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At least 613 records · Page 34Linked to original sources
PubMed1977

Basement membrane changes under neoplastic oral mucous membrane. Ultrastructural observations, review of the literature, and a unifying concept.

This study explores the morphologic nature of the basement membrane under neoplastic oral mucous membrane. Of particular interest is the progression of changes associated with dysplasia, carcinoma in situ, and invasive carcinoma. On the basis of a critical review of the literature and our own ultrastructural observations, we present a unifying concept for the development of these basement membrane changes. This concept proposes that neoplastic epithelial cells may produce a collagenolytic enzyme which is released into the epithelial intercellular spaces. This enzyme permeates to the basement membrane, causes breaks in the basement membrane, and focal loss of stromal area contiguous with intercellular spaces. The neoplastic basal cells develop pseudopodia that eventually extend through the breaks in the basement membrane. This concept suggests that the basement membrane changes herald the progression of carcinoma in situ to invasive carcinoma.

Animals↗
PubMed1978

Intraoral isolated herpes zoster.

A case of herpes zoster limited to the right palate and the edentulous alveolar ridge in the absence of concurrent skin lesions or predisposing systemic disease is presented. Because of the relative rarity of isolated mucous membrane lesions of this viral disease, the tendency for intraoral vesicles to break down and ulcerate early, and, in this patient, the additional clinical findings of marked swelling and induration, malignancy rather than herpes zoster was suspected; cytologic smear furthered the suggestion of the former. A biopsy provided the definitive diagnosis.

Aged↗
PubMed1978

Myxomas of the paraoral--oral soft tissues.

Fifteen cases of soft-tissue myxoma of the paraoral-oral structures have been presented. Eleven cases were garnered from an extensive review of the literature, and four previously unreported cases are described. The myxomas were slow-growing, insidious, infiltrative tumors which occurred in all age groups, with an average patient age of 38 years. Most frequent locations were the cheek, floor of the mouth, and palate. The lesions were present from 2 weeks to 6 years prior to treatment. In this series all the myxomas were treated by surgical excision, with no evidence of recurrences or metastases. The recommended therapy is surgical resection with adequate margins. Other myxomatous lesions which may mimic a myxoma are mentioned.

Adult↗
PubMed1978

Oral squamous acanthoma. Two additional cases with comments on etiology.

Two new cases of squamous acanthoma are presented, and the their clinical characteristics are compared to the eight cases previously reported. These two additional examples of this lesion are clinically similar to those previously reported. However, one of the two cases exhibits resolution after the removal of sources of trauma, thus lending support to the previously proposed theory of traumatic etiology.

Adult↗
PubMed1978

Osteoma cutis: cutaneous ossification with oral manifestations.

Subcutaneous and mucosal calcifications are rare lesions which present problems in diagnosis. A large bony mass is presented, with dermal and mucosal findings. The literature is reviewed on this non-neoplastic bony lesion and differential diagnosis is discussed.

Adolescent↗
PubMed1978

Alcohol and hamster buccal pouch carcinogenesis.

Alcohol was shown to enhance the carcinogenic effect of DMBA applied to hamster buccal pouch. DMBA animals given alcohol developed dysplastic leukoplakic lesions and epidermoid carcinomas 2 weeks ahead of water-drinking control animals. The tumors also grew to larger size, were more invasive, and were more anaplastic histologically. Forty young adult Syrian hamsters were divided into four groups (alcohol-DMBA, DMBA control, untreated control, and alcohol control) and were killed after 10, 12, and 14 weeks of DMBA applications three times weekly. Alcohol was given as a 10 percent solution instead of drinking water.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1979

Chievitz's organ: a potential pitfall in oral cancer diagnosis.

It has been reported that epithelial nests associated with sensory nerve fibers may simulate perineural invasion and pose a potential diagnostic problem for surgical pathologists working on frozen tissue specimens from patients with oral cancer. The epithelial structures are not neoplastic, and no known pathologic condition has been associated with them. They are believed to be those structures described scantily in the English literature as Chievitz's organ. The fact that the epithelial nests lie near the plane of injection for the inferior alveolar nerve should be of special interest to dentists, especially oral surgeons and pathologists. Controversy exists as to the exact nature of Chievitz's organ, but the potential hazard of misdiagnosis exists nonetheless. This study of cadaver and autopsy material reaffirms the existence of the epithelial rests and outlines a simple technique for locating them.

Aged↗
PubMed1979

Maxillary osteotomy and vestibuloplasty for the correction of maxillary anterior atrophy: preliminary report.

A one-step procedure has been designed to help the patient with abnormal maxillary anterior alveolar atrophy. The technique combines an anterior maxillary osteotomy with a maxillary vestibuloplasty. Bone grafting and skin grafting are not required, and prosthetic rehabilitation can begin 6 to 8 weeks postoperatively. This is a preliminary report; however, 18-month follow-up examinations show continued stability and minimal regression.

Alveoloplasty↗
PubMed1979

Ultrastructural studies of intraoral verruca vulgaris.

The literature offers conflicting views regarding the existence of verruca vulgaris in the oral cavity. In an attempt to clarify this issue, a series of ten oral lesions which had been diagnosed as verruca vulgaris and ten oral lesions diagnosed as squamous-cell papilloma were examined ultrastructurally. Six of the lesions diagnosed as verruca vulgaris contained the characteristic intranuclear viral particles which are normally found in that lesion. None of the lesions diagnosed as squamous-cell papilloma exhibited this type of intranuclear viral inclusions.

Cell Nucleus↗
PubMed1979

Benign nerve sheath myxoma: light and electron microscopic features of two cases.

Two new cases of the rare benign nerve sheath myxoma (NSM) are presented. The light microscopic findings are compared with previously reported cases. In addition, the ultrastructural features of three constitutent cell types are described. The lesion is confirmed as a neural sheath neoplasm, and its similarities to other myxomas are discussed.

Adult↗
PubMed1979

Oral leiomyomas.

Oral leiomyomas are considered to be rare neoplasms, but they may be encountered more frequently than generally believed. Three types of leiomyomas are commonly described: solid leiomyomas, angiomyomas, and epithelioid leiomyomas. Three cases of solid leiomyoma are presented, all of which occurred in the anterior mandibular mucobuccal fold. Leiomyomas can be easily confused with other spindle-cell tumors. The necessity of using special stains, especially Mallory's phosphotungstic acid hematoxylin, is discussed.

Adult↗