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At least 595 records · Page 33Linked to original sources
PubMed1976

The granulation of binary mixtures: the effects of the properties of the component powders on granules.

Sulphanilamide and citric acid individually and in various proportions with lactose, have been granulated by massing and screening. There was an optimum blend, that produced granules of maximum mean size and strength, for each binary system examined. The proportion of the components of this optimal blend was dependent on the physical properties of the second component in a mixture with lactose. Results from three systems, lactose:boric acid, lactose:sulphanilamide and lactose:citric acid indicate that although part dissolution of powder during granulation is a factor affecting granule properties, in some systems other physical properties of the second component may become dominant. It is suggested that the combined effect of cohesiveness and wettability of the powders may make the major contribution to granule strength with the sulphanilamide systems. The ultimate mean granule size produced is determined by the wettability or solubiluty of the powders, or both, in all cases examined. The great affinity of citric acid for aqueous binder solution was the dominant factor determining the properties of granules prepared from lactose:citric acid mixtures.

Boric Acids↗
PubMed1998

Effect of chemical nutrients on aconitase activity during citric acid fermentation by a mutant strain of Aspergillus niger.

An ethyleneimine and UV irradiated mutant strain Aspergillus niger AB 1801 was explored for its aconitase activity, citric acid production and cell growth during citric acid fermentation. 10% sucrose and 0.25% urea served as the best carbon and nitrogen sources, respectively. Fe2+ stimulated aconitase activity and Co2+ (upto 5 micrograms/mL) and Ni2+ (10 micrograms/mL) strongly depressed enzyme activity. Boric acid (0.5 mg/L) had very good stimulatory response towards citric acid production. Aconitase activity has been found to vary inversely with the citric acid production upto a certain limit after which the activity was absent in the mycelial extract. Cell growth varied with the production parameter.

Aconitate Hydratase↗
PubMed1991

[Principles of conservative treatment of trophic leg ulcers].

Long-term experience gained in the treatment of 647 patients suffering from trophic ulcer of the leg due to chronic venous insufficiency led the author to the conclusion on minimal benefit of chemotherapy in the treatment of the condition. Good therapeutic effect was achieved with enzymes used for cleansing purposes and local elastic compression of the leg with 3% boric acid solution fomentation. Epithelialization ++ of the ulcer occurred in 86.2% of the patients.

Administration, Cutaneous↗
PubMed1976

The preparation of simulated water samples for the purpose of bacteriological quality control.

As part of the bacteriological quality control programme of the Public Health Laboratory Service, we were asked to investigate the possibility of providing simulated water samples for distribution to the laboratories. For this purpose it was necessary to find some means whereby suspensions of coliform organisms and Escherichia coli could be kept relatively stable in number at room temperature for a period of 7-10 days. This, it was finally found, was best achieved by adding selected strains of the organisms to improved formate lactose glutamate medium (Gray, 1964) without the lactose but with added boric acid to a final concentration of 1-8%. The procedures adopted in the successful quality control programme are described.

Boric Acids↗
PubMedDate not supplied

Recurrent vulvovaginal candidiasis.

Recurrent vulvovaginal candidiasis affects five percent of women of child-bearing age. The most common organism is Candidia albicans, but an increasing number of infections are caused by nonalbicans species. Fungal culture directs treatment as nonalbicans species may be azole resistant. C. albicans will respond to anyazole antifungal. Treat C. glabrata with boric acid. Maintenance therapy should be started immediately after treatment of the acute episode and should last for six months.

Acute Disease↗
PubMed2004

Mechanism of the decrease of tetrodotoxin activity in modified seawater medium.

This study was designed to clarify the mechanism of the decrease of tetrodotoxin (TTX) toxicity during storage in a modified seawater medium (MSWM). When TTX was added to sterilized MSWM, the toxicity of TTX in the medium markedly decreased within 1 day, as determined by a mouse bioassay. HPLC (high-performance liquid chromatography) analysis showed that the peak of TTX was reduced and new unidentified peaks were observed. Omission of the P-1 metal solution from MSWM suppressed the decrease in TTX toxicity and the disappearance of TTX. Further studies indicated that boric acid in the P-1 metal solution triggers this toxicity decrease, indicating that TTX is chemically, not microbiologically, converted to unknown compounds in MSWM.

Animals↗
PubMed1993

EPR signal enhancement of alanine irradiated with thermal neutrons.

A method to enhance the electron paramagnetic resonance signal amplitude response of alanine to thermal neutrons is presented. The method is based on the production of additional free radicals caused by alpha-particle and 7Li interactions on the alanine. These particles emerge from the neutron capture 10(5)B (n, alpha) 7(3)Li reaction. For this purpose, alanine and boric acid are intimately mixed. Mixture intimacy is critical for optimum enhancement. A way to achieve good mixture intimacy is suggested. A signal enhancement up to 2200% is obtained.

Alanine↗
PubMed1980

Large-scale purification of IgM from human sera. Comparison of three optimized procedures utilizing protein A chromatography.

for the preparation of gram amounts of IgM from human sera sedimentation at 100,000 g or treatment with ZnSO4 of the redissolved "euglobulin"-precipitate was compared to direct precipitation from the clarified serum by boric acid. Three alternative large scale purification procedures were developed, leading to an IgM-sample characterized as pure by various criteria. Inclusion of protein A chromatography proved to enhance the yield very considerably.

Boric Acids↗
PubMedDate not supplied

Aflatoxin in betel nut and its control by use of food preservatives.

The occurrence of aflatoxins in market betel nut samples was studied. It was observed that several betel nut samples were infested with aflatoxin-producing fungus, Aspergillus flavus. Out of 32 samples collected from various places, 12 were positive for aflatoxin. Aflatoxin B1 was detected in all the positive samples. Other aflatoxins were also detected in some samples. Boric acid, propionic acid and potassium metabisulphite were used for the control of aflatoxin B1 on betel nuts. Propionic acid was most effective in inhibiting aflatoxin production on betel nut after intervals of 2 (62%) and 4 (85%) weeks. Controlling the occurrence of aflatoxin could safeguard the users from the health hazards of aflatoxins.

Aflatoxins↗
PubMed2003

Inactivation of jack bean urease by allicin.

Allicin--diallyl thiosulfinate--is the main biologically active component of freshly crushed garlic. Allicin was synthesized as described elsewhere and was tested for its inhibitory ability against jack bean urease in 20 mM phosphate buffer, pH 7.0 at 22 degrees C. The results indicate that allicin is an enzymatic inactivator. The loss of urease activity was irreversible, time- and concentration dependent and the kinetics of the inactivation was biphasic; each phase, obeyed pseudo-first-order kinetics. The rate constants for inactivation were measured for the fast and slow phases and for several concentrations of allicin. Thiol reagents, and competitive inhibitor (boric acid) protected the enzyme from loss of enzymatic activity. The studies demonstrate that urease inactivation results from the reaction between allicin and the SH-group, situated in the urease active site (Cys592).

Binding Sites↗
PubMed1987

[Pseudomonas aeruginosa: pathogenicity, prevention and therapeutic approaches].

Pseudomonas aeruginosa has proved to be a dangerous nosocomial pathogen is growing importance. Its pathogenicity is attributable to its great variety of toxic mechanisms which are capable of attacking all parts of the organism, primarily organs with impaired resistance. Antibiotics had been found to yield little lasting success. Therefore, an attempt was made to apply to 30 patients three-per-cent boric acid to cope with locally delimited Pseudomonas wound infections. Therapy could be completed with good success in less than six days on average. Only germ reduction was achievable on three patients with chronic osteomyelitis. Toxic side-effects were not recordable.

Anti-Bacterial Agents↗
PubMed2001

Chromogenic urinary tract infection medium: evaluation and introduction for routine urine culture in a large clinical microbiology laboratory.

Evaluation and introduction of a chromogenic urinary tract infection (UTI) medium for the primary culture of routine urine specimens in a very large clinical microbiology laboratory is described. A modified scheme for the direct identification of the main groups of organisms causing UTI has led to quality improvements, with enhanced discrimination of mixed cultures and in efficiencies in staffing and working time that counterbalance increases in media costs. These improvements, together with the concurrent introduction of boric acid preservative for specimens from general practice, significantly reduced the level of positive results by 4.6% (2383 specimens) over an eight-month period (P <0.001). Chromogenic medium provided a reliable alternative to CLED medium for the routine culture of urine specimens.

Bacteriological Techniques↗
PubMed1975

The effects of additives on the thermal behaviour of gypsum-bonded casting investments. Part I.

In the formulation of gypsum-bonded casting investments, small amounts of certain modifiers are sometimes added to increase the investment's thermal expansion. In the present investigation, a systematic study has been made of the effects on thermal expansion of adding boric acid and sodium chloride to the investment powder, and glycerol to the mixing water. The combination of 0.2 per cent of sodium chloride in the powder, and 10 per cent of glycerol in the mixing water, appears to offer most promise in the formulation of an investment with a high thermal expansion.

Boric Acids↗
PubMed1984

Influence of isotonic agents on the stability of thimerosal in ophthalmic formulations.

Storage tests on the stability of thimerosal in trimethoprim-polymyxin B eyedrop formulations containing isotonic agents other than sodium chloride have been carried out. The HPLC assay of thimerosal in stored formulations containing boric acid and EDTA decreased with time and temperature, while formulations containing propylene glycol, glycerol, and mannitol showed no significant decrease in thimerosal assay compared with a formulation containing no isotonic agent. The latter group provide suitable alternatives to sodium chloride, which has been shown to have a seriously detrimental effect on thimerosal stability.

Boric Acids↗
PubMed1985

A urine preservative system to maintain bacterial counts. A laboratory and clinical evaluation.

The urinary tract is a common site of infection in the hospitalized, institutionalized, or ambulatory patient population. Ideally, urine should be cultured immediately or refrigerated up to 24 hours for quantitative examination for microorganisms. In the evaluation of patients at their homes or in long-term care facilities, rapid plating or refrigeration may not be practical. This is also true when evaluating small children in whom external collection devices are required to obtain a specimen. Because of these limitations, we evaluated a urine preservative and transport system, the Sage Products Urine Culture Tube, in a study of 1469 clinical specimens. This tube utilizes boric acid (1.1% final concentration) as a preservative. The Urine Culture Tube was easy to use and was as effective as refrigeration in maintaining bacterial counts. This system may be particularly useful where rapid transport or refrigeration is limited.

Bacteria↗
PubMed1986

Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds.

The usefulness of N-acetylcysteine (NAC) as a chelating agent was studied for the toxin potassium dichromate, lead tetraacetate, and boric acid. Mature Sprague-Dawley rats were intoxicated with these substances and placed in metabolic cages. Urinary excretion rates of intoxicant and total urine volume were determined during treatment with N-acetylcysteine, calcium EDTA, and/or dimercaptosuccinic acid, N-acetylcysteine proved to be the most effective agent at increasing the excretion of chromium and boron and was also able to reverse the oliguria associated with these toxins. Dimercaptosuccinic acid was most effective at the chelation of lead. NAC did not increase the excretion of lead. We conclude that NAC may be useful in intoxications due to chromate and borate and is effective at reversing the oliguria associated with these intoxicants.

Acetylcysteine↗
PubMed2000

Terconazole cream for non-Candida albicans fungal vaginitis: results of a retrospective analysis.

OBJECTIVE: Although it is FDA-approved for use in vulvovaginal candidiasis caused by non-Candida albicans species, terconazole cream has not been been studied in patients with these infections. We sought to assess the clinical and mycological efficacy of terconazole cream in women with non-C. albicans vaginitis. METHODS: The records of patients who had received a 7-day course of terconazole cream for culture-proved non-C. albicans vaginitis were reviewed. Data with regard to patient demographics, clinical and mycologic response to therapy within 1 month of treatment, and outcome with other antifungal therapies were analyzed. RESULTS: Twenty-eight patients received terconazole cream for non-C. albicans infections. Three patients did not return for follow-up. The median age was 45 years. Seven (28%) patients were nulliparous. The median duration of symptoms was 3 years. Nine patients (36%) had received terconazole within the 6 months prior to referral. Overall, there were 20 C. glabrata cases, 3 C. parapsilosis, and 2 C. lusitaniae. Fourteen (56%) patients achieved a mycologic cure; 11 (44%) noted a resolution of their symptoms. Prior terconazole use was not associated with treatment failure (P = 0.09). Ten failures received boric acid suppositories as subsequent treatment; a cure was effected in 4 (40%). Two of three patients (67%) were eventually cured with flucytosine cream. Five (20 %) patients remained uncured. CONCLUSIONS: Terconazole cream may be an appropriate first-line treatment for non C. albicans vaginitis, even in patients who have previously received the drug.

Antifungal Agents↗