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PubMed1993

Cardiac transplantation: role of endomyocardial biopsy and immunosuppressive agents.

The field of cardiac transplantation has made tremendous strides since the first transplant procedure in 1967. This paper reviews the role of endomyocardial biopsy to diagnose and follow rejection as well as the standard immunosuppressive regimens employed. With continued refinements in immunosuppressive therapy, further improvements in mortality and morbidity rates should be realized.

Biopsy↗
PubMed1980

Time of day of taking immunosuppressive agents after renal transplantation: a possible influence on graft survival.

Large-amplitude circadian rhythms in immune responses and the known variations in the effects of glucocorticoids with the time of day of administration suggest that immunosuppressive regimens may need to take this variable into account. In two similar groups of patients with renal transplants functioning satisfactorily after three months subsequent graft failure developed in 66% of those taking all immunosuppressives in the evening, compared with only 22% of those taking immunosuppressives twice daily (p < 0.05). A survey of other transplant units showed that one unit with outstanding results--graft survival at three years 82%--had a unique policy of morning-only administration of immunosuppressives. Doctors need to consider more carefully the time of drug administration when prescribing, as it may be possible to obtain better results with less toxicity.

Adult↗
PubMed1992

[Genetic aspects of the action of immunosuppressive agents].

The data were obtained formerly that mice of certain strains essentially differ in the sensitivity to the immunodepressive and antiproliferative action of the alkylating agents (so-called opposite strains: DBA/2--highly sensitive, BALB/c--resistant). It is shown in the present work that with the use of the other non-alkylating immunodepressive agents (cytarabine, cyclosporin A, dexamethasone) that differ in the action mode, DBA/2 mice retain a high sensitivity whereas BALB/c mice a low sensitivity to all the immunodepressants. The sensitivity to the immunodepressive action in vivo directly correlates with that of the immunocompetent cells in vitro. Potential mechanisms determining the same type sensitivity to diverse immunodepressant in mice belonging to the above-indicated genotypes are under discussion.

Alkylating Agents↗