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Belief-desire reasoning as a process of selection.

Human learning may depend upon domain specialized mechanisms. A plausible example is rapid, early learning about the thoughts and feelings of other people. A major achievement in this domain, at about age four in the typically developing child, is the ability to solve problems in which the child attributes false beliefs to other people and predicts their actions. The main focus of theorizing has been why 3-year-olds fail, and only recently have there been any models of how success is achieved in false-belief tasks. Leslie and Polizzi (Inhibitory processing in the false-belief task: Two conjectures. Developmental Science, 1, 247-254, 1998) proposed two competing models of success, which are the focus of the current paper. The models assume that belief-desire reasoning is a process which selects a content for an agent's belief and an action for the agent's desire. In false belief tasks, the theory of mind mechanism (ToMM) provides plausible candidate belief contents, among which will be a 'true-belief.' A second process reviews these candidates and by default will select the true-belief content for attribution. To succeed in a false-belief task, the default content must be inhibited so that attention shifts to another candidate belief. In traditional false-belief tasks, the protagonist's desire is to approach an object. Here we make use of tasks in which the protagonist has a desire to avoid an object, about which she has a false-belief. Children find such tasks much more difficult than traditional tasks. Our models explain the additional difficulty by assuming that predicting action from an avoidance desire also requires an inhibition. The two processing models differ in the way that belief and desire inhibitory processes combine to achieve successful action prediction. In six experiments we obtain evidence favoring one model, in which parallel inhibitory processes cancel out, over the other model, in which serial inhibitions force attention to a previously inhibited location. These results are discussed in terms of a set of simple proposals for the modus operandi of a domain specific learning mechanism. The learning mechanism is in part modular--the ToMM--and in part penetrable--the Selection Processor (SP). We show how ToMM-SP can account both for competence and for successful and unsuccessful performance on a wide range of belief-desire tasks across the preschool period. Together, ToMM and SP attend to and learn about mental states.

Choice Behavior↗

Visual landmark orientation by flying bats at a large-scale touch and walk screen for bats, birds and rodents.

Orientation depends on multi-modal information about the locally perceptible environment (local view) in many situations. We developed a behavioural paradigm for investigating visual orientation of flying bats based on a large-scale touch screen (1.2 m x 1.8 m). It functions by a grid of rows and columns of infra-red beams just in front of a screen with back-projected visual stimuli. Approaching animals interrupt the beams and thus permit automatic recording of the time and place of an animal's locational choice. We used it as a vertical touch surface. Installed as a horizontal walk surface, it may also serve as a more natural 'firm ground', circular arena analogue to the 'Morris water maze' for investigating orientation behaviour and spatial cognition from rodents to birds while offering automatic real-time recording of paths, times and latencies with enhanced possibilities to score details of motor behaviour and to control stimuli interactively. Bats offer a unique possibility to investigate the use of both echo-acoustic and visual information processing pathways for the process of self-localization and orientation. In our first experiment, a bat was presented with five identical targets, one central and four peripheral and had to choose the central target. After task acquisition, the array was shifted by the distance between targets, so that a formerly peripheral landmark was now in the absolute location of the formerly central target. At small inter-target distances, the bat 'went with' the array, and chose the new central target (at a new absolute location). With 30 cm or more of inter-target distance (60 cm across the landmark configuration), however, the bat went with absolute location, and chose a peripheral target. In experiment 2, the bat was presented with two landmarks 30 cm apart and an unmarked target located at midline beneath them. On tests, the landmarks either maintained training distance or were expanded to 50 cm apart. On such expansion tests, the bat chose most the location at the correct vector from the right landmark. This showed that the bat first identified a single landmark by the configuration and then applied a previously learnt vector (angle and distance) to locate the target. Glossophaga did not orient by pure angular geometry between landmarks and target.

Animals↗

The effects of saliency and task difficulty on visual search performance in ageing and Alzheimer's disease.

We asked whether the poor performance on visual search tasks typical of patients with Alzheimer's disease (AD) is the result of a selective deficit in the ability to shift attention from item to item, or the consequence of an inefficient processing of each item within the search set. We attempted to manipulate the ease of attention shifting and item processing in a visual search task by manipulating target salience and task difficulty, respectively. Significant effects of both target saliency and task difficulty for both AD patients and age-matched controls were obtained, with the AD group displaying greater effects of both of these manipulations than the controls. This interaction remained even when the reaction time data were log-transformed to account for the overall slower reaction times of the AD group. We conclude that inefficiency in visual search tasks in AD probably represents the product of both attention shifting and target processing factors.

Aged↗

Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats.

Pfiesteria piscicida, an estuarine dinoflagellate, which has been shown to kill fish, has also been associated with neurocognitive deficits in humans. With a rat model, we have demonstrated the cause-and-effect relationship between Pfiesteria exposure and learning impairment. In several studies, we have replicated the finding in Sprague-Dawley rats that exposure to fixed acute doses of Pfiesteria cells or filtrates caused radial-arm maze learning impairment. Recently, this finding of Pfiesteria-induced learning impairment in rats has been independently replicated in another laboratory as well. We have demonstrated significant Pfiesteria-induced learning impairment in both the win-shift and repeated-acquisition tasks in the radial-arm maze and in reversal learning in a visual operant signal detection task. These learning impairments have been seen as long as 10 weeks after a single acute exposure to Pfiesteria. In the current study, we used a hydrophilic toxin isolated from clonal P. piscicida cultures (PfTx) and tested its effect when applied locally to the ventral hippocampus on repeated acquisition of rats in the radial-arm maze. Toxin exposure impaired choice accuracy in the radial-arm maze repeated acquisition procedure. The PfTx-induced impairment was seen at the beginning of the session and the early learning deficit was persistent across 6 weeks of testing after a single administration of the toxin. Eventually, with enough practice, in each session, the PfTx-exposed rats did learn that session's problem as did control rats. This model has demonstrated the cause-and-effect relationship between exposure to a hydrophilic toxin produced by P. piscicida and learning impairment, and specifically that the ventral hippocampus was critically involved.

Animals↗

The relationship between employment and neuropsychological impairment in HIV infection.

The relationship between neurocognitive impairment and employment in a cohort of 130 predominantly symptomatic individuals with HIV-1 infection was examined. Participants were classified as employed (full or part-time for pay) or unemployed (N = 64) and administered a neuropsychological test battery. When covarying for CD4 count, age, and physical limitations, the results revealed that unemployed men performed below that of employed participants on tasks of memory, set shifting-cognitive flexibility, and psychomotor speed. The results are discussed within the context of similar findings in other illnesses.

Adult↗

The restless mind.

This article reviews the hypothesis that mind wandering can be integrated into executive models of attention. Evidence suggests that mind wandering shares many similarities with traditional notions of executive control. When mind wandering occurs, the executive components of attention appear to shift away from the primary task, leading to failures in task performance and superficial representations of the external environment. One challenge for incorporating mind wandering into standard executive models is that it often occurs in the absence of explicit intention--a hallmark of controlled processing. However, mind wandering, like other goal-related processes, can be engaged without explicit awareness; thus, mind wandering can be seen as a goal-driven process, albeit one that is not directed toward the primary task.

Attention↗

Adaptive decision processes in perceptual comparisons: effects of changes in the global difficulty context.

Adaptive decision processes were investigated in experiments involving an unexpected change in the global ease or difficulty of the task. Under accuracy stress, a shift from an easy to a difficult context induced a marked increase in decision time, but a shift from a difficult to an easy context did not. Under speed stress, a shift to a more difficult context induced lower accuracy and rated confidence, depending on the difficulty of the decisions. A view of caution developed in D. Vickers's (1979) accumulator theory--whereby one seeks to base decisions on more information--is compared with a view based on slow and fast guessing theory (W. M. Petrusic, 1992; W. M. Petrusic & J. V. Baranski, 1989a)--whereby one seeks to base decisions on more diagnostic information. On balance, the findings support the latter view.

Adaptation, Physiological↗

THE RELATIONSHIP BETWEEN ACUTE GLUCOCORTICOID LEVELS AND HIPPOCAMPAL FUNCTION DEPENDS UPON TASK AVERSIVENESS AND MEMORY PROCESSING STAGE.

This review evaluates the effects of glucocorticoids (GCs), the adrenal steroids released in response to stress, on memory functions requiring the hippocampus in animals and humans. The data support the hypothesis that the learning function between GCs and hippocampal-dependent memory is modulated by 1) the aversive nature of the learning paradigm and 2) stage of memory processing (acquisition, consolidation, retrieval). When tasks are minimally aversive, the glucocorticoid receptor (GR) mediates an inverted U-shaped relationship between GC levels and hippocampal function, while the mineralocorticoid receptor (MR) mediates attentional processes and/or reaction to novelty. This inverted U-shaped relationship during minimally aversive training paradigms describes GC-mediated memory processing at both acquisition and consolidation. In contrast, highly aversive paradigms activate the amygdala and elevate GCs as part of the training procedure, revealing a nonlinear inverted U-shaped relationship during acquisition and a positive linear function during consolidation. Thus, highly aversive tasks that activate the amygdala shift the memory function from an inverted U-shaped curve to a linear representation between GC levels and memory consolidation.

Journal Article↗

Profiles of executive function in parents and siblings of individuals with autism spectrum disorders.

Delineation of a cognitive endophenotype for autism is useful both for exploring the genetic mechanisms underlying the disorder and for identifying which cognitive traits may be primary to it. This study investigated whether first-degree relatives of individuals with autism spectrum disorders (ASDs) demonstrate a specific profile of performance on a range of components of executive function (EF), to determine whether EF deficits represent possible endophenotypes for autism. Parents and siblings of ASD and control probands were tested on EF tasks measuring planning, set-shifting, inhibition and generativity. ASD parents showed poorer performance than control parents on a test of ideational fluency or generativity, and ASD fathers demonstrated a weakness in set-shifting to a previously irrelevant dimension. ASD siblings revealed a mild reduction in ideational fluency and a weakness in non-verbal generativity when compared with control siblings. Neither ASD parents nor siblings displayed significant difficulties with planning or inhibition. These results indicated that the broad autism phenotype may not be characterized primarily by impairments in planning and cognitive flexibility, as had been previously proposed. Weaknesses in generativity emerged as stronger potential endophenotypes in this study, suggesting that this aspect of EF should play a central role in cognitive theories of autism. However, discrepancies in the EF profile demonstrated by parents and siblings suggest that factors related to age or parental responsibility may affect the precise pattern of deficits observed.

Adult↗

Determination of language dominance: Wada test confirms functional transcranial Doppler sonography.

OBJECTIVE: To determine the efficacy of the invasive Wada test in determining language dominance, and to validate the functional transcranial Doppler sonography (fTCD) examination in patients. BACKGROUND: Previous work shows that simultaneous bilateral fTDC may identify cognitive hemispheric dominance in healthy individuals. METHOD: fTDC and the Wada test were performed prospectively in 14 patients with various diseases (tumors, cerebrovascular events, head injury, intractable epilepsy). fTDC hemispheric dominance was determined based on the hemispheric blood flow velocity shift for language and visuospatial tasks. RESULTS: fTDC was performed easily in patients. One patient could not be examined by fTDC because of absent temporal bone window for ultrasonic transmission. Two Wada tests were inconclusive due to patient somnolence. One of these patients suffered from right frontal tumor and had aphasia remitted under steroids when examined. fTDC indicated a bilateral language dominance. In the remaining 11 patients the correlation between fTDC and Wada language lateralization indices was 0.75 (p = 0.008). If a post hoc cutoff score was taken for the fTDC language lateralization index, in eight patients, both fTDC and Wada testing determined the left hemisphere to be dominant for language; in the other three patients, language function was bilateral in both examinations. CONCLUSION: Although the current results are preliminary and require replication in a larger sample, fTDC seems to be able to assess hemispheric language dominance not only in healthy individuals, but also in patients. It might become an alternative noninvasive or complementary tool to the Wada test, particularly in patients in whom the Wada test is impractical or gives inconclusive results.

Adolescent↗

[Reported morbidity and use of health services by working women, Brazil].

OBJECTIVE: Inclusion in the work force has become part of women's daily lives, and they have to cope with multiple tasks and manage double working shifts. A study was carried out to assess working women's morbidity and their use of health services. METHODS: By means of a household survey, chronic and acute morbidity (i.e. within 30 days of data collection) was reported by 1,157 women aged 10 to 49 years living in the southern area of the city of São Paulo, Brazil. Data were collected from January 1992 to January 1993. The relationship between employment and marital status, educational level and socioeconomic status was evaluated. RESULTS: Women who had a paid job were more likely to complain of acute or chronic morbidity. Also, these women tended to be less likely to seek medical services for their health problem. The most prevalent acute illnesses were: respiratory illnesses, especially influenza or colds (72/1,000), abdominal and pelvic pain (13.2/1,000), headaches (11.4/1,000), and hypertension (9.5/1,000). Regarding chronic complaints, hypertension (39.7/1,000), back pain (26.5/1,000), gastritis or inflammation of duodenum (24.6/1,000), and bronchitis (24.6/1,000) were the most prevalent conditions. CONCLUSIONS: Although employed women reported more health complaints than women who were not employed, their use of health services was equal to or less than that of women who were not employed for most health conditions studied.

Acute Disease↗

Relationship between discrimination tasks of the cantab and the corpus callosum morphology in Alzheimer's disease.

The relationship between performances on a simple discrimination task of the Attentional Set Shifting of the Cambridge Neuropsychological Test Auto mated Battery (CANTAB) and morphometry of the corpus callosum is examined in patients with Alzheimer's disease. Analysis showed patients with probable Alzheimer's disease are heterogeneous for the relationship between performances in the attentional test of the CANTAB and the anterior callosal atrophies. Interest in these results for clinical diagnosis of this mental disease is discussed.

Aged↗

Quality control pharmacy tasks: big five personality model and accuracy of error detection.

The relationships between extraversion, conscientiousness, neuroticism, and performance were examined in the context of an error detection task completed under stable and shifting workload conditions. 114 participants checked two sets of 40 fictitious prescriptions for errors. Errors were inserted at rates varying from 26% to 38%. Workload was manipulated by altering the amount of time allowed to complete each set. The stable workload group had 45 min. per set, the workload up-shift group had 60 min. for the first set and 30 min. for the second set. Performance was measured using hit rates and false alarms. Analysis indicated that extraversion and conscientiousness were correlated with hit rates, but only in the stable workload condition. Results are discussed and research directions are considered.

Adolescent↗

Effects of an overnight fluid infusion on cognitive functions in preoperative patients.

The results of the present study show that subjects who received an overnight infusion of isotonic fluid did significantly less well at particular neuropsychological tests than controls who did not receive such an infusion. The relevant test parameters involved aspects of word list learning, and concept shifting on a complex speed task. Potentially biasing factors such as anxiety, disturbed sleep, education and age could be discarded. With respect to the physiological mechanism involved, the results suggest that a relatively expanded extracellular volume without dilutional hyponatremia might underlie the diminished performance. The experimental group did not lose weight overnight, and the hemoglobin and haematocrit level of the experimental group were significantly different from those of the control group; the blood pressure, plasma electrolytes and osmolality were not different. The present results provide evidence that disturbances in fluid homeostasis may affect cognitive performance.

Adult↗

The relationship between serum testosterone and visuomotor learning in hand skill in right-handed young women.

The relationship between serum testosterone level and motor learning in hand skill was studied in right-handed young women. Hand skill was assessed by a peg moving task. Subjects were required to shift 25 pegs from one of two parallel rows to the corresponding holes as fast as possible, first with right and then with left hand. One trial consisted of the time elapsed to move 25 pegs with one hand. Ten trials were performed by each hand. Peg moving times for the right and left hands linearly decreased at each successive trial (visuomotor learning). Subjects were divided into two subgroups as those having serum testosterone concentrations below and above the mean. The right hand skill and its motor learning was found to be better in subjects with low testosterone than those with high testosterone. The left hand skill was better in subjects with low testosterone than those with high testosterone; there was no significant difference in the left-hand learning in subjects with low and high testosterone (parallel regression lines). Motor learning linearly decreased with testosterone for the right hand, not for the left hand. These results seem to be in accord with the testosterone theory of cerebral lateralization (Geschwind & Behan, 1982).

Adolescent↗

Inhibition of attended processing during saccadic eye movements.

People are unable to perform some, but not all, cognitive tasks while moving their eyes. A possible common denominator among disrupted processes is the use of attention. The present research proposes and tests an attentional suppression hypothesis to evaluate this claim. This hypothesis states that because attention is obligatorily allocated to a to-be-fixated location prior to the onset of a saccade, during saccadic events attentional resources are unavailable to direct processing associated with higher order cognitive tasks. Subjects were engaged in a task that combined saccades and shifts of attention across global and local levels of hierarchical figures. When the eyes did not move, this shift took place between stimulus presentations. When saccades intervened between the stimuli, the global-local shifts of attention were interrupted, suggesting that saccades suppress cognitive processes requiring attention.

Attention↗

The effects of single-dose fexofenadine, diphenhydramine, and placebo on cognitive performance in flight personnel.

BACKGROUND: Sedation and functional impairments are side effects associated with the use of first-generation antihistamines that preclude their use in aviation. Selected second-generation antihistamines do not have such side effects and have been proposed for use in aircrew. METHODS: Forty-two healthy naval aviation personnel served as subjects in this double-blind, randomized, placebo-controlled crossover study. Subjective drowsiness, cognitive performance, and vigilance were measured under three conditions: 180 mg fexofenadine (F), 50 mg diphenhydramine (D) as a positive control, or placebo (P). RESULTS: Subjects receiving F vs. D tended to have a faster mean hit reaction time (adjusted mean difference +/- SE, -10.5 +/- 6.8 ms, p = 0.127). Subjects performed faster and better with F vs. D on measures of omission errors and commission errors (p < 0.05). Variable symbol digit coding delayed recall accuracy was better for F vs. D (p = 0.023), and approached significance for shifting attention and divided attention tasks (p = 0.062 and p = 0.057, respectively). Subjects reported significantly more drowsiness (p < 0.005) with D than F. CONCLUSIONS: Diphenhydramine administration resulted in significant psychomotor decrements compared with fexofenadine, while the effects of fexofenadine were similar to placebo. These results provide additional support for the safe use of fexofenadine by aviation personnel.

Administration, Oral↗

Mortality for pancreatic cancer among aluminium smelter workers in Sardinia, Italy.

To investigate the relationship between exposure to polycyclic aromatic hydrocarbons (PAHs) and mortality for specifc cancer sites, 1152 men, employed for at least 1 year at a prebake aluminium smelter, were followed-up from 1972 until 31 December 2001. Exposure to PAHs was estimated from a detailed reconstruction of the working history experienced in the plant by each cohort member and from several environmental and personal shift-sampling measurements available, by task and working department, since 1979. Furthermore, information on smoking habits, previous jobs before engagement in the smelter and main clinical findings observed during the follow-up were collected from the personal medical files. This study showed no increased mortality for lung cancer or bladder cancer associated to exposure to PAHs. Mortality for pancreatic cancer, based on 6 observed deaths, was significantly higher than expected in the whole cohort (SMR 2.4; 95%CI 1.1-5.2) and particularly among workers employed in the anodes factory of the plant (SMR 5.0, 95%CI 2.1-12.1), where a relatively consistent exposure to PAHs has been estimated. The nested case-control study planned for pancreatic cancer cases, confirmed that, also after controlling for cigarette smoking, PAH exposure experienced in the anodes factory was associated with a significant increased risk of pancreatic cancer. A pre-existent diabetes mellitus and a potential occupational exposure to pesticides experienced in previous agricultural jobs were found as concurrent significant covariates increasing the risk. In conclusion, the relatively high exposure to PAHs, experienced in the anodes factory and particularly in the green-mill department of this prebake aluminium reduction plant, cannot be ruled out as one of the main factors in the multifactorial aetiology of the pancreatic cancers observed in this study.

Adult↗