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PubMedDate not supplied

[Predictive value of sudden death in repetitive ventricular extrasystole].

Prognostic significance of repetitive ventricular premature contractions (RVPC) were evaluated retrospectively in 452 patients studied with a 24 hours continuous electrocardiographic monitoring (Holter System). The patients were analysed in two groups: Group 1.- 199 patients; with primary heart disease: previous myocardial infarction (MI) in 114 patients, angina pectoris (AP) in 29 cases, congestive cardiomyopathy in 19 cases (COCM); hypertensive heart disease (AHCD) in 14 cases, Atherosclerotic heart disease (AEC) with conduction disturbance and without angina pectoris 23 cases. Group 2.- 253 patients without heart disease. Two different types of RVPCs were defined: Type A: as the occurrence of self-terminating two (coupled) or multifocal. RVACs Type B: Self limited ventricular tachycardias or "R on T phenomena". Forty patients of group 1 had RVPCs (23 type A and 17 type B) and 22% of them had sudden death (SD). Among 199 patients with structural heart disease, 74 had congestive heart failure (CHF) and 12 of these had RVPCs. 83% of patients with RVPCs died suddenly. No patients with CHF and without RVPCs had SD. In group 2 (without heart disease no patients died on the follow up, and 6% of them had RVPCs (68% type A and 32% type B). Coronary arteriographic and ventriculographic findings were reviewed in 92 patients with previous MI. In the patients followed 40 has RVPCs, and 9 of them had SD. Those 4 cases were cases of MI (25% of the patients with MI having RVPCs), 4 (25%) with COCM, and 1 (2.5%) with hypertensive cardiac disease. Thus, patients with MI or COCM had higher incidence of RVPCs, so they are at a high risk for sudden cardiac death.

Cardiac Complexes, Premature↗
PubMedDate not supplied

[Predictive value of ventricular extrasystole in the exertion test and its relation to the magnitude of coronary damage].

The predictive value of ventricular arrhythmias, associated with treadmill exercise testing was evaluated in 115 patients undergoing coronary angiography and left ventriculography within three months of the exercise test. 39 patients with ventricular arrhythmias (at least one premature ventricular complex, paired complex or ventricular tachycardia) had a higher or multivessels disease than the patients without ventricular arrhythmias (P less than 0.05). This study demonstrated that ventricular arrhythmias detected at exercise testing are related to the extent of coronary artery disease, and the presence of the left ventricular disfunction.

Cardiac Complexes, Premature↗
PubMed1986

[Comparative study of the effectiveness of several anti-arrhythmia preparations in patients with a frequent extrasystole].

The efficiency and side effect rates of 7 antiarrhythmic drugs: mexitil, rhytmilen, propranolol, ethmosine, cordarone, finoptin, digoxin, were compared in 80 patients. Their heart rhythm was controlled by continuous Holter ECG monitoring. The efficacy of oral doses of the drugs was assessed both in acute pharmacologic tests and in short-term clinical courses. The smallest side-effect rates and the highest efficiency were shown by cordarone (in all clinical samples) and ethmosine (particularly in coronary patients), hence both can be recommended for long-term clinical use.

Adult↗
PubMed1986

[Optimization of the use of etmozin in treating patients suffering from frequent ventricular extrasystole].

Fifteen patients with frequent and stably recordable ventricular premature heart beat received etmozine treatment (the priming dose 500 mg, the maintenance dose 200 mg). Of these, 3 patients presented with coronary heart disease, 1 with mitral valve prolapse, and 11 with the idiopathic pattern of heart rhythm disorders. The drug was found to be highly effective. The 90% decrease in the number of ventricular premature heart beats during 2 h after administration of the priming dose can be used as criterion in predicting the efficacy of etmozine treatment.

Adolescent↗
PubMedDate not supplied

Heart rate and extrasystolic arrhythmias in active subjects aged over 90. A chronobiological study.

We analyzed the circadian rhythm of heart rate (HR), of simple atrial premature beats (APB) and of simple ventricular premature beats (VPB) in very old subjects undergoing dynamic ECG for 24 h. The 18 subjects under study (11 women and 7 men) were aged 90 or more (mean +/- SD 92.3 +/- 2.3, range 90-98), did not complain of acute cardiac pathologies, were not taking any medication and were synchronized as to time schedules. The mean duration of DECG recording was of 23 h and 54 min. The collection of data concerning the hourly mean of HR (6 ten-sec samples taken every 10 min) and of the number/hour of APB and VPB was carried out manually. A significant rhythm (single cosinor) was detected for heart rate in 14 subjects out of 18 and in the group (population cosinor); it was also detected for APB (9 subjects out of 15) and for VPB (5 subjects out of 15) also by the single cosinor. It was not detected for the group (population cosinor). No significant correlations, either direct or inverted, were revealed between HR and premature beats. We demonstrate therefore that, even in very old subjects, the circadian rhythm of HR still exists as in younger subjects.

Aged↗
PubMed1987

[When should ventricular extrasystole be treated?].

Arrhythmias can be variable in their clinical symptoms and are mostly even asymptomatic. Suppression of arrhythmias is usually not very difficult, but the clinical value of the intervention is questionable. Only in the case of a history of myocardial infarction does treatment with beta-blockers appear to improve the prognosis, but the mechanism does not appear to be related to the suppression of arrhythmias. In view of the potentially dangerous effects of all anti-arrhythmics, extreme caution should be exercised in using them. Only in the case of a hemodynamic or symptomatic emergency should anti-arrhythmics be prescribed.

Adrenergic beta-Antagonists↗