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At least 613 records · Page 34Linked to original sources

PubMed2005

Immunohistochemical evaluation of osteoclast recruitment during experimental tooth movement in young and adult rats.

OBJECTIVE: Orthodontic tooth movement starts slower in adults than in juveniles, but the rate of tooth movement in later phases is the same in both age groups. The hypotheses to be tested are that these phenomena are related to slower osteoclast recruitment in adults than in juveniles, but that in later phases the osteoclast numbers are the same in both age groups. DESIGN: Standardized orthodontic tooth movement was performed in two groups of 30 rats, aged 6 weeks and 9-12 months, respectively. All maxillary molars at one side were together moved mesially by a continuous force of 10 cN. The other side served as a control. After 1, 2, 4, 8 and 12 weeks, groups of animals were killed. After ED1 staining osteoclast numbers at the mesial and distal sides of selected roots were counted. RESULTS: At the compression sides osteoclast numbers increased in both age groups. In young rats, a maximum was reached at 2 weeks, in adults at 4 weeks. In later phases of tooth movement, the number of osteoclasts in the adults was approximately twice as high as in the juveniles, while the rate of tooth movement was the same. A positive correlation between the rate of tooth movement and osteoclast numbers was found only in young rats. CONCLUSIONS: Orthodontic forces induce faster osteoclast recruitment in young than in adult rats and more osteoclasts are needed to achieve a certain rate of tooth movement in adult than in young rats.

Age Factors↗

PubMed2006

Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering.

Tooth structure can be regenerated by seeding dissociated tooth cells onto polyglycolic acid fiber mesh, although the success rate of tooth production is low. The present study was designed to compare the performance of collagen sponge with polyglycolic acid fiber mesh as a 3-D scaffold for tooth-tissue engineering. Porcine third molar teeth at the early stage of crown formation were enzymatically dissociated into single cells, and the heterogeneous cells were seeded onto collagen sponge or the polyglycolic acid fiber mesh scaffolds. Scaffolds were then cultured to evaluate cell adhesion and ALP activity in vitro. An in vivo analysis was performed by implanting the constructs into the omentum of immunocompromised rats and evaluating tooth production up to 25 weeks. After 24h, there were a significantly higher number of cells attached to the collagen sponge scaffold than the polyglycolic acid fiber mesh scaffold. Similarly, the ALP activity was significantly higher for the collagen sponge scaffold was than the polyglycolic acid fiber mesh scaffold after 7 days of culture. The area of calcified tissue formed in the collagen sponge scaffold was also larger than in the polyglycolic acid fiber mesh scaffold. The results from in vivo experiments show conclusively that a collagen sponge scaffold allows tooth production with a higher degree of success than polyglycolic acid fiber mesh. Taken together, the results from this study show that collagen sponge scaffold is superior to the polyglycolic acid fiber mesh scaffold for tooth-tissue engineering.

Alkaline Phosphatase↗

PubMed2004

Accelerated bone formation and increased osteoblast number contribute to the abnormal tooth germ development in parathyroid hormone-related protein knockout mice.

Our previous study showed that tooth germs at late embryonic stage [later than embryonic day 17.5 (E17.5)] and neonatal homozygous parathyroid hormone-related protein (PTHrP)-knockout mice are compressed or penetrated by the surrounding alveolar bone tissue. In vivo and in vitro studies have shown that the development of the tooth germ proper is not disturbed, but insufficient alveolar bone resorption, due to the decreased number and hypofunction of osteoclasts, is the main cause of this abnormality. In addition to the insufficient alveolar bone resorption, progressive bone formation toward tooth germs was observed in homozygous mice, suggesting that accelerated bone formation also contributes to this abnormality. To further investigate this, homozygous mice at E14.0 and E15.5, when alveolar bone is forming, were used for histochemical and bone histomorphometric analyses. In contrast to the late embryonic stage, the alveolar bone did not yet compress developing tooth germs in homozygous mice on E14.0, but a larger amount of bone tissue was seen compared to wild-type littermates. Histomorphometric analysis of bone at E14.0 revealed that the osteoblast numbers and surfaces in the mandibles and in the bone collar of femora of homozygous mice were significantly higher than those of wild-type mice. However, unlike our previous study showing the osteoclast surface on E18.5 in homozygous mice to be significantly lower than that of wild-type mice, this study at E14.0 showed no significant difference between the two genotypes. To evaluate the amount of calcification around tooth germs, 3D images of mandibles were reconstructed from the calcein-labeled sections of the wild-type and mutant mice. Labeling was performed at E14.0, and the mice were sacrificed 1 h after the calcein injection to minimize the effect of bone resorption. Comparison of the 3D images revealed that the labeled surface was larger around developing tooth germs in homozygous mouse than in wild-type mouse. On day E15.5, osteoblasts approached the enamel organ of homozygous mice but this was not observed in wild-type mice. In this study, we report a systemic increase in osteoblast number and accelerated bone formation in homozygous PTHrP-knockout mice, both of which contribute to the abnormal tooth development.

Acid Phosphatase↗

PubMed2005

Type II/III Runx2/Cbfa1 is required for tooth germ development.

Runx2/Cbfa1 is an essential transcription factor for osteoblast differentiation and bone formation. Runx2/Cbfa1 knockout mice showed both a complete lack of ossification and the developmental arrest of tooth germ. We here report Runx2/Cbfa1 isoform-type specific functional roles in the development of tooth germ by the administration of antisense phosphorothioate oligodioxynucleotides (S-ODNs) into cultured mouse mandibles. The administration of type II/III Runx2/Cbfa1 antisense S-ODNs into the culture media resulted in an arrest of tooth germ growth at the bud-like stage in cultured mandible taken from the 11-day-old embryos, while also causing the inhibition of the differentiation of odontogenic cells into ameloblast and odontoblast in cultured tooth germs taken from the 15-day-old embryos. The expression of dentin matrix protein 1, dentin sialophosphoprotein, amelogenin, and ameloblastin was shown to be markedly suppressed in cultured tooth germ by the semi-quantitative RT-PCR. Meanwhile, no developmental arrest of tooth germ, no inhibition of gene expression, or differentiation of odontogenic cells was observed in samples treated with the type I Runx2/Cbfa1 antisense S-ODNs. The same findings were also observed in either the control or the sense and random sequence S-ODNs-treated samples. These data indicate that the type II/III Runx2/Cbfa1 isoform is closely related to the development and differentiation of tooth germ.

Animals↗

PubMed2004

Effects on bone formation in ovariectomized rats after implantation of tooth ash and plaster of Paris mixture.

PURPOSE: Our goal was to report on tooth ash and plaster of Paris mixture in bone defects in an ovariectomized rat osteoporosis model. MATERIALS AND METHODS: Sixty rats were randomly assigned to 4 groups and each group was further divided into 3 subgroups: 4, 8, and 16 weeks after implantation. The defect was filled with different grafting conditions as follows: group 1, ovariectomy and nongraft group; group 2, ovariectomy and tooth ash-plaster graft group; group 3, nonovariectomy and nongraft group; and group 4, nonovariectomy and tooth ash-plaster graft group. Histologic sections and histomorphometric analysis of defects were obtained 4, 8, and 16 weeks after surgery. RESULTS: For the 4-week ovariectomy group, there was significantly greater bone formation in tooth ash-plaster group compared with the nongraft group. In the nonovariectomy group, the tooth ash-plaster group also showed better bone formation than the nongraft group. However, there was no statistical significance. In both the ovariectomy and nonovariectomy groups, a significant increase in bone formation was observed according to the elapse of time. The nonovariectomy group showed increased new bone formation compared with the ovariectomy group, with the tooth ash-plaster group showing statistical significance in each subgroup (P =.048). CONCLUSIONS: Ovariectomy acts as a negative factor in new bone formation. For a critical size bony defect, the tooth ash-plaster treatment of the osseous defect produces more stable, effective, and rapid new bone formation.

Animals↗

PubMed2006

Tooth count in elderly women in relation to their skeletal status.

OBJECTIVES: Generalized bone loss may contribute to the development of tooth loss in elderly individuals. The aim of the study was to investigate the relationship of tooth count with hip and spine densitometry and phalangeal quantitative ultrasound (QUS) measurements and to compare skeletal status between women completely and partially edentulous and between women with caries or periodontal disease. METHODS: In the study, 67 postmenopausal women (37 edentulous and 30 with partial tooth loss) in the mean age of 62.8+/-7.2 years were evaluated. No reasons with potential influence on bone metabolism (chronic diseases or medications) were noted. In order to reveal the role of the factor underlying tooth loss, all patients were also divided into subjects with caries (n=27) and periodontal disease (n=40). Skeletal status was assessed by dual-energy X-ray absorptiometry (DXA) at the hip and spine (bone mineral density-BMD [g/cm(2)]) and by QUS at the hand proximal phalanges (amplitude-dependent speed of sound-Ad-SoS [m/s]). RESULTS: Women completely and partially edentulous did not differ significantly but a tendency to have lower values in women completely edentulous was noted. Comparisons between women with caries and periodontitis also did not show any significant differences (except for significantly lower Z-score of Ad-SoS in women with caries). Tooth count correlated only with hip BMD: in the whole group (r=0.25-0.30, p=0.04-0.01) and in women with caries (r=0.45-0.51, p=0.02-0.006). In women with periodontitis tooth count correlated only with Ad-SoS (r=0.36, p=0.002). CONCLUSION: Associations between dental and skeletal status indicate that systemic bone loss in skeletal sites being mostly cortical may contribute to the tooth loss.

Absorptiometry, Photon↗

PubMed2001

The reasons for the extraction of various tooth types in Scotland: a 15-year follow up.

OBJECTIVES: The aim of this survey was to investigate the reasons for extraction of the various tooth types in Scotland. This study replicated one which was undertaken 15 years earlier. A further aim, therefore, was to identify any changes in the frequency of extraction of each tooth type in the 15 years between the two studies. METHODS: The names of every fourth dentist on the list of the Scottish Dental Practice Board were obtained. Four hundred and twenty-five general dental practitioners were asked to record permanent tooth extractions for 1 week. Data requested for each extraction were: the patient's age, gender and dental attendance pattern, the type of tooth removed and the reason for the extraction. RESULTS: Three hundred and fifty-two dentists participated (a response rate of 82.8%). There were 25% fewer teeth extracted per patient and 30% fewer per dentist than in the 1984 study. In 1999, more teeth of most types were extracted from regular attenders whereas, in 1984, more teeth of all types were extracted from irregular attenders. Premolars and first and second molars were the tooth types most frequently extracted in both surveys. In 1999 premolars were the teeth most commonly removed below 21 years of age, accounting for 57.5% of extractions in this age range. Molars accounted for 33.8% of extractions in this age range compared with 52% in 1984. Overall, caries was found to be the principal reason for loss of all tooth types apart from lower incisors which were extracted mainly for periodontal reasons. However, below 21 years, 84.5% of premolar extractions were performed for orthodontic purposes. CONCLUSIONS: Over the last 15 years, the overall number of extractions has reduced and the proportion of extractions from regular attenders has increased. Proportionately more premolars and fewer molars were extracted from under-21-year-olds. This observation can be explained by an increase in orthodontic extractions or a decline in extractions for caries in this age group. However, when extractions from the population as a whole are considered, caries and its sequelae remains the principal reason for loss of all tooth types other than lower incisors which are extracted mainly for periodontal reasons.

Adolescent↗

PubMed2000

Sociodemographic correlates of tooth pain among adults: United states, 1989.

This study presents the sociodemographic distribution of tooth pain and the dental care utilization of affected individuals. Data for adults 20 years of age and over were derived from the 1989 National Health Interview Survey's supplements on dental health, orofacial pain, and health insurance (n=33073). Prevalence of tooth pain by socioeconomic status (SES) and adjusted odds ratios of reporting tooth pain in the past 6 months and of having no dental visits in the past year among persons reporting pain in the previous 6 months were computed taking into account the survey's complex sample design. Tooth pain in the past 6 months was reported by 14.5% (95% CI 14.0, 15.0) of adults aged 20-64 years and by 7.0% (95% CI 6.1, 7.9) of those 65 years and over. In the younger age group, tooth pain was more likely to be reported by those with low SES than it was by those with high SES; in the older age group, tooth pain was more likely reported by non-Hispanic blacks than it was by non-Hispanic whites or Hispanics. Of those reporting pain, younger and older non-Hispanic blacks and persons with lower educational attainment were more likely not to have a dental visit in the previous 12 months. Persons with low SES characteristics were more likely to report tooth pain and to endure their pain without the benefit of dental care while the pain was present.

Adult↗

PubMed1997

A longitudinal study of tooth wear in orthodontically treated patients.

The primary objective of this study was to determine whether there is a relationship between incisal/occlusal tooth wear during the mixed dentition and subsequent wear of the adult dentition. Pretreatment orthodontic records taken during the mixed dentition (T1), as well as follow-up records taken an average of 20 years later (T2), were available for 223 orthodontically treated patients. Incisal/occlusal tooth wear was measured on a tooth-by-tooth basis from T1 and T2 stone casts with a four-category scoring system. Multiple regression analysis (R2 = 0.33) indicated that wear could be predicted at a given age during adulthood from wear observed on the deciduous mandibular canines and molars at T1 (p < 0.0001). This predictive relationship was modified by the age at which the T1 wear was observed (p = 0.029) and possibly by the sex of the patient (p = 0.10). These results indicate that adult tooth wear is not independent of the tooth wear that occurred as a child. Bruxism is suggested as a possible common etiologic mechanism that may account for the relationship between childhood and adult tooth wear.

Adolescent↗

PubMed2001

Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation.

The shape and diversity of the mammalian molar teeth is suggested to be regulated by the primary and secondary enamel knots, which are putative epithelial signaling centers of the tooth. In search of novel molecules involved in tooth morphogenesis, we analyzed mRNA expression of Slit1, -2 and -3, earlier characterized as secreted signals needed for axonal pathfinding and their two receptors Robo1 and -2 (Roundabout1 and -2) in the developing mouse first molar. In situ hybridization analysis showed that Slit1 mRNAs were expressed in the primary enamel knot of the bud and cap stage tooth germ and later the expression continued in the secondary enamel knots of the late cap and bell stage tooth. In contrast, expression of Slit2 and -3 as well Robo1, and -2 was largely restricted to mesenchymal tissue components of the tooth until the bell stage. At the late bud stage, however, Robo1 transcripts were evident in the primary enamel knot, and at the cap stage a pronounced expression was noted in the middle of the tooth germ covering the primary enamel knot and dental papilla mesenchyme. During the bell stage, Robo1 and Slit2 expression became restricted to the dental epithelia, while Slit3 continued in the dental mesenchyme. Prior to birth, Robo1 and -2 were co-localized in the predontoblasts. These results indicate that Slits and Robos display distinct, developmentally regulated expression patterns during tooth morphogenesis. In addition, our results show that Slit1 is the second known gene specifically located in the primary and secondary enamel knots.

Animals↗

PubMed1999

Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants.

Members of the transforming growth factor-beta (TGF-beta) superfamily signal through their cognate receptors to determine cell phenotypes during embryogenesis. Our previous studies on the regulation of first branchial arch morphogenesis have identified critical components of a hierarchy of different TGF-beta isoforms and their possible functions in regulating tooth and cartilage formation during mandibular morphogenesis. Here we tested the hypothesis that TGF-beta type II receptor (TGF-beta IIR) is a critical component in the TGF-beta signaling pathway regulating tooth formation. To establish the precise location of TGF-beta ligand and its cognate receptor, we first performed detailed analyses of the localization of both TGF-beta2 and TGF-beta IIR during initiation and subsequent morphogenesis of developing embryonic mouse tooth organs. A possible autocrine functional role for TGF-beta and its cognate receptor (TGF-beta IIR) was inferred due to the temporal and spatial localization patterns during the early inductive stages of tooth morphogenesis. Second, loss of function of TGF-beta IIR in a mandibular explant culture model resulted in the acceleration of tooth formation to the cap stage while the mandibular explants in the control group only showed bud stage tooth formation. In addition, there was a significant increase in odontogenic epithelial cell proliferation following TGF-beta IIR abrogation. These results demonstrate, for the first time, that abrogation of the TGF-beta IIR stimulates embryonic tooth morphogenesis in culture and reverses the negative regulation of endogenous TGF-beta signaling upon enamel organ epithelial cell proliferation.

Adenoviridae↗

PubMed2001

The development of the tooth pattern and dentigerous bones in Polypterus senegalus (Cladistia, Actinopterygii).

The formation sequence of the tooth-bearing bones and the tooth pattern in early ontogeny of Polypterus senegalus is investigated using transparent preparation, histological sections, and SEM. During the attachment step of the yolk-sac larva the first dermal bones and teeth are formed. Teeth appear simultaneously in the areas of the maxillary, dentary, dermopalatine, prearticular, and coronoid 1 along with the first separate anlagen of these bones. A monostichous arrangement of primary teeth is established on the maxillary, dentary, and dermopalatine. Polystichous tooth arrangements do not occur before the early pterolarval phase, and then only in connection with bones of the palate and inner dental arcades. Especially pronounced is the influence of tooth formation on the structure of the parasphenoid that becomes much thickened by accretion of denticulate platelets, but we found neither evidence for a distinct vomeral contribution to the parasphenoid, nor a composite origin of the ectopterygoid in ontogeny. First replacement teeth are found in association with the maxillary and dentary as early as the late apterolarval phase. Primary teeth are of a single general type, whereas from the pterolarval phase onward three tooth types can be distinguished that are restricted to certain tooth bearing bones. Relatively late in ontogeny, dermo-metapterygoid and entopterygoid become formed and colonised by teeth, whereas first branchial teeth and tooth plates appear earlier during the first phase of extrinsic larval feeding. Characteristics of development of the dentition are discussed in comparison with character states of other better known fossil and recent taxa among Actinopterygii and Sarcopterygii. Compared to the assumed basic pattern of actinopterygian fishes, Polypteriformes show a derived condition with respect to structure, arrangement, replacement, and differentiation of teeth, which arises in sequence during larval development. This also corresponds to observed changes of feeding behaviour and functional demands during larval life.

Aging↗

PubMed2002

Charcot-Marie-Tooth disease type 2C: a distinct genetic entity. Clinical and molecular characterization of the first European family.

Charcot- Marie-Tooth disease type 2 is clinically and genetically heterogeneous. A particular clinical subtype of autosomal dominant Charcot-Marie-Tooth disease type 2, characterized by diaphragm and vocal cord paralysis, is labelled Charcot-Marie-Tooth disease type 2C but no genetic locus has been mapped for this form. We describe the first European family affected by Charcot-Marie-Tooth disease type 2C. Genetic analysis excluded linkage to locus of Charcot-Marie-Tooth disease type 2A, B, D, E and F, and to locus of distal hereditary motor neuronopathy type VII. In this family the disease has high penetrance, variable severity and apparently the most severe limb muscle involvement in the youngest generation. Vocal cord paralysis is unrelated to the degree of muscular weakness and patients with the most severe muscle involvement have absent or minimal respiratory symptoms. Charcot-Marie-Tooth disease type 2C is clinically and genetically different from Charcot-Marie-Tooth disease type 2A, B, D, E and F, and is not allelic with distal hereditary motor neuronopathy type VII.

Adult↗

PubMed2002

Distribution pattern of versican, link protein and hyaluronic acid in the rat periodontal ligament during experimental tooth movement.

The ability of the periodontal ligament (PDL) to rapidly remodel is the basis of orthodontic tooth movement. During the tooth movement, matrix proteoglycans (PGs) may play important roles in spatial, mechanical and biological aspects for the maintenance and repair of the PDL. The aim of this study was to characterize the distribution of a large hyaluronic acid (HA)-binding proteoglycan, versican, link protein (LP) and HA in the rat molar PDL during experimental tooth movement by histochemical and immunohistochemical methods. Experimental tooth movement was performed according to Waldo's method. Histologically, regressive changes, such as decrease of fibroblasts and collagen fibers and exudative change of edema were observed in the compressive side and progressive changes, such as proliferation of fibroblasts and collagen fibers, in the strain side one day after treatment. By 3 days after tooth movement, regressive or progressive changes were not observed in either side. Using monoclonal antibodies specific to versican core protein or LP, the positive immunoreactivity for both molecules was constantly observed throughout the PDL. After the experimental force was applied to the tooth, however, the immunostainings of versican and LP became significantly intense only in the compressive side but decreased in the strain side. The intensity in the compressive side was strongest one day after the force was applied and gradually diminished thereafter. HA of both sides did not change during experimental tooth movement. Since HA is present in the PDL, large amounts of versican and LP expressed in the compressive side may create large hydrated aggregates via their association with HA that dissipates the compressive force applied to this tissue.

Animals↗

PubMed2001

Apoptosis of periodontal ligament cells induced by mechanical stress during tooth movement.

The mechanical force generated during tooth movement creates compressed and cell-free areas in the periodontal membrane. The way in which periodontal ligament cells disappear at the compressed area during tooth movement remains unclear. In the present study we examined whether periodontal ligament cells undergo apoptosis by mechanical stress during tooth movement using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end-labelling method (TUNEL). TUNEL-positive stainings of periodontal ligament cells began to appear at the compressed areas 12 h after tooth movement, and the number of those cells reached maximum at 24 h after tooth movement. Thereafter TUNEL-positive cells disappeared at 48 h, and direct and undermining bone resorption began at the same area 72 h after tooth movement. These results showed that compressed periodontal ligament cells were eliminated by apoptosis in the early phase of tooth movement.

Alveolar Bone Loss↗

PubMed1998

Tooth rotation associated with aplasia of nonadjacent teeth.

The prevalence of tooth rotation concomitant with aplasia of nonadjacent teeth in uncrowded, nonsyndromic subjects was assessed. The sample consisted of 1620 subjects (mean age 14 years 9 months). The findings were compared with the prevalence calculated for a matched control group of 1000 subjects. Rotation of maxillary lateral incisors in subjects with premolar aplasia and rotation of premolars in subjects presenting with maxillary lateral incisor aplasia were studied. Associations between both tooth position anomalies and tooth aplasia were significant (p < 0.01). In addition, the presence of rotated maxillary lateral incisors was also associated with aplasia of the homologous tooth on the opposite side of the dental arch; the same result was found for premolars. These data suggest a genetic component in the etiology of tooth malpositions, such as tooth rotation, which may be considered a covariable in a complex of genetically controlled dental disturbances, including tooth aplasia.

Adolescent↗

PubMed2006

A new, accurate and fast digital method to predict unerupted tooth size.

The sum of the lower incisor tooth width has been proposed as the best predictor for calculating unerupted canine and premolar mesiodistal tooth sizes. The aims of this study were to develop a new, fast, and accurate computerized method to predict unerupted mesiodistal tooth sizes and to determine which reference tooth or combination of reference teeth was the best predictor for canines and premolars in a Spanish sample. The dental casts of 100 Spanish adolescents with permanent dentition were measured to the nearest 0.05 mm with a two-dimensional computerized system. The goal was to predict unerupted canine and premolar mesiodistal tooth sizes using the sizes of the upper central incisor, upper and lower first molar, or a combination of these as a reference and using a specific mesiodistal tooth-size table. The results showed that the Digital Method proposed was very accurate in predicting unerupted canine and premolar tooth size. The combination of the sums of the permanent upper central incisor and the lower first molar was the best predictor for canines and premolars in this sample. Upper arch teeth were better predicted than lower arch teeth. The upper lateral incisor provided the worst predictions.

Adolescent↗

PubMed1998

Correlation of the characteristics of temporomandibular joint and tooth contact sounds.

In this study tooth contact sounds have been compared with temporomandibular joint (TMJ) sounds elicited during opening and closing movements. One hundred and eight subjects were instructed to open as far as possible and then close with sufficient force to produce a tooth contact sound. At least four cycles from each subject were recorded on tape, The first and last sounds in the recording were the tooth contact sounds, these were identified automatically. The mean duration and rise time of each tooth contact sound was calculated and their standard deviations for each subject were calculated to give a measure of the reproducibility. The number and mean amplitude of TMJ sounds occurring during tooth separation were also calculated for each cycle. Highly significant correlations were found between the number and amplitude of the TMJ sounds within a cycle and the duration and rise time, and particularly their standard deviations. Acoustic quiescence during the open-close cycle was associated with short, reproducible tooth contact sounds characterized by a short rise time. The longest and most variable tooth contact sounds were associated with TMJ sounds in all three phases of the open-close cycle. This supports previous clinical findings associating occlusal interferences with TMJ dysfunction.

Acoustics↗