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A review of the 308-nm excimer laser in the treatment of psoriasis.

The 308-nm excimer laser is a new modality for the treatment of psoriasis. With the 308-nm UVB radiation generated by this laser, it is possible to clear psoriasis with as little as one treatment and to have a moderately long remission. In contrast to traditional phototherapy techniques, this handheld excimer laser UVB therapy is selectively directed toward lesional skin, thus sparing the surrounding normal skin from unnecessary radiation exposure. This modality may offer a new alternative in the treatment of limited psoriasis and other inflammatory diseases.

Dose-Response Relationship, Radiation↗

Vitamin D and UVB radiation therapy.

Several studies have examined the combination of calcipotriene and UVB radiation in the treatment of psoriasis. Most show greater clearing with the combination than with monotherapy with either treatment. Data from one study found that calcipotriene had a UVB-sparing effect when combined with broadband UVB phototherapy, resulting in fewer UVB exposures and a lower cumulative dose. This finding suggests that patients treated with calcipotriene may be able to achieve lesion clearing with less frequent UVB radiation treatments than those not treated with calcipotriene. The combination of calcipotriene and UVB radiation does not alter the tolerability or safety of therapy. Calcipotriene may be applied at any time up to 2 hours before or immediately after UVB radiation.

Calcitriol↗