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At least 595 records · Page 33Linked to original sources
PubMed1984

Postnatal modification of hippocampal circuitry alters avoidance learning in adult rats.

In rats and mice, the genetically mediated extent of the mossy fiber projection that synapses on the basal dendrites of hippocampal pyramidal cells is inversely correlated with rate of two-way avoidance (shuttle-box) learning. Postnatal hyperthyroidism, induced in 51 rat pups, resulted in marked variations of this infrapyramidal mossy fiber projection. The number of trials required for criterion performance of these rats in adulthood remained correlated with the neuroanatomical trait (r = 0.74, P less than 0.0001).

Animals↗
PubMed1983

Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning.

Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease.

Acetylcholine↗
PubMed1995

Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning.

Carbon monoxide (CO), produced through the action of haem oxygenase (HO) isoenzymes, has been recently postulated as a retrograde messenger in the early stages of long-term potentiation (LTP). In the present study, rats submitted to an inhibitory avoidance task there is a significant increase (+76%) in hippocampal HO activity immediately after training (0 min), but not at 60 min post-training. No changes were observed in cerebral cortical and cerebellar HO activity. Bilateral intrahippocampal infusion of the HO inhibitor zinc-protoporphyrin-IX (ZnPP) (2 micrograms side-1) caused full amnesia for inhibitory avoidance when given 10 min before training or immediately after training, but not 60 min after training. These findings provide evidence that CO production in the hippocampus is important for the early stages of memory processing of an inhibitory avoidance training.

Animals↗
PubMed1998

Inhibitory avoidance learning inhibits ectonucleotidases activities in hippocampal synaptosomes of adult rats.

Several lines of evidence indicate that ATP may play an important role in Long-Term Potentiation. In this investigation we evaluated the effect of a memory task (step-down inhibitory avoidance) on the synaptosomal ecto-enzymes (ATP diphosphohydrolase and 5'-nucleotidase) involved in the degradation of ATP to adenosine. After the training session, a decrease in the ATPase (40%) and ADPase (29%) activities of ATP diphosphohydrolase as well as was a decrease in 5'-nucleotidase activity (31%) was observed in hippocampal synaptosomes of rats trained and killed immediately after training. In synaptosomes of rats killed 30 minutes after training, a decrease in ATPase activity (28%) was observed. In the test session, no significant changes were observed in the enzyme activities studied. These results provide new information about the activity of ecto-enzymes involved in nucleotide degradation and their possible participation in mechanisms of acquisition and modulation of memory processing.

5'-Nucleotidase↗
PubMed1992

Differences in one-way active avoidance learning in mice of three inbred strains.

DBA/2J, C57BL/6J, and C3H/HeJ mice were given 10 one-way avoidance training trials per day, using an unconditioned stimulus intensity that provided equivalent motivation for learning to mice of all three strains, and were found to differ in their abilities to learn and retain the response. DBA/2J mice acquired the response in fewer days than did the mice of the other two strains, although C57BL/6J mice eventually reached a level of performance similar to that of DBA/2J mice. Both the rate of acquisition and the level at which avoidance performance stabilized were significantly lower in C3H/HeJ, than in DBA/2J or C57BL/6J, mice. In addition, DBA/2J mice showed a significantly greater task retention from one testing day to the next than did C57BL/6J or C3H/HeJ mice.

Animals↗
PubMed2000

Molecular signalling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats.

Rats were implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus, the entorhinal cortex, anterior cingulate cortex, posterior parietal cortex, or the basolateral complex of the amygdala. The animals were trained in one-trial step-down inhibitory avoidance and tested 24 h later. Prior (10 min) to the retention test, through the cannulae, they received 0.5 microl infusions of a vehicle (2% dimethylsulfoxide in saline), or of the following drugs dissolved in the vehicle: the glutamate NMDA receptor blocker, aminophosphonopentanoic acid (AP5, 2.0 or 5.0 microg), the AMPA receptor blocker, 6,7-dinitroquinoxaline-2,3 (1H,4H)dione (DNQX, 0.4 or 1.0 microg), the metabotropic receptor antagonist, methylcarboxyphenylglycine (MCPG, 0.5 or 2.5 microg), the inhibitor of cAMP-dependent protein kinase (PKA), Rp-cAMPs (0.1 or 0.5 microg), the PKA stimulant, Sp-cAMPs (0.5 microg), or the inhibitor of the mitogen-activated protein kinase (MAPK), PD098059 (10 or 50 microM). All these drugs, at the same doses, had been previously found to alter long-term memory formation of this task. Here, retrieval test performance was blocked by DNQX, MCPG, Rp-cAMPs and PD098059 and enhanced by Sp-cAMPs infused into CA1 or the entorhinal cortex. The drugs had similar effects when infused into the parietal or anterior cingulate cortex, except that in these two areas AP5 also blocked retrieval, and in the cingulate cortex DNQX had no effect. Infusions into the basolateral amygdala were ineffective except for DNQX, which hindered retrieval. None of the treatments that affected retrieval had any influence on performance in an open field or in a plus maze; therefore, their effect on retention testing can not be attributed to an influence on locomotion, exploration or anxiety. The results indicate that the four cortical regions studied participate actively in, and are necessary for, retrieval of the one-trial avoidance task. They require metabotropic and/or NMDA glutamate receptors and PKA and MAPK activity. In contrast, the basolateral amygdala appears to participate only through a maintenance of its regular excitatory transmission mediated by glutamate AMPA receptors.

2-Amino-5-phosphonovalerate↗
PubMed1981

Chloramphenicol administration during brain development: impairment of avoidance learning in adulthood.

Rats treated with chloramphenicol from days 7 to 21 of intrauterine life (50 milligrams per kilogram per day, injected subcutaneously into the mothers) or in the first 3 days of extrauterine life (50 to 100 milligrams per kilogram per day) were trained for avoidance conditioning when 60 days old. The acquisition of the avoidance response was impaired to a highly significant degree in all the treated groups.

Aging↗
PubMed1993

A peptide muscarinic toxin from the Green Mamba venom shows agonist-like action in an inhibitory avoidance learning task.

A peptide, muscarinic toxin 2 (MTX2), isolated from Dendroaspis angusticeps venom was previously shown to displace the specific binding of [3H]pirenzepine, a muscarinic M1 receptor ligand, from rat brain synaptosomal membranes. We have tested MTX2 for muscarinic agonist or antagonist actions in an inhibitory avoidance task in rats. Infusion of the muscarinic receptor antagonist scopolamine into the hippocampus of rats immediately after the training period produced amnesia, whereas the muscarinic agonist oxotremorine increased retention. When MTX2 was injected into the hippocampus of rats after the inhibitory avoidance task, it caused memory facilitation, which could be suppressed by the concomitant infusion of scopolamine. Hence, in this test, MTX2 showed muscarinic receptor agonist-like actions, which are probably mediated by the M1 subtype of muscarinic acetylcholine receptors.

Animals↗
PubMed1988

Passive avoidance learning produces focal elevation of bursting activity in the chick brain: amnesia abolishes the increase.

Presentation of a bright bead to day-old chicks (Gallus domesticus: Ross 1 Chunky Chicks) elicits spontaneous pecking. If the bead is coated with an aversive substance (e.g., methylanthranilate), they will avoid similar beads subsequently; if it is coated with water, they peck avidly on re-presentation. Formation of a memory for this one-trial passive avoidance task is unaffected by subconvulsive transcranial electroshock when applied 10 min after training in 60% of birds, whereas "immediate" post-training electroshock renders 63% of chicks amnesic. Memory formation and retention is associated with a large bilateral enhancement in trained over control chicks (320 and 350% in left and right hemispheres, respectively; p less than 0.001) of a particular spontaneous multi-unit activity firing pattern, that is, short-duration (15-40 ms) bursts of large-amplitude (greater than or equal to 200 microV, 450 microV max p-p), high-frequency (400-450 Hz) spiking in anesthetized chicks. This effect is observed in data lumped from 1-13 h after training and is restricted to the intermediate medial hyperstriatum ventrale. When chicks are rendered amnesic by electroshock immediately following training, there is a complete abolition of this increase in burst firing; in those chicks where this treatment fails to elicit amnesia, the increase in bursting is still observed. In birds in which the shock is delayed and memory formation occurs, the increase in bursting activity is maintained; however, if the delayed shock produces apparent amnesia, then the increase is once again abolished. The electroshock had no effect on bursting per se in untrained chicks. There was no significant difference in tonic spiking between the chicks. A marked increase in the occurrence of bursting epochs in the IMHV of anesthetized chicks following passive avoidance training is therefore closely associated with memory formation, but not with the nonspecific concomitants of the training procedure.

Amnesia↗