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PubMed1983

[Relation between the inhibitory effect on the synthesis of the rabbit aorta contracting substance and prostaglandins and the anti-inflammatory activity of ketoprofen and other non-steroidal anti-inflammatory agents].

This study showed that, relative to the other antiinflammatory drugs studied, ketoprofen is a stronger inhibitor of the synthesis of prostaglandins and Rabbit aorta Contracting Substance ("RCS") by guinea pig lung tissue in vitro. Although there seems to be no close correlation between their potency as inhibitors of prostaglandin synthesis and their effectiveness as antiinflammatory agents, evaluation of both activities results in classification of the drugs in the same order.

Animals↗
PubMed1984

[Non-steroidal anti-inflammatory agents. III. Synthesis and analgesic-anti-inflammatory activity of 4-(pyrrol-1-yl)phenylacetamides and 4-(pyrrol-1-yl)phenethylamines].

Preparation of some 4-(pyrrol-1-yl)phenylacetamides and 4-(pyrrol-1-yl)phenylethylamines starting from 4-(pyrrol-1-yl)phenylacetic acid is reported. The new compounds were tested as analgesic-antiinflammatory agents. Data from pharmacological screening indicate 1-[4-(pyrrol-1-yl)phenylethyl]piperidine as the most active substance.

Acetamides↗