Individual differences in addictive liability: associated behavioral and biochemical features.
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OBJECTIVE: Establish the epidemiological characteristics and urinary toxicological profiles of a population of cocaine addicts under police custody. METHOD: A series of 60 cocaine addicts consulting the medico-legal emergency unit of the Hôtel-Dieu hospital in Paris was studied prospectively on the following elements: clinical characteristics, method of cocaine administration and association with other licit or illicit substances. Urinary toxicological analysis, using immuno-chemistry and chromatography linked to a mass spectrometer was systematically proposed to each patient. RESULTS: Half of the 17 to 26 year-old patients declared having consumed cocaine for the past 2 to 5 years. Inhalation of the vapours and the intravenous route were used more than the cigarette or nasal route. The majority of 26 to 35 year-olds were multi-drug addicted, generally associating cocaine, heroine and tobacco. Analysis of the urine provided an objective assessment of the cocaine consumption of these persons under police custody in Paris. CONCLUSION: Screening for urinary toxicity gives better knowledge on the consumption of addictive products by the person in whom urine was sampled. This study was conducted in cocaine addicts under police custody, and for the majority were social misfits. In this population, the consumption of crack by inhalation predominated.
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From autumn 1985 until 31.12.1988, 127 drug addicts were examined for HIV-antibodies. Twenty-five (19.7%) were positive. No connection was found between age, sex and HIV-status. The incidence of positive test results fell from 32.8% in 1985/1986 to 0% in 1988. From autumn 1987, 49 drug addicts completed a questionnaire about risk behaviour as regards sharing syringes or needles during the month prior to commencement of treatment. Thirty-nine had no risk behaviour and the remainder very limited risk behaviour. The majority had reduced their risk behaviour on account of AIDS. Drug addicts have shown their will and abilities to reduce their risk behaviour. It is thus important to continue the informative efforts and prescription of syringes and needles. The therapeutic efforts should be extended with the object of preventing further infection in drug addicts and heterosexual and perinatal infection from the infected drug addicts.
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