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At least 613 records · Page 34Linked to original sources
PubMed1999

Glial heterotopia in the subcutaneous tissue overlying T-12.

Heterotopic glial nodules occur most commonly in the head and neck area, and are theorized to arise following abnormalities in the development of the facial and skull bone plates. However, in spite of the fact that some of these lesions are associated with communication with the central nervous system (CNS), the lack of a meningeal component, argues against simple herniation and separation of brain tissue through a defect in the skull. We present an infant with a nodule directly over the spine present in the T-12 region with no skin abnormalities. Magnetic resonance imaging (MRI) and computerized axial tomography (CT) showed no spinal abnormalities with an overlying fibrotic soft tissue mass. The patient had no other associated clinical findings. Histologic findings showed a cellular component arising within the reticular dermis with a deep circumscribed margin. The nodule contained irregularly shaped cells containing abundant cytoplasm and indistinct cellular margins with bland nuclei. These cells were clustered around and between a fibro-mucinous stroma. Immunohistochemical stains showed positive staining for S-100 protein, vimentin, GFAP, NSE, and CD57, and negative staining for Ki-67, CD34, Neurofilament protein, cytokeratin, and EMA. The spindle cells showed positive staining for CD34 and vimentin. The clinical and histologic features and immunohistochemical profiles are used to separate this lesion from the closely related, ependymal rests, ependymomas, and primary cutaneous chorodomas.

CD57 Antigens↗
PubMedDate not supplied

Separation of Mycobacterium lepraemurium from the subcutaneous tissues of the rat.

In an effort to obtain cell suspensions free from blood cells which interfere in spectrophotometric studies, a method was devised by which relatively large quantities of whole cell suspensions of M. lepraemurium are obtained for experimental purposes. We have routinely employed this procedure which is quite reliable, technically simple, moderate in equipment requirements, and in a matter of five minutes it can be ascertained whether or not the preparations are free from contaminants which render the purified bacillary suspensions unsuitable for studies involving spectrophotometric technics. However, in this procedure, certain points are essential in order to obtain large quantities of purified bacillary suspensions. It is important to homogenize the lepromata for only a few seconds at brief intervals. Excessive homogenization may cause considerable damage to the bacilli and it may be difficult to separate the bacilli from the host tissues. It is also important to use transparent bottles and tubes during centrifugation as the material can be seen and thus each fraction can be separated easily. Very few bacilli are lost in the discarded material and we have repeatedly obtained 2.5 to 3 gm wet weight of M. lepraemurium from one leproma weighing 25 gm to 30 gm.

Animals↗
PubMed1975

[A case of granuloma caused by a plant foreign body retained in the perineal subcutaneous tissue].

A case of granuloma caused by a foreign vegetal body (part of a thorn of Triticum vissosum) lodged in the subcutis of the perineum, observed at the Department of Surgical Symptomatology of Palermo is reported. The clinical case was of interest for the rarity of the way in which the foreign body reached the perineal tissues, the abnormal resulting clinical episode, and the histological finding. The intention is also to demonstrate how at times symptomatology and clinical objectivity are not always enough to guide the physician to correct diagnosis; where historical data are lacking, clinical objectivity, often suggest neoformation of heteroplastic type or aspecific chronic inflammation rather than granulomatous reactions due to foreign bodies.

Foreign-Body Reaction↗