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[The results of overloading of the lower extremity during sports (author's transl)].

Nowadays an increasing number of persons have to interrupt their training in competitive or recreational sports because of injuries resulting from overloading of the musculoskeletal system. At least 60% of all athletes who consult a department of traumatology do so because of recurrent micro-trauma. Sixty to eighty percent of all sports injuries and sequelae of overloading are located in the lower limb. The typical results of overloading of the musculoskeletal system during sports are: Inflammation of tendinous insertions, myopathies, peritendinitis, stress fracture, destruction of hyaline cartilage. The commonest of these are insertion tendinitis and destruction of cartilage. This reflects the disproportion between the ultimate strength of the connective tissues, which varies between individuals, and the loads actually imposed during physical training. In the last 7 years (1971-77) we have operated on 1278 knee joints, 63% of which had suffered damage to the cartilage. The etiology, prophylaxis, and medical and surgical treatment of chondropathies are therefore discussed in detail. Careful coordination of the various rehabilitation measures is especially important if a satisfactory therapeutic result is to be achieved.

Athletic Injuries↗

Absence attributed to incapacity and occupational disease/accidents among female and male workers in the fish-processing industry.

Sick-leave between 1984 and 1989 was higher among both female (n = 515) and male (n = 304) fish-processing workers [observed/expected (O/E) 2.24 and 1.69, respectively] than among non-exposed groups (0.62 and 0.89). Diagnoses in the musculoskeletal system dominated (i.e., neck/upper limbs; females, exposed vs. non-exposed workers: 30 vs. 12%; males: 11 vs. 5.8%). In subjects who left employment, the O/E-ratio decreased (females: 3.02 vs. 1.55; males: 2.40 vs. 1.55). Among those women hired before the start of the observation period, exposed subjects had higher frequencies of sick-leave than non-exposed, for both total illness and musculoskeletal diagnoses. In the men, there were corresponding differences, though not fully statistically significant. Reported occupational diseases [O/E: females: 4.5; (95% confidence interval) CI = 3.2-6.1; males: 2.3; CI = 1.3-3.9] and accidents (females: 4.3; CI = 3.0-5.9; males: 1.8; CI = 1.2-2.7) were also higher in female than in male fish-processing workers, and much higher than in non-exposed workers. In conclusion, work in the fish-processing industry was associated with increased frequencies of sick-leave, especially because of diagnoses of the musculoskeletal system, and occupational disorders and accidents, in particular among female workers.

Accidents, Occupational↗

Tensegrity and mechanoregulation: from skeleton to cytoskeleton.

OBJECTIVE: To elucidate how mechanical stresses that are applied to the whole organism are transmitted to individual cells and transduced into a biochemical response. DESIGN: In this article, we describe fundamental design principles that are used to stabilize the musculoskeletal system at many different size scales and show that these design features are embodied in one particular form of architecture that is known as tensegrity. RESULTS: Tensegrity structures are characterized by use of continuous tension and local compression; architecture, prestress (internal stress prior to application of external force), and triangulation play the most critical roles in terms of determining their mechanical stability. In living organisms, use of a hierarchy of tensegrity networks both optimizes structural efficiency and provides a mechanism to mechanically couple the parts with the whole: mechanical stresses applied at the macroscale result in structural rearrangements at the cell and molecular level. CONCLUSION: Due to use of tensegrity architecture, mechanical stress is concentrated and focused on signal transducing molecules that physically associate with cell surface molecules that anchor cells to extracellular matrix, such as integrins, and with load-bearing elements within the internal cytoskeleton and nucleus. Mechanochemical transduction may then proceed through local stress-dependent changes in molecular mechanics, thermodynamics, and kinetics within the cell. In this manner, the entire cellular response to stress may be orchestrated and tuned by altering the prestress in the cell, just as changing muscular tone can alter mechanical stability and structural coordination throughout the whole musculoskeletal system.

Biomechanical Phenomena↗

Tendon and ligament insertions--a possible source of musculoskeletal pain.

In many cases of musculoskeletal pain, the source of the pain is still elusive as indicated by the number of acceptable, but different types of treatments that are available. Within the musculoskeletal system, the tendino-periosteal attachment of the muscles (enthesis) appears to be an area that is especially susceptible to injury as a result of trauma. Because it is a structurally flawed, richly innervated, and metabolically active area, it may be the "weakest link" and most reactive site in the musculoskeletal system. Following episodes of trauma, lesions at the enthesis may result in a wide range of symptoms. Treatment of these lesions may be crucial to the success of post-traumatic pain management.

Bone and Bones↗

Muscle-based gene therapy and tissue engineering.

The development of new biological approaches based on cell and gene therapies, in combination with tissue engineering, may create innovative ways to treat various tissues of the musculoskeletal system. It is vital for practicing orthopaedic surgeons to understand the terminology, fundamental concepts, and current research in this burgeoning field so that they may practice their discipline in its fullest form. Such techniques, coupled with advances in cell biology and polymer chemistry, are resulting in novel approaches to treating musculoskeletal disorders in which surgeons, who have traditionally used the tools of excision and reconstruction to treat patients, may now serve as surgical gardeners who create microenvironments that are conducive for tissue regeneration. Gene therapy and tissue engineering applications for bone healing, articular disorders, and skeletal muscle diseases and injuries are currently being explored. This review is intended to update readers on the principles and current advances in muscle-based gene therapy and tissue engineering for the musculoskeletal system.

Animals↗

All-trans-retinoic acid-induced myositis: a description of two patients.

All-trans-retinoic acid (ATRA) induces complete clinical remissions in a high proportion of patients with acute promyelocytic leukemia and has become the standard induction therapy. Its use as a single agent results in short-lived remissions; thus, cytotoxic drugs are used for "consolidation" therapy. Side effects reported during treatment with ATRA include retinoic acid syndrome and Sweet's syndrome. Sweet's syndrome has been associated with acute myelogenous leukemia at presentation, but only two cases of Sweet's syndrome involving the musculoskeletal system in patients treated with ATRA have been described. We describe two additional patients with acute promyelocytic leukemia who had unexplained fever and myalgias (cutaneous lesions in one patient) during induction therapy with ATRA. Radiologic findings were similar to those in previously reported ATRA-associated Sweet's syndrome of the musculoskeletal system. The clinical course was characterized by a rapid resolution of the symptoms during treatment with dexamethasone. Recognition of the syndrome is important, especially considering the rapid resolution of symptoms after early institution of therapy with corticosteroids.

Adult↗

Use of animal models in musculoskeletal research.

Understanding of the human musculoskeletal system and common clinical disorders of bones, joints and soft tissues has been enhanced by the use of experimental animal models. Articles reporting on the results of these biomedical experiments frequently include conclusions that are based on the assumption that the biology of the animal model is similar to that of a human being for the disease process under investigation. The purpose of this investigation was to study the criteria and the considerations for selection of an animal model in musculoskeletal research. Selected journals from the musculoskeletal literature published between January 1991 and November 1995 were scrutinized for the use of animal models, and several criteria used in the selection of the various animal models were investigated. The selection criteria analyzed in this study included the biologic characteristics of the model, budget issues, the reproducibility of a musculoskeletal disease, and animal handling factors. A computer-assisted search of the musculoskeletal literature published from 1965 to 1995 was also performed to screen for reports comparing mammals used as animal models in terms of these selection criteria. Our findings imply that the selection of animal models in research of the musculoskeletal system is based partly on non-standardized criteria that are not necessarily based on the biology of the disease process being studied. In addition, there are limited comparative data on the selection and use of different animals for musculoskeletal research. We believe the selection of models should be more standardized based on both biological and non-biological criteria. Researchers would then be able to put in a more meaningful perspective the results of research using animal models and their clinical implications.

Anatomy, Comparative↗

Model Predictive Impedance Control: A Model for Joint Movement.

Impedance control has been suggested as the strategy employed by the central nervous system to control human postures and movements. A realization of this strategy is presented that uses a model predictive control algorithm as a higher motor controller. External disturbances are explicitly included in the model. The combination of 3 key factors-joint impedance control, model predictive controller, and external disturbance input-forms the basis for the generality of this model. The model was applied to 3 different types of joint movements: a tracking movement with an unpredicted disturbance, a rhythmic movement, and an unstable biped model of human walking. Computer simulation results showed excellent performance of the model in all 3 cases for optimal values of active joint impedances and an exact match between the musculoskeletal system and the model internal to the model predictive controller. The controller was also able to maintain acceptable performance in the presence of a 25% mismatch between the musculoskeletal system and its internal model.

equilibrium-point hypothesis↗

Health and health care utilization among early retirement pensioners with musculoskeletal disorders.

OBJECTIVE: To estimate subjective health status among early retired individuals pensioned due to disorders of the musculoskeletal system. DESIGN: A survey of self-reported health status and health care utilization by means of a mailed questionnaire. SETTING: Early retirees (cases) and a random sample (controls) of individuals from the municipality of Kristianstad, Sweden. SUBJECTS CASES: all individuals aged 25-59 years granted a full-time early retirement pension during the period 1986-1990 due to disorders of the musculoskeletal system (n = 450). The response rate was 83.6%. CONTROLS: An age- and sex-matched sample (n = 450). The response rate was 82.7%. MAIN OUTCOME MEASURES: Self-reported health status and health care utilization. RESULTS: Early retirement entailed a deterioration in self-reported health status among men, all ages, and women aged 25-54 years. Female retirees aged 55-64 reported an improvement in health status since retirement. Early retired female immigrants were less satisfied with their health status than the Swedish ones. Early retirees reported higher health care utilization than controls, but with a reduction since retirement. Drug consumption was high. CONCLUSION: The beneficial effects of early retirement were evident among old women. Men and young and middle-aged women may need support to adjust to life as a retiree. Special attention should be given to the female immigrant retiree.

Adult↗

Bone position estimation from skin marker co-ordinates using global optimisation with joint constraints.

Widespread use of gait or motion analysis in the diagnosis of patients with locomotor pathology and the subsequent planning and assessment of treatment has been limited because of its reliability, particularly in evaluating frontal and transverse plane components. This is because spatial reconstruction of the musculoskeletal system and calculation of its kinematics and kinetics via a skin marker-based multi-link model are subject to marker skin movement artefacts. Traditional methods treat each body segment separately without imposing joint constraints, resulting in apparent dislocations at joints predominantly because of skin movement artefacts. An optimisation method for the determination of the positions and orientations of multi-link musculoskeletal models from marker co-ordinates is presented. It is based on the minimisation of the weighted sum of squared distances between measured and model-determined marker positions. The model imposes joint constraints. Numerical experiments were performed to show that the new method is capable of eliminating joint dislocations and giving more accurate model position and orientation estimations. It is suggested that, with joint constraints and a global error compensation scheme, the effects of measurement errors on the reconstruction of the musculoskeletal system and subsequent mechanical analyses can be reduced globally. The proposed method minimises errors in axial rotation and ab/adduction at the joints and may extend the applicability of gait analysis to clinical problems.

Biomechanical Phenomena↗

Dose response effect of diaspirin crosslinked hemoglobin (DCLHb) on systemic hemodynamics and regional blood circulation in rats.

Diaspirin crosslinked hemoglobin (DCLHb, Baxter Healthcare Corporation) a hemoglobin-based blood substitute has been found to increase mean arterial pressure (MAP) in a dose limiting manner. The present study was undertaken to determine dose-dependent effects of DCLHb on systemic hemodynamics and regional blood circulation. DCLHb (10% solution) in doses of 133, 400 and 1200 mg/kg i.v. was given to urethane anaesthetized rats. Normal saline (12 ml/kg) served as a control. Cardiovascular parameters were determined using a radioactive microsphere technique. DCLHb in the doses of 133, 400 and 1200 mg/kg i.v. produced a 46%, 67% and 65% increase in MAP, respectively. Total peripheral resistance (TPR) increased significantly with 133 and 400 mg/kg dose, while cardiac output increased significantly with 400 and 1200 mg/kg dose. There was no change in heart rate. A dose of 133 mg/kg of DCLHb produced a significant decrease in blood flow to the musculoskeletal system, kidney and liver. DCLHb in the dose of 400 and 1200 mg/kg significantly increased blood flow to the heart, gastrointestinal tract (GIT), mesentery & pancreas and skin. All doses of DCLHb produced a significant increase in vascular resistance to the musculoskeletal system and liver. DCLHb in the dose of 133 mg/kg increased resistance to the GIT. heart, skin and kidneys, while the dose of 400 mg/kg increased resistance to the kidneys. A dose of 1200 mg/kg decreased coronary vascular resistance. It is concluded that cardiovascular effects appear to be different with higher (1200 mg/kg) and lower (133 mg/kg) doses of DCLHb.

Animals↗

[Sickness absence in persons who leave their jobs due to various reasons].

BACKGROUND: The present analysis is a continuation of studies carried out in the same plant during the economic transformation and after the restructure. It is aimed at indicating variations in sickness absence, its extent and morbid causes in persons who leave their jobs due to various reasons (disability pension, retirement pension, plant under economic constraint, agreed change of affiliation, or a worker's notice to terminate the employment contract). MATERIALS AND METHODS: The study was carried out in a large transport industrial plant during its economic transformation (1989-1994) in a group of 8588 workers, and after its restructure (1997-1999) in a group of 2702 workers. The analysis was based on such absence parameters as the age standardized sickness absence rate, sickness absence cases and the average duration of sickness absence. The linear regression and Poisson regression models were used in the analysis. RESULTS: The onset of the transformation was characterized by a growing number of workers who got retired or applied for disability pension prior to the period of redundancy procedures. After the restructure, affiliation changed to the private sector prevailed (44% of the staff), and the second place was occupied by the termination of employment contracts due to economic reasons (25%). The analysis revealed that sickness absence among workers who left the plant in 1989-1994 was twice as high as that among workers who continued their employment, whereas among workers who left their jobs in 1997-1999 it was 50% higher in men and 20% higher in women than that among workers who continued their employment. The highest rate of sickness absence was noted in 1989-1994, when workers applied for or left due to disability pension. This rate accounted for about 25, which means that those workers had failed to work one fourth of the required time. Diseases of the circulatory, respiratory and musculoskeletal systems formed the major group of causes of applying for disability pension. A high rate of sickness absence was noted in the group of workers discharged because of economic reasons. Interestingly, after the restructure of the plant sickness absence in this group of workers did not diminish, on the contrary it increased both in men (21%) and women (8%) mostly due to mental disorders and diseases of the musculoskeletal system. In 1989-1994, the sickness absence rate among men who continued their employment was 3.46 on average, and it remained low during the whole period covered by the study. In 1997-1999, this rate fell to 3.09. In the former period, the sickness absence rate among women was higher accounting for 5.87 and in the latter it decreased to 3.89% (a 34% decrease). The lowest rates were observed in workers who joined the private sector in 1997-1999 (2.29 for men and 3.48 for women). An analysis of dynamics showed that the decrease in the risk of sickness absence was significantly depended on the proportion of workers leaving the job because of the enterprise's economic constraints, and the increase in the average duration of sickness absence, especially in the onset of economic transformation, was also dependent on the percentage of workers discharged because of economic reasons. CONCLUSIONS: The plant restructure as a result of economic transformation in Poland contributes to the increase in sickness absence mostly through earlier retirement, disability pensions and discharge because of economic reasons. The increase in sickness absence is determined by still longer duration of sickness absence, as the number of identified cases decreases with the increasing lapse of time following the transformation.

Absenteeism↗

The Sock Test for evaluating activity limitation in patients with musculoskeletal pain.

BACKGROUND AND PURPOSE: Assessment within rehabilitation often must reflect patients' perceived functional problems and provide information on whether these problems are caused by impairments of the musculoskeletal system. Such capabilities were examined in a new functional test, the Sock Test, simulating the activity of putting on a sock. SUBJECTS AND METHODS: Intertester reliability was examined in 21 patients. Concurrent validity, responsiveness, and predictive validity were examined in a sample of 337 patients and in subgroups of this sample. RESULTS: Intertester reliability was acceptable. Sock Test scores were related to concurrent reports of activity limitation in dressing activities. Scores also reflected questionnaire-derived reports of problems in a broad range of activities of daily living and pain and were responsive to change over time. Increases in age and body mass index increased the likelihood of Sock Test scores indicating activity limitation. Pretest scores were predictive of perceived difficulties in dressing activities after 1 year. CONCLUSION AND DISCUSSION: Sock Test scores reflect perceived activity limitations and restrictions of the musculoskeletal system.

Activities of Daily Living↗

Evaluation of outcome of care in patients with haemophilia.

Haemophilia is a potentially disabling condition associated with high financial costs, and so the need for robust measures to evaluate outcome of care is essential. This paper is a review of some of the outcome measures commonly used to evaluate treatment in haemophilia and includes quality of life measures, evaluation of the musculoskeletal system and orthopaedic surgical procedures. Quality-of-life questionnaires are discussed with particular reference to the SF36 and AIMS2. Results of published studies to date have demonstrated variable results. Overall, haemophilia appears to reduce quality of life compared to normal population figures. Several factors are perceived to reduce quality of life, and these include being human immunodeficiency virus (HIV) positive, having impairments, and a history of orthopaedic surgery. The evaluation of the musculoskeletal system is important in order to detect any deterioration over time. Various standardized measurement tools are described. Orthopaedic surgical procedures have also been evaluated in patients with haemophilia. To date, the Hospital for Special Surgery Knee rating scale has been the most commonly used to evaluate the outcome of total knee replacement. The limitations of this system for patients with haemophilia are outlined. Overall, these measures provide useful tools for evaluating outcome, but none have been specifically developed for patients with haemophilia. Further studies would be useful to evaluate these tools and others in more depth.

Health Status Indicators↗

[Limited efficacy of opioids in chronic musculoskeletal pain].

After excluding malignant disease in 21 patients with unremitting strong pain of the musculoskeletal system despite long-term opioid medication, the opioids were withdrawn to search for reasons of the limited effectiveness of the opioids. The opioid withdrawal was integrated in multimodal pain coping therapy. Besides the somatic diagnoses, pain-relevant psychosomatic diagnoses were evaluated with the structured clinical interview for DSM-IV (SCID). At the time of admission and discharge pain medication, physical functions, mood, and pain intensity were recorded. In the SCID interview, all patients were diagnosed with a relevant comorbid psychiatric condition (pain disorder, anxiety, depression). Despite reduction of the opioid medication, there was no increase of pain, but an improvement of the physical functions. In patients with chronic pain of the musculoskeletal system and limited effectiveness of opioid medication, psychosomatic comorbidities should be evaluated. Instead of continued and increased opioid medication, pain coping strategies and opioid withdrawal should be tested.

Analgesics, Opioid↗

Three-dimensional reconstruction of the hip muscles on the basis of magnetic resonance images.

MRI in combination with three-dimensional reconstruction is pre-eminently suitable for the study of the human musculoskeletal system in vivo in an accurate and detailed way. MRI provides the possibility of studying superficial as well as deep muscles under tension in the living state. Bones, muscles, tendons and adipose tissue are clearly visible. Parts can also be distinguished within a muscle. After reconstruction of the 2-D images the geometry of the muscles and muscle parts can be visualized from different angles. This leads to a deeper understanding of the biomechanics and functional anatomy of the musculoskeletal system of the human body. In this paper the morphology of the muscles around the hip was studied in three subjects in vivo on the basis of three-dimensional (3-D) reconstructions of two-dimensional (2-D) MR images.

Adult↗

A rationale for the treatment of back pain and joint pain by manual therapy.

Manual therapy, with its emphasis on joint movement and exercise, has become increasingly important for the treatment of pain and dysfunction of the musculoskeletal system. The rationale used to explain the success of manual therapy has changed radically in recent years. Early explanations, which included concepts such as adjusting joint subluxations, restoring bony alignment, and reducing nuclear protrusion, have been shown to have no basis in fact. Current biological research shows the value of movement in maintaining the health and strength of collagenous, muscular, and bony tissues and emphasizes the need for joint movement and for relatively high levels of activity throughout the life cycle. The musculoskeletal system thrives on stress and movement and reacts adversely to prolonged rest or immobilization. The problems associated with working or recreational postures involving prolonged loading at or near the limit of joint range of motion are considered together with a rationale for appropriate therapeutic management. Explanations are provided to enable an understanding of the success of intensive physical therapy for chronic back pain and for manipulation in the treatment of the acute painful locked back.

Bed Rest↗

Longer moment arm results in smaller joint moment development, power and work outputs in fast motions.

Effects of moment arm length on kinetic outputs of a musculoskeletal system (muscle force development, joint moment development, joint power output and joint work output) were evaluated using computer simulation. A skeletal system of the human ankle joint was constructed: a lower leg segment and a foot segment were connected with a hinge joint. A Hill-type model of the musculus soleus (m. soleus), consisting of a contractile element and a series elastic element, was attached to the skeletal system. The model of the m. soleus was maximally activated, while the ankle joint was plantarflexed/dorsiflexed at a variation of constant angular velocities, simulating isokinetic exercises on a muscle testing machine. Profiles of the kinetic outputs (muscle force development, joint moment development, joint power output and joint work output) were obtained. Thereafter, the location of the insertion of the m. soleus was shifted toward the dorsal/ventral direction by 1cm, which had an effect of lengthening/shortening the moment arm length, respectively. The kinetic outputs of the musculoskeletal system during the simulated isokinetic exercises were evaluated with these longer/shorter moment arm lengths. It was found that longer moment arm resulted in smaller joint moment development, smaller joint power output and smaller joint work output in the larger plantarflexion angular velocity region (>120 degrees/s). This is because larger muscle shortening velocity was required with longer moment arm to achieve a certain joint angular velocity. Larger muscle shortening velocity resulted in smaller muscle force development because of the force-velocity relation of the muscle. It was suggested that this phenomenon should be taken into consideration when investigating the joint moment-joint angle and/or joint moment-joint angular velocity characteristics of experimental data.

Ankle Joint↗