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Results for “Isometric Contraction”

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PubMed1979

[Index of isometric contraction--a comparison with invasive methods of cardiac function testing in patients with ischemic heart diseases and post-myocardial infarct status].

In 81 patients with an ischaemic heart disease and myocardial infarction the evidence of the presphygmic index PI (non-invasive index) was tested concerning a beginning myocardial functional disturbance and a latent heart insufficiency, respectively, with the help of an invasive cardiopulmonary functional diagnostics which was performed under dosed bicycle ergometer load in the steady state. The presphygmic index PI correlates in significantly positive way with the end-diastolic pressure of the heart and the quotient from minute volume of the heart and the end-diastolic pressure of the pulmonary arteries (VM/PAEDP). The presphygmic index is on the basis of this correlation of the left-ventricular function suitable to establish disturbances of the myocardial functions and to give the possibility of a separation of the patients in cardially sufficient and cardially insufficient ones. Here the evidence of the presphygmic index might be larger concerning the recognition of a latent heart insufficiency than concerning the recognition of beginning myocardial functional disturbances. The presphygmic index apparantly possesses a high degree of sensibility then, when the myocardial functional disturbances coincide with a beginning reduction of the pumping action of the heart.

Adult↗
PubMed1984

Inhibition of capillary transport reserve by sodium pentobarbital anesthesia in isometrically contracting dog heart.

We tested the hypothesis that different anesthetic may produce different effects on the ability of the myocardium to recruit capillaries. The experiments were performed on the isolated hearts of five dogs anesthetized with sodium pentobarbital (Nembutal), and six dogs anesthetized with chloralose. The isolated hearts were perfused with heparinized blood at controlled flows from a support dog anesthetized with the same agent. The adaptive capacity of the heart to recruit capillaries in response to rising left ventricular pressure (LVP) was determined by measuring the permeability-surface area product. (PS) of 22Na and 51Cr-ethylenediamine tetraacetic acid (EDTA). The myocardial ability to recruit functional capillary perfusion and transport was estimated by the ratio of the PS-Na (and EDTA) obtained at a given LVP to the PS-Na (and EDTA) at LVP = 0. In chloralose-anesthetized dogs there was a gradual increase in PS as a function of LVP. At systolic LVP ranges of 60-120 mm Hg and 130-200 mm Hg, mean PS-Na ratios were 1.15 and 1.60, while mean PS-EDTA ratios were 1.10 and 1.50, respectively. In Nembutal-anesthetized dogs there was no increase in PS associated with the increases in LVP. For the same range of LVP, the mean PS ratios for both Na and EDTA varied between 1.05 and 1.18. The results show the inhibition of capillary recruitment in Nembutal anesthetized dogs for LVP of 130-200 mm Hg. They also support the concept that Nembutal inhibits the ability of the myocardium to increase blood tissue transport of nutrients in response to increased metabolic demands.

Adaptation, Physiological↗