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Results for “BLOOD ALKALINE PHOSPHATASE”

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PubMedDate not supplied

[Methods and results of studying serum alkaline phosphatase isoenzymes (intestinal and liver fractions) in acute surgical diseases of the abdominal cavity organs].

Separate estimation of intestinal and liver fractions of blood serum alkaline phosphatase in patients with acute forms of impairments corroborated the tissue specificity of these isoenzymes and showed the stable character of alterations in their activity at the initial steps of inflammatory-destructive processes in liver tissue, bile and intestinal tracts. The express methods for estimation of blood serum alkaline phosphatase isoenzymes enabled to carry out the examination within 1.5-2 hrs; the diagnostic methods may be widely used in urgent abdominal surgery.

Abdomen, Acute↗
PubMed1994

Prognostic predictors in colorectal cancer.

PURPOSE: Better prognostic predictors in colorectal cancer than the Dukes stage are necessary for individualized therapy and follow-up. METHODS: Survival among 212 patients operated on for colorectal cancer was examined regarding various clinical, histopathologic, cellular, and serologic tumor characteristics. RESULTS: Beside the Dukes stage, which was the most powerful variable, the erythrocyte sedimentation rate, leukocyte blood count, alkaline phosphatase, aspartate aminotransferase, six different serum tumor markers, number of small blood vessels, and age were found to be significantly associated with survival. The leukocyte blood count, alkaline phosphatase, and aspartate aminotransferase retained their significance in a multivariate model including tumor differentiation, local tumor stage, and age. Inclusion of tissue polypeptide antigen, the most powerful tumor marker in the multivariate model, showed that only the tumor stage, tissue polypeptide antigen, and age were statistically significantly correlated to survival. This was valid both for the group of patients considered as potentially curable and for those who potentially have been cured (Dukes Stages A-C). CONCLUSIONS: A great number of prognostic predictors failed to discard Dukes stage as the best one. One serum tumor marker, tissue polypeptide antigen, contains independent additional prognostic information.

Adult↗
PubMed1979

Localization of acid and alkaline phosphatase activities in the blood vessels of normotensive and hypertensive rats.

Samples of aortae and caudal arteries from normotensive and hypertensive rats were studied for cytochemical and biochemical determinations of acid and alkaline phosphatase activities. Cytochemical examination revealed an increased amount of acid phosphatase reaction product in hypertensive samples, with extensive localization to the extracellular matrix. Alkaline phosphatase activity was localized to the plasma membrane of fibroblasts and vascular smooth muscle cells and to the extracellular matrix. Biochemical assays of enzyme activities supported the cytochemical findings, showing increased activity in aortae from hypertensive rats.

Acid Phosphatase↗