Effect of sulphinpyrazone and aspirin on latelet adhesion to activated charcoal and dialysis membranes in vitro.
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Adult↗
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Results for “SULFINPYRAZONE”
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Synthesis of prostaglandin D2 and thromboxane B2 by human platelets.
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Blood Platelets↗
Reversible and irreversible inhibition of platelet cyclooxygenase and serotonin release by nonsteroidal antinflammatory drugs.
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Animals↗
Effects of sulphinpyrazone and aspirin on gastrointestinal blood loss in man.
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Aspirin↗
Determination of sulphinpyrazone in patient plasma by gas chromatography.
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Chromatography, Gas↗
The effect of sulphinpyrazone on the aggregation and release reactions of human platelets.
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Acetylglucosaminidase↗
The influence of antiplatelet drugs on platelet survival after aortic damage or implantation of a dacron arterial prothesis.
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Animals↗
Antiplatelet drugs in a rat microsurgical model of arterial thrombosis.
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Animals↗
The effect of sulphinpyrazone and other drugs on the platelet response during the acute phase of the active Arthus reaction in guinea pigs.
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Acute Disease↗
Evaluation of antiinflammatory and antithrombotic drugs in pulmonary and arterial thrombosis.
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2',3'-Cyclic-Nucleotide Phosphodiesterases↗
The release of beta-thromboglobulin from platelets during the clotting of whole blood.
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Adolescent↗
Effect of anti-platelet agents on circulating platelet aggregates in patients with glomerulonephritis.
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Adult↗
Effect of orally administered sulphinpyrazone (Anturan) on platelet aggregation in vitro.
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Adenosine Diphosphate↗
Platelet adhesion to collagen in normal and von Willebrand's disease subjects.
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Animals↗
Sulphinpyrazone and indomethacin for inhibition of platelet prostaglandin synthesis.
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Blood Platelets↗
Effect of sulphinpyrazone and aspirin on platelet adhesion to subendothelium following oral administration to rabbits.
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Animals↗
Prolonged inhibition of ex vivo sodium arachidonate-induced platelet aggregation and malondialdehyde (MDA) production by sulphinpyrazone (Anturan) in man.
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Adult↗
The effect of sulphinpyrazone on whole blood thromboxane and prostacyclin generation in man.
A new method, based on the observation that leukocytes contain PGI2-synthetase activity, was used to measure the effect of pharmacological levels of sulphinpyrazone on the TXA2 and PGI2 production in whole blood. Four human volunteers took 400 mg sulphinpyrazone twice daily for 5 1/2 days. Blood was drawn before the study started, 3-4 h after the initial dosage, 12 h after the 10th dosage on the 5th day, and 3-4 h after the 11th (final) dosage on the 6th day. Collagen was added to the citrated blood samples to stimulate prostaglandin production. Aliquots were removed at regular intervals and TXB2 and 6-keto-PGF1 alpha measured by radioimmunoassay. The production of PGI2 was significantly inhibited in all the samples collected after sulphinpyrazone intake (p less than 0.01). The production of TXA2 was significantly inhibited only in the samples collected 3-4 h after sulphinpyrazone intake on the 6th day (p less than 0.01). These results confirmed the cyclooxygenase inhibitory action of sulphinpyrazone and also showed that in the whole blood system, PGI2 production was more effectively inhibited than TXA2 production.
Adult↗