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At least 613 records · Page 34Linked to original sources
PubMed2002

Genetics (molecular biology) and Meniere's disease.

COCH is not the FMD gene detected in our linkage study; furthermore, COCH and FMD are not allelic. The indications are that FMD is heterogenetic. The linkage analysis points to the possibility of one FMD mutation in one of the neighboring candidate genes on chromosome 14, and, with anticipation, possibly a triple repeat amplification. Recently, the myotonic dystrophy type 2 locus has been shown to contain an expanded tetranucleotide repeat [46], so the search for a similar repeat on 14q is indicated.

Adolescent↗
PubMed1984

Surgical management of Meniere's disease with endolymphatic sac decompression by wide bony decompression of the posterior fossa dura: technique and results.

The results of wide bony decompression of the posterior fossa in 49 consecutive individuals with idiopathic unilateral Meniere's disease are reported. These results are similar to many previously published series, 71% of individuals are free of vertigo and 86% have unchanged or improved hearing. Utilizing the classification proposed by the American Academy of Ophthalmology and Otolaryngology, 73% fell into Class A, B, or C with relief of vertigo. These results together with the low complication rate encourages us to consider surgery at an earlier date, hoping to stabilize hearing at a more useful level and to relieve vertigo.

Adolescent↗
PubMed1982

Summating potential in Meniere's disease.

This study assesses several electrocochleographic (ECoG) duration and amplitude measures in a clinically defined Meniere's group and compares the results with those from a normal hearing control group and a hearing loss group (cochlear). The summating potential (SP)/action potential (AP) amplitude ratio was the most efficient diagnostic measure, with 62% of the Meniere's group demonstrating abnormal ratios compared to 4% of the normal control group and 17% of the cochlear group. The SP changes were then studied from three angles: 1. Comparison of SP changes with glycerol test results; 2. Comparison of ECoG results before and after shunt surgery; and 3. Recording of SP's in guinea pig ears in which hydrops had been created by obliterating the endolymphatic duct.

Action Potentials↗