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At least 631 records · Page 35Linked to original sources
PubMed1982

Leiomyosarcoma of the skin: a case report.

A middle-aged man presented with an ulcerated nodule of the right posterior thigh that was histologically evaluated as leiomyosarcoma of the skin. A wide excision of the tumor was followed by split-thickness skin grafting. Leiomyosarcomas of the skin and subcutaneous tissue are rare tumors, usually occurring in the proximal lower extremities. The treatment of choice is a wide local excision with a 3- to 5-cm margin including the subcutaneous tissue and fascia. The defect is covered by a split-thickness skin graft.

Humans↗
PubMed1983

Massive intraabdominal bleeding due to a retroperitoneal leiomyosarcoma.

Retroperitoneal leiomyosarcomas are rare and show a tendency toward large size, cystic degeneration, bleeding, and extensions by infiltration to the adjacent structures. An unusual case of a retroperitoneal cystic leiomyosarcoma with massive intraabdominal bleeding is presented.

Hemoperitoneum↗
PubMed1983

Leiomyosarcoma of the rectum: report of three cases.

Leiomyosarcoma is a malignant tumor which rarely occurs in the rectum. Three patients with leiomyosarcoma of the rectum are presented. Treatment should include wide surgical excision followed by adjuvant chemotherapy. Emphasis is placed upon computerized tomography as the method of choice for the diagnosis of recurrent disease. Recurrent tumor should be resected whenever possible.

Aged↗
PubMed1983

Hepatic leiomyosarcoma.

A case of hepatic leiomyosarcoma is reported and the literature on smooth muscle tumors of the liver is reviewed. All 15 patients with hepatic leiomyosarcoma presented initially with hepatic or abdominal mass. About half of these patients also had abdominal pain or weight loss or both. Elevated levels of serum alkaline phosphatase, SGOT, and lactic dehydrogenase were frequent but inconsistent findings. The prognoses appeared grave, but potentially curable. All but four patients died in less than 3 years. One patient was not followed. The three patients who were alive in follow-ups survived 8 months, 1 year, and 6.5 years, respectively, with no evidence of disease. All three surviving patients had resectable tumor and were surgically treated.

Aged↗
PubMed1984

Advanced leiomyosarcoma of the stomach.

Retrospective studies of twelve patients with advanced gastric leiomyosarcomas were undertaken to evaluate radical surgical resection and combined modality treatment with regard to the patient survival and symptom palliation. All but one patient were found to have metastases or involvement of adjacent organs at the initial operation. Despite radical resection, multidrug chemotherapy, and radiation therapy, no patient survived beyond the third year. Patients with objective response to chemotherapy and radiation and chemotherapy had a mean survival of 27 months, while those who did not respond survived only 7 months. The longest survival among untreated group was 8 months. Successful palliation of advanced gastric leiomyosarcoma requires early diagnosis, surgical resection and multimodal therapy.

Adult↗
PubMed1986

Metachronous leiomyosarcoma in colostomy after abdominoperineal resection for rectal carcinoma.

Leiomyosarcoma of the colon is a rare neoplasm. It is widely known that primary malignant lesions may present either simultaneously (synchronous tumor) or at different times (metachronous tumor). The incidence of metachronous colonic mucosal carcinoma is generally considered to range from 3 to 5%. Metachronous leiomyosarcoma in colostomy 4 years after abdominoperineal resection for rectal carcinoma is unusual and we have found no reports on this in the literature. The clinical symptoms, diagnostic features, and mode of treatment are discussed.

Adenocarcinoma↗
PubMed1980

Leiomyosarcoma of the stomach: results of surgery and chemotherapy in an eleven-year-old girl with liver metastases.

This report describes an 11-7/12-year-old girl with leiomyosarcoma of the stomach metastatic to liver who was treated with surgical resection and combination chemotherapy, which included adriamycin. She remains well 52 months after diagnosis and 27 months after cessation of chemotherapy. The favorable course of this patient suggests that aggressive adjuvant chemotherapy should be considered for patients with leiomyosarcoma who have poor prognostic features.

Antineoplastic Agents↗
PubMed1975

Leiomyosarcoma of the saphenous vein.

A case of primary leiomyosarcoma of the greater saphenous vein with metastatic spread to the thyroid gland and subcutaneous tissue is described. The literature of saphenous vein leiomyosarcomas is reviewed.

Humans↗
PubMed2002

Primary bronchopulmonary leiomyosarcoma of the left main bronchus in a child presenting with wheezing and atelectasis of the left lung.

Primary lung tumors are rare in children, and primary bronchopulmonary leiomyosarcomas are very rare in children, with only 10 cases reported in the English-language literature. We report on the eleventh case of primary bronchopulmonary leiomyosarcoma in a child, and it is the first case in Taiwan, and also in Asia. In addition, this is the second case of this tumor arising in the left main bronchus. Before the present case, there were only 2 cases of this tumor in the main bronchus: one was in the right main-stem bronchus, and the other in the left-stem main bronchus. Ours is the second case showing pleural effusion. Chest roentgenogram and bronchoscopy are helpful in the diagnosis of primary bronchopulmonary tumors, but a definitive diagnosis can only be made by biopsy. The tumor is potentially curable if total excision is possible; irradiation has little therapeutic value, and early excision offers the only hope of cure. The child is alive and well 19 months after pneumonectomy, without having received radiotherapy or chemotherapy.

Asthma↗
PubMed1993

Myxoid leiomyosarcoma of the uterus.

BACKGROUND: A case of myxoid leiomyosarcoma of the uterus is presented. In contrast to 10 of the 11 previously published cases, our patient has a tumor with a high mitotic rate. CASE: The patient presented with a 2-month history of vaginal bleeding and a 20-week-size uterine mass. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. At the time of surgery, the tumor appeared well circumscribed. Microscopically, an infiltrative growth pattern, bizarre nuclei, and 30 abnormal mitotic figures per 10 high power fields were noted. The patient was treated with ifosfamide and mesna. After the fifth course of chemotherapy, a pelvic mass was palpated. Exploratory laparotomy demonstrated a large sidewall recurrence and upper abdominal metastases which were completely resected. The patient is currently being treated with combination chemotherapy consisting of vincristine, Adriamycin, and cyclophosphamide. CONCLUSION: Ten of the 11 previously reported cases of myxoid leiomyosarcoma had a low mitotic count. However, our patient has a high mitotic count in combination with an infiltrative growth pattern. Ifosfamide was ineffective as adjuvant chemotherapy and there was aggressive tumor growth while the patient was on this regimen.

Female↗
PubMed1993

Primary leiomyosarcoma of the ovary in a perimenarchal female.

A case of primary leiomyosarcoma of the ovary in a perimenarchal female is presented. Previous to this report, ovarian leiomyosarcoma was thought to arise predominantly in postmenopausal women and, indeed, this is the first reported case in a pubertal adolescent. The sarcoma was associated with bilateral cellular ovarian leiomyomas, suggesting malignant degeneration of such tumors. After complete resection, the patient is alive without evidence of recurrent disease 20 months after diagnosis. A review of the literature suggests that chemoradiation is of unproven benefit and aggressive surgical management is recommended.

Cerebellar Neoplasms↗
PubMed1993

Primary leiomyosarcoma of the fallopian tube.

Primary leiomyosarcoma of the fallopian tube is an extremely uncommon neoplasm. We report a 39-year-old premenopausal woman with leiomyosarcoma confined to the right fallopian tube, who is alive without evidence of disease 2 years after surgical resection followed by adjuvant doxorubicin and cisplatin chemotherapy. An accompanying literature review indicates that the clinical signs and symptoms of fallopian tube sarcomas are usually nonspecific and include lower abdominal pain and pelvic pressure. The age at diagnosis varies from 21 to 70 years, with a median of 47 years. Prognosis is poor, however, several longterm survivors have been reported. The primary treatment remains surgical excision, although adjunctive chemotherapy or radiation may be of some benefit.

Adult↗
PubMed1994

Leiomyosarcoma of the uterus metastatic to brain: a case report and a review of the literature.

Central nervous system metastases are an unusual sequela of uterine sarcomas. A single brain metastasis from a leiomyosarcoma occurred in a 60-year-old woman, 6.5 years after hysterectomy and more than 2 years following the diagnosis of bilateral lung metastases, treated by combination chemotherapy. After resection of the cerebral metastasis, she was treated with brain radiation therapy and survived 2.5 years. Only seven other cases of uterus leiomyosarcoma metastatic to the brain have been published.

Brain Neoplasms↗
PubMed1995

Retroperitoneal leiomyosarcoma: eight cases and a literature review.

Leiomyosarcoma, a rare malignancy of smooth muscle, may arise from the retroperitoneum and present with the same vague symptoms as a malignancy of the pelvic organs. The purpose of this paper is to review eight cases of retroperitoneal leiomyosarcoma and to illustrate the presenting symptoms, prognostic indicators, and outcomes of patients seen at Indiana University Medical Center between 1989 and 1994. Patients in this study were white females who presented between the ages of 46 and 73 (mean age of 61.4) with nonspecific presenting symptoms of weight loss and back pain (37.5% for each). Tumor size (mean diameter of 14.6 cm in the range 4 to 35 cm), tumor extension, and the presence of distant metastases were of greater prognostic significance than tumor grade (7/8 were grade II, 1/8 was grade I). Surgical resection improved long-term prognosis; three of five patients undergoing resection are alive with no evidence of disease compared to zero of three treated nonsurgically. Due to location and vague presenting symptoms, this tumor continues to have a bleak prognosis and further evaluation and innovative treatment are required before a reasonable cure rate may be expected.

Aged↗
PubMed1996

Ifosfamide and doxorubicin in the treatment of advanced leiomyosarcomas of the uterus: a Gynecologic Oncology Group study.

This is a Phase II groupwide study of the Gynecologic Oncology Group (GOG) to determine the toxicity and efficacy of a combination of ifosfamide and doxorubicin in patients with advanced or metastatic leiomyosarcomas of the uterus who had not received other chemotherapy. Thirty-five women were entered into this study; 1 patient was ineligible (primary not documented), leaving 34 patients treated with ifosfamide, 5.0 g/m2/24 hr, and mesna, 6.0 g/m2/36 hr, by continuous IV infusion preceded by doxorubicin, 50 mg/m2 iv over 15 min. Each course of therapy was repeated every 3 weeks if counts allowed. One patient was inevaluable for response, leaving 34 evaluable for toxicity and 33 evaluable for response of chemotherapy. GOG grade 3 or 4 granulocytopenia occurred in 17 patients (48.6%), 2 patients developed granulocytopenic fever (5.7%), and 1 died of sepsis. Two patients developed grade 3 thrombocytopenia, and 1 died of cardiotoxicity. There were nine partial and one complete responses for an overall response rate of 30.3%; the response duration averaged 4 months. The combination of ifosfamide and doxorubicin is toxic but has moderate activity in patients with advanced or metastatic leiomyosarcoma of the uterus.

Adult↗
PubMed1996

Phase II trial of etoposide in leiomyosarcoma of the uterus: a Gynecologic Oncology Group study.

Twenty-eight patients with advanced, persistent or recurrent leiomyosarcoma of the uterus not previously exposed to cytotoxic drugs were entered into a study of single-agent intravenous etoposide 100 mg/m2 daily for 3 days every 3 weeks. No complete or partial responses were observed. Thirteen patients demonstrated stable disease, while 15 exhibited increasing disease. Median progression-free interval was 2.1 months, median survival 9.2+ months. The most frequent and severe adverse effects were the result of myelosuppression and manifested primarily as leukopenia and neutropenia. Based on the absence of activity, no further study of intravenous etoposide in leiomyosarcoma of the uterus at the dose and schedule tested is planned.

Adult↗
PubMed1998

Leiomyosarcoma of the uterine cervix.

The clinicopathologic features of a patient with uterine leiomyosarcoma arising in the cervix are presented. A 47-year-old Japanese woman was admitted with complaints of hypermenorrhea and abdominal distention. A hysterectomy with bilateral salpingo-oophorectomy revealed a tumor weighing 10.5 kg, which was the largest cervical leiomyosarcoma reported in the literature. She was given eight courses of combination chemotherapy (VADIC and Hydroxyurea, DTIC, Etoposide) and is alive without evidence of recurrence 35 months after the initial therapy.

Female↗