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At least 631 records · Page 35Linked to original sources
PubMed1981

[Kurloff's thymic inclusion : action on rat gonads in culture].

Thymic and splenic extracts rich in FOA-KURLOFF (F.K.) body cells, obtained from guinea-pigs treated with oestrogen, were added to rat testis or ovaries in culture. Controls were prepared with extracts from thymus and spleen of non treated animals and from kidneys of treated or non treated animals. After five hours the level of sexual hormones and the germinal cells were studied. The F.K. substance has no effect on germinal cells and on progesterone and testosterone secretion. The F.K. substance induces a significative decrease of oestrogen secretion. In an other paper we established that F.K. bodies induced a hyperactivity of internal theca folliculi and of ovarian interstitial cells. It is a false image of activity in connection with a hypersecretion of FSH. The F.K. substance inhibits oestrogen synthesis.

Animals↗
PubMed1978

Properties of TFX-A product obtained from calf thymus.

Properties of TFX--a product obtained from calf thymus by Pharmaceutical Comp. in Jelenia Góra--are described. The preparate is a mixture of polypeptides and peptides of various molecular weights with various biological activities. Attempts of isolation of active fractions, devoid of balast proteins are described.

Animals↗
PubMedDate not supplied

[Biorhythms of the lymphoid system and possibilities of immunomodulating chronotherapy].

The paper provides the authors' own data and the data available in the literature concerning diurnal rhythms of immunological parameters in the development of experimental immunopathological conditions. Desynchronizing these rhythms, a change in the light regime is shown to accelerate the time course of the development of an autoimmune process in mice. The potentialities of chronotherapy of experimental immunodeficiencies with thymic preparations have been studied. It is emphasized that chronobiological studies are particularly essential in solving the biomedical problems of the Far North with its extreme conditions and a great deal of desynchronizing factors.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Endocrine function of the thymus and ionizing radiation].

It is shown that external as well as incorporated radiation inhibit the endocrine function of the thymus in the result of the direct and indirect effects. Postradiation deficiency of thymic hormones plays a significant role in pathogenesis of functional disorders in the immunity system. Immunocorrection with thymic agents is the most effective method when the mechanism of inhibition of thymic hormonal function are taken into account.

Adult↗
PubMed1995

Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients.

OBJECTIVE: To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS). METHODS: Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed. RESULTS: ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients. CONCLUSION: The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.

Adolescent↗
PubMed1976

[The association of myasthenia and disseminated lupus erythematosus. 2 cases].

Two cases of the association myasthenia/systemic lupus erythematosus are described. This association is rare but of particular interest from a pathogenic point of view. The discussion includes the suggestion of an immunological disturbance which might be the common denominator of the two disorders. Recent data concerning the role of the thymus and of "suppressor" T cells support such a hypothesis.

Adult↗
PubMed1976

Heterogeneity of stem cells in severe combined immunodeficiency.

Two patients with severe combined immunodeficiency disease (SCID) having variable B-cell development have been shown to have marrow precursors of lymphoid cells which can be induced in vitro by thymic factors to express certain T-cell surface characteristics (HTLA+ phenotypes). Their marrow cells could not, however, be induced by these same factors to develop the E-rosette marker or functional activities of T lymphocytes. The marrow of these children also showed, when compared to that of normal adults, a different distribution of cellular elements on density gradient fractionation. The findings support the view that the disorder under study has a different pathogenesis from other forms of SCID previously analysed.

Age Factors↗
PubMed1994

[Chronic liver diseases: secondary thymic insufficiency and immunocorrection with T-activin].

105 patients with chronic diffuse diseases of the liver were examined clinically, biochemically and immunologically. The examination included investigation of serum thymic activity, subpopulation of peripheral blood lymphocytes using monoclonal antibodies, immunoglobulins (A, M, G) and CIC. Thymic activity in the serum was low in chronic persistent hepatitis, much lower in chronic active hepatitis and the lowest in hepatic cirrhosis. Thymic activity correlated with the process activity and compensation, peripheral blood levels of T-lymphocytes, T-helpers, T-suppressors. The conclusion is made on thymic deficiency in chronic diffuse hepatic diseases. Correction of chronic secondary thymic insufficiency with T-activin produced a good clinical response.

Adjuvants, Immunologic↗