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PubMed1986

[Evaluation of elementary radiologic images of Crohn's ileitis. Retrospective study of a homogeneous series of 238 double-contrast transits in the small intestine].

An homogeneous series of 238 double contrast examinations of the small bowel were reviewed. In this study, 32 regional enteritis (RE) were encountered. Statement of different semiologic signs of RE was established. This study exhibited various signs in RE; some of them were observed in various other enteritis (mainly tumors, ischemia and variation enteritis). Sensitivity varies between 6 and 84%. Highest values are noted with ulcerations, nodules, narrowing of the lumen wall. Specificity and predictive values vary from 64% to 100%. The best results are obtained with graduate lesions, fistulae, skipped area and cobblestone. Only graduate lesions are really pathognomonical but uncommon lesions. Analysis of double contrast small bowel examination has to be compared with the whole medical report in order to improve diagnosis accuracy.

Adolescent↗
PubMed2002

Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation.

BACKGROUND & AIMS: Ileal malabsorption of bile salts is observed in Crohn's ileitis. We define the transcriptional mechanisms involved in cytokine-mediated repression of the rat apical sodium-dependent bile acid transporter (ASBT). METHODS: ASBT regulation was studied in IL-1beta-treated IEC-6 and Caco-2 cells and in indomethacin-treated rats. RESULTS: Indomethacin-induced ileitis in Lewis rats leads to specific reductions in ileal ASBT messenger RNA and protein levels, whereas c-jun and c-fos are induced. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor repress the activity of the ASBT promoter in Caco-2 and intestinal epithelial cell-6 cells. This effect is blocked by the proteasome inhibitor, MG-132, or by the phosphatidyl inositol 3-kinase inhibitor, wortmannin. Indomethacin (in vivo) or proinflammatory cytokine (in vitro) treatment leads to serine phosphorylation and nuclear translocation of c-fos. Mutation of a 5' activated protein (AP)-1 site inactivates the ASBT promoter, whereas mutation of the 3' site abrogates the proinflammatory cytokine-mediated repression. The 5' site binds a c-jun homodimer, whereas the 3' site binds a c-jun/c-fos heterodimer. c-Jun overexpression enhances ASBT promoter activity, whereas a dominant negative c-jun construct inactivates the promoter. c-Fos overexpression represses promoter activity. A 27 base pair cis-element from the 3' site in the ASBT promoter imparts cytokine-mediated down-regulation to a heterologous SV40 promoter construct. CONCLUSIONS: The ASBT promoter contains 2 distinct cis AP-1 elements; the 5' element binds homodimeric c-jun and mediates basal transcription. Inflammation is associated with up-regulation, phosphorylation, and nuclear translocation of c-fos, which then represses ASBT promoter activity via binding of the 3' AP-1 element by a c-fos/c-jun heterodimer.

Androstadienes↗
PubMed1976

[Is there a connection between infection with Yersinia enterocolitica and regional enteritis? (Preliminary communication) (author's transl)].

After a brief description of the micro-biological, pathological, anatomical and clinical picture of infections with Yersinia enteroclitica, attention is drawn to the striking radiological similarity between three patients with Yersinia infection and regional enteritis (Crohn's disease). Whilst the radiological findings due to Yersinia infection usually resemble the group of so-called non-sclerosing ileitis (Golden) they occasionally differ from this group and resemble the findings in Crohn's disease. In each case the infection was confirmed bacteriologically. The underlying pathology has not been elucidated and it is doubtful whether there is any connection with Crohn's disease.

Adolescent↗