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At least 613 records · Page 34Linked to original sources
PubMed2002

Association of cagA and vacA genotypes of Helicobacter pylori with gastric diseases in Estonia.

Gastric biopsy specimens from 156 adult patients from southern Estonia suffering from chronic gastritis, peptic ulcer disease, and perforated peptic ulcer were analyzed by PCR. The cagA gene was evenly distributed throughout 87% of the specimens from the patients with the different gastric diseases. The presence of the cagA gene correlated with that of vacA signal sequence type s1a (99%). However, no clear differences were found in the distribution of cagA and vacA genotypes among patients in Estonia with severe perforated peptic ulcer, uncomplicated peptic ulcer, or chronic gastritis.

Antigens, Bacterial↗
PubMed1977

Drug consumption before perforation of peptic ulcer.

In a retrospective study of 195 patients with a perforated peptic ulcer 18 per cent of the patients had taken aspirin, phenylbutazone or corticosteroids during the period before the perforation. In a controlled prospective trial, 18 of 22 patients (82 per cent) had taken drugs known to be potentially harmful to the stomach. Aspirin was the drug mainly used. Thirteen of 22 patients had taken the drugs within 12 hours of the perforation, usually because of symptoms not related to the gastro-intestinal tract. Drug consumption and perforation of pre-pyloric ulcers were most closely associated; the latter applies particularly to female patients, who either had only a short history of upper gastro-intestinal dyspepsia or were asymptomatic.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Surgical management of acute perforation of peptic ulcers. A single centre experience.

INTRODUCTION: Acute perforation may occur in gastric and duodenal ulcers. During the past decade, the need for elective operation for peptic ulceration has decreased as medical treatment has improved. However, emergency operations for acute complications such as perforation or bleeding remain constant. Actually, the treatment of choice is simple suture-closure, with or without omentoplasty, and peritoneal lavage or even omentoplasty alone, associated with a high intravenous dose of inhibitors of the proton pump and Helicobacter pylori eradication, if needed. PATIENTS AND METHOD: The standard treatment in our team is to perform a peritoneal lavage and drainage and a simple closure of the ulcer with an omentoplasty. A first retrospective analysis was made on data collected from 1996 to 2001 and we completed a prospective study from 2001 to 2003 to compare our results with our old data and with data collected from other teams. RESULTS: The mean age and the mean ASA score were similar in the two groups. For the majority of the patients, the diagnosis was made from symptoms and the presence of free abdominal air. The delay between arrival in the emergency room and the operating room was significantly shorter in the second group, but operating time was longer in this group. Morbidity was more frequent in the first group but mortality remained quite similar. Our results indicate that in a trained team the morbidity has decreased as the delay in surgery decreased and that the rate of diagnosis on plain abdominal film has increased. Laparoscopic suture of a perforated peptic ulcer is as safe as the open procedure but allows the surgeon to search for another cause of free air and offers the possibility, if conversion is needed, to perform a shorter laparotomy.

Acute Disease↗
PubMed1990

Survival following perforation of peptic ulcer.

Between 1979 and 1989, 92 patients were treated at St George Hospital, Kogarah, for perforated duodenal or prepyloric ulcer. Mortality rate at 28 days was 18%. Life table analysis showed 1-, 5- and 10-year survival rates for this group to be 78%, 60% and 46% respectively. During the second half of the study period, increasingly older females with a history of cardiovascular disease, arthropathy, chronic renal impairment and non-steroidal anti-inflammatory drugs (NSAIDS) intake were identified and found to be at greater risk of dying from their perforation. Age, cardiovascular disease and chronic renal impairment were demonstrated to be independent factors affecting survival. Patients treated by simple closure of the perforation had a long-term survival rate equivalent to that of patients treated in other ways, although the number of these latter patients is small. Implications for the administration of NSAIDS are considered in the light of these findings. These results suggest that orthodox simple closure of perforated peptic ulcer and administration of H2 blocking agents is the most appropriate treatment for patients presenting with perforated peptic ulcer.

Actuarial Analysis↗
PubMed1979

Perforation of peptic ulcers related to fiberoptic endoscopy.

Three cases of perforation of peptic ulcers related to either fiberoptic endoscopy or esophageal dilation are presented. A correct preoperative diagnosis can be made by recognising the onset of acute abdominal symptoms and signs after an uneventful fiberoptic examination or dilation of stricture in patients with preexisting ulcer symptoms. The complication is especially likely to occur in peptic ulcer disease coexisting with esophageal stricture, possible due to air trapping in the stomach.

Duodenal Ulcer↗
PubMed1990

[Perforated gastroduodenal ulcer. I. postoperative mortality and late results following simple suturing].

Following the introduction of H2-blockers in the treatment of gastroduodenal ulcer disease, there has not been a change in the incidence of perforated peptic ulcer. By the diagnosis of perforated peptic ulcer the indication for an emergency operation is shown in generally. The postoperative mortality amount now as before 10% and the ulcer relapse rate behave less or more high, dependent on operative procedures, which optical choice is open. Therefore the perforated gastroduodenal ulcer has not lost any actuality. The following paper takes into account the informations of 245 patients from 1970 to 1988, which perforation of peptic ulcer were treated only with simple suture. The collection of data was retrospective till 1985 and since then prospective. Beside analysis of postoperative mortality, reasons of death, complications during healing and preoperative false diagnosis we have done a follow up of operated patients till 1987 (n = 232). On the basis of the results a statement was given for the therapeutical management of ulcer perforations.

Adolescent↗
PubMed1983

Trends in hospital admission, perforation and mortality of peptic ulcer in Hong Kong from 1970 to 1980.

During 1970-1980, admissions for peptic ulcers per 100,000 population to all government and government-assisted hospitals in Hong Kong increased by 21% from 152 to 185. At the same time, peptic ulcer perforations per 100,000 population increased by 71% from 9.3 to 15.9. The percentage of men greater than 60 yr of age with ulcer perforation rose from 18.1 to 24.4, while that in the general population rose from 2.9 to 3.9. However, the male/female ratio has remained stable at approximately 6:1. During the same period, mortality rate per 100,000 population due to peptic ulcer declined by 26% from 4.2 to 3.1. Thus, while the hospitalization and perforation rates for peptic ulcer appeared to be falling in the United States and the United Kingdom over the past decade, the opposite has occurred in Hong Kong.

Adult↗