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PubMed1986

[Frequency of respiratory allergens involved in rhinitis and bronchial asthma in adults. Prospective study].

In a prospective study of 100 adults, we determined the frequency of hypersensitivity to allergens most often diagnosed in patients suffering from rhinitis and bronchial asthma. Skin-prick tests and RAST for 15 allergens were performed in all patients. The most frequent allergen detected by skin-prick test was the extract "total house dust" (50%) but the corresponding RAST was rarely positive (16%); then came grass pollens (46%), house dust mites (D. pteronyssinus, 38%) and animal danders (cat 33%). On the other hand, a positive skin test with the two moulds chosen was rare (Alternaria tenuis 5%, Cladosporium herbarum 4%). For all the allergens investigated, the correlation between positive skin test and positive RAST was proportional to the intensity of the skin reaction (94% for the skin tests +, 40% for the skin tests ++). 35% of the patients with at least a positive skin test and a RAST for one of the allergens tested had in fact a total IgE concentration not suggestive of atopy (less than 100 kU/1). The results indicate that, with the exception of the 2 moulds chosen, the frequency of allergens diagnosed in Switzerland is very similar to what has been found in other countries with different climates.

Adolescent↗

PubMed1985

Delayed type hypersensitivity in atopic dermatitis.

Three different aspects of delayed type hypersensitivity in atopic dermatitis (A.D.) were studied. (a) Intradermal testing demonstrated that positive reactions to bacterial vaccines were distinctly lower in patients with A.D. (b) Patch testing in patients with A.D. compared to tests in patients with anal eczema showed a striking difference in results concerning the substances to which positive reactions were found. (c) Patients with A.D. (n = 18), atopics without A.D. (n = 10), patients with contact dermatitis (n = 10), and normal controls (n = 10), were patch tested with various human dander (H.D.) fractions after stripping the stratum corneum with skin tape. Only patients with A.D. showed positive reactions, the maximum response being at 24-48 hours. There was no difference in reaction pattern between partially purified H.D. subfractions. Histopathological examination revealed an eczema-reaction. Patch testing within the same patient groups with purified house dust mite allergen P1 demonstrated similar results. Although this finding argues against a specific role of H.D. allergen in A.D. it may at least be concluded that H.D. preparations have the capacity to provoke immediate as well as delayed type skin reactions.

Adolescent↗

PubMed1985

Inhalant allergy to wild animals (deer and elk).

We studied 15 highly atopic persons with historic and/or skin test evidence of allergy to deer or elk. All 15 were also reactive to domestic animal danders (dog, cat, or horse). Twelve patients had elevated IgE antibody levels to deer hair/dander and six patients had elevated IgE antibody levels to elk hair/dander. Elevated IgE antibody levels to serum or urine from deer or elk were found in six persons. By using individual patient sera in RAST inhibition experiments we showed that IgE antibodies were directed to allergens common to hair/dander, urine, and serum. One individual reacted to an allergen common to both deer and cat hair/dander. We concluded that atopic individuals sensitive to domestic animals may develop IgE-mediated reactions to deer or elk allergens following recreational or professional hunting contact with these animals.

Adolescent↗

PubMed1985

[1st description of an "atopic family anamnesis" in the Julio-Claudian imperial house: Augustus, Claudius, Britannicus].

On the basis of various literature sources--mainly Suetonius, Plinius the Younger--typical symptoms of atopic diseases are described in some members of the Julio-Claudian family. Emperor Augustus could have suffered from bronchial asthma, seasonal rhinitis and atopic eczema, while Emperor Claudius showed signs of perennial rhinoconjunctivitis and Britannicus of horse dander allergy. Based on present-day standards, this can be regarded as a typical positive family history of atopy.

Famous Persons↗

PubMed1985

[Allergic desensitization: review of controlled clinical trials].

Allergic desensitization is still a subject of controversy. Several controlled studies have demonstrated its efficacy in allergy to hymenoptera venoms and in hayfever; results obtained in hypersensitivity to house dust mites, animal danders and molds are still controversial and those obtained with mixtures of various allergens and bacterial extracts have been most often negative. In the 80's, a new type of allergen preparation has become available in which the allergen content (and not only the protein content) is well determined ("standardized extract"). The use of this new type of preparation should allow a better quantitative approach to allergologic investigations, which are very useful for assessment of the desensitization value.

Allergens↗

PubMedDate not supplied

Atopic dermatitis in Norwegian dogs.

Of 122 dogs showing clinical symptoms of atopic dermatitis, 65.6% exhibited immediate skin test reactivity to one or more well defined allergen extracts, when intradermal skin tests were performed. The Prausnitz-Küstner test performed on two non-atopic recipient dogs, with serum from affected dogs, showed that "reaginic" antibodies transferred in serum from all affected dogs remained bound within the skin of the recipient dogs for 192 hours. House dust, house dust mite (D. farinae) and human dander were the allergens which most commonly caused immediate skin reactions and West Highland White Terriers and Boxers were the most affected breeds. Age at onset of clinical symptoms proved to be 1-4 year in 72.2% of the dogs.

Allergens↗

PubMed1985

The occurrence of indoor allergens in Saudi Arabia.

Investigations on indoor airborne allergens in Saudi Arabia were performed by mold cultures and dust analyses by counter-current immunoelectrophoresis. Twenty fungal genera were isolated, with Aspergillus as the most often encountered. Most of the dust-bound fungi found are ubiquitous and common. Antibodies against Dermatophagoides pteronyssinus, cat- cow- and rat dander, and Cynodon dactylon pollen were used in the dust analyses. Animal antigens were found in five of the ten dust samples. House dust mites were extraordinarily rare. Pollen of Cynodon dactylon (Bermuda grass) was present in nearly all the samples, and in a concurrent clinical study this antigen was found to be the most common cause of perennial rhinitis.

Air Pollution↗

PubMed1985

[Study on the genesis of atopic dermatitis--atopic dermatitis and IgE].

For the purpose of investigating how IgE is correlated in the genesis of Atopic dermatitis (abbreviated as AD) micronizing method of RIST (necessary serum 10 microliter) was utilized. Serum IgE obtained from 369 cases AD, age ranged from 1 month old to 52 years old were studied. In 78 cases, IgE of the objects' parents were also studied as well. Serum IgE of the healthy control, age ranging from 3 days old to 49 years old, were studied and made comparison with those of the objects. Analysis was made in accordance with the factors like age, complication, disease type and prognosis. RAST (house dust, mite, egg, milk) and SKIN TEST (Scratch test) were carried out in order to observe the correlation between serum IgE and Specific IgE or to see the possible induction of eczematous lesion by specific IgE. The following were obtained as conclusion. Serum IgE of AD will show high level in significant manner in comparison with the healthy control from the time of infantile period. Low IgE group will show high rate of improvement after 3 years period of time. High IgE of parents will more or less affect serum IgE of their child or children. Correlation between serum IgE and the severity of AD is not noted in the infantile period but significant in the adult period. In the Scratch test immediate type of reaction could not induce eczematous lesion of AD. Induction of eczematoid reaction in AD was noted with high incidence following the Scratch test of Candida antigen. From the above it is assumed that in AD, although serum IgE level is high, induction of eczematous lesion could not be made by skin invasion of specific IgE antigen to the skin, pruritus by immediate type of reaction following release of chemical mediator will bring the tearing off the skin by scratch and invasion to the epidermis of inflammation inducing materials like human dander, sweat, bacteria or mycological agents eczematous lesion will start to take place.

Adolescent↗

PubMed1981

Allergic sensitivity confirmed by the release of histamine from small blood samples.

An enzymatic-isotopic microassay that can measure picogram amounts of histamine in 20 microliter samples of plasma has been used to confirm diagnosis of allergic sensitivity to extracts of house dust mite, cat dander, grass, plantain, Cladosporium mould and bee sting venom by the skin test procedure. Multiple assays for allergic histamine release can be performed on minimal blood samples resulting in a qualitative and quantitative prediction of allergic sensitivity from an in vitro biochemical procedure.

Animals↗

PubMed1980

The human factor--the weakest link?

The German Animal-Laboratory-Information-System (ALIS) was used to assist the laboratory animal care program. The transmission of disease from man is a hazard to the health of laboratory animals. Mycoplasmas, Escherichia coli, staphylococci and Listeria were considered as hazards to laboratory animals. Special consideration was given to Escherichia coli strains of O groups 7 and 146 and to different lysotypes of Staphylococcus aureus. Important areas where human mistakes can be prevented are discussed. These include distance of animal quarters from processing areas, the diameter of sanitary sewers, air conditioning, noise, drinking water, cage changing procedures, wetting of animals, quarantine areas and separation of species. Training of laboratory animal technicians in Germany consists of both in-service and formal types. The formal training lasts 2 years. People selected for formal training should be tested to assure they are not allergic to laboratory animal dander.

Animal Husbandry↗

PubMedDate not supplied

Successive effects of a vagolitic and a betadrenergic in the differential diagnosis of nonimmunologic and allergic asthma.

In order to determine whether the vagal mechanism is predominant in the physiopathology of asthma, we investigated in the first part of this work. If the new vagolithic, ipratropium can improved the respiratory parameters of asthmatic patients. If the effect is complete or admits yet the supplementary effect of a betadrenergic, Fenoterol. 46 asthmatic patients were registered in some spirographic parameters, e.g. FEV1 (Forced Expiratory Volume in 1 sec.), MMFR25-75 (Maximum Mid-expiratory Flow Rate between the 25 per cent and the 75 per cent of the forced vital capacity) and FEF 200-1200 (Forced Expiratory Flow between 200 ml. and 1200 ml. of the forced vital capacity). The same registers were made 30 minutes after aerolization with 0.05 mg of Ipratropium (two shots) and 10 minutes after 60 micrograms of Fenoterol (three shots). It was found that 78.5 per cent of the patients improved one of the parameters with Ipratropium more than 20 per cent. But 58 per cent of the patients showed an additional improvement with the betadrenergic in one or more of the parameters. This shows that in many cases the physiopathology of asthma is mixed, vagal and betareceptor dependent, in which the medication with Ipratropium plus Fenoterol will obtain better results. Only in some patients the bronchial spasm is vagolithic dependent exclusively, while few others responded to betadrenergic and only 9 per cent of patients did not respond to either one. In the second part of this work we tried to verify if by anamnestic inquiry and additional use of Ipratropium and Fenoterol it is possible to recognize one group of patients with asthma produced by nonimmunologic irritant factors acting on the large airways from another group with asthma due to inhalants allergens and spasm of the small bronchi. The same 46 patients were divided in two groups: Patients who recognize that asthmatic accesses begin after exercise, laughter cold weather, cigarette smoker exposure sprays, synthetics and insecticides. This is the predominantly irritative nonimmunologic group. Patients who recognize that coughing or wheezing begins after contact either with pollen, dust or danders. This is the predominantly allergic group. We proved that patients A improve more with Ipratropium and the opposite is true with patients B. The results with the two drugs are roughly parallel to the anamnestic records.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗

PubMed1983

The diagnostic approach to immediate hypersensitivity in patients with allergic rhinitis; a comparison of nasal challenges and serum rast.

Nasal challenges performed in 182 patients with allergic rhinitis revealed 273 positive and 125 negative responses to house dust, grass pollen, cat and dog danders and aspergillus fumigatus, which all correlated with disease history and intracutaneous tests. In these randomly selected patients the specific IgE antibodies in the serum to the same allergens as those used for nasal challenges were determined quantitatively by serum RAST. Additionally, blood and nasal eosinophilia were recorded during the nasal provocation tests. In all 273 positive challenges protection tests with disodium cromoglycate (DSCG) were also performed. In 24.2% of the positive nasal challenges serum RAST was found positive and in 18.7% of them serum RAST was doubtful. In 52% of the negative nasal challenges negative serum RAST also occurred. No significant correlation was found between serum RAST and nasal challenges (X2 = 0.92; d.f. = 1; 0.20 less than p less than 0.40). No significant correlation was found between serum RAST and nasal challenges for individual allergens tested. Since the nasal provocation test is an in vivo technique, it is likely to be of value for the diagnostic confirmation of the allergic component (due to immediate hypersensitivity) in patients with allergic rhinitis than serum RAST alone. Although serum RAST cannot substitute the nasal provocation tests, it may be a useful supplementary diagnostic parameter.

Humans↗

PubMed1983

Aerobiology of schools and public institutions--part of a study.

The influence of the indoor climate in relation to the health of persons has mainly been connected with the physico-chemical properties of the environment. Complaints from patients concerning eye, nose and throat problems, hoarseness, headache and fatigue are common, especially in schools and other public institutions with heavy traffic and badly cleaned or water damaged wall-to-wall carpets. The significance of specific allergenic components in dust such as mites, mould, animal dander and pollen is well-known. However, the influence of a dirt-factor or a moisture-factor in the carpets or from ventilation systems leading to accumulation, liberation and inhalation of dust and micro-organisms, on allergic and non-allergic persons has, until recently, been neglected. To obtain knowledge on this influence, a systematical registration of the biological factors based on consecutive investigation has started. Results from registration of airborne micro-organisms show a tendency towards a larger amount of micro-organisms measured 1 m above carpets than above bare floors.

Air Microbiology↗

PubMed1983

Efficiency of different skin prick testing methods in the diagnosis of allergy to dog.

The study of 202 asthmatic children shows that prick testing with standardized dog allergen extract is very useful in the diagnosis of allergy to dog dander. A good correlation was demonstrated with clinical history, RAST and the provocation tests. The use of the histamine control system improves the specificity of the prick test when compared with the simple measuring of the mean wheal diameter. End-point titration of the skin prick reactivity did not further improve the specificity when compared with the histamine control system.

Adolescent↗

PubMedDate not supplied

Complement consumption and IgE binding by house dust allergen in the serum of atopic patients.

The reactivity of complement (C) with housedust allergen has been investigated in separate groups of sera from atopic patients with seasonal hay fever, bronchial asthma, atopic dermatitis, animal dander allergy or asthmatic bronchitis as compared to controls. Complement consumption was more pronounced on average in the allergy groups, with the exception of atopic dermatitis. Total IgE levels were elevated in all groups, especially in atopic dermatitis. There was no correlation between C-sensitivity and IgE data (RAST and RIST). The mean levels of C1-inhibitor, 1-antitrypsin and 2-marcroglobulin in the atopic group were found normal. A significant correlation was found between the extent of C-consumption by house dust allergen and the level of C4 in sera. It is concluded that both C and IgE differ from normal in atopic patients, but that neither one is suited for the routine diagnosis of atopy in individual serum samples.

Adult↗

PubMed1980

[Considerations in diagnosis and therapy of house dust and house dust mites allergy (author's transl)].

In all patients with perennial complaints an allergy should be considered. This predominantly monosymptomatic disease is most often caused by house dust mites (Dermpteron. and Derm. farinae) and less often by animal dander, occupational dust and molds. The diagnosis and treatment of allergies includes anamnesis, skin tests with industrially produced allergenes, skin tests with house dust and occupational dust, the avoidance of the allergenes and the hyposensitization.

Child↗

PubMed1982

A diagnostic study of immediate hypersensitivity in asthmatic patients: a comparison of bronchial challenge and serum RAST.

The present study consisted of 124 patients with bronchial asthma or chronic asthmatic bronchitis due to immediate hypersensitivity (Type I allergy). A total of 329 bronchial challenges with house dust, grass pollen, cat and dog danders were performed in these patients who were randomly selected and the specific IgE antibodies in the serum to the same allergens were quantitatively determined (serum RAST). Of 329 bronchial challenges, 147 positive and 109 negative bronchial challenges correlated with intracutaneous tests and disease history (77.8%). In the group of 147 "positive correlating bronchial challenges" (positive challenges, positive skin tests, positive histories), 29.9% showed as positive serum RAST while 50.3% were RAST plus doubtful. In the group of 109 "negative correlating bronchial challenges" (negative challenges, negative skin tests, negative histories), negative serum RAST was found in 51.4% cases. The over-all correlation between the serum RAST and the "correlating bronchial challenges" (chi 2 = 5.19; d.f. = 2; 0.05 less than p less than 0.10) as well as the correlation for the individual allergens were found to be non-significant. It is concluded that bronchial challenges with allergens, being an in vivo parameter, are of a greater value for the diagnostic confirmation of the allergic component due to the immediate hypersensitivity (Type I allergy) in asthmatics than the serum RAST, being only a useful in vitro supplementary parameter. Serum RAST cannot substitute the bronchial challenges generally, only in some special cases.

Asthma↗

PubMed1981

[Immunologic studies in allergic children].

IgG-mediated allergic reaction can be provoked by inhalants (pollens, moulds, dust, animal danders), by food allergens, drugs and by hymenoptera venoms. The level of total-IgE is higher in allergic patients than in normal children. The degree of clinical sensitivity can be evaluated by the estimation of allergen specific IgE together with the patient's history and the results of the skin test. The allergy against bee venom is a suitable model for the immediate hypersensitivity. The assessment of the therapeutic efficacy of hyposensitization treatment can be achieved by the course of the allergen specific IgE- and IgG-antibodies and the insect sting challenge.

Antibody Specificity↗