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PubMed1985

[Infectious mononucleosis and splenic pseudocyst: presentation of a case].

The authors report the clinical case of an 18-year-old patient who presented with a symptomatic mass in the left upper quadrant 6 months after having infectious mononucleosis. The preoperative investigation consisted principally of echography and computerized axial tomography of the abdomen, which demonstrated a cystic mass of the lower pole of the spleen. Splenectomy was carried out. Histologic examination showed a pseudocyst of the spleen with a fibrous capsule without an epithelial lining. The treatment and pathogenesis of pseudocysts of the spleen secondary to infectious mononucleosis are discussed.

Adolescent↗
PubMed2006

Diagnosis of infectious mononucleosis by combined detection of atypical lymphocytes and transaminase.

In order to explore the value of combined detection of atypical lymphocytes (ATL) and transaminase (alanine aminotransferase, ALT; asparate aminotransferase, AST) in the diagnosis of infectious mononucleosis (IM), The data of blood routine and liver function were collected from 54 IM patients, 34 acute hepatitis (AH) patients, 44 upper respiratory infection (URI) patients in Union Hospital during March 2002 to March 2005. Same data were also collected from 40 healthy children as normal control. These data were analyzed retrospectively. Both proportion of atypical lymphocytes and enzyme activity of transaminase were elevated simultaneously (ALT > 40 IU/L, AST > 45 IU/L) in 57.4% (31/54) IM patients. There was significant difference (P < 0.01) between IM group and the other groups. Combined detection of atypical lymphocytes and transaminase can be regarded as a diagnostic marker of infectious mononucleosis.

Alanine Transaminase↗
PubMed2001

[Quality of rapid tests for determination of infectious mononucleosis].

BACKGROUND: The Norwegian centre for quality assurance in primary health care, NOKLUS, was established in 1992 to ensure the quality of laboratory analyses performed in primary health care. This article evaluates results from the surveys of infectious mononucleosis. MATERIAL AND METHODS: From 1996 to 2000, five serum panels were sent to participating practices in order to control test-kits designed for serological rapid diagnosis of infectious mononucleosis. 648 practices participated in this external quality assessment in 2000. Target values were determined using the Paul Bunell Davidsohn test. The results obtained for each type of test and variables that might have affected the results were evaluated. RESULTS: Outdated kits or kits close to the date of expiration showed poorer results than the other test-kits. The quality of the results depended mainly on the type of test-kit used and the training level of the persons performing the analyses. INTERPRETATION: The best performing tests in these surveys were Clearview IM (Unipath Limited) and Contrast Mono (Genzyme diagnostics). These two tests are among the three most frequently used tests, out of a total of thirteen, in our surveys.

Agglutination Tests↗
PubMed1985

Infectious mononucleosis. Appendiceal lymphoid tissue involvement parallels characteristic lymph node changes.

Appendectomy with mesenteric lymph node biopsy was performed in an 18-year-old man because of acute abdominal pain that was subsequently attributed to infectious mononucleosis. The appendix demonstrated intense hyperplasia of the lymphoid tissue with marked expansion of the interfollicular lamina propria by a mixed diffuse proliferation of immunoblasts including Reed-Sternberg-like forms, together with large and small lymphoid cells. Germinal centers were reactive but inconspicuous. This pattern was distinguishable from malignant lymphoma and, like the characteristic lymph node changes, may be strongly predictive of infectious mononucleosis. Involvement of gut-associated lymphoid tissue may contribute importantly to abdominal symptomatology in this infection.

Adolescent↗
PubMed1982

Horse erythrocyte glycoprotein-latex reagent that reacts with infectious mononucleosis heterophile antibody.

A sialoglycoprotein from horse erythrocytes was isolated in essentially homogeneous form and found to contain the neuraminidase-sensitive determinant of the horse erythrocyte for Paul-Bunnell heterophile antibodies of infectious mononucleosis. This reactivity was retained after covalent coupling of the antigen to latex particles. The latex reagent has greater stability (greater than 3 years) than either fresh or preserved horse erythrocytes. It can be used in a direct slide test; no absorption of the serum is necessary. The new test compared favorably with some standard tests for infectious mononucleosis antibody which use horse erythrocytes. Agreement of the latex test with the absorbed fresh horse cell test was 100%, and agreement with a stabilized horse erythrocyte spot test was 94%. The latex test also agreed 100% with a radioimmunoassay for the detection of heterophile antibody with 125I-labeled horse erythrocyte glycoprotein. The new latex test was compared with a bovine erythrocyte glycoprotein-latex test, and a correlation of 94% was observed. In addition, it was compared with the Wöllner test (enzyme-treated sheep cell-absorbed sheep cell agglutination test) with which it agreed in 92% of samples tested.

Animals↗
PubMed1984

Radionuclide diagnosis of splenic rupture in infectious mononucleosis.

Spontaneous splenic rupture is a rare but serious complication of infectious mononucleosis. Although radionuclide spleen imaging is a well accepted method for diagnosis of traumatic rupture, interpretation can be difficult in the setting of mononucleosis, as tears may be ill-defined and diagnosis hampered by inhomogeneous splenic uptake. Four proven cases of spontaneous rupture are presented, three of which illustrate these diagnostic problems.

Adult↗
PubMed1989

Infectious mononucleosis with acute thrombocytopenia.

Three cases of severe acute thrombocytopenia complicating infectious mononucleosis are described. Although spontaneous remission may be a feature of this rare complication, in each of these cases steroid therapy resulted in a rapid rise in the platelet count.

Adolescent↗
PubMed1972

The sea-blue histiocyte syndrome with hepatic porphyria and infectious mononucleosis.

The syndrome of sea-blue histiocyte, hepatic porphyria, and infectious mononucleosis occurring simultaneously in a young girl is described. The cytochemical staining character of the bone marrow histiocytes strongly suggested that the storage material was glycolipid. The possible relationship between the multiple disorders in the same patient is discussed.

Adolescent↗
PubMed1975

A prospective evaluation of heterophile and Epstein-Barr virus-specific IgM antibody tests in clinical and subclinical infectious mononucleosis: Specificity and sensitivity of the tests and persistence of antibody.

Three heterophile antibody tests and a test specific for IgM antibody to Epstein-Barr virus were evaluated during prospective studies of infectious mononucleosis. Specificity was judged by the frequency of false-positive results in sera of known qualities taken before illness; except for two patients bled during early, unrecognized illnes,, titers of greater than or equal to 1:40 were detected in 12% by the absorbed sheep red cell test, in 6.7% by the absorbed horse red cell test, and in none by the beef cell hemolysin test. None had IgM antibody specific for Epstein-Barr virus in sera obtained before illness. In addition, no rises in titer of heterophile antibody were detected by the horse cell test in 38 patients with proved rubella and/or influenza infection. In terms of sensitivity (indicated by the percentage of cases with diagnostic titers during infectious mononucleosis), 97% were positive by the Epstein-Barr virus IgM test, 96% by the horse cell agglutination test, 85% by the beef hemolysin test, and 81% by the sheep cell agglutination test. Persistence of antibody was judged by serial bleedings up to three years after illness; titers of heterophile antibody by the sheep agglutination and beef hemolysin tests as well as titers of IgM antibody to Epstein-Barr virus returned to normal in two to three months, whereas the horse cell heterophile test remained positive for a year or more in 75%. Inapparent and mild infections with Epstein-Barr virus resulted in the production of horse cell heterophile antibody in 48.4% of 122 subjects.

Antibodies, Heterophile↗
PubMed1987

Fulminant course of infectious mononucleosis with virus-associated hemophagocytic syndrome.

A fatal case of infectious mononucleosis due to serologically verified Epstein-Barr virus infection in a previously healthy 30-year-old man is presented. The clinical course was characterized by severe prostration, persistently high spiking fever, and continuous development of enlarged lymph nodes. Hematologic examination revealed peripheral leukopenia and thrombocytopenia, and in the bone marrow an increased number of benign histiocytes showed marked hemophagocytosis. At autopsy abnormal lymphoid infiltrates were present in several tissues. The pathogenesis of this infection-associated hemophagocytic syndrome is discussed in terms of the possibility of an impaired immune response to infectious agents.

Adult↗
PubMed2001

Bacterial coating with immunoglobulins on the palatine tonsils during infectious mononucleosis: immunocytochemical study with gold markers.

Epithelial cells and bacteria were sampled from the tonsillar surfaces of seven patients (six males, one female; median age 16 years, range 10 to 21 years) suffering from acute infectious mononucleosis with concomitant pharyngotonsillitis. By using gold-labelled antiserum to human IgG and secretory IgA (sIgA), micro-organisms on the tonsillar surfaces coated with these immunoglobulins could be identified by tracing the gold particles in the transmission electron microscope. The patients harboured significantly fewer bacteria coated with immunoglobulins than did healthy controls. More bacteria were coated with IgG immunoglobulins than with sIgA. Reduced immunoglobulin-coating of the bacteria on the tonsillar surfaces during infectious mononucleosis can explain their tendency to immense local colonization and proneness to penetrate into the epithelial cells.

Acute Disease↗
PubMed1966

Serological screening test for infectious mononucleosis using papain-treated sheep erythrocytes.

A screening test for infectious mononucleosis is described, based on the fact that antibodies against sheep red cells remaining after absorption of the serum by papain-treated sheep red cells appear to be specific for the disease. The test appears to be more useful in diagnosis than classical absorption techniques and has the advantage of being specific while maintaining a high degree of sensitivity.

Humans↗
PubMed1972

A 'virus-free' cell line derived from a patient with infectious mononucleosis.

A continuous cell culture line, derived from a nurse with infectious mononucleosis, is described. Electron microscopic and immunofluorescent examination suggested that it was substantially free from detectable complete virus particles, although the presence of a soluble complement-fixing antigen showed the persistence of other antigenic components of the EB virus.

Adult↗
PubMed2004

Infectious mononucleosis, diffuse pneumonia and acute respiratory failure in an elderly woman.

Infectious mononucleosis (IM) is a benign disease and is frequently associated with mild respiratory symptoms. The pulmonary manifestations rarely dominate the clinical picture. We report a case of an older adult patient with IM who developed diffuse pneumonia and acute respiratory failure. The diagnosis of IM was confirmed serologically, whereas other possible causes of pneumonia were excluded in this study. Pulmonary manifestations of IM are discussed, and the atypical features that may be seen in older adults are simultaneously reviewed.

Acute Disease↗
PubMed1971

Platelet defect of infectious mononucleosis.

Platelet function has been studied in 16 patients with uncomplicated infectious mononucleosis. Some abnormality of platelet aggregation and/or release of platelet factor III or platelet factor IV was found in all patients. Six patients with platelet defects were retested after three to four months and were found to have normal platelet function and appreciably higher platelet counts. Abnormal platelet function may reflect a platelet defect which predisposes to premature platelet destruction. Recent viral illness should be excluded before attributing abnormal platelet function to other factors or to a congenital disorder.

Adolescent↗
PubMed1973

Immunity of Epstein-Barr virus in Hodgkin's disease preceded by infectious mononucleosis.

A patient who developed Hodgkin's disease four years after infectious mononucleosis had elevated serum antibody titres to Epstein-Barr virus and delayed hypersensitivity reactions to membrane antigens prepared from fresh autologous spleen, from spleen cells of another Hodgkin's patient, and from cell lines known to carry the Epstein-Barr virus genome. Additional studies in more lymphoma patients will be needed to determine the significance of the reactivity against tumour and virus-associated antigens which has been documented in this patient.

Adult↗
PubMed1982

Some factors of immunopathogenesis of infectious mononucleosis in children.

Sixty-eight children with the symptoms of infectious mononucleosis were examined. In 25 of them anti-EBV antibodies were found and in 10 heterophilic antibodies. In serum of 16 children sero-positive to EBV A, M, G, D immunoglobulins were determined as well as T and B lymphocytes. A statistically significant increase in the number of B-IgA, B-IgG and B-IgM lymphocytes, augmentation of T lymphocyte number and polyclonal hypergammaglobulinemia were detected.

Adolescent↗