on the rate of malalignment. Those cases that had tibial osteotomy below the proximal one third of the original tibial length and those cases in which the fixator was placed > 5 degrees out of parallel had higher rates of angulation or manipulation (p < 0.001 and p = 0.002). Although the percentage of original bone lengthened was not statistically significant (p = 0.083), it did have an important effect on rates of axial malalignment. From this study we conclude that relatively high rates of malalignment in the tibia during distraction osteogenesis with monolateral external fixation are predominately the result of more distal osteotomies and nonparallel fixator placement. Attention to these details in general, and particularly where long lengthenings are planned, may significantly reduce this common complication.

Adolescent↗

Effects of phytase supplementation on calcium and phosphorus output, production traits and mechanical stability of the tibia in broiler chickens.

A feeding trial was performed using 4 x 60 day-old chickens (Ross 208 cockerels) raised up to 42 days of age to determine whether exogenous phytase addition increases phosphorus utilisation by broiler chickens, and to assess its effects on some production traits as well as on the ash content and mechanical stability of the tibia. The chickens' feed consisted of maize, wheat, soybean meal, fish meal, yeast, and fat powder. The basic feed was supplemented with inorganic phosphorus in groups A and B. In groups C and D, the amount of the inorganic phosphorus supplement (DCP) was decreased by 50%, at the same calcium/phosphorus ratio. The 50% reduction of inorganic phosphorus supplementation represents a 20% decrease of total phosphorus. To the diets of groups B and D a phytase enzyme preparation (Phytase Novo CT) was added. The calculated exogenous phytase activity was 600 FYT/kg feed. The decrease of inorganic phosphorus did not cause significant differences in the daily weight gain but lowered the feed conversion rate by 10%. Calcium and phosphorus excretion decreased by 18% and 15%, and the breaking strength of the tibia was also lower. Phytase supplementation of the feed at a lower rate of inorganic phosphorus supplementation did not cause changes in the body weight gain but improved the feed conversion rate by 5.6%. Phosphorus and calcium output decreased by 21% and 11%, respectively, but chemical composition and mechanical stability of the tibia were unaltered.

6-Phytase↗

A standardized experimental fracture in the mouse tibia.

The increased use of transgenic mice as experimental animals provides new opportunities to study the biology of fracture repair. We have developed a technique for the production of a standard closed experimental fracture in the mouse tibia. A 0.2 mm stainless-steel rod was introduced into the medullary cavity and the pre-nailed tibial shaft was fractured by an impact device, which resulted in a reproducible transverse or slightly oblique fracture pattern. The intramedullary rod maintained axial alignment, and the fractures united without displacement. On the basis of measurements of callus geometry, four-point bending tests, biochemical analyses, and quantitative histology, the progress of callus formation and remodeling occurred in a predictable sequence of healing phases. The ultimate bending loads of the fractures increased with time, reaching 74% of the strength of intact control tibias in 4 weeks. The stiffness values of the fractures returned to normal levels and, as determined radiographically, the fractures united by external callus in 4 weeks. Radiographically, callus size, cross-sectional callus area, and callus mass peaked at 2 weeks and decreased thereafter, indicating the start of external remodeling. Histologically, the amount of mesenchymal tissue was maximal at days 5 and 7. The callus cartilage area peaked at day 9; at its maximum, it accounted for 46% of the total callus area. Early periosteal formation of membranous new bone, followed by endochondral ossification, resulted in a linear increase of callus bone during the healing process. The healing sequence of the mouse tibial fracture was similar to that seen in the rat tibia.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Proximal tibia medial open-wedge osteotomy using plates with wedges: early results in 58 cases.

We evaluated in this study indications, surgical technique, and results of wedge plates for fixation in proximal tibia medial opening wedge osteotomy. Fifty-eight knees in 56 consecutive patients (9 men, 47 women; mean age 52 years; ranging between 36 and 66 years) with medial compartment osteoarthrosis were treated with proximal tibia medial open-wedge osteotomy. For fixation, plates which were designed by the first author and which support the osteotomy surface with wedge-shaped projections were used. The plates were either rectangular in shape with two or four holes or had an inverse "L" shape with four holes, and had bearing metal wedges of varying heights from 5 to 15 mm. Tricortical (n=8) and bicortical (n=43) iliac bone autografts and allografts (n=7) were used. The average follow-up time was 21 months (ranging between 6 and 44 months). The mean preoperative tibiofemoral angle was 4.6 degrees varus (0 degrees -11 degrees ) while it was 5.6 degrees valgus (2 degrees -11 degrees ) postoperatively. The mean preoperative HSS score was 58 (range 51-75) and it was found 89 (range 79-96) postoperatively. As complications, lateral tibial plateau fracture in 5 knees (8.6%) and lateral cortex fracture in 15 knees (25.8%) were encountered during surgery. Deep vein thrombosis in two cases (3.4%) and nonfatal pulmonary embolism in one case (1.7%), delayed wound healing in two knees (3.4%), and delayed union as well as breakdown of a distal screw in one knee (1.7%) were encountered postoperatively. In conclusion, using wedge plates for fixation of proximal tibia medial opening wedge osteotomy in the treatment of medial osteoarthritis with unicompartmental involvement of the knee, provides adequate stabilization to allow early movement for functional rehabilitation and keeps the obtained correction level.

Adult↗

Supramalleolar fatigue fractures of the tibia.

OBJECTIVE: The objective of this paper is to describe fatigue fractures in the supramalleolar area of the tibia. The spectrum of imaging findings in 14 cases is presented, with emphasis on plain film radiographic findings. DESIGN AND PATIENTS: Fourteen patients with fatigue fractures in the supramalleolar area of the distal tibia were seen in a 6-year period. The 13 men and 1 woman had an age range from 14 to 64 years (mean 30 years). These patients had no underlying conditions that would predispose them to fractures. Sequential plain film radiographs and other special imaging studies (technetium-99m scans and computed tomography) were retrospectively reviewed. RESULTS AND CONCLUSIONS: Initial plain film radiographs showed a horizontal linear band of increased density in only 2 cases, a subtle cortical bulge in 5 cases, a focal "graying" of the cortex in 2 cases, a single layer periosteal reaction in 1 case, and no abnormality in the final 4 cases. Technetium-99m scans were done in 11 cases and showed focal areas of increased uptake in all 11. These areas of increased uptake were vertically orientated in 10. One patient had computed tomography showing cortical thickening around a linear lucency. The spectrum of imaging findings is similar to that seen in fatigue fractures in more common locations. Supramalleolar fatigue fractures should be suspected in patients who have pain in the distal tibia even when initial plain film radiographs are normal. When initial radiographs are normal, technetium-99m scans can confirm the diagnosis.

Adolescent↗

Oncogenic osteomalacia presenting as bilateral stress fractures of the tibia.

We report on a patient with bilateral stress fractures of the tibia who subsequently showed classic biochemical features of oncogenic osteomalacia. Conventional radiographs were normal. MR imaging revealed symmetric, bilateral, band-like low-signal lesions perpendicular to the medial cortex of the tibiae and corresponding to the only lesions subsequently seen on the bone scan. A maxillary sinus lesion was subsequently detected and surgically removed resulting in prompt alleviation of symptoms and normalization of hypophosphatemia and low 1,25-(OH)2 vitamin D3. The lesion was pathologically diagnosed as a hemangiopericytoma-like tumor. Patients with oncogenic osteomalacia may present with stress fractures limited to the tibia, as seen in athletes. The clue to the real diagnosis lies in paying close attention to the serum phosphate levels, especially in patients suffering generalized symptoms of weakness and not given to unusual physical activity.

Adult↗

Endoprosthetic replacement of the distal tibia and ankle joint for aggressive bone tumours.

Below knee amputation remains the treatment of choice for most patients with aggressive tumours of the distal tibia. We report the clinical and functional outcome of limb preserving surgery and endoprosthetic reconstruction of the distal tibia and ankle joint in five patients who declined amputation. The mean age was 32 years. Two had osteosarcoma, one Ewing's sarcoma, leiomyosarcoma and Giant cell tumour. Three patients developed significant complications including local recurrence, wound dehiscence and infection, and fibula impingement. Despite these complications the patients declined amputation even in the presence of significant discomfort. Early function was excellent in all patients but deteriorated with time. The patients still maintained an Enneking Score of more than 50%. Some patients are unwilling to undergo amputation for aggressive tumours of the distal tibia. For these, excision and reconstruction with endoprosthesis allow early functional recovery but there is significant medium term morbidity and functional deterioration.

Adult↗

Unreamed tibia nail (UTN) bending: case report and problem solution.

BACKGROUND: An unreamed tibia nail (UTN), implanted for operative stabilization of the tibia after a distal shaft fracture of the lower leg, was bent by excessive load prematurely applied during the healing process, whereby the cross-section-dependent maximum torque permitted in the edge fiber of the UTN during bending load was exceeded. Straightening of the bent, not broken UTN by hand was impossible. Therefore, the bent UTN could only be removed by causing additional damage to the tibia, which is why bending of the nail must be avoided. CONCLUSION: Our analysis shows that modification of the arrangement of the locking holes by 45 degrees increases bending load capacity of the UTN, which can minimize the probability of the occurrence of a bent nail.

Biomechanical Phenomena↗

Concomitant double epiphyseal injuries of the tibia with vascular compromise: a case report.

A rare case of double epiphyseal injuries in the same tibia is reported. A 4-year-old child was struck by a vehicle and presented with the above fractures and vascular compromise to the extremity. Following localization of the vascular occlusion level by arteriography, popliteal vessel anastomosis was attempted. The vascular repair failed, resulting in disarticulation through the knee. Simultaneous displaced proximal and distal epiphyseal injury in the same tibia has not been previously reported in the literature. The most serious complication of injury to the proximal tibia is vascular compromise. A delay in recognition or intervention in such cases can be devastating.

Child, Preschool↗