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PubMed2005

Continuous sorption of copper and cobalt by crab shell particles in a packed column.

The ability of crab shell to remove copper and cobalt from aqueous solutions was examined in an up-flow packed column. The experiments were conducted to study the effect of important design parameters such as bed height and flow rate. At a bed height of 25 cm, metal uptake capacity of crab shell for copper and cobalt was 52.07 and 20.47 mg g(-1) respectively. In addition, the results obtained at different flow rates indicated that an increase in flow rate decreased the sorption performance of the crab shell. The Bed Depth Service Time model and the Thomas model were used to analyze the experimental data and the model parameters were evaluated for copper and cobalt sorption. The column regeneration studies were carried out for five sorption-desorption cycles. Loss of sorption performance was observed as the cycles progressed, indicated by a shortened breakthrough time and a broadened mass transfer zone. However, crab shell maintained a good metal sorption capacity for all the five cycles. The elutant used for the regeneration of the crab shell, 0.01 M EDTA at pH 3.5 adjusted using HCI, exhibited elution efficiencies greater than 98%.

Absorption↗

PubMed2002

The in vitro dissolution of theophylline from different types of hard shell capsules.

The in vitro dissolution of theophylline from two-piece hard shell capsules has been investigated using different types of capsule shells (gelatin, gelatin/polyethylene glycol, hydroxypropyl methylcellulose), different formulations, different capsule fill weights, and different tamping forces. Analysis of variance confirmed that the formulation and the capsule shell materials were the most important factors influencing drug dissolution. The maximum extent of drug dissolution was significantly increased when hydroxypropyl methylcellulose (HPMC) capsules were used. The mean dissolution time (MDT) was significantly reduced, indicating a faster dissolution rate of the drug from HPMC capsules. The addition of microfine cellulose to the formulations as filler reduced the MDT in all cases, whereas the addition of lactose monohydrate did not enhance drug dissolution. The study confirmed that a change from gelatin hard shell capsules to gelatin/PEG or HPMC hard shell capsules should not pose problems with respect to drug absorption or bioavailability.

Administration, Oral↗

PubMed1962

The influence of environment on the shell structure of starch granules.

It is well known from light microscope studies of potato starch that the granules formed in a constant environment (of light and temperature) have a ring formation indistinguishable from that of granules formed under field conditions. Electron microscope studies have confirmed that normal potato starch granules have a fine shell structure not usually resolved by the light microscope, and also that shells do not develop in barley granules grown in a constant environment. The paper presented here reports a further study of the dependence of shell formation on environment. Potatoes were grown in a constant environment and starch granules from the newly formed tubers were examined in the light microscope, and in the electron microscope after corrosion by acid. No difference between these granules and normal granules was observed; both wide (light microscope) rings and fine lamellae developed in both granules. Parallel studies were made on wheat starch granules. In this case, shells were not differentiated in granules that developed in a constant environment, but they could be produced at will by imposing a dark period. Thus, shell formation in potato granules must be controlled by an endogenous rhythm, whereas in wheat granules it must be controlled by external environment.

Electrons↗

PubMed2006

Clathrate hydrates of oxidants in the ice shell of Europa.

Europa's icy surface is radiolytically modified by high-energy electrons and ions, and photolytically modified by solar ultraviolet photons. Observations from the Galileo Near Infrared Mapping Spectrometer, ground-based telescopes, the International Ultraviolet Explorer, and the Hubble Space Telescope, along with laboratory experiment results, indicate that the production of oxidants, such as H2O2, O2, CO2, and SO2, is a consequence of the surface radiolytic chemistry. Once created, some of the products may be entrained deeper into the ice shell through impact gardening or other resurfacing processes. The temperature and pressure environments of regions within the europan hydrosphere are expected to permit the formation of mixed clathrate compounds. The formation of carbon dioxide and sulfur dioxide clathrates has been examined in some detail. Here we add to this analysis by considering oxidants produced radiolytically on the surface of Europa. Our results indicate that the bulk ice shell could have a approximately 1.7-7.6% by number contamination of oxidants resulting from radiolysis at the surface. Oxidant-hosting clathrates would consequently make up approximately 12-53% of the ice shell by number relative to ice, if oxidants were entrained throughout. We examine, in brief, the consequences of such contamination on bulk ice shell thickness and find that clathrate formation could lead to substantially thinner ice shells on Europa than otherwise expected. Finally, we propose that double occupancy of clathrate cages by O2 molecules could serve as an explanation for the observation of condensed-phase O2 on Europa. Clathrate-sealed, gas-filled bubbles in the near surface ice could also provide an effective trapping mechanism, though they cannot explain the 5771 A (O2)2 absorption.

Ice↗

PubMed2006

Overview and summary of the Food Safety and Inspection Service risk assessment for Salmonella enteritidis in shell eggs, October 2005.

In 1998, the United States Department of Agriculture's Food Safety and Inspection Service (FSIS) and the Food and Drug Administration completed a risk assessment that indicated multiple interventions along the farm-to-table chain were needed to reduce the risk of human illness from Salmonella Enteritidis in shell eggs. Based on newly available data and improved modeling techniques, FSIS completed an updated risk assessment to examine the effect of pasteurization and refrigeration on reducing human illnesses from S. Enteritidis in shell eggs. The risk assessment model was written in Visual Basic for Applications (Microsoft, Redmond, WA) and run using Monte Carlo methods. The model estimated that if all shell eggs produced in the United States were pasteurized for a 3-log10 reduction of S. Enteritidis, the annual number of illnesses from S. Enteritidis in eggs would decrease from approximately 130,000 to 40,000. Pasteurization for a 5-log10 reduction of S. Enteritidis was estimated to reduce the annual number of illnesses to 19,000. The model also estimated that if all eggs produced in the United States were stored and held at 7.2 degrees C within 12 hours of lay, the annual number of illnesses from S. Enteritidis in eggs would decrease from 130,000 to 28,000. As a result, rapid cooling and pasteurization of shell eggs were predicted to be highly effective mitigations for reducing illnesses from consumption of S. Enteritidis in shell eggs.

Animals↗

PubMed2002

Acid-induced movements in the glycoprotein shell of an alphavirus turn the spikes into membrane fusion mode.

In the icosahedral (T = 4) Semliki Forest virus, the envelope protomers, i.e. E1-E2 heterodimers, make one-to-one interactions with capsid proteins below the viral lipid bilayer, transverse the membrane and form an external glycoprotein shell with projections. The shell is organized by protomer domains interacting as hexamers and pentamers around shell openings at icosahedral 2- and 5-fold axes, respectively, and the projections by other domains associating as trimers at 3- and quasi 3-fold axes. We show here, using cryo- electron microscopy, that low pH, as occurs in the endosomes during virus uptake, results in the relaxation of protomer interactions around the 2- and the 5-fold axes in the shell, and movement of protomers towards 3- and quasi 3-fold axes in a way that reciprocally relocates their putative E1 and E2 domains. This seemed to be facilitated by a trimerization of transmembrane segments at the same axes. The alterations observed help to explain several key features of the spike-mediated membrane fusion reaction, including shell dissolution, heterodimer dissociation, fusion peptide exposure and E1 homotrimerization.

Alkanesulfonic Acids↗

PubMed1997

Comparative study of cytomegalovirus (CMV) antigenemia assay, polymerase chain reaction, serology, and shell vial assay in the early diagnosis and monitoring of CMV infection after renal transplantation.

BACKGROUND: Early diagnosis of cytomegalovirus (CMV) infection, which is an important cause of morbidity and mortality in renal transplant recipients, remains of great importance. This prospective study was performed in kidney transplant recipients to determine the diagnostic value of the CMV antigenemia assay in comparison with polymerase chain reaction (PCR), serology, and shell vial assay. METHODS: Seventy-five consecutive renal transplant recipients were enrolled in this study and monitored by both antigenemia assay and serology. The initial 34 of the 75 patients were subjected to PCR and shell vial assay. RESULTS: Antigenemia, PCR, and shell vial assay became positive before the onset of CMV-related symptoms in 31/34 (89%), 13/16 (81%), and 2/16 (13%), respectively. None of the 34 patients who had symptomatic CMV disease showed a significant increase in IgG or IgM before the onset of symptoms. Antigenemia and PCR assays turned positive, 7 and 11 days (median), respectively, before the onset of clinical symptoms. Serology and shell vial assay became positive 21 and 25 days (median), respectively, after the onset of CMV-related clinical symptoms. To examine the clinical value of these assays, "good correlation" was defined based on the correlation between the clinical course and the results of the assays. Good correlation with the antigenemia assay was observed in 33 (96%) out of 34 renal transplant recipients who recovered from their CMV disease after ganciclovir therapy. Only one of 16 (7%) patients showed good correlation by shell vial assay, whereas PCR and serology did not show a good correlation. Consequently, antigenemia was considered the best way to monitor CMV infections after kidney transplantation. CONCLUSIONS: Only the CMV antigenemia assay can be successfully employed after renal transplantation for the early diagnosis and extensive monitoring of active CMV infection.

Adolescent↗

PubMed2003

Dollo's law and the re-evolution of shell coiling.

Gastropods have lost the quintessential snail feature, the coiled shell, numerous times in evolution. In many cases these animals have developed a limpet morphology with a cap-shaped shell and a large foot. Limpets thrive in marginal habitats such as hydrothermal vents, the high-energy rocky intertidal areas and fresh water, but they are considered to be evolutionary dead-ends, unable to re-evolve a coiled shell and therefore unable to give rise to the diversity seen among coiled snails. The re-evolution of a coiled shell, or any complex character, is considered unlikely or impossible (Dollo's law) because the loss of the character is followed by the loss of the genetic architecture and developmental mechanisms that underlie that character. Here, we quantify the level of coiling in calyptraeids, a family of mostly uncoiled limpets, and show that coiled shells have re-evolved at least once within this family. These results are the first demonstration, to our knowledge, of the re-evolution of coiling in a gastropod, and show that the developmental features underlying coiling have not been lost during 20-100 Myr of uncoiled evolutionary history. This is the first example of the re-evolution of a complex character via a change in developmental timing (heterochrony) rather than a change in location of gene expression (heterotopy).

Adaptation, Biological↗

PubMed1995

The 25 amino acid residues at the carboxy terminus of the herpes simplex virus type 1 UL26.5 protein are required for the formation of the capsid shell around the scaffold.

Herpes simplex virus type 1 (HSV-1) polypeptides specified by overlapping genes UL26 and UL26.5 form a scaffold around which the icosahedral capsid shell is assembled. In a series of cleavage events catalysed by the UL26-encoded protease, the full-length UL26 product is processed into capsid proteins VP24 and VP21 and the UL26.5 protein is converted into the capsid protein VP22a by the loss of 25 amino acids from its carboxy terminus. The roles of the UL26 and UL26.5 products were investigated using the baculovirus expression system, focusing on the function of the 25 residues cleaved from the UL26.5 protein. A key conclusion from electron microscopic analysis and protein expression studies is that the 25 amino acids at the carboxy terminus of the full-length UL26.5 protein are required for the interaction of the capsid shell proteins with the scaffold in the formation of intermediate capsids. When cells were multiply infected with baculoviruses expressing a truncated form of the UL26.5 product corresponding to VP22a and the essential components of the capsid shell, no capsids were detected, whereas large numbers of capsids were observed when the full-length UL26.5 product was used as a scaffold. The results are consistent with the proposal that cleavage of the UL26.5 product occurs after capsid assembly or when the UL26.5 protein is in a complex with one or more capsid shell proteins. Expression of VP22a in the absence or presence of capsid shell proteins resulted in the formation of large numbers of 60 nm scaffold-like particles. Since VP22a expressed from baculovirus was unable to participate in capsid assembly, these particles cannot be intermediates in the capsid assembly pathway but may be similar in structure to the protein cores present in HSV-1 immature (B) capsids.

Amino Acid Sequence↗

PubMed2002

Quasisolitons and asymptotic multiscaling in shell models of turbulence.

A variation principle is suggested to find self-similar solitary solutions (referred to as solitons) of shell model of turbulence. For the Sabra shell model the shape of the solitons is approximated by rational trial functions with relative accuracy of O(10(-3)). It is found how the soliton shape, propagation time t(n) (from a shell n to shells with n --> infinity), and the dynamical exponent z(0) (which governs the time rescaling of the solitons in different shells) depend on parameters of the model. For a finite interval of z the author discovered quasisolitons which approximate with high accuracy corresponding self-similar equations for an interval of times from -infinity to some time in the vicinity of the peak maximum or even after it. The conjecture is that the trajectories in the vicinity of the quasisolitons (with continuous spectra of z) provide an essential contribution to the multiscaling statistics of high-order correlation functions, referred to in the paper as an asymptotic multiscaling. This contribution may be even more important than that of the trajectories in the vicinity of the exact soliton with a fixed value z(0). Moreover there are no solitons in some regions of the parameters where quasisolitons provide a dominant contribution to the asymptotic multiscaling.

Journal Article↗

PubMed2003

Implosion of indirectly driven reentrant-cone shell target.

We have examined the implosion of an indirectly driven reentrant-cone shell target to clarify the issues attendant on compressing fuel for a fast ignition target. The target design is the hydrodynamic equivalent of a NIF cryoignition target scaled to be driven by Omega. Implosions were imaged with backlit x radiographs and modeled with LASNEX. The simulations were generally in good agreement with the experiments with respect to the shell diameter, density, and symmetry, but did not show the prestagnation central absorption maximum. The existence of material between the original cone and the shell is sensitive to gold M-band radiation, which penetrates the shell and ablates gold from the cone. The simulated radiographs using recently measured M-band fractions showed absorption between the cone and shell similar to the experiment. This gold ablation might be a problem in a cryoignition target.

Journal Article↗

PubMed2001

Frequency-dependent open-circuit acoustic sensitivity of fluid-filled, coated, radially polarized piezoelectric ceramic cylindrical shells of arbitrary thickness and infinite length.

The frequency-dependent free-field open-circuit voltage generated by radially polarized piezoelectric ceramic fluid-filled shells of infinite length coated with an elastic layer and excited by a plane acoustic wave is studied. The shell and the coating are of arbitrary thickness and are anisotropic. It is shown that the charge density in the piezoelectric shell is zero by using the electrostatic and open-circuit conditions. General expressions for the pressures and radial velocities in the interior and exterior fluids are obtained by using the finiteness and radiation conditions, respectively. General expressions for the radial stresses and velocities in the piezoelectric shell and elastic coating are also determined by using two-dimensional equations of state and axisymmetric equations of motion. The coefficients in the general expressions are then determined by using the continuity conditions at the various interfaces. Finally, an expression for the open-circuit sensitivity is obtained by using a piezoelectric equation of state. Numerical results are presented for air, water, and vacuum in the interior, two types of elastic coating, and piezoelectric shells with various thicknesses. The effect of neglecting anisotropy on the sensitivity is also illustrated.

Journal Article↗

PubMed1991

Corneal hazards in use of Simmons shell.

A Simmons tamponade shell was used in 10 cases of post-trabeculectomy overfiltration leading to shallow (iridocorneal touch) or flat anterior chamber. The Simmons shell was an unqualified success in only three cases. Corneal abscess (one case) and corneal abrasion/epithelial loss (four cases) necessitated premature removal of the shell. Three of the patients with corneal abrasions had a formed anterior chamber at the time of shell removal but this shallowed again within 12 hours. Two of these required surgical reformation of the anterior chamber and one reformed spontaneously. Air entrapment causing corneal dessication was probably responsible for the abrasion/epithelial loss. The patient who developed a corneal abscess was grossly malnourished. Use of the Simmons shell needs close monitoring and it should be removed at the first sign of corneal toxicity (abrasion/epithelial loss). Extreme care is necessary in malnourished cases.

Adolescent↗

PubMed1994

Immunohistochemical characterization of the shell and core territories of the nucleus accumbens in the rat.

The nucleus accumbens in the rat has been parcelled into shell and core subdivisions. Despite accumulating evidence for such a division of the nucleus accumbens, these territories have not been delineated throughout the rostrocaudal extent of the nucleus. In the present study, an attempt has been made to delineate the shell and core using the distribution of calcium-binding protein immunoreactivity, substance P immunoreactivity and acetylcholinesterase activity in transverse and horizontal sections through the nucleus accumbens. It was found that the pattern of calcium-binding protein immunoreactivity provides the most unequivocal criterion to divide the nucleus accumbens into a ventral and medial, peripheral shell displaying low to moderate immunostaining, and a more laterally and dorsally located, strongly stained inner core. In most parts of the nucleus, borders seen in the calcium-binding protein immunoreactivity pattern can also be recognized in the distributions of substance P immunoreactivity and acetylcholinesterase activity. It is concluded that the shell occupies most of the rostral part of the nucleus accumbens, whereas rostrally the core is represented only in the most lateral part. Differences in staining intensities for all three markers indicate that both the shell and core have a heterogeneous structure. Patterns of connectivity appear to support the division of the nucleus accumbens as indicated by calcium-binding protein immunoreactivity in the present study.

Acetylcholinesterase↗

PubMed2005

Double dissociation of the effects of selective nucleus accumbens core and shell lesions on impulsive-choice behaviour and salience learning in rats.

The nucleus accumbens can be subdivided into at least two anatomically distinct subregions: a dorsolateral 'core' and a ventromedial 'shell', and this distinction may extend to a functional dissociation. Here, we contrasted the effects of selective excitotoxic core and medial shell lesions on impulsive-choice behaviour using a delayed reward choice paradigm and a differential reward for low rates of responding (DRL) test, against a form of salience learning known as latent inhibition (LI). Core lesions led to enhanced impulsive choices as evidenced by a more pronounced shift from choosing a continuously reinforced lever to a partially reinforced lever, when a delay between lever press and reward delivery was imposed selectively on the former. The core lesions also impaired performance on a DRL task that required withholding the response for a fixed period of time in order to earn a reward. Medial shell lesions had no effect on these two tasks, but abolished the LI effect, as revealed by the failure of stimulus pre-exposure to retard subsequent conditioning to that stimulus in an active avoidance procedure in the lesioned animals. As expected, selective core lesions spared LI. The double dissociations demonstrated here support a functional segregation between nucleus accumbens core and shell, and add weight to the hypothesis that the core, but not the shell, subregion of the nucleus accumbens is preferentially involved in the control of choice behaviour under delayed reinforcement conditions and in the inhibitory control of goal-directed behaviour.

Animals↗

PubMed2001

Leaky helical flexural wave scattering contributions from tilted cylindrical shells: ray theory and wave-vector anisotropy.

At sufficiently high frequencies, cylindrical shells support a wave whose properties are analogous to those of the lowest antisymmetric Lamb wave on plates. When the shell is in water and the frequency exceeds the coincidence frequency, the flexural wave is a leaky wave that can be a major contributor to the scattering by tilted shells [G. Kaduchak, C. M. Wassmuth, and C. M. Loeffler, J. Acoust. Soc. Am. 100, 64-71 (1996)]. While the meridional ray-scattering contributions for such leaky flexural waves were previously modeled, the helical contribution can also be significant. A ray theory for those contributions is compared with the exact partial wave series (PWS) solution for infinitely long empty shells. The agreement between the ray theory and the PWS is only possible when a weak anisotropy of the flexural wave parameters is included in the evaluation of the ray theory. The anisotropy is determined numerically from the roots of a denominator in the PWS because approximations for the anisotropy from thin-shell mechanics are not applicable significantly above the coincidence frequency.

Journal Article↗

PubMed2002

Scattering and active acoustic control from a submerged spherical shell.

This paper is concerned with the scattering from a submerged (heavy fluid) bilaminate spherical shell composed of an outer layer of steel, and an inner layer of radially polarized piezoelectric material. The methodology used includes separation formulas for the stresses and displacements, which in turn are used (coupled with spherical harmonics) to reduce the governing equations to linear systems of ordinary differential equations. This technique uses the full equations of elasticity rather than any of the various thin-shell approximations in determining the axisymmetric scattering from a shell, normal modes of vibration for the shell, as well as voltages necessary for annihilation of a scattered pressure due to insonification of the shell by an incident plane wave.

Acoustics↗

PubMed2002

A systematic study of water-filled submerged elastic spherical shells and the resolution of elastic- and water-included resonances.

Water-filled elastic shells present more complicated backscattered echoes when compared to evacuated shells and are less well understood. The objective here is to determine and explain features peculiar to such objects and to use these features to aid in object characterization. Towards that end, an acoustic background suitable for such targets in conjunction with "residual" partial wave analysis obtained from subtracting the background from the elastic response is used. This analysis is aided by the determination and comparison of plate modes and resonance locations of evacuated unloaded, evacuated loaded, and loaded water-filled shells. Analysis of water-filled shells suggests that there exist isolated narrow, uniformly spaced eigenmodes in addition to the elastic modes. The broader elastic modes appear split in comparison to their unloaded counterparts. Otherwise, the elastic modes are not greatly affected by the included eigenmodes. The isolated (included) eigenmodes are extremely well modeled by a water inclusion in an infinite elastic matrix composed of the elastic shell material. The splitting of elastic modes proves to be due to interference of the included eigenmodes and the elastic body resonances. This leads to what appear to be separate branches of dispersion curves related to the elastic modes. Because of the numerous and usually evenly spaced included eigenmodes, dispersion curves are dominated by the abundance of these modes. A clear picture of the physical processes emerges from this analysis that explains all features of this event. Simple sets of rules that lead to tractable calculations are introduced that facilitate analysis of this interesting physical process.

Journal Article↗