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Results for “PITUITARY IRRADIATION”

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At least 613 records · Page 34Linked to original sources
PubMed2006

[Proton irradiation of the pituitary gland for alleviating pain in patients with disseminated prostate cancer].

Central Research Institute of Roentgeno-Radiology; Medical Academy for Further Education, St. Petersburg Stereotactic ablation of the frontal lobe of the pituitary with narrow beams of 1,000 MeV protons was performed in 80 patients to alleviate pain caused by bone metastases. Pain was aborted for a long time so that pain-relieving medication was suspended in 56 (70%) patients. The remaining patients cut down on taking analgetics: peripheral drugs were taken by 11(13.75%), non-narcotic opioids (tramal)--4 (5%), class III opioid narcotics--7 (8.75%), and morphine-type drugs--only 2. No untoward side-effects were reported.

Aged↗
PubMed1990

[Treatment of disseminated breast cancer with combined irradiation of the hypophysis by protons and zone gamma irradiation of the skeleton].

Survival was assessed in three groups of disseminated breast cancer with multiple bony metastases. Group I (194 patients) was given a combination of proton irradiation of the pituitary and sequential zone gamma-ray teletherapy of the skeleton, group II (98) received the first component and group III (162 cases)--the latter component of the modality only. Cumulative survival curves for groups I and II were well approximated by exponential function of the follow-up period; mean survival was 36.4 and 11.4 months, respectively. The difference was statistically significant. Within a period of about 12 months, survival curves for groups I and III were nearly identical. However, with the increasing number of bony metastases, the group III curve slope tended to match that of group II. Corresponding mean survival for that segment of the curve was 13 months. Mean survival for historic control was 12.1 months. Thus, pronounced and lasting increase in survival was not observed unless the procedures were used together.

Adult↗
PubMed1994

A prospective study of hypothalamus pituitary function after cranial irradiation with or without radiosensitizing chemotherapy.

Hypopituitarism can occur after cranial irradiation. Combined chemotherapy (CT) and radiotherapy (RT) have greatly improved the survival of patients with nasopharyngeal carcinoma (NPC). We studied 37 NPC patients who received RT and/or CT prospectively to determine if combined CT worsens the radiation damage. Patients were studied before, 6 months, 1 year and 2 years after treatment, with 4 combined hypothalamic releasing hormones stimulation test and insulin hypoglycemic test. Five developed hypothyroidism and 3 developed hyperprolactinemia after treatment. The TSH response to TRH progressively increased. In male patients who received RT only, the LH response to GnRH was reduced after RT. The FSH response to GnRH increased 6 months and 1 year after RT, and returned to pretreatment level 2 years after RT. In male patients who received RT and CT, after an initial rise 6 months after treatment, both FSH and LH responses to GnRH declined. The ACTH response to ovine CRH was decreased 6 months after RT and remained so later on, while the cortisol response became prolonged and enhanced progressively after RT. The peak GH response to GRH increased significantly 1 year after RT in patients who also received CT. The GH response to insulin hypoglycemia was also increased after RT while the cortisol response remained the same. In conclusion, cranial irradiation caused a progressive impairment of the hypothalamus-pituitary-endocrine axes. Combined CT may mask the radiation damage to GnRH neuron by inducing primary hypogonadism. There may be hippocampal damage in addition to hypothalamo-pituitary damage after cranial irradiation.

Adolescent↗
PubMed1980

Prolactin-secreting pituitary adenoma. Observations in irradiated patients.

Six women with clinical, biochemical and radiologic evidence of a prolactin-secreting pituitary adenoma were irradiated with 50 Gy in 5 1/2 weeks. In 3 of the 6 patients, irradiation preceding maintenance bromocriptine medication was followed by a normalization of serum prolactin levels which resulted in a normal pregnancy in 2 and reestablishment of the menstrual cycle in the third. In 5 of 6 patients serum prolactin was substantially reduced by the end of the treatment, but without reaching normal levels, although no correlation was found between the degree of this decrease and the clinical result.

Adenoma↗