[Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid in patients with migraine during attacks and in the intercritical period].
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A study was made of the excretion of the luteinizing hormone (LH) of the hypophysis and of the 5-oxyindolacetic acid in the course of 18 clinically-normal menstrual cycles. There proved to be a significant correlative association in the excretion of dophamine and of the LH in the middle of the cycle. As a rule, the peak of dophamine excretion coincided with the peak of the LH excretion. No statistically significant association between the 5-oxyindolacetic acid excretion and the LH excretion was found in the course of the cycle.
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In the first note, we have demonstrated a 5-hydroxyindole acetic acid binding to plasma proteins. By gel filtration on Sephadex G 200 and polyacrylamide gel electrophoresis, the 5-hydroxyindole acetic acid carrier protein was identified to serum-albumin.