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At least 613 records · Page 34Linked to original sources

PubMed1996

[Does propofol have advantages over isoflurane for sufentanil supplemented anesthesia in children for strabismus surgery?].

OBJECTIVE: The present study investigates the effectivity and the incidence of side effects of sufentanil-supplemented propofol versus isoflurane anaesthesia in children undergoing elective strabismus surgery. METHODS: 130 children (aged 3-11; ASA I-II) were randomly allocated to one of four groups. In group 1 and 2, anaesthesia was induced with 2 mg/kg propofol and maintained with 15-20 mg/kg x h propofol and 30% O2 in air (group 1) or 10-15 mg/kg x h propofol in N2O (group 2). After induction with either 2 mg/kg propofol (group 3) or 5 mg/kg thiopentone (group 4), anaesthesia was maintained with 0.8-1.5 Vol% isoflurane and N2O in 30% O2 in these groups. All children were orally premedicated with midazolam and atropine and received a single dose of intravenous sufentanil (0.5 micrograms/kg) and atracurium (0.5 mg/kg) prior to intubation. Heart rate, mean arterial blood pressure and pulse oximetry were registered 5 min prior and after intubation as well as 10 min before and 5 min after extubation. The incidence of pain and involuntary movements during injection, oculocardiac reflex (OCR), laryngospasm and postoperative shivering were as well registered as the duration of the operation and the time of extubation. Episodes of nausea and vomiting were documented during 24 hours postoperatively. RESULTS: TIVA with Propofol resulted in a decreased heart rate (p = 0.002) and a higher frequency of OCR (p = 0.01) than thiopentone/isoflurane anaesthesia with a higher sensitivity of children younger than 6 years (p = 0.007) in all groups. There were no differences in extubation time between groups. The overall incidence of nausea (p = 0.002) and vomiting (p = 0.007) was lower in group 1 and 2 when compared to group 3 and 4. CONCLUSION: Propofol as an induction agent of balanced anaesthesia fails to show advantages over thiopentone. During total intravenous anaesthesia propofol increases the risk of bradycardia especially in younger children. However, a significantly lower incidence of postoperative nausea and vomiting after TIVA with propofol and sufentanil, irrespective of N2O administration, may be an advantage over isoflurane anaesthesia in paediatric patients after strabismus surgery.

Anesthesia, General↗

PubMed1998

[Screening for amblyopia, strabismus and refractive abnormalities in 1,030 kindergarten children].

BACKGROUND: There are controversies concerning the necessity of pre-school vision screening. AIM OF THE STUDY: evaluation of the prevalence of pathologic ophthalmologic findings in kindergarten children. MATERIALS AND METHODS: 1030 families were offered a vision screening. Of these, a total of 948 children, aged 3 to 6 years, voluntarily underwent a screening for strabismus, amblyopia and refractive anomalies. The examination was performed in the kindergarten in the absence of the parents. METHODS OF EXAMINATION: A questionnaire concerning general and ophthalmologic history of the child and of the family was evaluated. Visual acuity, cover-uncover-test, Lang-stereotest, retinoscopy, ophthalmoscopy (undilated pupils) were performed and the glasses were evaluated. RESULTS: The screening was highly accepted by the parents and 92% of the families (n = 948) took part. The compliance of the children was very good. A total of 38.7% (n = 381) of the children showed one or more abnormal parameters. 21.4% (n = 229) showed a reduced visual acuity. Strabismus was found in 3.7%. Half of the children with abnormal findings already had had a vision screening, but only 25% had received ophthalmologic treatment. Of those who possessed glasses, 25% came without them, and another 25% had a reduced visual acuity even with their glasses. The main problems were many false-positive results and high costs. CONCLUSIONS: Ophthalmologic and orthoptic screening in kindergarten is technically easy and conclusive in experienced hands. Ideas to reduce costs and to avoid overreferrals are an age-related lowering of the visual acuity limit and a rescreening of suspected children in a screening-setting a second time before sending them to an ophthalmologist. Another possibility to reduce costs would be to perform examinations not by ophthalmologists but by "screening-orthoptists" who should be trained in retinoscopy and ophthalmoscopy.

Amblyopia↗

PubMed1996

[Functional and structural abnormalities in the visual cortex in early childhood strabismus].

BACKGROUND: To investigate the structural basis for functional deficits in infantile strabismus we used a neuroanatomic tracer and a histochemical label to examine the primary visual cortex (area V1) of adult esotropic macaque monkeys. ANIMALS AND METHODS: The animals had developed natural esotropia in the first months of life, alternated fixation, and exhibited the ocular motor signs that typify strabismus with onset in infancy. After behavioral and VEP testing, ocular dominance columns (ODCs) in V1 were injected with a neuronal traser and labeled for cytochrome oxidase activity. RESULTS: The strabismic monkeys showed striking deficits in binocular luminance visually-evoked potentials (VEPs) and characteristic directional asymmetries in motion VEPs. Binocular horizontal connections between ODCs were reduced an average of 50-60% in strabismic as compared to normal monkeys. ODCs also showed unequal metabolic activity with contralaterally (i.e. nasal retina) driven ODCs showing greater activity in each V1. DISCUSSION AND CONCLUSION: The maldevelopment of connections in upper V1 layers correlates with the abnormalities in binocular and motion VEPs. The unequal metabolic activity suggests interocular suppression. These results provide the first neuroanatomic evidence for cerebral cortex maldevelopments in natural infantile esotropia.

Animals↗

PubMed1996

[Effect of strabismus operation of corneal topography].

BACKGROUND: In order to determine the short- and long-term influence of strabismus surgery on corneal curvature, a prospective study was carried out measuring corneal topography before and after operation. PATIENTS AND METHODS: Corneal topography was performed using a computer assisted videokeratoscope. 77 eyes of 74 patients were examined 1 day before and 1 day as well as 3 months after surgery. Data of the semimeridians at 0 degree, 90 degrees, 180 degrees and 270 degrees in the 3-, 5- and 7-mm zone and of the corneal center were analyzed. Objective refraction, induced astigmatism and simulated keratometer reading were evaluated. 39 horizontal recess-resect procedures. 12 inferior rectus recessions, 10 horizontal resections. 10 inferior oblique recessions and 6 other procedures were performed. RESULTS: The spheric equivalent of objective refraction decreased by 0.23 D. The absolute astigmatism increased by 0.16 D, the maximum change was 1 D. Changes of objective refraction were statistically not significant. The simulated keratometer reading increased by 0.2 D postoperatively and returned to the initial value after 3 months. With few exceptions, corneal topographic changes were small, statistically not significant and nearly disappeared after 3 months. Corneal flattening tended to occur in the semimeridian of resection while corneal steepening was observed at the site of recession. CONCLUSIONS: The influence of strabismus surgery on corneal astigmatism is usually small and mostly transitory. In a few cases, however, the induced astigmatism persists. Patients should be informed about this possibility preoperatively.

Adolescent↗

PubMed1988

[Torsional shift operation, a tool in complete early childhood strabismus].

By means of torsional shift operation, or "rotatory Kestenbaum procedure" - in which both ocular bulbs are rotated to the side to which the head is inclined - head malpostures can be eliminated or alleviated in three out of four cases. This applies both to the smaller group of patients with true nystagmus compensation as well as to the large group with "tilt" as a part-symptom of Lang's early-onset strabismus syndrome. The procedure for all four oblique muscles is described in detail, including the strategies for preventing side effects. The results of 98 operations are presented in tabular form. Additionally, the authors describe on the basis of case histories how to apply and modify the procedure when other typical, severe symptoms of early-onset strabismus syndrome require surgical correction. The discussion considers facts and hypotheses relating to the pathophysiological background.

Adolescent↗

PubMed1981

[Prognosis of functional healing of infantile strabismus].

One hundred and forth-three patients suffering from infantile strabismus, who had undergone surgery on the horizontal eye muscles between the ages of 0 and 6 years were re-examined with the aim of establishing a correlation between the date of operation and functional healing (binocular single vision in space). In 89 patients (62%) a cosmetically satisfactory result (alignment) was achieved. The number of operations and functional healing (binocular single vision in space). In 89 patients (62%) a cosmetically satisfactory result (alignment) was achieved. The number of operations needed decreased with increasing age. Of the 89 patients with alignment, 61 (69%) were found to have binocular single vision in space, while 13 (15%) patients presented with stereopsis. Impairment of functional results was found to correlate with higher age at the first operation or on the date when alignment was reached for the first time, respectively. In cases with amblyopia or vertical divergences which had received insufficient postoperative treatment, attainment of binocular single vision or, respectively, the stability thereof was impaired. Therefore, with respect to functional healing, early surgical correction of strabismus is only recommended if adequate postoperative conservative and/or surgical after-treatment is assured. The postulate that successful functional healing can only be achieved by operations up to the second year (early surgery) is not supported by our data.

Child↗

PubMed2000

Strabismus surgery complicated by "pulled in two syndrome" in a case of breast carcinoma metastatic to the medial rectus muscle.

Metastatic carcinoma to the extraocular muscles is extremely rare; it is reported to occur from breast, lung, and gastric carcinoma as well as skin melanoma. (1-3) Overall, intraocular metastases occur much more frequently than orbital metastases.(4) The most common primary tumors causing orbital metastases are breast and lung carcinomas.(5) Strabismus due to orbital metastases from breast carcinoma usually results from fibrosis of the muscle, which often causes painful ophthalmoplegia and enophthalmos. (6,7) We report a case of presumed metastatic carcinoma to the medial rectus muscle causing restrictive strabismus in which surgery was complicated by the "pulled in two syndrome," or PITS.

Aged↗

PubMed2001

Thermal cautery as a treatment for conjunctival inclusion cyst after strabismus surgery.

Conjunctival cysts may be congenital or acquired. A common cause of acquired conjunctival inclusion cysts is the implantation of conjunctival epithelium after surgery or trauma. These cysts often form at the site of muscle reattachment after strabismus surgery. They may disappear spontaneously, but persistent cases often require surgical excision. We report a new technique using cauterization under slit-lamp visualization to treat conjunctival inclusion cysts that can form after strabismus surgery. This procedure is fast, effective, and well tolerated by patients.

Adolescent↗

PubMed2001

Telemedicine: Strabismus e-consultation.

BACKGROUND: Volunteer ophthalmologists can achieve success with teaching and service programs working with high intensity over a short term. Continuation of initially successful programs may be limited by lack of timely, effective communication and follow-up. In an attempt to overcome these limitations, a total of 6 telemedicine programs were established after a successful trial program at the Ramon Pando Ferrer Hospital in Havana, Cuba. METHODS: Two pediatric ophthalmology-strabismus clinics, one in Cuba and one in Romania, were provided a digital camera and a computer in order to obtain and then transmit by e-mail patient images obtained according to a prescribed format. Ophthalmologists in both of these programs were instructed personally during an orientation period in their clinics. Training included use of a digital camera and computer, patient examination, and surgical technique in the operating room. Four additional programs referred patients via digital images after receiving only written and oral instruction. RESULTS: The diagnosis and treatment plan determined by one of us (E.M.H.) for each of the first 15 Cuban patients after study of digital images sent by e-mail was the same as the diagnosis and treatment plan determined by the same observer after in-person examination of the patients. On the basis of the level of confidence attained in these patients, 35 additional patients from a total of 6 clinics were seen by digital consultation only. CONCLUSION: A store-and-forward telemedicine consultation technique that uses digital images and e-mail holds promise to be an effective means for carrying out consultation for patients with strabismus.

Child↗

PubMed2002

Evaluation of the ultrasound biomicroscope in strabismus surgery.

PURPOSE: This study was done to determine the ability of the ultrasound biomicroscope (UBM) to define the distance of the horizontal extraocular muscle insertions from the limbus in children undergoing strabismus surgery. METHODS: A total of 51 children undergoing primary surgery on their horizontal muscles were recruited for this study. The 50 MHz UBM was used before surgery on the muscle(s) requiring an operation to define the distance of the insertion of the horizontal rectus muscle(s) from the limbus. These data were stored on a computer and masked from the surgeon who measured the actual insertion from the limbus with calipers intraoperatively. An intraclass correlation coefficient was calculated to determine the correlation of the UBM measurement with that performed during surgery. RESULTS: Measurement of the distance of the insertions from the limbus were taken on 79 muscles of the 51 patients: 44 medial rectus (MR) and 35 lateral rectus (LR). Mean age of the patients was 6.4 +/- 3.7 years (range, 1-15). A total of 29 children (56.9%) were female. The mean distance of MR from the limbus measured surgically was 5.2 +/- 0.6 mm (range, 4-6 mm; median, 5 mm) and measured with the UBM was 5.2 +/- 0.9 mm (range, 4-7.6 mm; median, 5.3 mm). Comparable results for the LR muscles were 6.4 +/- 0.6 mm (range, 5.5-7.5 mm; median, 6.5 mm) and 6.9 +/- 0.7 mm (range, 5.9-8.4 mm; median, 6.9 mm), respectively. An intraclass correlation coefficient of 0.71 signified good agreement between the surgical and UBM measurements of the distance from the limbus of the horizontal rectus muscle insertions. CONCLUSION: The UBM could be used reliably as a tool before surgery to estimate the distance of the horizontal rectus muscles from the limbus in children with strabismus.

Adolescent↗

PubMed2002

Up-slanting palpebral fissures and oblique astigmatism associated with A-pattern strabismus and overdepression in adduction in spina bifida.

PURPOSE: To describe the spectrum of adnexal and ophthalmologic features in spina bifida. METHODS: A retrospective review of the medical records of 73 patients was conducted. Data concerning ocular motility, palpebral fissure orientation, presence and axis of astigmatism, visual acuity, amblyopia, and stereopsis were analyzed. RESULTS: Forty-three (59%) of the 73 patients had strabismus: 28 (65%) had esotropia, 12 (28%) had exotropia, and 3 (7%) had orthotropia in primary gaze and a significant A-pattern. Of the strabismic patients, 20 (47%) had an A-pattern, of which 13 (65%) demonstrated overdepression in adduction. Twenty-seven (84%) of the 32 patients with documented palpebral fissure orientation had exaggerated up-slanting palpebral fissures. Forty-nine (77%) of 64 patients exhibited astigmatism greater than 0.75 D in at least 1 eye, with a mean power of 1.6 D. The axis of cylinder was oblique in 76% of these patients. The astigmatic axis was consistently oriented perpendicular to the eyelid fissure orientation in the group of patients with up-slanting palpebral fissures, with the mean axis of cylinder being incyclorotated (OD axis, 77; OS axis, 108). Up-slanting palpebral fissures were associated with a 15-fold increased chance that the axis of cylinder would be incyclorotated (P =.07, chi-square test). An orbital computed tomographic (CT) scan of a spina bifida patient with A-pattern esotropia, overdepression in adduction, and up-slanting palpebral fissures demonstrated significant incyclorotated extraocular muscle pulley heterotopy. CONCLUSIONS: Exaggerated up-slanting palpebral fissures are a prominent feature in spina bifida. Up-slanting palpebral fissures in spina bifida patients are associated with incyclorotated oblique astigmatism, A-pattern strabismus, and overdepression in adduction. These associations might be related to an anomaly of orbital skeletal or extraocular muscle pulley development. Further prospective study is encouraged.

Adolescent↗

PubMed2003

Subtenons lidocaine injection for postoperative pain relief after strabismus surgery in children: a pilot study.

BACKGROUND: Ophthalmologists are now encouraged to perform strabismus surgery as an outpatient procedure, but postoperative pain may be a barrier to discharge. Systemic analgesics have side effects or are contraindicated in some patients. We designed a trial to determine the efficacy of subtenons lidocaine injection at reducing postoperative pain and systemic analgesia requirements. METHODS: Children having unilateral primary horizontal muscle surgery were randomized to either receive an injection of 1 mL of 2% lidocaine into the inferonasal subtenons space or not. The child's parents, who were masked to the intervention, assessed pain over 4 hours postoperatively using an objective pain-scoring tool. RESULTS: Seventeen children received injections and 14 did not. Five of the subtenons group required additional analgesia (29%) compared to 9 of the controls (64%, chi(2): P =.052). The pain scores at each time interval tended to be lower in the treatment group, compared to controls, statistically significantly so at the 2-hour observation (Mann-Whitney U test: P =.01). CONCLUSIONS: These data provide some evidence of an association between the use of subtenons lidocaine injection and a reduction of pain experienced by children in the immediate postoperative period following primary strabismus surgery.

Anesthetics, Local↗

PubMed2003

Extraocular muscle force generation after ricin-mAb35 injection: implications for strabismus treatment.

PURPOSE: Ricin-mAb35 is an immunotoxin targeted against skeletal muscle. Previously, we have shown that injection of ricin-mAb35 into rabbit extraocular muscle results in long-term muscle loss, and we have proposed this as a potential treatment for strabismus. In this study, we assessed the effects of ricin-mAb35 injection on extraocular muscle force generation. METHODS: Ricin-mAb35, 0.2 microg/kg in a volume of 0.1 mL, was injected into 1 superior rectus muscle in 16 adult rabbits. The contralateral superior rectus was injected with an equal volume of normal saline. Muscle force generation was assessed in vivo at 1, 6, and 12 weeks. Isometric length-tension curves were developed. Single-twitch tension, peak tetanic force generation, and fatigue rate were determined at optimal preload. Data from treated and control muscles were compared with the paired t test. RESULTS: Force generation declined in ricin-mAb35 treated muscles at each postinjection interval. At 12 weeks, mean tetanic tension (200 Hz) in treated muscles was 13.8 mN/cm(3) compared with 27.7 mN/cm(3) in saline-injected controls (P =.02), a reduction of 50%. Single-twitch tension at 12 weeks was reduced 33% compared to controls (P =.04). Similar effects were noted at 1 and 6 weeks. Fatigue rate was not greater in treated muscles at any postinjection intervals. CONCLUSIONS: Injection of ricin-mAb35 results in sustained weakness in extraocular muscle, although additional studies will be required to determine the duration of physiologic effect. These results confirm our histological analysis and suggest that ricin-mAb35 may be a more long-term alternative to botulinum toxin A for the treatment of strabismus.

Animals↗

PubMed2004

Diagnostic occlusion test in cases of unilateral strabismus sursoadductorius.

PURPOSE: To investigate the diagnostic occlusion test (OT) according to Marlow in strabismus sursoadductorius (StS; also known as 'unilateral superior oblique palsy') and its implications for surgical treatment. METHODS: In 67 cases of StS, angles of strabismus were measured before and after patching the affected eye for three days. Horizontal, vertical and torsional deviations were measured in front of the tangent screen of Harms in nine directions of gaze. RESULTS: After OT, most cases of StS showed the following distribution of vertical deviation (VD) on horizontal versions: setting the VD in 30 degrees adduction to 100%, VD in primary position (PP) was 50%, VD in abduction 14%, excyclotropia in PP about 40% of the amount of VD. Those StS-cases showing the same distribution of VD on horizontal versions before and after OT were called 'typical' ones (27% of the patients). However, 73% of the patients showed a different distribution before OT: 68% VD in PP, 36% VD in abduction, excyclotropia of 20% in PP. After OT these cases converted to the normal pattern described above: VD in PP was 53 % and VD in 30 degrees abduction was 19%, excyclotropia in PP was 36%. CONCLUSION: In 'typical' StS-cases, OT is not necessary. 'Atypical' cases, however, can be converted into 'typical' ones: they get more incomitant VD on horizontal versions and greater excyclotropia in PP. As VD in adduction remains almost the same in both groups after OT, surgery can be based on the angle in adduction. In individual 'atypical' patients the amount of oblique muscle surgery has to be modified after OT.

Diagnostic Techniques, Ophthalmological↗

PubMed2000

The optimal stimulus to elicit suppression in small-angle convergent strabismus.

PURPOSE: To determine the optimal stimulus duration as well as the most appropriate luminance profile to elicit suppression in small-angle convergent strabismus. METHODS: In 10 subjects with small-angle convergent strabismus, using a device allowing binocular viewing and peripheral fusion, we determined what the optimal stimulus would be to elicit suppression. Three control subjects were also included in the study. Stimuli were shown randomly in the central 3 degrees of the visual field of either eye. Stimulus durations were varied in seven steps from 50 to 1000 ms and three luminance-time profiles were used: square wave, triangle and half-sinus, thus yielding 21 different stimuli. The peak light intensity was the same for all stimuli. RESULTS: Suppression, defined as the difference in the threshold sensitivities under monocular vs. binocular viewing, was found with our test device in five of the ten subjects, and ranged between 3 and 33 dB. Suppression was deepest with triangular or half-sinusoidal stimuli of 400 ms duration. Square wave stimuli elicited the smallest amount of suppression. CONCLUSION: Stimuli with a gradual increment and decrement, like triangular or half-sinusoidal stimuli, with a duration of 400 ms are the most effective to elicit suppression

Adolescent↗

PubMed2005

Is there a relationship between the degree of preoperative motility impairment or the muscle thickness and the outcome of strabismus surgery in patients with graves' orbitopathy after decompression surgery?

There is considerable controversy regarding the performance of strabismus surgery in patients with Graves' orbitopathy (GO). The spectrum of recommendations extends from variable dose-effect correlations for these procedures (Esser, 1994; Mourits et al., 1990; Nguyen et al., 2002) to individualized approaches such as passive intraoperative motility testing and postoperative adjustment of sutures (Lueder et al., 1992; Nguyen et al., 2002), and to local anesthesia for intraoperative assessment of active motility (Kalpadakis et al., 2004). Furthermore, prior decompression surgery is known to contribute to an unpredictable outcome (Eckstein and Esser, 2003; Esser, 1994). We retrospectively analyzed the charts of 34 patients undergoing strabismus surgery for this condition, with the aim to evaluate whether muscle size or preoperative muscle impairment are related to the outcome of surgery.

Decompression, Surgical↗

PubMed2004

Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits.

PURPOSE: To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits. METHODS: Twenty-one New Zealand white rabbits were used in this prospective, masked, controlled trial. Both eyes of 20 animals underwent 3-mm recession of the superior rectus muscle (SRM). In group I (io animals), one eye of each animal received topical application of MMC (0.2 mg/ml) for 5 minutes and the other eye (control eye) was treated with balanced salt solution (BSS) using an intraoperative sponge. In group II (10 animals), a randomly chosen eye of each animal was treated with 5-FU soaked sponges (50 mg/ml) for 5 minutes and the fellow eye (control eye) with BSS. Two eyes of a rabbit were included as unoperated controls. Four weeks after the surgery, conjunctival vascularity and postoperative adhesions between the SRM Tenon's capsule (TC) and SRM sclera (scl) were assessed. Additionally, eyes were enucleated and evaluated histopathologically for evidence of scarring, granuloma formation, and muscle tissue changes under a light microscope. RESULTS: MMC-treated eyes had a higher rate of avascular conjunctiva compared to both controls and 5-FU-treated eyes. Mean adhesion scores, particularly between the SRM-scl, were lower in eyes treated with antiproliferative agents compared to controls. The difference was statistically significant in MMC-treated eyes for the adhesions between SRM-scl (p = 0.03). Histopathological examination revealed less scarring and granuloma formation in MMC- and 5-FU-treated eyes compared to their control eyes. CONCLUSIONS: MMC, and to a lesser extent 5-FU, are shown to be effective in reducing postoperative scarring following strabismus surgery in rabbits. It seems reasonable to suggest that antimetabolites should be used for cases having an increased risk of postoperative adhesions.

Animals↗

PubMed1982

A matched comparison of four suxamethonium administration techniques in patients with strabismus.

Four methods of administering suxamethonium were composed in patients undergoing surgery for strabismus who were matched for sex, age, weight and height. Pre-treatment with tubocurarine afforded the best control of suxamethonium-induced sequelae. Serum potassium remained within normal limits suggesting that individuals with strabismus behave differently from those free of this defect.

Adolescent↗