SEARCH · PubMed Health

Results for “motor function”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 631 records · Page 35Linked to original sources

PubMed2003

Cognitive and motor function after administration of hydrocodone bitartrate plus ibuprofen, ibuprofen alone, or placebo in healthy subjects with exercise-induced muscle damage: a randomized, repeated-dose, placebo-controlled study.

RATIONALE: Medications combining hydrocodone bitartrate and non-steroidal anti-inflammatory agents appear more beneficial than anti-inflammatory medications alone in treating pain and inflammation from acute soft tissue trauma, but opiate side effects may include sedation and impaired cognitive and motor performance. OBJECTIVE: Performance on complex cognitive and motor tasks was evaluated in healthy subjects with exercise-induced muscle damage who were treated with a hydrocodone-ibuprofen combination, ibuprofen alone, or placebo. METHODS: This double-blind, randomized, placebo-controlled, repeated-dose clinical trial compared the effects of hydrocodone bitartrate (7.5 mg) plus ibuprofen (200 mg), ibuprofen alone, and placebo on cognitive and motor function in 72 healthy college men. Muscle damage in the quadriceps of each subject's dominant leg was induced by an eccentric exercise protocol. Subjects took the study medication four times daily (every 4-6 h) for 5 days. Forty minutes after medication ingestion at the same time each day, subjects underwent tests of attention/concentration, motor performance, and reaction time. Four trained assessors rotated among subjects so that none tested the same participant on more than three occasions. RESULTS: Repeated measures analyses of covariance revealed no between-group differences on a complex memory and cognition task or complex reaction time. Subjects using hydrocodone bitartrate plus ibuprofen performed significantly less well on a simple tracking task and made significantly more errors on a simple reaction-time task than the other two groups. These deficits were found to be highly transitory and not related to confusion or fatigue. CONCLUSION: Hydrocodone plus ibuprofen was not associated with deterioration in complex cognition but was related to very transitory decrements in tasks involving simple hand-eye coordination.

Adolescent↗

PubMed1997

Sign language and motor functioning in students with autistic disorder.

Sign language production of 14 low-functioning students diagnosed with autistic disorder was examined. Videotapes of the students signing with their teachers were analyzed for frequency and accuracy of sign location, handshape, and movement production. The location aspect of signs was produced more accurately by the subjects than either the handshape or movement aspects. Wide individual differences were evident among the students in the number of signs they produced, accuracy of sign formation, and performance on measures of motor functioning. Students' sign vocabulary size and accuracy of sign formation were highly correlated with their performance on two measures of apraxia and with their fine motor age scores.

Adolescent↗

PubMed1984

Comparison of effects of nifedipine, propantheline bromide, and the combination on esophageal motor function in normal volunteers.

Both intracellular calcium ions and neural input are important in esophageal smooth muscle contraction. The aim of this study was to compare the effects of well-tolerated doses of the calcium-channel blocker, nifedipine (20 mg sublingually/buccally) with the anticholinergic, propantheline bromide (15 mg orally) and the combination of these two agents on esophageal motor function. Seven healthy volunteers underwent manometric evaluation after nifedipine, propantheline bromide, the combination, and placebo on different days. Lower esophageal sphincter pressure decreased significantly (P less than 0.05 vs basal and placebo) by 32% after nifedipine, but fell only 21% after propantheline bromide. After the combination lower esophageal sphincter pressure fell by 45% (P less than 0.05 vs basal and placebo and nifedipine alone). Contraction amplitude in the body of the esophagus decreased significantly (P less than 0.05 vs basal and placebo) by 26% after propantheline bromide, but fell only 11% after nifedipine. The combination led to a decrease of 37% in contraction amplitude, but this was not significantly different from that obtained with propantheline bromide alone. No drug or combination had any effect on other manometric parameters. These data show that in the normal subjects studied with the above doses: (1) nifedipine has a greater effect than propantheline bromide on the lower esophageal sphincter; (2) propantheline bromide has a greater effect than nifedipine on esophageal contraction amplitude; and (3) the combination of nifedipine and propantheline bromide has an enhanced effect on both lower esophageal sphincter pressure and esophageal contraction amplitude.

Administration, Oral↗

PubMedDate not supplied

[Entacapone++ : a new catechol-O-methyltransferase inhibitor which improves the response to levodopa in patients with Parkinson disease and fluctuating motor function].

INTRODUCTION AND DEVELOPMENT: Selective inhibitors of peripheral catechol-O-methyltransferase (COMT) seem to be useful drugs for the treatment of patients with Parkinson's disease. When associated with levadopa and a dopa-decarboxylase inhibitor they are clearly effective in patients with progressive illness, who are particularly dependent on the plasma concentration of levadopa, or may have fluctuating motor function when the effect of the dose is wearing off. Entacapone, a prototype of this group of drugs, has been shown to modify the pharmacokinetics of levadopa in such a way that the plasma concentration of levadopa is raised (between 21% and 50% in different studies): to reduce variations in plasma level between doses, which allows some patients to reduce the total daily dose of levadopa at the same time as the response time (time 'on') increases by between 20% and 78%. CONCLUSION: Entacapone is a well tolerated drug and could form part of a regular 'triple therapy' in the patients described.

Antiparkinson Agents↗

PubMed1993

Postoperative motor function and mucosal blood flow of lower esophagus: comparison between terminal esophagoproximal gastrectomy and esophageal transection for esophageal varices.

Reflux esophagitis and anastomotic ulcer are potential complications associated with surgery for esophagogastric lesions. This study compared 10 cases following terminal esophagoproximal gastrectomy (TEPG) for esophageal varices and 20 cases following esophageal transection (ET) for esophageal varices with respect to postoperative motor function and mucosal blood supply, to ascertain the reason for the development of anastomotic ulcer. Endoscopic findings showed that anastomotic ulcers were detected more often after TEPG than after TR. Maximum swallowing pressure, high pressure zone pressure, and length did not differ between the two groups. However, maximum swallowing pressure in the lower esophagus after both procedures was significantly lower than in the control group (20 cases; p < 0.01). The results, measured by reflectance spectrophotometry, showed that the index of esophageal mucosal blood volume following TEPG is significantly lower than that following ET and in non-operated esophageal varices (10 cases; p < 0.01). Yet the index of oxygen saturation of hemoglobin was similar in the three groups. This study has demonstrated that patients undergoing TEPG have mucosal ischemia of the lower esophagus, causing the development of anastomotic ulcers.

Anastomosis, Surgical↗

PubMed1991

Central and peripheral actions of calcitonin gene-related peptide on gastric secretory and motor function.

CGRP exerts a potent central action to inhibit gastric acid secretion in rats and dogs and gastric emptying, contractility and ulcer formation in rats. The site of action to inhibit acid secretion has been localized in the dorsal vagal complex. The inhibition of acid secretion is related primarily to the decrease in vagal efferent activity whereas the inhibition of gastric motor functions involves increases in sympathetic outflow. The central action of CGRP to prevent ethanol-induced lesions is unique to this peptide and not shared by other centrally acting inhibitors of gastric function. It may be related to the increase in gastric mucosal blood induced by central CGRP. The presence of CGRP-like immunoreactivity and receptors in medullary nuclei receiving visceral information and influencing vagal outflow suggests a possible role of the peptide in the vagal regulation of gastric secretion. Peripheral injection of CGRP also inhibits acid secretion when administered peripherally in rats, dogs, rabbits and humans. Its antisecretory effect is unlikely to be related to a direct action on the parietal cells. It involves specific and marked release of gastric somatostatin through an interaction with CGRP receptors characterized on D cells and coupled with cAMP. In addition, CGRP induces a decrease in acetylcholine transmission in the enteric nervous system which may contribute to the inhibition of acid. Peripheral CGRP inhibits gastric emptying and motility by a direct action on smooth muscles through receptors linked with cAMP. The release of CGRP from spinal afferents innervating the stomach in response to stimulation of capsaicin-sensitive fibers suggests a role of the peptide in the regulation of gastric function.

Animals↗

PubMed1986

Pathological cerebral blood flow during motor function in schizophrenic and endogenous depressed patients.

In this investigation we examined eight Type I (positive symptoms without marked negative symptomatology), eight Type II (marked negative symptoms) schizophrenic patients of the disordered and paranoid diagnostic subgroups (DSM-III 295.1 and 295.3), eight severely (HAMD above 35) and eight less severely (HAMD below 20) endogenous depressed patients, and eight control persons using the 133Xe inhalation method in resting condition and during motor activity of the dominant right hand. In all patient groups we found flow activation patterns that were different from those observed in normal control persons. During motor activation in Type I schizophrenics and in less severely endogenous depressed patients, we found a bilateral hyperflow and a diffuse cortical flow increase, also involving deeper cerebral structures. In Type II schizophrenics and severely endogenous depressed patients, however, we found a widespread nonreactivity of the regional cerebral blood flow (rCBF) to motor activation, with no flow increase in the contralateral primary motor area. In normal control individuals, we reproduced a 25% flow increase that was strictly limited to the contralateral primary motor area, as already reported by other authors. As only the schizophrenic patients were not under antipsychotic medication (4 with a washout of at least 1 week prior to the investigation, 12 never treated with drugs before), contaminating effects of the medication cannot be ruled out for the endogenous depressed patient groups. However, in schizophrenic patients, these results suggest a diffuse disorganization and lack of laterality of motor functional systems. In addition, the change from hyperactivity to hyporeactivity might indicate cerebral functional correlates of the change from Type I to Type II symptomatology in schizophrenic patients, which could possible prove to be of clinical importance.

Adolescent↗

PubMedDate not supplied

Effects of levobupivacaine, bupivacaine, and ropivacaine on tail-flick response and motor function in rats following epidural or intrathecal administration.

BACKGROUND AND OBJECTIVES: Commercially available bupivacaine is a racemic mixture of S (-)- and R(+)-enantiomers. Although the S(-)-enantiomers levobupivacaine and ropivacaine are less toxic to the cardiovascular and central nervous systems than bupivacaine, their relative efficacy has not been determined. This study directly compares the dose response of levobupivacaine, ropivacaine, and bupivacaine following epidural and intrathecal administration in the rat. METHODS: The time course of change in tail-flick latency and qualitative motor function was studied in rats following epidural or intrathecal administration of 0.25-0.75% levobupivacaine, ropivacaine, or bupivacaine in blinded, randomized fashion. RESULTS: Levobupivacaine and bupivacaine produced comparable and significantly enduring antinociceptive effects compared with ropivacaine at all test concentrations following both epidural and intrathecal administrations. Duration of motor block at lower local anesthetic concentrations (epidurally and intrathecally) was comparable with levobupivacaine and ropivacaine but significantly shorter than with bupivacaine. Epidural 0.75% levobupivacaine and bupivacaine showed more enduring motor block than ropivacaine. CONCLUSIONS: Levobupivacaine, given epidurally or intrathecally, produces longer lasting antinociceptive action than ropivacaine at equivalent concentrations and similar motor blocking effect at lower concentrations in both epidural and intrathecal administrations. Levobupivacaine-induced prolongation of the tail-flick latency is comparable to that of bupivacaine, as is motor blocking effect at higher concentrations. The possibility of significant differential block with levobupivacaine compared with bupivacaine warrants further study.

Amides↗

PubMed2004

Motor functions of the Broca's region.

Broca's region in the dominant cerebral hemisphere is known to mediate the production of language but also contributes to comprehension. This region evolved only in humans and is constituted of Brodmann's areas 44 and 45 in the inferior frontal gyrus. There is, however, evidence that Broca's region overlaps, at least in part, with the ventral premotor cortex. We summarize the evidence that the motor related part of Broca's area is localized in the opercular portion of the inferior frontal cortex, mainly in area 44 of Brodmann. According to our own data, there seems to be a homology between Brodmann area 44 in humans and the monkey area F5. The non-language related motor functions of Broca's region comprise complex hand movements, associative sensorimotor learning and sensorimotor integration. Brodmann's area 44 is also a part of a specialized parieto-premotor network and interacts significantly with the neighboring premotor areas.

Animals↗

PubMed1999

Deletion of the myopathy loop of Dictyostelium myosin II and its impact on motor functions.

One of the putative actin-binding sites of Dictyostelium myosin II is the beta-strand-turn-beta-strand structure (Ile(398)-Leu-Ala-Gly-Arg-Asp(403)-Leu-Val(405)), the "myopathy loop, " which is located at the distal end of the upper 50-kDa subdomain and next to the conserved arginine (Arg(397)), whose mutation in human cardiac myosin results in familial hypertrophic cardiomyopathy. The myopathy loop contains the TEDS residue (Asp(403)), which is a target of the heavy-chain kinase in myosin I. Moreover, the loop contains a cluster of hydrophobic residues (Ile(398), Leu(399), Leu(404), and Val(405)), whose side chains are fully exposed to the solvent. In our study, the myopathy loop was deleted from Dictyostelium myosin II to investigate its functional roles. The mutation abolished hydrophobic interactions of actin and myosin in the strong binding state during the ATPase cycle. Association of the mutant myosin and actin was maintained only through ionic interactions under these conditions. Without strong hydrophobic interactions, the mutant myosin still exhibited motor functions, although at low levels. It is likely that the observed defects resulted mainly from a loss of the cluster of hydrophobic residues, since replacement of Asp(403) or Arg(402) with alanine generated a mutant with less severe or no defects compared with those of the deletion mutant.

Actins↗

PubMed1990

Day and night esophageal motor function.

Circadian rhythmic variation has been documented in gastric, small bowel and colonic motility. Morning and evening studies of esophageal motility were performed to assess whether similar rhythmicity exists in esophageal function. Fifteen healthy male subjects were studied twice on separate study days. Esophageal manometry was performed either at 10 AM or 10 PM after a standardized meal given 10 h prior to each study. Lower esophageal sphincter pressures, distal esophageal contractile amplitudes, distal esophageal contractile durations, and the velocity of propagation of peristaltic waves in the proximal and distal esophagus were measured. No significant differences were detected in esophageal function between day and night studies. These findings suggest either 1) nocturnal slowing of gastrointestinal motility is not a generalized characteristic of the entire GI tract, or 2) a two time-point study is not adequate to detect a true circadian rhythm in esophageal motor function.

Adult↗

PubMed1989

[The role of oxytocin in realizing hypothalamic effects on the motor function of the digestive tract].

Chronic experiments in dogs showed that, after i.v. injection of oxytocin, the latency of activation of gastrointestinal motility by the stimulation of median hypothalamic structures was increased and inhibitory effects of posterior hypothalamic structures on the contractile activity of the digestive tract were intensified. The data obtained suggests that oxytocin facilitates the manifestation of inhibitory effects of the hypothalamus on the motor function of gastrointestinal tract.

Animals↗

PubMed1979

[Characteristics of the restoration of motor functions in patients who have had a cerebral stroke depending on a lesion of the right and left hemispheres].

A group of 227 patients was observed, who following brain strokes underwent rehabilitative and residual phases. The lesion focus was localized in the right and left hemispheres in 116 and 111 patients, respectively. The results of clinical and clinical-neuropsychological studies showed a worse rehabilitation of motor functions in patients with right hemispheric lesions. It was conditioned by components of an apractognostical syndrome and particularly of anozognosia. Therefore, rehabilitation specialists should treat patients who had brain strokes, taking into consideration the localization of the lesion focus and promote the use of techniques directed toward a correction of specific right hemispheric defects.

Aged↗

PubMed1982

Assessment of the effects of acrylamide, methylmercury, and 2,5-hexanedione on motor functions in mice.

Neurotoxic effects of acrylamide, methylmercury, and 2,5-hexanedione were studied in forth female BALB/c mice. The chemicals were dissolved in distilled water and administered via light-tight drinking bottles. Three control groups were used. The first received distilled water, the second received concentrated saccharin solution to assess the effects of reduced water intake, and the third was maintained on a reduced food diet. Motor functions were quantified by measuring landing foot-spread and rotarod performance. Baseline data were collected before dosing started. Mice were placed, twice weekly, on an accelerating rotarod, and their retention time was recorded. In the landing foot-spread test, the experimenter dropped mice from 15 cm onto a flat, smooth surface once a week. The hindlimb splay was then measured by the examiner. Both experimenter and examiner were unaware of the identity of each group (except of the food deprived group, in the case of the experimenter) during the first exposure. Decreased retention time and increased hindlimb splay were observed in mice after 12 d of exposure to acrylamide. Recovery followed treatment cessation. Increased hindlimb splay preceded an obvious decline of rotarod performance in the group receiving the 10 ppm of methylmercury solution. Mice receiving the 20 and 40 ppm of methylmercury solutions did not display any change in these tests before overt signs of toxicity. 2,6-Hexanedione produced a small decline in performance to a constant level after 85 d of exposure. After dosing termination, performance returned to baseline values. Control groups showed no change in performance on either the rotarod or the landing foot-spread test. Our data show that the rotarod and hindlimb splay tests in mice are about equal in sensitivity to the effects of the neurotoxic chemicals tested.

Acrylamides↗

PubMedDate not supplied

Recovery of sensory and motor function after nerve repair. A rationale for evaluation.

In order to identify an effective test for evaluating the results of nerve repair, 25 patients, age 10-53 years (mean 27 years), were evaluated two to five years after median or ulnar nerve repair at the distal forearm level. The initial assumption was that evaluation after nerve repair should reflect four aspects of recovery: reinnervation, tactile gnosis, integrated sensory and motor functions, and pain or discomfort. The evaluation included a number of assessment methods addressing these aspects. Attention was paid to the usefulness of the tests with reference to their relevance for assessing hand functions. Clinical utility and possibilities for standardization and quantification of the results were considered important. Statistical analysis showed no correlations between the results obtained in clinical tests for reinnervation and the results from neurophysiologic examination. Grip strength and cold intolerance together accounted for a significant 51% of the variance in activities of daily living (ADL) capacity. Tactile gnosis correlated weakly with ADL capacity and strongly with age. Based on these findings, the following design for evaluating the result after median and ulnar nerve repair is suggested. To assess reinnervation: Semmes-Weinstein monofilaments and manual muscle-testing; to assess tactile gnosis: classic 2PD and a test with the features of the used shape identification test; to assess integrated functions: selected parts of Sollerman's grip test and grip-strength test with Jamar dynamometer; to quantify pain and discomfort: a four-ranked scale for grading perceived problems from cold intolerance and hypersensitivity.

Activities of Daily Living↗

PubMed1985

[Electromyographic characteristics of recovery of motor function in patients with lesions of the cervical division of the spinal cord].

Electromyographic examination used for determining spontaneous activity of the muscles in patients with an injury at the level of C3-C6 showed that at the first stage the most significant sign was the presence of at least weak activity in the muscles of the lower extremities. This was usually a precursor of the successful restoration of motor functions and indicated the smallest volume of the injury and the absence of complications. At the later stages of treatment of these patients EMG revealed considerable activity in all major muscle groups ensuring walking and the maximum independence of the patient.

Adult↗

PubMed2004

Gross Motor Function Classification System: impact and utility.

In summary, the GMFCS has had, and continues to have, a major effect on the health care of children with CP. The number of citations of the GMFCS has been increasing every year, and the classification system has had good uptake internationally and across the spectrum of health professionals for use in research design and clinical practice by providing a system for clearly communicating about children's gross motor function. The utility of diagnostic labels such as diplegia has been questioned. However, although by definition CP is a disorder of posture and movement, the movement disability is often only one of the neurodevelopmental problems for many children with CP. When a complete description of a child's clinical presentation is required we recommend that the GMFCS be used together with the Surveillance of Cerebral Palsy in Europe classification indicating the type and topography of movement impairment. When appropriate the clinical profile will similarly be enhanced with details of other impairments and disabilities such as epilepsy or sensory, learning, feeding, or emotional disturbance. The observations in this annotation are constrained by the amount of information in the public domain. Although these sources adequately represent the effect of the GMFCS on research design, they are less likely to inform us of how the GMFCS is being used in administration, clinical practice, or education. It is not yet clear whether information is being used for these purposes or in assisting with case load management, as intended by the developers. By its localized nature, such information might remain difficult to gauge. We would therefore be interested to hear from others who are using the system for these or any other purposes.

Cerebral Palsy↗

PubMed1987

Secreto-motor function of intestinal segments used in lower urinary tract reconstruction.

Mucus excretion, sialic acid excretion and secretory IgA (sIgA) production from patients with a substitution caecocystoplasty (20), augmentation "clam" ileocystoplasty (20) or ileal conduit (10) were measured. Significant amounts of all of these substances were present in the urine of reconstructed patients and showed no evidence of diminution with time. Motility was studied by videocystourethrography. In patients with a neuropathic aetiology the amplitude of contractions was significantly increased and produced incontinence. The results demonstrate that intestinal secreto-motor function in gut segments incorporated into the lower urinary tract continues normally and must be taken into account when considering the long-term management of these patients.

Colon↗