PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ENDOMYOCARDIAL FIBROSIS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 649 records · Page 36Linked to original sources
PubMed1968

Ethiopian cardiovascular studies. Case-finding by mass miniature radiography.

No large series of patients with cardiovascular disease has yet been reported from Ethiopia, where only limited means for investigation are at present available. The authors therefore studied the types of heart disease detected by mass miniature radiography in a largely self-selected population at the Addis Ababa Tuberculosis Centre, and examined the value of this method of cardiac case-finding. Rheumatic heart disease occurred in 34.8% of patients, but syphilitic aortitis, hypertension, "cardiomyopathy" and tuberculous pericarditis were also common. Endomyocardial fibrosis was not seen; this may be a further significant fact in the search for its cause. Mass miniature radiography is valuable for detecting symptomatic patients with the cardiovascular diseases mentioned above. The technique described in this paper could be used in other developing countries as it uses a single method of screening for 2 groups of diseases.

Adolescent↗
PubMed1977

Cardiac lymphatic obstruction: ultrastructure of acute-phase myocardial injury in dogs.

Cardiac lymphatics exist as a network of intercommunicating channels in the myocardium and heart valves, and chronic obstruction of these vessels may result in endomyocardial fibrosis and mucoid degeneration of heart valves. The acute effects of experimental cardiac lymphatic obstruction were studied in the dog. Subendocardial edema and hemorrhage occurred within 150 minutes of the ligation of cardiac lymphatics. Ischemia-type myocardial injury was also observed. Attional changes detectable ultrastructurally included lymphangiectasia, myofibrillar degeneration, disruption of Z-band and intercalated disks, and various mitochondrial derangements. The spottiness of the changes was attributable to the known anatomic variability of lymphatic distribution in the heart. The findings reinforce the belief that greater attention should be focused on the role of cardiac lymphatics in the pathogenesis of a multitude of myocardial and vavular heart diseases.

Animals↗
PubMed1982

[The electrocardiogram in myocardial diseases].

From 1970 to 1980 75 patients with dilatative, 51 patients with hypertrophic, and 8 patients with restrictive cardiomyopathy (endomyocardial fibrosis) have been investigated. The routine electrocardiogram showed premature ventricular beats in patients with dilatative (53%) and hypertrophic (59%) cardiomyopathy. Atrial fibrillation was observed in 16% of the patients with dilatative and 37% of the patients with restrictive cardiomyopathy. Left axis deviation was seen in dilatative (45%) cardiomyopathy and right axis deviation in restrictive (37%) cardiomyopathy. A left bundle branch block was seen in 33% of the patients with dilatative cardiomyopathy and left ventricular hypertrophy in 55% of the patients with dilatative and 67% of the patients with hypertrophic cardiomyopathy. Left and right atrial hypertrophy was observed in patients with restrictive cardiomyopathy (50%) and left atrial hypertrophy in patients with dilatative cardiomyopathy (40%). It is concluded that the electrocardiogram in patients with dilatative cardiomyopathy is characterized by premature ventricular beats, left ventricular and left atrial hypertrophy and a left bundle branch block. Hypertrophic cardiomyopathy is characterized by left ventricular hypertrophy with negative T-waves and premature ventricular beats, and restrictive cardiomyopathy by atrial fibrillation, right axis deviation and left and right atrial hypertrophy.

Adult↗
PubMed1982

Cardiomyopathy in cystic fibrosis: lymphoedema of the heart with focal myocardial fibrosis.

Cardiomyopathy in cystic fibrosis (CF) is an unusual heart disease, mainly characterized by a multifocal fibrosis of the left ventricle. The disorder chiefly occurs in the age group of 1-2 years and leads to fatal cardiac failure. The causal pathogenesis of the disease has not been discovered up to now. In two cases of CF-associated cardiomyopathy we found an oedema (mainly lymphoedema) of the myo- and epicardium and a lymph stasis in lymph vessels and lymph nodes of the heart. Based on a comparative study using animal models we speculate that a) CF may be complicated by a disorder of cardiac lymph circulation, and b) chronic cardiac lymphoedema of the heart in CF can cause focal myocardial damage with fibrosis.

Cardiomegaly↗
PubMed1984

[Cardiac manifestations of the hypereosinophilic syndrome. The value of 2-dimensional echography (12 cases)].

The prognosis of the hypereosinophilic syndrome (HS) depends mainly on the development of endomyocardial fibrosis (EMF). This complication may be overlooked at an early stage, although its presence is an indication for steroid or antimitotic therapy of the HS. Even at an advanced EMF and associated intracardiac thrombi may not be visualised by angiography. This study was undertaken to assess the diagnostic value of 2D echocardiography in 12 patients. The patients were all men (12 of them) aged 22 to 64 years with unexplained eosinophilia 1 500/mm3 for over 6 months, and visceral lesions. The patients were divided into 3 clinical groups. Group A comprised 4 "allergic" patients with chronic asthma and a significant elevation of IgE; Group B comprised 5 "myeloproliferative" patients with splenomegaly and/or hepatomegaly and a significant elevation of serum B12 levels. The 3 remaining patients who could not be allocated to either Group A or B formed the third group (Group C). 2D echocardiography was carried out on average 30 months after diagnosis of the HS and six planes of examination were used systematically (two parasternal, two apical, one extreme apical and one subcostal). Right and left ventriculography was performed in 6 patients (less than one month before or after 2D-echo). Anatomical studies were obtained in 4 cases (2 operations, 3 autopsies). Echocardiographic signs of EMF were observed in 8 cases. Four patients had a restrictive cardiopathy associated to a large LV thrombus in 2 cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[57 cases of infectious endocarditis: diagnosis, clinical course, prognostic factors].

Through a retrospective study on 57 patients, the authors have studied the diagnosis signs, the clinical course, and the factors which affect the prognosis of bacterial endocarditis. Echocardiography has allowed them to establish a diagnosis with 72 p.c. of cases and the bacteriological investigations with 42 p.c. Out of these endocarditides, 39 were found on natural valves, 6 were associated with congenital cardiopathies, 9 followed the replacement of a valvula, and 3 were associated with endomyocardial fibrosis. Cardiac insufficiency (56 p.c.), and renal insufficiency (24 p.c.) were prevailing. The discussion turns on the diagnosis factors and the factors involved in the prognosis. Considering that the death rates were 64 p.c. with the patients who had undergone medical treatment and 14 p.c. with those who had undergone operations, the relevance of the surgical treatment has been emphasized.

Adolescent↗
PubMed1982

The assessment and selection of patients for heterotopic heart transplantation.

In the 2-year period 1979-1980, 34 patients were assessed at Groote Schuur Hospital as candidates for heterotopic heart transplantation. Ischaemic heart disease was the most common underlying cause (19 patients), with cardiomyopathy (9), rheumatic heart disease (2), failed transplants (3), and endomyocardial fibrosis (1) as the other causes of myocardial disease. Five patients were not accepted into the transplant programme, 2 declined after being accepted, and in 3 the initial decision of acceptance was later reversed. Nine patients died while awaiting suitable donors, the mean survival time from the date of acceptance being only 26 days. Fifteen patients underwent heterotopic heart transplantation, 11 remaining alive at the end of the period of study; 8 had normally functioning donor hearts but 3 had suffered irreversible rejection and awaited a second transplant.

Adolescent↗
PubMed1982

A hypereosinophilic syndrome with retinal arteritis and tuberculosis.

A 35-year-old man was initially seen with a decrease in visual acuity, renal insufficiency, and elevation of the eosinophil count in the blood. The ocular syndrome was caused by extensive arterial occlusions of the retina. The subsequent apparition of cardiac, pulmonary, and neurologic signs fulfilled the criteria for the diagnosis of hypereosinophilic syndrome (HES). Most symptoms, including ocular, were temporarily but notably improved by hydroxyurea. The patient died after two years. An autopsy showed an endomyocardial fibrosis and disclosed destruction of the left kidney by an active tuberculosis. A pathogenic relationship between the infectious disease and the HES is envisaged.

Adult↗
PubMed1981

[Cardiac manifestations of the hypereosinophilia syndrome: a report on fifteen cases (author's transl)].

A retrospective study was conducted in fifteen patients with the hypereosinophilia syndrome to assess the cardiac manifestations of the affection. Clinical, electrical, and radiological findings, together with the results of ultrasonography (8 cases), hemodynamic tests (6 cases), and pathological examinations (7 cases) were used to classify the fifteen patients into four groups: 7 cases with endomyocardial fibrosis (EMF), 5 with non-obstructive cardiomyopathy (NOCM), 2 with pre-existing cardiopathies, and 1 with a normal heart. The manifestations in the 7 EMF cases varied according to the extent of the fibrosis present: 2 adiastolies, 3 valve incompetences, and 2 asymptomatic forms. Cardiac insufficiency can occur in the absence of fibrosis, pathological examination in one case demonstrating that it was due to a myocarditis, with infiltration of eosinophils and necrotic foci. The results of this study underline the close relationship between Loëffler's fibroplastic endocarditis and Davies' fibrous endomyocarditis. The presence of vascular lesions in the hypereosinophilia syndrome leads to difficulties in nosological distinction with some forms of necrotizing angitis especially Churg and Strauss' syndrome.

Adult↗
PubMed1980

Pattern of cardiac failure in Northern Savanna Nigeria.

A prospective study of 315 cases of cardiac failure admitted to the General Hospital at Katsina, in the northern savanna region of Nigeria, is presented and the pattern emerged is compared with that of the southern forest region of the country. Although the diseases causing cardiac failure were similar in these two areas, their incidence and pattern showed wide variations. Cardiomyopathies were the commonest cause (47%) of cardiac failure in the northern savanna, congestive cardiomyopathy being the predominant type (31%). Endomyocardial fibrosis (EMF) commonly encountered in the south, was absent in the north; Peripartum Cardiac Failure (PPCF), rarely reported from the south, formed the commonest cause of cardiac failure among the females in the north. Rheumatic heart diseases (RHD) showed a uniform distribution throughout the country. Anaemia caused a higher percentage (13%) of cardiac failure in the north. Hypertension caused relatively fewer (12%) cardiac failures. The variations in the pattern of cardiac failure in these two areas of Nigeria are probably partly attributable to geographic geo-climatic, socio-economic, ethnic and cultural differences.

Adolescent↗
PubMedDate not supplied

Ventricular tachycardia with left bundle branch block morphology in the absence of ischaemic heart disease--clinical and electrophysiological observations.

Clinical and electrophysiological features of 20 patients presenting with ventricular tachycardia (VT) of left bundle branch block (LBBB) morphology without evidence of coronary artery disease were studied. The mean age of the patients was 35.2 +/- 12 (range 15-57 years). The rate of VT varied between 140-240/min (182 +/- 80). Six (30%) patients experienced giddiness or syncope during palpitations. Structural heart disease was found in 10 (50%) of these patients, which included arrhythmogenic right ventricular dysplasia in five, submitral left ventricular (LV) aneurysm in one, anterolateral LV dyskinesis in one, dilated cardiomyopathy in one, endomyocardial fibrosis in one and nonobstructive hypertrophic cardiomyopathy in one case. Ten patients were free of structural heart disease. Electrophysiological study was done in all patients. VT with same morphology as spontaneous VT was inducible in only 14 patients. Seventeen patients were treated medically with total or partial amelioration of symptoms. In three patients, two with arrhythmogenic right ventricular dysplasia and one with structurally normal heart, who were unresponsive to drug therapy, the VT focus could be mapped in right ventricular outflow tract and successful electrical ablation was done. Thus in patients who present with VT with LBBB morphology, the heart is often structurally normal but organic disease is not uncommon, and should be carefully searched.

Adult↗
PubMed1994

Pericarditis: a persisting surgical problem.

A study of pericarditis treated surgically over a period of 14.5 years was conducted to evaluate the current pattern and management of this disease in a tropical environment. The series comprised 86 patients (58 males and 28 females) aged from 5 months to 60 years (mean 21.1 years). Pericarditis was effusive in 41 patients, calcific in 33 and fibrous in 12. Aetiological or associated factors were non-specific, pyogenic infection, rheumatic heart disease, endomyocardial fibrosis, tuberculosis and amoebiasis in 36, 21, eight, eight, six and four patients, respectively. All the patients were in New York Heart Association (NYHA) functional class III or IV. Operative treatment involved pericardiotomy with tube drainage in 32 patients, pericardiectomy in 49, and pericardiotomy with subsequent pericardiectomy in five. The total hospital mortality rate was 8.0%, and was largely a result of severe pre-operative cardiac decompensation and multiple organ failure. Of the 79 early survivors, 91% reverted to NYHA functional class I or II. Surgical treatment remains the most effective management of chronic pericarditis which still constitutes a major clinical problem in some countries.

Adolescent↗
PubMed1994

[Pathological-anatomical findings after serologic and molecular biologic evidence of Hantaan virus infection].

Post-mortem findings in a girl aged 2 years and 4 months who had been infected with Hantaan virus are reported. The child fell ill with acute renal failure in her 8th month of life and had to be subjected to chronic dialysis. There was a progressive cardiac insufficiency. Specific IgG and IgM antibodies to Hantaan virus were demonstrated by serology from the 18th month of life. Autopsy revealed endomyocardial fibrosis and cardiomegaly. Hantaan RNA could be demonstrated in formalin-fixed, paraffin-embedded specimens of lung, liver and spleen tissue by means of RT-PCR followed by DNA sequencing. A possible association between the Hantaan virus infection and the pathological findings in the heart are discussed.

Antibodies, Viral↗
PubMed1975

[Coronary diseases in the black African. Apropos of a 2d group of 50 patients. Diagnostic and epidemiological aspects].

1. Study of a group of 50 patients suspected to have coronary artery disease. This is a complement to a previous study concerning "definite" coronary patients. 2. The method followed consisted in cross-examination of the files by three observers in order to separate the subjects who seemed really affected by coronary artery disease. This treble examination led to a rather restrictive selection. To facilitate the study, the patients were subdivided into 4 groups: patients with arterial hypertension, with diabetes mellitus, with cardiac failure, with a heart disease and miscellaneous patients. 3. The study of the 20 files which were discarded was peculiarly interesting as it provided the opportunity to underline the differential diagnosis either with common diseases (left ventricular overload, heart block, brain vascular accident), or with more specific diseases for Black Africa (endomyocardial fibrosis, aneurysm of the left ventricle, cardiomyopathy). In that respect, it is underlined that, in the absence of any anatomical or functional disease, the electrocardiogram of the healthy Black is identical to that of the White. 4. Study of the 30 patients considered as coronary made it possible to underline aetiological and epidemiological factors, although some are still lacking. However the facts observed could be compared with those reported in a previous work concerning 45 "definite" coronary patients. The overall documents thus gathered in 75 patients suggest that the African candidate to coronary artery diseases resembles his Occidental homologue, but that he might have kept a traditional diet.

Adult↗
PubMed1993

[Hypereosinophilia syndrome].

The authors of the submitted paper describe the diagnosis, course and treatment of hypereosinophilic syndrome in a 36-year-old female patient with marked affection of the right ventricle: endomyocardial fibrosis with parietal thrombi obliterating the cavity of the right ventricle. The clinical picture was dominated by rapid progression of severe cardiac decompensation with a fatal outcome.

Adult↗