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At least 613 records · Page 34Linked to original sources
PubMed2002

Blood flow patterns in an anatomically realistic coronary vessel: influence of three different reconstruction methods.

Many clinical studies suggest that local blood flow patterns are involved in the location and development of atherosclerosis. In coronary diseases, this assumption should be corroborated by quantitative information on local hemodynamic parameters such as pressure, velocity or wall shear stress. Nowadays, computational fluid dynamics (CFD) algorithms coupled to realistic 3-D reconstructions of such vessels make these data accessible. Nevertheless, they should be carefully analysed to avoid misinterpretations when the physiological parameters are not all considered. As an example, we propose here to compare the flow patterns calculated in a coronary vessel reconstructed by three different methods. In the three cases, the vessel trajectory respected the physiology. In the simplest reconstruction, the coronary was modelled by a tube of constant diameter while in the most complex one, the cross-sections corresponded to the reality. We showed that local pressures, wall shear rates and velocity profiles were severely affected by the geometrical modifications. In the constant cross-section vessel, the flow resembled to that of Poiseuille in a straight tube. On the contrary, velocity and shear rate exhibited sudden local variations in the more realistic vessels. As an example, velocity could be multiplied by 5 as compared to Poiseuille's flow and area of very low wall shear rates appeared. The results obtained with the most complex model clearly outlined that, in addition to a proper description of the vessel trajectory, the section area changes should be carefully taken into account, confirming assumptions already highlighted before the rise of commercially available and efficient CFD softwares.

Arteries↗
PubMed1990

[Relation between the duration of cardiac pain and the state of the coronary vessels in patients with acute myocardial infarction].

The study compared specific characteristics of cardiac pain syndrome with coronary arteriography findings for 100 patients in acute period of myocardial infarction. The evidence obtained suggests that duration of cardiac pain does not depend on the type of obstruction in the infarction-related coronary artery. Long-standing radiating pain occurred in affected anterior interventricular branch. The pain seems related to total asynergia severity and the lesion of coronary bed. Neuroleptanalgesia induced more continuous anesthesia in patients with infarction-related circumflex branch and anterior coronary artery while its effect reduced in ++multi-vascular affection of the coronary bed. No relapses of pain syndrome were recorded in responders to intracoronary thrombolytic therapy.

Adult↗
PubMed1984

Nonrandom occurrence of single-vessel coronary artery disease.

The location of obstructive coronary artery lesions in single-vessel disease is nonrandom. The circumflex coronary artery is protected relative to the right coronary artery. This may have important implications regarding the causation of coronary obstructive lesions.

Coronary Angiography↗