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Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

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At least 649 records · Page 36Linked to original sources
PubMed2006

Antimicrobial stewardship.

Antimicrobial stewardship is a key component of a multifaceted approach to preventing emergence of antimicrobial resistance. Good antimicrobial stewardship involves selecting an appropriate drug and optimizing its dose and duration to cure an infection while minimizing toxicity and conditions for selection of resistant bacterial strains. Studies conducted over the years indicate that antibiotic use is unnecessary or inappropriate in as many as 50% of cases in the United States, and this creates unnecessary pressure for the selection of resistant species. Because the pharmaceutical industry pipeline for new antibiotics has been curtailed in recent years, and it may be > or = 10 years before important new antibiotics to treat certain resistant bacteria find their way to market, a premium has been set on maintaining the effectiveness of currently available agents. Several strategies, including prescriber education, formulary restriction, prior approval, streamlining, antibiotic cycling, and computer-assisted programs have been proposed to improve antibiotic use. Although rigorous clinical data in support of these strategies are lacking, the most effective means of improving antimicrobial stewardship will most likely involve a comprehensive program that incorporates multiple strategies and collaboration among various specialties within a given healthcare institution. Computer-assisted software programs may be especially useful in implementing these comprehensive programs. The antimicrobial stewardship program at the Hospital of the University of Pennsylvania, which has been shown to improve appropriateness of antibiotic use and cure rates, decrease failure rates, and reduce healthcare-related costs, is used as an example in support of this multifaceted, multidisciplinary approach. At this time, data from well-controlled studies examining the effect of antibacterial stewardship on emergence of resistance are limited, but available data suggest that good antibiotic stewardship reduces rates of Clostridium difficile-associated diarrhea, resistant gram-negative bacilli, and vancomycin-resistant enterococci.

Anti-Infective Agents↗
PubMed2005

Systematic strategies for improved outcomes for the hyperglycemic hospitalized patient with diabetes mellitus.

Diabetes mellitus is reaching epidemic proportions in the United States. It is now the fourth most common comorbid condition complicating hospital discharges. There is a rapidly evolving body of literature assessing the short-term and long-term effects of strict glycemic control in the hospital setting. Results from several landmark studies have challenged the long-held notion that stress hyperglycemia is beneficial. This article will focus on these studies, postulated mechanisms of action, and finally, description of an insulin infusion protocol developed at a community hospital for patients undergoing cardiac surgery.

Cardiac Surgical Procedures↗
PubMed2003

Is it time to move to multidrug combinations?

The clinical benefit of aggressive blood pressure (BP) control in reducing adverse cardiovascular and renal outcomes is well documented. However, a majority of patients with hypertension remain poorly controlled with monotherapy and require two or more agents to achieve their target BP levels. Patients with hypertension who also have diabetes or renal disease benefit from even lower BP targets, but may be more difficult to treat and require three or more drugs to achieve control. Using two or more drugs, each at lower doses, is usually more effective and less commonly associated with adverse effects than higher doses of a single drug. With the increasing prevalence of diabetes and renal disease, the treatment of hypertensive patients with multidrug combinations will become even more common. Knowing how specific combinations can be used effectively will be an important component of the treatment strategy for hypertension.

Antihypertensive Agents↗
PubMed2006

[Mechanical cardiac assistance and artificial heart: historical perspectives].

The impact of heart failure on patients and economical burden on health insurance resources is increasing. Cardiac transplantation is still the primary treatment for patients who are in end stage heart failure. The development of artificial hearts (total and partial) was implemented by the discrepancy between the scarcity of available donors and the importance of waiting lists for cardiac transplantation. The technical progresses achieved since the first works of Kolff in 1957 now allow these patients to have their circulation restored and go home to wait for their transplantation. The encouraging results of the artificial heart and the miniaturization of these devices allow them to be considered as a possible destination therapy for patients not eligible for cardiac transplantation.

Adolescent↗
PubMed2006

Drug-eluting stents and the future of coronary artery bypass surgery: facts and fiction.

The treatment of patients with coronary artery disease continues to evolve. Recent, exciting data on the use of drug-eluting stents in diseased coronary vessels has generated immense enthusiasm within the interventional community leading to claims that "drug-eluting stents will put bypass surgeons out of business." However, despite promising short-term and midterm outcomes of this revolutionary new technology, valid concerns regarding long-term safety and efficacy of drug-eluting stents persist. This review article evaluates current status of drug-eluting stents with special emphasis on real and potential drawbacks of this emerging percutaneous coronary interventional modality and its impact on the practice of coronary artery bypass surgery.

Cardiovascular Agents↗
PubMed2004

What is evidence?

The evidence-based practice movement rests on the premise that the scientific evidence regarding treatment should be used judiciously to inform treatment decisions. This article focuses on the most fundamental question regarding evidence-based practice: What is evidence? To address this question, the authors first review several of the definitions, criteria, and strategies that have been used to define scientific evidence. Second, a number of critical issues that have been raised regarding the nature of treatment evidence are discussed. Finally, suggestions for further consideration in the process of synthesizing evidence for clinicians are offered.

Adolescent↗
PubMed2005

Treatment options for status epilepticus.

Status epilepticus is a neurological emergency requiring prompt pharmacological intervention. Recent advances in the treatment of this condition include the introduction of treatment algorithms that are tailored more specifically to clinical situations, a trend towards more aggressive therapies if initial treatment with front-line agents fail, and a better understanding of the role of treatment for patients in status epilepticus in the out-of-hospital setting.

Adult↗
PubMed2004

How to synthesize evidence for imaging guidelines.

AIM: To provide guidance on how to gather and evaluate evidence from the literature on the efficacy of imaging, using as an example the assessment of the role of magnetic resonance imaging (MRI) in the diagnosis of osteomyelitis. This method was adopted for evaluating evidence for the musculoskeletal section of the 5th edition of the Royal College of Radiologists' (RCR) guidelines. MATERIALS AND METHODS: A systematic review of the literature published between 1966 and July 2001 was carried out. Eligible articles described studies in patients with suspected osteomyelitis and who were diagnosed using MRI. Search strategies were developed to identify relevant imaging studies. Studies included in the systematic review were selected using predefined criteria. The sensitivity, specificity, accuracy and likelihood ratios for MRI reported in the studies were used to evaluate the value of the procedure in osteomyelitis. Where the above were not reported, they were calculated by the reviewers. RESULTS: The average sensitivity of MRI in osteomyelitis was 91% (range 76-100%), the average specificity was 82% (range 65-96%), average accuracy was 88% (range 71-97%), and the average positive likelihood ratio was 7.8 (range 2.3-21.1). Four studies evaluated the use of MRI in the diagnosis of osteomyelitis in the diabetic foot, two in osteomyelitis of the lower extremities, while four each evaluated the use of MRI in vertebral osteomyelitis, in the diagnosis of any form of osteomyelitis, osteomyelitis in spinal cord-injured patients and in cranial osteomyelitis. CONCLUSION: Systematic reviews of literature can be used to obtain evidence on the value of imaging procedures. The quality of the studies included in the review should always be considered when selecting studies to limit bias. In our example, MRI appears sensitive, specific and accurate in the diagnosis of osteomyelitis at different sites.

Evidence-Based Medicine↗