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At least 595 records · Page 33Linked to original sources
PubMed1991

[Early diagnosis and prognosis of bacterial tubulo-interstitial nephritis in children].

The authors provide the data of a prospective follow-up of children with diseases of the urinary system organs. Analysis was made of the role of endogenous and exogenous factors in the formation of abacterial and bacterial tubulointerstitial nephritis (TIN) in children with predisposing conditions. It has been established that progression of the tubulointerstitial process can be seen in patients infected with causative agents capable of intracellular parasitizing and persistence in the body. Depending on the intensity of membranopathological and immune disorders the clinicopathogenetic manifestations of different stages of TIN are described in detail. It is shown that there is a possibility of early diagnosis of the bacterial stage of the disease on the basis of detecting the persistent microflora according to an assay of the antilysozyme activity of the causative agent and the urine content of beta-lysines in urine. The authors base the necessity of the preventive treatment of children with predisposing conditions and abacterial TIN to avert the formation and progression of bacterial TIN by means of agents that may prevent the persistence of causative agents and raising the efficacy of antiinfectious defence of the macroorganism.

Adolescent↗
PubMed1990

[Acute interstitial nephritis with uveitis in children and adolescents].

Acute non-suppurative tubulointerstitial nephritis was recorded within a five-month interval in 1988 in one girl and two boys aged 15, 16 and 12 years. The common feature was non-selective proteinuria, slight glycosuria, anaemia, a sedimentation rate of more than 100 mm/2 hrs hyperatotaemia not calling for dialyzation treatment (268, 354 and 266 mumol/l plasma creatinine resp.), a markedly impaired concentrating capacity (540, 593 and 520 mOsm/kg urine resp.). In all patients circulating serum immunocomplexes were elevated (PEG-IKEM). One patient developed acute uveitis at the onset of the disease, the remainder after 5 and 6 months resp. and in all there was a tendency of a protracted course and relapses resp. In two patients uveitis was diagnosed by an aimed examination by means of a slit lamp at a time when there were not yet any clear signs of affection of the eyes. All patients were subjected to percutaneous renal biopsy which revealed an interstitium with uneven lymphoplasmacytic cellulization with infrequent eosinophil and neutrophil polynuclear cells. Electron microscopy revealed sections of varying size with fibrotization of the tubular basal membrane; the glomerular changes were not typical. All patients had prednisone treatment and their renal functions were gradually restored. Despite extensive serological examinations, the aetiology was not cleared, however before the onset of the disease the patients had penicillin, cotrimoxazol and erythromycin resp.

Acute Disease↗