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[Pharmacokinetics of norethindrone enanthate 200 mg after intramuscular injection in 25 Chinese women].

Pharmacokinetic profile was studied in 25 healthy fertile Chinese female volunteers after im norethindrone enanthate (NET-EN) 200 mg. The results were compared with the data from British women in our previous paper. Following a single im NET-EN 200 mg, the times to reach peak levels of NET-EN and NET were 4.0 +/- 2.8 d and 5.4 +/- 2.0 d, and their peak values were 5.0 +/- 1.8 and 12.6 +/- 0.9 ng.ml-1, respectively. Mean elimination T1/2 of NET was significantly longer than that of NET-EN. Mean apparent elimination T1/2 were 14.8 +/- 3.8 d for and 11.4 +/- 5.7 d for NET-EN. The elimination rate of NET in Chinese women was significantly slower than that in British women. There was no significant ethnic difference in absorption kinetics of NET and NET-EN.

Adult↗

[Tetanus after intramuscular injection in an infectious disease service in Dakar. 12-year review (1978-1989)].

Tetanus is a serious toxic-infection common to men and animals produced by a strict anaerobic bacillus: Clostridium Tetani or Nicolaier's Bacillus. It is an infectious, non-contagious, non-immunizing illness, which must be officially notified. Although Tetanus has been known from antiquity and a very efficient specific vaccine is available, in developing countries its frequency and high mortality make it a major problem for Public Health authorities. This dramatic situation in underdeveloped countries is due to: inadequate vaccination and health education; poor infrastructure in health services; the persistence of harmful traditional practices; and disregard for elementary principles of antiseptics and sterilization, leading to the terrible form of tetanus after-muscular injection, a real "tragedy" according to Bourgeade. The aim of this study is to draw attention to the frequency, seriousness and hopeless prognostic of this type of tetanus, all of which could be avoided if simple, elementary, prophylactic measures, such as rigorous disinfection and adequate sterilization of equipment, were undertaken.

Adolescent↗