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At least 631 records · Page 35Linked to original sources
PubMed1996

Microcalcification clustering parameters in breast disease: a morphometric analysis of radiographs of excision specimens.

X-ray microradiography of surgically excised breast specimens offers the possibility of morphological characterization of calcifications. When combined with digital imaging techniques there exists added potential for obtaining valuable basic quantitative morphometric information regarding differences between microcalcifications in tissues exhibiting evidence of fibrocystic change, benign and malignant tumours. A total of 157 excised breast specimens from 84 patients were microradiographed using a Softex Super Soft X-ray unit and Kodak AA high resolution industrial film. A Quantimet 570C image analysis system was used to digitize and analyse the microradiographs. Of the 157 microradiographs, 51 (from 30 patients) revealed microcalcification clusters. The existence of significant differences between the three identified categories of tissue were indicated by clustering parameters. These included the number of particles per cluster, area of clusters, maximum distance to nearest neighbour, and geometric mean distance to nearest neighbour. The distribution pattern index (DPI), another of the clustering parameters used in this study, has been observed to be a particularly powerful discriminator. The value for fibrocystic change was found to be significantly smaller (0.514) than that for benign tumour (0.796) whilst that for benign tumour was observed to be significantly larger than that for malignant tumour (0.604) at a p-value of less than 0.05 (Kruskal-Wallis one-way analysis of variance).

Adolescent↗
PubMedDate not supplied

Benign breast disease: the cost of the service and the cost to the patient.

The patients attending a hospital breast clinic during 1 year have been reviewed to assess the impact and cost of benign conditions. Four of 5 patients referred do not have cancer. The cost to the patient lies predominantly in anxiety related to the possibility of cancer and, to a lesser extent, in cosmetic damage due to multiple biopsies. Benign breast disease is a common problem that creates severe anxiety in many women and a heavy burden on an overstretched National Health Service. A policy of reeducating general practitioners when it is safe not to refer may reduce this problem. Cyst aspiration or needle aspiration cytology may reduce the burden to both the patient and the health service, while desensitization of women's groups and women themselves to the needs for breast self-examination can also reduce this burden.

Breast Diseases↗
PubMedDate not supplied

Dynamic MR mammography: a technique for potentially reducing the biopsy rate for benign breast disease.

Thirty-five women with a total of 39 breast lesions detected at mammography and/or physical examination and who were scheduled for surgical biopsy were studied with dynamic magnetic resonance (MR) mammography. Fat-suppressed, spoiled GRASS (gradient-recalled acquisition in the steady state) sequences were performed before and after administration of gadopentetate dimeglumine. T1-weighted spin-echo and fat-suppressed T2-weighted fast spin-echo images were also obtained. By measuring percentage signal intensity change in lesions on the spoiled GRASS images after contrast agent injection, the authors achieved a sensitivity of 100% and a specificity of 83.3% in differentiating benign from malignant lesions (24 benign, 15 malignant), with biopsy results as the standard. This dynamic MR mammography technique deserves further evaluation.

Aged↗
PubMed1998

An audit of patient acceptance of one-stop diagnosis for symptomatic breast disease.

AIMS: The impetus for optimizing outpatient provision of breast-care services has come both from the patient and management in order to reduce anxiety and make full use of scarce resources. The one-stop diagnostic clinic for the investigation of symptomatic breast lesions is a relatively recent concept with well-known service benefits. However, acceptance to the patient has not been previously investigated. RESULTS: The results of this prospective audit demonstrate a high level of patient satisfaction with the multi-disciplinary, one-stop breast clinic.

Ambulatory Care↗
PubMed1992

[Immunohistochemical evidence of vimentin in fibrocystic breast disease and mammary carcinoma].

Immunohistochemical investigations were conducted of cryostat sections taken from 25 cases of fibrocystic breast disease and 100 cases of mammary carcinoma (among them 15 cases with lymph node metastases) to obtain information on expression of vimentin. Immunoreactive epithelial cells were recordable from 12 cases of fibrocystic disease (48%) and 32 tumors (32%). In the majority of all cases with vimentin-expressing carcinoma, positive staining was exhibited by less than 10% of the neoplastic cells. No correlation was found to exist between histological tumor grade, lymph node status and vimentin expression.

Breast Neoplasms↗
PubMed1993

Application of a mixed imaging sequence for MR imaging characterization of human breast disease.

Single slice MR images were obtained from 9 normal breasts, 17 breasts with benign tumors, and 11 breasts with malignant tumors using an interleaved (mixed) spin echo (SE) inversion-recovery (IR) imaging sequence. SE and IR MR images were synthesized with variable repetition, echo and inversion times from the mixed sequence data. These images were used to qualitatively evaluate the contrast possibilities available when imaging the breast with MR imaging. Proton T1 and T2 relaxation times were determined for normal breast tissues and malignant and benign breast tumors from pure T1 and T2 images calculated using the mixed sequence data. The mean T1 value in benign tumors of 1,049.02 +/- 40.31 was found to be significantly longer (p < 0.0001) than the mean value of malignant tumors (876.09 +/- 27.83) and normal tissues (795.64 +/- 21.12). The value of T2 in benign tumors (89.15 +/- 8.33) was significantly longer (p < 0.01) than the value of T2 in normal tissues (62.82 +/- 4.06). The mixed sequence can be applied to improve image contrast between malignant tumors, benign tumors, and normal tissues of the breast and can potentially differentiate between these tissues in vivo.

Breast Diseases↗
PubMed1985

Detection of Ca antigen in sera from normal individuals and patients with benign and malignant breast disease.

Two assay procedures, an inhibition radioimmunoassay (Inhibition-RIA) and an immunoradiometric assay (IRMA), were established for the detection of circulating tumour-associated Ca antigen. There was a good correlation between results (r = 0.987) but the Inhibition-RIA was selected for extended tests on human sera from patients with breast disease because of its greater ease and economy in use. Circulating Ca antigen was not exclusive to malignancy and the level failed to discriminate between patients with primary carcinoma and those with benign disease. Ca antigen was present in sera of 100 healthy individuals (median 7.1 micrograms ml-1, range 1.8-24.4 micrograms ml)-1, 39 patients with benign disease (median 9.9 micrograms ml-1, range 2.5- greater than 100 micrograms ml-1) and in 67 patients with primary carcinoma (median 11.0 micrograms ml-1, range 3.8- greater than 100 micrograms ml-1). Elevated Ca antigen levels were found in 50% of patients with metastatic spread (median 30.7 micrograms ml-1, range 8.2- greater than 100 micrograms ml-1) and in some patients with primary disease but further studies are needed to determine the prognostic significance. Immunochemical studies confirmed that Ca antigen is a normal serum product but its function is unclear.

Antigens, Neoplasm↗
PubMed1981

Serum hormones and lipoproteins in benign breast disease.

Seventeen young women with clinically confirmed mammary dysplasia and six age-matched controls were treated with alpha-tocopherol. Serum samples collected during the luteal phase of each woman at monthly intervals for the 4-month duration of the study were analyzed for serum luteinizing hormone, follicle-stimulating hormone, and prolactin concentrations by radioimmunoassay and for lipoprotein levels by a combination of precipitation, ultracentrifugation, and enzymatic techniques. Fifteen patients showed objective and subjective remission from disease. While prolactin levels did not change significantly, elevated levels of luteinizing and follicle-stimulating hormones were decreased to normal levels. Ratios of serum cholesterol to high-density lipoprotein cholesterol decreased; high-density lipoprotein and free cholesterol associated with low-density lipoproteins increased as a result of therapy. The results suggest that alpha-tocopherol may serve as an effective agent not only to treat patients with benign breast disease but also to normalize abnormal hormone and lipid levels in subjects at high risk for breast cancer.

Breast Diseases↗
PubMed1977

[Estrogen and progesterone receptors in non carcinomatous breast diseases (author's transl)].

Cytosolic receptors for estrogens and progesterone are studied using an exchange method in various types of benign breast diseases: fibroadenomas, fibrocystic mastosis, phylloid tumors and gynecomastias. The results show clearly that, contrary to breast carcinomas, receptors are generally not present in benign tumors. These results are statistically significant for all the women studied. Studying the pathological aspects of the tumors, it can be noted that the presence of receptors, is correlated with proliferation forms with large epithelial components. Furthermore, these results show that receptors are not found in gynecomastia. In conclusion, the physician should follow up very carefully the patients with a benign tumor, when hormono-receptors are present.

Adolescent↗
PubMedDate not supplied

The establishment and operation of a computerized data bank in benign breast disease. (Preliminary results on 297 cases).

The principles of setting up and utilization of a data bank for breast benign pathology and medical gynecology are described. In presenting these principles the authors make an analysis of the loading phases with the two afferent programs for adding, changing and wiping out information. With respect to utilization, two applicative programs for computing the efficiency of the selective hormonal treatment (regarding each and all patients) are analyzed. The paper provides the necessary instructions which enable the specialist physician to work directly with the computer. The principles are exemplified by the results obtained with a first series of 297 menstruated patients with several clinical forms of benign breast disease (unique or multiple cysts, lesions corresponding to an adenoma or fibroadenoma, mammary lumps) hormonally treated in an average series of 3 therapeutic cycles.

Adenofibroma↗
PubMed1989

Surgical assessment of benign breast disease in screening.

In summary, the purpose of breast screening is to identify early cancers with the aim of reducing mortality from the disease. However, the specificity of mammography is such that a considerable number of women will require assessment for benign disease particularly in the prevalent round. Knowledge of the particular types of benign breast disease which are commonly seen in screening, together with careful assessment using the techniques which have been described, will allow the benign to malignant biopsy rates to be kept acceptable without missing the very lesions which screening hopes to identify.

Breast Diseases↗
PubMed1985

[Thermobiologic evaluation of benign and malignant breast diseases].

This paper is a review of the recent technical and clinical advances in the area of breast thermography. Emphasis is placed upon thermal imaging using liquid crystal films, and computer-assisted analysis of breast thermograms. New data are presented concerning the value of thermography for the identification of women at high risk of developing breast cancer, the early detection of mammary carcinomas, and the detection of cancer in fibrocystic breasts.

Adult↗