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At least 649 records · Page 36Linked to original sources
PubMed1981

Behavioural effects of GABA-agonists and antagonists infused in the mesencephalic reticular formation - deep layers of superior colliculus.

Unilateral infusion of GABA-receptor antagonists (picrotoxin, bicuculline) in the mesencephalic reticular formation-deep layers of the superior colliculus (MRF-DLSC) elicits tight head-to-tail contralateral posturing but not active circling. Bilateral infusion of the GABA antagonists in the MRF-DLSC elicits compulsive gnawing and biting but not licking or sniffing. Infusion of GABA-receptor agonists (muscimol, THIP) in the MRF-DLSC while producing only minor or no motor or behavioural effects, drastically altered apomorphine effects; thus, unilateral infusion of muscimol resulted i tight, head-to-tail ipsiversive circling while bilateral infusion of muscimol converted the apomorphine-syndrome from stereotypy of high-intensity into pure compulsive forward locomotion devoid of sniffing. The results indicate that GABAergic mechanisms in the MRF-DLSC are of primary importance in the expression of motor and behavioural syndromes arising from the striatum.

Animals↗
PubMed1995

On the parameter estimation for diffusion models of single neuron's activities. I. Application to spontaneous activities of mesencephalic reticular formation cells in sleep and waking states.

For the Ornstein-Uhlenbeck neuronal model a quantitative method is proposed for the estimation of the two parameters characterizing the unknown input process, namely the neuron's mean input per unit time mu and the infinitesimal standard deviation per unit time sigma. This method is based on the experimentally observed first- and second-order moments of interspike intervals. The dependence of the estimates mu and ŝigma on the moments of the observed interspike intervals and on the neuronal parameters is clarified, and a comparison is made between the estimates based on the classical Wiener model and those yielded by the Ornstein-Uhlenbeck model. Comprehensive tables are included in which the displayed values of mu and ŝigma have been calculated in terms of physiologically realistic pairs of first- and second-order moments. Our method is finally applied to interspike interval data recorded from neurons in the mesencephalic reticular formation of the cat during hypothetical sleep, slow-wave sleep stage, and wake stage.

Animals↗
PubMed1989

The midbrain reticular formation as an integration center for the 'near reflex' in the cat.

This report describes an experimental study on the localization of converging organization of the near-reflex triad in the chloralose-anesthetized encéphale-isolé cat, in which electromyographic (EMG) recordings were used to elicit responses from the intrinsic and extrinsic eye muscles. Electrical stimulation to several subdivisional areas in the oculomotor nuclear complex evoked EMGs in both the iris sphincter and ciliary muscles. Conduction time from the caudal Edinger-Westphal nucleus to the postganglionic ciliary nerve was about 1.8 ms, whereas that to the iris sphincter muscle was about 6.5 ms. Conduction time from the anteromedian nucleus to the muscle was about 4.5 ms; however, that from the postganglionic short ciliary nerve to the muscle was about 6.7 ms. A direct pathway without synapse in the ciliary ganglion is suggested. Excitatory responses were elicited in the effectors of the near-reflex triad by electrical stimulation of the midbrain reticular formation of the dorsomedial division adjacent to the magnocellular red nucleus (MRFdmMRN). Converging movements in electro-oculography (EOG) were also observed. Conduction time from the MRF to the iris sphincter muscle was about 5.6 ms, whereas that to the postganglionic short ciliary nerve was 5.1 ms. The neural connection between the MRF and the muscle is thought to be mediated by the anteromedian subnucleus. Electrical stimulation of the posteromedial division of the Clare-Bishop (C-B) area evoked a discharge on the MRF and EMGs of all effectors of the triad. The sum of the conduction time from the C-B area to the MRF and that from the MRF to EMGs corresponds well to the latency of EMGs evoked by C-B area stimulation. We conclude that the MRFdmMRN is the supranuclear organization which converges the sensory-motor cortical activities on the precise linkage of the near-reflex triad and becomes an integration center for each nucleus in the oculomotor nuclear complex.

Animals↗
PubMed1989

How visual inputs to the ponto-bulbar reticular formation are used in the synthesis of premotor signals during orienting.

The primate superior colliculus (SC) is known as a structure subserving the transformation of visual information into "commands" for orienting eye movements. Collicular burst neurons discharging with short lead times in relation to visually triggered or spontaneous saccades are supposed to be the output elements linking the SC to immediately premotor pattern generators. In this paper we summarize some data available for the cat's SC neurones, identified as tecto-reticulo-spinal projection cells (TRSN), and reticulospinal neurones (RSN), identified as receiving excitatory collicular input. Some TRSNs respond to visual stimuli in the absence of orienting movements and, hence, their signals cannot be regarded as motor "commands", in spite of their proven connections with premotor pools in the brain stem and with the spinal cord. Moreover, a small fraction of RSNs belonging to polysynaptic descending collicular pathways also displays visual responses dissociated from movement, in addition to discharges related to the performance of orienting eye-head synergies. The processes of visual to motor transformation, assumed by current models as being definitively accomplished in the SC, appear thus to be partially performed in the reticular network incorporating the overlapping collaterals of tectal projection cells and their target neurons in the reticular core. It is concluded that, at least as for visuomotor transformations underlying orienting movements in the cat, the deep division of the SC and the brain stem reticular formation represent an ensemble, rather than a sequence of hierarchically arranged levels of processing.

Action Potentials↗
PubMed1984

The effects of microiontophoretically-applied opioids and opiate antagonists on nociceptive responses of neurones of the caudal reticular formation in the rat.

Opioids, when applied by microiontophoresis to caudal reticular neurones (CRF) in the rat, were found to be predominantly inhibitory in action. When the actions of a series of analogues of enkephalin, that have very different potencies on peripheral tissues, were applied microiontophoretically to caudal reticular neurones, only small differences in their ability to depress the firing of these neurones were observed. Analogues of enkephalin with differing affinities for mu- and delta-receptors also produced comparable inhibitions of neuronal activity. These inhibitory actions were reduced by opiate antagonists. Many caudal reticular neurones have peripheral receptive fields which are activated by noxious stimuli. Excitatory responses produced by noxious stimuli were depressed by microiontophoretically-applied opioids and this effect was antagonised by naloxone or naltrexone. The reduction in firing rate evoked in some neurones by peripheral noxious stimulation was very resistant to change when opiate antagonists were applied microiontophoretically but could sometimes be totally blocked by systemic injection of opiate antagonists.

Action Potentials↗