PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “STRING”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 649 records · Page 36Linked to original sources
PubMed2005

Harmonising the response to DSBs: a new string in the ATM bow.

Ataxia telangiestasia mutated protein (ATM) is the major kinase that initiates the DNA damage signal transduction response following exposure to ionising radiation (IR) in mammalian cells. DNA non-homologous end-joining (NHEJ) is the most significant double strand break (DSB) repair pathway in mammalian cells. ATM-defective cell lines display cell cycle checkpoint defects and show pronounced radiosensitivity. ATM signalling was previously thought to be dispensable for NHEJ. This review discusses recent findings that ATM activates an end-processing mechanism dependent upon Artemis, a nuclease that also functions to cleave the hairpin intermediate generated during V(D)J recombination. ATM/Artemis-dependent end-processing is required for the repair of a sub-fraction (approximately 10%) of DSBs induced by IR and makes a significant contribution to survival following exposure to ionising radiation. This result represents a new role for ATM and demonstrates a novel cross communication between the DNA repair and signal transduction machinery.

Animals↗
PubMed2006

Two-string technique to manage dislocated posterior chamber plate-haptic intraocular lens.

We describe a technique for repositioning and transscleral fixation of a dislocated plate-haptic foldable collamer posterior chamber intraocular lens (PC IOL). The displaced IOL was positioned in the anterior chamber, and a double-armed suture on a curved needle was fixed to the sclera at 10:30 o'clock. The needle then entered the globe and passed through the superior haptic eyelet of the IOL. Both were withdrawn through the scleral wound on the opposite side. The inferior haptic was fixed at 4:30 and 7:30 o'clock and provided the mirror reflection of the suture path of the upper fixed haptic. This technique may be a useful alternative to lens removal or exchange.

Anterior Chamber↗
PubMed2006

Salmonella type III secretion effectors: pulling the host cell's strings.

The enteric pathogen Salmonella employs type III secretion systems to transport a cocktail of effector proteins directly into its host cell. These effectors act in concert to control a variety of host cell processes to successfully invade intestinal cells and to establish an intracellular, replication-permissive niche. Recent studies reveal new insights into the molecular mechanisms that underlie effector protein injection, host cell invasion, and manipulation of vesicle trafficking induced by the interplay between multiple effectors and host systems. These findings corroborate the importance of spatio-temporal regulation of effector protein function for fine-tuned modulation of the host cell machinery.

Animals↗
PubMed2000

The heart string: a simple, inexpensive exposure of the heart during coronary artery operations.

A method of heart retraction during coronary artery bypass operations is described. The technique improves exposure of the coronary arteries, especially of the circumflex and posterior descending coronary branches during grafting. In addition, it is simple, safe, and inexpensive. Furthermore, this technique can be applied for off-pump coronary artery bypass surgery.

Cardiac Catheterization↗
PubMed2003

Oligomerization characteristics of cysteine string protein.

CSP function is vital to synaptic transmission, however; the precise nature of its role remains controversial. Conflicting reports support either a role for CSP: (i) in exocytosis or (ii) in the regulation of transmembrane calcium fluxes. Here we have examined the self-association of CSP to form oligomers that are stable upon SDS-PAGE. To understand the structural requirements for CSP self-association a series of CSP deletion mutants were constructed, expressed, and purified. This analysis revealed an interesting pattern of oligomerization. Amino acids between 83 and 136 were observed to be important for self-association. The recombinant CSP oligomers as well as the CSP monomers directly associate with Ni(2+)-NTA agarose. Thus CSP-CSP interactions may be an important consideration for current working models of CSP chaperone activity at the synapse.

Animals↗
PubMed1988

How long is a piece of string? A study of line bisection in a case of visual neglect.

We report a case of severe left visual neglect consequent upon extensive infarction in the territory of the right middle cerebral artery. A detailed analysis is given of the patient's performance on line bisection. The stimuli cover a wider range of lengths than is usually employed in such studies (11'' to 1''). The magnitude of the patient's rightward displacement of his transections is linearly related to the length of the stimulus line, such that the longer the line, the greater the left 'neglect'. At line length 2'', the patient's transections are relatively accurate, and at length 1'', the transections cross the objective midpoint to give a reliable left displacement (= 'right neglect'). On some occasions, these latter transections are placed beyond the leftmost point of the stimulus line. We interpret the data in terms of two constructs: (a) an 'attentional boundary' placed slightly to the left of the objective midline; (b) 'representational completion' that extends to the attentional boundary.

Adult↗