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[Interaction of types of drug resistance and immunity in patients with pulmonary tuberculosis].

The authors carried out a comparative clinical and immunological study of different types of drug-resistance (mono-, poly-, MDR of primary and secondary genesis) and immunity in 54 patients with a specific process in the lung. The level of suppression, immunodeficiency, and the incidence of adverse effects were found to be on the increase in the group with the preserved sensitivity to the that with mono-, poly-, and MDR. Impaired immune homeostasis was more pronounced in patients with secondary MDR versus those with primary MDR.

Antitubercular Agents↗

[Effects of altiazem PP and dilren on clinical symptoms, hemodynamic parameters and their chronologic structure in patients with stable angina].

Effects of altiazem PP-180 ("Berlin Chemie", Germany; "Menarini Group". Italy) and dilren-300 ("Sanofi", France) on clinical symptoms and circadian hemodynamic chronostructure were studied in 22 patients with coronary heart disease (CHD) with stable angina pectoris of functional class II-III. Tetrapolar chest rheography (TCR), echocardiography (Echo-CG), ECG, arterial pressure measurement (APM) by N. S. Korotkov were used for examination. TCR, ECG and APM were made 6 times a day: at 10.00, 14.00, 18.00, 22.00, 02.00 and 06.00. The drugs were given in a single daily dose at 08.00 for 10 days. The information was processed statistically and by F. Halberg's cluster analysis. The results showed that altiazem PP and dilren had an antianginal activity which is stronger in dilren administration. The drugs produced moderate hypotensive and vasodilating effects. Altiazem PP raised mean daily level of stroke and minute volumes and their indices. Dilren raised ejection fraction and reduced the double product. Dilren normalized chronostructure of hemodynamic circadian rhythms.

Adult↗