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The application of titanium alloy wires for the reattachment of the greater trochanter in total hip arthroplasty.

We developed a new fixing method using titanium alloy wires in order to facilitate the attachment of the greater trochanter in total hip arthroplasty. This wire is composed of Ti-3Al-2.5V by weight. According to the fatigue test in vitro, the titanium alloy wire had better fatigue properties than Ortron 90 wire of the same diameter. In experiments in vivo, both titanium alloy wires and SUS-316L wires were used for the reattachment of the greater trochanter of dogs, and the titanium alloy wires showed better biocompatibility than the latter. Thus, titanium alloy wires seem applicable for the reattachment of the greater trochanter in human total hip arthroplasty.

Alloys↗

Corrosive properties of fluoride-containing odontologic gels against titanium.

OBJECTIVES: The purpose of this study is to determine, on a quantitative basis, the kinetics of ionization of pure and alloyed titanium in various electrolytic media including commercial dental gels containing fluoride ions (Fluogel). METHODS: The experimental method is a linear sweep voltammetric analysis, making use of a rotating disc electrode. Several successive analyses of different titanium samples are carried out, particularly as a function of the nature of the electrolytic solutions. The current corrosion I(cor) is measured by the determination of linear polarization resistance Rp. RESULTS: Rp and I(cor) measurements by the voltammetric and analysis confirm the excellent resistance of titanium in physiological solutions; they also show that a fluoride-containing dental gel, which is a fluoridated and acidic preparation, is significantly harmful with respect to the corrosion process of titanium. CONCLUSION: The results of this study must draw our attention towards the use of prophylactic gels in which pH is acidic. Indeed titanium suffers an important corrosion process in fluoridated acidic media. Recommendations for the prescription and for the optimized composition of the dental gels could be derived.

Acids↗

Mandibular reconstruction using a titanium plate: the impact of radiation therapy on plate preservation.

PURPOSE: To evaluate the soft tissue and bone tolerance of radiation therapy (RT) in patients undergoing radical composite resection and mandibular reconstruction using a bridging titanium plate with myocutaneous flap closure. METHODS AND MATERIALS: From 1990 to 1994, 47 patients with primary or recurrent oral cavity or oropharyngeal carcinomas were treated with radical composite resection and mandibular reconstruction using a bridging titanium plate with myocutaneous flap closure. Eleven patients received no RT (no RT), 10 patients received RT greater than 10 months from the time of surgery (remote RT), and 26 patients received RT within 12 weeks of surgery (perioperative RT). The radiation dose to the reconstructed mandible ranged from 45 to 75 Gy (median 63 Gy). The effect of the titanium plate on the radiation dose was measured using film dosimetry and soft tissue and bone-equivalent materials. The median follow-up was 17 months (range: 3-50 months). RESULTS: Late complications included four patients with osteomyelitis or necrosis, two plate exposures requiring flap revision, one chronic infection, two cases of chronic pain, two fistulae, and one case of trismus and malocclusion. The crude incidence of late complications by treatment was: (a) no RT: 3 of 11 patients (27%); (b) remote RT: 2 of 10 patients (20%); and (c) perioperative RT: 9 of 26 patients (35%). One patient in the no-RT group lost the plate due to chronic pain. Five patients in the perioperative RT group also had plate loss, four due to osteomyelitis and/or necrosis, and one due to pain related to a recurrent tumor. No patients in the remote RT group had plate loss. The actuarial prosthesis preservation rate at 2 years was 88% for the no RT, 100% for the remote RT, and 57% for the perioperative RT groups (p = 0.05). Phantom dose measurements showed that for parallel opposed 6 MV photon beams, there was no significant increase in the dose proximal or distal to the plate in either a soft tissue- or bone-equivalent phantom. CONCLUSIONS: The impact of radiation therapy on plate preservation after mandibular reconstructive surgery using a titanium plate may be dependent on the timing of RT relative to surgery. Significantly more mandibular reconstruction plates were lost when the involved mandible received RT in the perioperative period than when RT was delivered beyond 10 months from surgery or when no RT was given. The use of alloplastic implants such as titanium plates in conjunction with myocutaneous flap coverage for mandibular reconstruction is attractive because it allows immediate reconstruction of the defect and promotes a good functional and cosmetic result; however, administration of perioperative RT may result in a higher plate failure rate.

Adolescent↗

Particulate titanium and cobalt-chrome metallic debris in failed total knee arthroplasty. A quantitative histologic analysis.

Histologic examination of synovial tissue from the revisions of six cobalt-chrome and six titanium alloy total knee arthroplasties was made. Aseptic polyethylene wear-through had resulted in metal-on-metal contact of bearing surfaces and was the primary indication for revision surgery in all knees. The cobalt-chrome alloy prostheses failed at the femorotibial articulation at a mean of 92 months, while the titanium prostheses experienced patellofemoral failure at a mean of 39 months after implantation. Neither alloy was associated with any meaningful inflammatory infiltrate, and cement debris was comparable in both groups. Titanium alloy knees generated significantly more metallic debris than the cobalt-chrome alloy knees (P < .001). Cobalt-chrome alloy knees had more polyethylene debris (P < .01) and a greater number of histiocytes (P < .005). Titanium and polyethylene debris were associated with a prominent giant cell reaction. Titanium exhibited greater abrasive wear and elicited a different cellular response than cobalt-chrome under conditions of polyethylene failure allowing metal-on-metal contact. The variability of this foreign body reaction may be due to important differences in particle size and number, as well as in the material properties of the two alloys.

Aged↗

Influence of fluoride, hydrogen peroxide and lactic acid on the corrosion resistance of commercially pure titanium.

Titanium is widely used in dental implantology and orthopaedics due to its excellent corrosion resistance and mechanical properties. However, it has been reported that Ti is sensitive to F(-), H(2)O(2) and lactic acid. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) were used to investigate the corrosion resistance of CP-Ti disks after 9 days immersion in different test solutions, based on artificial saliva containing F(-) (0.5% and 2.5%), H(2)O(2) (0.1% and 10%) and/or lactic acid. Because activated macrophages and bacteria can also release locally some of these oxidative compounds, we investigated the role of these cells when plated onto titanium disks. The surface roughness (R(a)) was highly increased when titanium disks were immersed in artificial saliva containing F(-), H(2)O(2) and lactic acid. After 21 days of cell culture, R(a) was significantly increased on disks incubated with activated-J774.2 cells or Streptococcus mitis. AFM appeared to be more sensitive than SEM in evaluating the corrosion of the titanium. Chemical species, either environmental or those released by macrophages and bacteria, can provoke a marked attack of the titanium surface.

Animals↗

Comparisons of surface roughnesses and sliding resistances of 6 titanium-based or TMA-type archwires.

Six titanium-based or TMA-type archwires (Beta III, Resolve, CNA, TMA, low-friction ion-implanted TMA or TMAL, and TiMolium) were studied as functions of composition, morphology, surface roughness, and sliding mechanics by using a scanning electron microscope, an x-ray energy dispersive wavelength analyser, a laser specular reflectometer, and a frictional testing machine. In the last instrument, all wires were coupled with 0.022-in stainless steel brackets in which normal forces were applied by 0.010-in stainless steel ligatures. With regard to composition, 5 wires were true beta-titanium alloys having nominal compositions of 80% titanium, 10% molybdenum, 6% zirconium, and 4% tin, and 1 was an alpha-beta alloy having a nominal composition of 90% titanium, 6% aluminum, 3% vanadium, and 1% other. Morphologies varied from surfaces with striations, scale, or layers of drawn material that suggested surface steps or fissures. Specular reflectance and optical roughness measurements divided the archwires into 2 groups of 3: Beta III, Resolve, and CNA had an overall mean value of 0.148 microm; and TMA, TMAL, and TiMolium had a mean overall value of 0.195 microm. These roughness measurements and their accompanying details of the compositional analyses suggested that there could be as few as 2 vendors manufacturing the 5 beta-titanium products. For 6 different values of angulation that embraced the passive and active regions of sliding, the coefficients of friction varied rather narrowly from 0.17 to 0.27 and were independent of surface roughnesses. Although these contemporary products are better than their predecessors of over a decade ago, other issues might be more important than surface finishes or frictional resistances because all products appear fairly comparable.

Alloys↗

Electrochemical activation of titanium for biomimetic coating of calcium phosphate.

This article reports an electrochemical method to activate titanium surface for biomimetic calcium phosphate (Ca-P) coatings. Titanium serving as cathode was treated in an electrochemical cell with a supersaturated calcium and phosphate solution serving as electrolyte. This treatment generated a gel-like film with thickness of about 100 nm on the titanium surface. The amorphous film was composed by calcium and phosphate ions and contained a large number of crystal nuclei of octacalcium phosphate (OCP). The effectiveness of this novel treatment was demonstrated by comparing the behavior of treated and untreated titanium when used for biomimetic coating. A uniform Ca-P coating was formed on the treated titanium after immersion for several hours in aqueous solution. This work explored a new method to activate surfaces of metal implants for osseointegration, which is considerably faster than treatments currently in use, such as alkaline treatment.

Biomimetic Materials↗

Biological fabrication of nacreous coating on titanium dental implant.

Titanium screws with 3.5mm diameter and 8mm length, as well as titanium flat sheets with size 4 mm x 8 mm x 0.3mm, were implanted into the epithelial mantle pearl sacs of a fresh water bivalve (Hyriopsis cumingii Lea) by replacing the pearls. After 45 days of cultivation, the implant surfaces were deposited with a nacre coating with iridescent luster. The coating could conform to some extent the thread topography of the screw implant and was about 200-600 microm in thickness. The coating was composed of a laminated nacreous layer and a transitional non-laminated layer that consisted mainly of vaterite and calcite polymorphs of calcium carbonate. The transitional layer was around 2-10 microm thick in the convex and flat region of the implant surface and could form close contact with titanium surface; while the transitional layer was much thicker in the steep concave regions and could not form close contact with the titanium surface. The reasons for inhomogeneity in thickness and the variation in interface character were discussed and the improvement to the design of the dental implant with respect to this coating method was suggested in the paper. The results suggest that it is possible to fabricate a biologically active and degradable, and mechanically tough and strong nacre coating on titanium dental implant by this novel coating technology.

Animals↗

Three-dimensional growth of differentiating MC3T3-E1 pre-osteoblasts on porous titanium scaffolds.

The present work assesses the potential of three-dimensional porous titanium scaffolds produced by a novel powder metallurgy process for applications in bone engineering through in vitro experimentation. Mouse MC3T3-E1 pre-osteoblasts were used to investigate the proliferation (DNA content), differentiation (alkaline phosphatase activity and osteocalcin release) and mineralisation (calcium content) processes of cells on titanium scaffolds with average pore sizes ranging from 336 to 557 microm, using mirror-polished titanium as reference material. Scanning electron microscopy was employed to qualitatively corroborate the results. Cells proliferate on all materials before reaching a plateau at day 9, with proliferation rates being significantly higher on foams (ranging from 123 to 163 percent per day) than on the reference material (80% per day). Alkaline phosphatase activity is also significantly elevated on porous scaffolds following the proliferation stage. However, cells on polished titanium exhibit greater osteocalcin release toward the end of the differentiation process, resulting in earlier mineralisation of the extracellular matrix. Nevertheless, the calcium content is similar on all materials at the end of the experimental period. Average pore size of the porous structures does not have a major effect on cells as determined by the various analyses, affecting only the proliferation stage. Thus, the microstructured titanium scaffolds direct the behaviour of pre-osteoblasts toward a mature state capable of mineralising the extracellular matrix.

3T3 Cells↗

The uptake of titanium ions by hydroxyapatite particles-structural changes and possible mechanisms.

In order to understand the effect of titanium ions on the molecular structure of hydroxyapatite (HAp), HAp powders were incubated in solutions with different titanium concentrations. After incubation, the powders obtained were analysed using different techniques, namely X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), differential thermal analysis (DTA), X-ray photoelectron spectroscopy (XPS), and energy dispersive spectroscopy (EDS). The results suggest that, depending on the concentration of titanium in solution, two different mechanisms of interaction with HAp occur. For concentrations equal to or smaller than 200 ppm, the titanium uptake by the solid seems to be primarily due to incorporation in the lattice. For higher concentrations, a dissolution-precipitation process seems to occur, leading to formation of a titanium phosphate compound.

Biocompatible Materials↗

Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium.

In order to improve orthopedic implant performance, the objective of this in vitro study was to synthesize nanocrystalline hydroxyapatite (HA) powders to coat titanium. HA was synthesized through a wet chemical process. The precipitated powders were either sintered at 1100 degrees C for 1h in order to produce UltraCap HA (or microcrystalline size HA) or were treated hydrothermally at 200 degrees C for 20 h to produce nanocrystalline HA. Some of the UltraCap and nanocrystalline HA powders were doped with yttrium (Y) since previous studies demonstrated that Y-doped HA in bulk improved osteoblast (or bone-forming cell) function over undoped HA. The original HA particles were characterized using X-ray diffraction (XRD), inductively coupled plasma-atomic emission spectroscopy (ICP-AES), BET, a laser particle size analyzer, and scanning electron microscopy (SEM). These powders were then deposited onto titanium by a novel room-temperature process, called IonTite. The properties of the resulting HA-coatings on titanium were compared to respective properties of the original HA powders. The results showed that the chemical and physical properties of the original HA powders were retained when coated on titanium by IonTite, as determined by XRD, SEM, and atomic force microscopy (AFM) analysis. More importantly, results showed increased osteoblast adhesion on the nanocrystalline HA IonTite coatings compared to traditionally used plasma-sprayed HA coatings. Results also demonstrated greater amounts of calcium deposition by osteoblasts cultured on Y-doped nanocrystalline HA coatings compared to either UltraCap IonTite coatings or plasma-sprayed HA coatings. These results encourage further studies on nanocrystalline IonTite HA coatings on titanium for improved orthopedic applications.

Biocompatible Materials↗

Surface modification of surface sol-gel derived titanium oxide films by self-assembled monolayers (SAMs) and non-specific protein adsorption studies.

Biological events occurring at the implant-host interface, including protein adsorption are mainly influenced by surface properties of the implant. Titanium alloys, one of the most widely used implants, has shown good biocompatibility primarily through its surface oxide. In this study, a surface sol-gel process based on the surface reaction of metal alkoxides with a hydroxylated surface was used to prepare ultrathin titanium oxide (TiOx) coatings on silicon wafers. The oxide deposited on the surface was then modified by self-assembled monolayers (SAMs) of silanes with different functional groups. Interesting surface morphology trends and protein adhesion properties of the modified titanium oxide surfaces were observed as studied by non-specific protein binding of serum albumin. The surface properties were investigated systematically using water contact angle, ellipsometry, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM) measurements. Results showed that the surface sol-gel process predominantly formed homogeneous, but rough and porous titanium oxide layers. The protein adsorption was dependent primarily on the silane chemistry, packing of the alkyl chains (extent of van der Waals interaction), morphology (porosity and roughness), and wettability of the sol-gel oxide. Comparison was made with a thermally evaporated TiOx-Ti/Si-wafer substrate (control). This method further extends the functionalization of surface sol-gel derived TiOx layers for possible titanium alloy bioimplant surface modification.

Adsorption↗

Does the nanometre scale topography of titanium influence protein adsorption and cell proliferation?

To investigate the influence of titanium films with nanometre scale topography on protein adsorption and cell growth, three different model titanium films were utilized in the present study. The chemical compositions, surface topographies and wettability were investigated by using X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and water contact angle measurement, respectively. The films share the same surface chemistry but exhibit different topographies on a nanometre scale. Thus, they act as model systems for biological studies regarding surface topography effects. The films were obtained by varying the deposition rate and the film thickness, respectively. These films displayed nanometre scale surface roughness (root mean square roughness, R(rms)) from 2 to 21 nm over areas of 50 microm x 50 microm, with different grain sizes at their surfaces. Albumin and fibrinogen adsorption on these model titanium films were performed in this study. Bicinchoninic acid assay was employed to determine the amount of adsorbed protein on titanium film surfaces. No statistically significant differences, however, were observed for either albumin or fibrinogen adsorption between the different groups of titanium films. No statistically significant influence of surface roughness on osteoblast proliferation and cell viability was detected in the present study.

Adsorption↗

Internal porosity of cast titanium removable partial dentures: influence of sprue direction and diameter on porosity in simplified circumferential clasps.

OBJECTIVE: The behavior of molten titanium in molds of complicated shape is still insufficiently understood; consequently, definite spruing criteria are not yet available for titanium RPD frameworks. This study investigated the influence of sprue design on porosity in pressure-cast titanium circumferential clasps. METHODS: The patterns of 90 circumferential clasps were sprued with three directions (0, 30 and 60 degrees , as measured between the sprue and the symmetry plane of the clasp assembly) and three sprue diameters (1.5, 2.0 and 2.5mm). CPTi was cast in a one-chamber pressure casting machine. Pore number and size were assessed on radiographs of the castings. Statistical analysis was done by two-way analysis of variance (ANOVA), followed by Fisher's PLSD post hoc test. RESULTS: The porosity in lingual arms increased significantly with increase of sprue diameter and sprue angle, while the porosity in minor connectors had an inversely proportional distribution. Very low porosity, uninfluenced by sprue design, was found in buccal arms. In conclusion, internal porosity in titanium circumferential clasp arms can be minimized through sprue design: the 0 degrees sprue direction produced the least porosity, while for the 30 and 60 degrees directions, 1.5mm diameter sprues produced lower porosity than 2.0 and 2.5mm diameter sprues. SIGNIFICANCE: In this study, the lowest porosity in titanium circumferential clasp arms was obtained with sprues attached perpendicularly to the minor connectors, regardless of sprue diameter. Conventional sprue directions produced significantly higher porosity in clasp lingual arms, the amount of porosity increasing with sprue diameter.

Analysis of Variance↗

Modeling the investment casting of a titanium crown.

OBJECTIVE: The objective of this study was to apply computational modeling tools to assist in the design of titanium dental castings. The tools developed should incorporate state-of-the-art micromodels to predict the depth to which the mechanical properties of the crown are affected by contamination from the mold. The model should also be validated by comparison of macro- and micro-defects found in a typical investment cast titanium tooth crown. METHODS: Crowns were hand-waxed and investment cast in commercial purity grade 1 (CP-1) titanium by a commercial dental laboratory. The castings were analyzed using X-ray microtomography (XMT). Following sectioning, analysis continued with optical and scanning electron microscopy, and microhardness testing. An in-house cellular-automata solidification and finite-difference diffusion program was coupled with a commercial casting program to model the investment casting process. A three-dimensional (3D) digital image generated by X-ray tomography was used to generate an accurate geometric representation of a molar crown casting. Previously reported work was significantly expanded upon by including transport of dissolved oxygen and impurity sources upon the arbitrarily shaped surface of the crown, and improved coupling of micro- and macro-scale simulations. RESULTS: Macroscale modeling was found to be sufficient to accurately predict the location of the large internal porosity. These are shrinkage pores located in the thick sections of the cusp. The model was used to determine the influence of sprue design on the size and location of these pores. Combining microscale with macroscale modeling allowed the microstructure and depth of contamination to be predicted qualitatively. This combined model predicted a surprising result--the dissolution of silicon from the mold into the molten titanium is sufficient to depress the freezing point of the liquid metal such that the crown solidifies the subsurface. Solidification then progresses inwards and back out to the surface through the silicon-enriched near-surface layer. The microstructure and compositional analysis of the near-surface region are consistent with this prediction. SIGNIFICANCE: A multiscale model was developed and validated, which can be used to design CP-Ti dental castings to minimize both macro- and micro-defects, including shrinkage porosity, grain size and the extent of surface contamination due to reaction with the mold material. The model predicted the surprising result that the extent of Si contamination from the mold was sufficient to suppress the liquidus temperature to the extent that the surface (to a depth of approximately 100 microm) of the casting solidifies after the bulk. This significantly increases the oxygen pickup, thereby increasing the depth of formation of alpha casing. The trend towards mold materials with reduced Si in order to produce easier-to-finish titanium castings is a correct approach.

Chemical Phenomena↗

The effect of five silane coupling agents on the bond strength of a luting cement to a silica-coated titanium.

OBJECTIVES: The adhesive performance of five silane coupling agents in adhering resin composite cement (3M ESPE) to silica-coated titanium was evaluated. Titanium was tribochemically silica-coated by using the Rocatec system. METHODS: Two volume percent solutions of 3-acryloyloxypropyltrimethoxysilane (Toray Dow Corning Silicone), N-[3-(trimethoxysilyl)propylethylenediamine] (Dow Corning), 3-mercaptopropyltrimethoxysilane (Toray Dow Corning Silicone) and bis-[3-(triethoxysilyl)propyl]polysulfide (Dow Corning) were prepared in 95 vol.% acidified ethanol and allowed to activate (hydrolyze). A pre-activated ca. 2 vol.% 3-methacryloyloxypropyltrimethoxysilane (ESPE Sil) was used as a control. The silanes were applied onto silica-coated titanium slides. Chemical activation reactions of the silanes were monitored by Fourier transform infrared spectrometry (Perkin-Elmer Spectrum One). RelyX ARC (3M ESPE) resin composite cement stubs were applied and photo-polymerized onto silica-coated titanium. The specimens were thermo-cycled (6000 cycles, 5-55 degrees C). RESULTS: Statistical analysis (ANOVA) showed that the highest shear bond strength (n=8 per group) value after thermocycling, 14.8 MPa (S.D. 3.8 MPa), was obtained with 2.0 vol.% 3-acryloyloxypropyltrimethoxysilane. Silanization and results with 3-methacryloyloxypropyltrimethoxysilane (control, ESPE Sil) did not statistically differ from 3-acryloyloxypropyltrimethoxysilane, 14.2 MPa (S.D. 5.8). The lowest shear bond strength was 7.5 (S.D. 1.9) MPa for N-[3-(trimethoxysilyl)propylethylenediamine] and 7.5 (S.D. 2.5) MPa for bis-[3-(triethoxysilyl)propyl]polysulfide. Both the type of silane (p<0.001) and storage conditions affected significantly the shear bond strength values (p<0.001). All silanes became activated according to the infrared spectroscopic analysis. SIGNIFICANCE: Silanization with 3-acryloyloxypropyltrimethoxysilane or 3-mercaptopropyltrimethoxysilane might offer an alternative for bonding a luting cement to silica-coated titanium.

Acrylates↗

Enhancement of titanium dioxide photocatalysis by water-soluble fullerenes.

Fullerenes are known for their unique electronic properties including high electron affinity. Although use of fullerenes for scavenging photo-generated electrons from titanium dioxide particles has been demonstrated, no attempts have been made to utilize the unique properties of fullerenes to increase the efficacy of photocatalysis. The present study has demonstrated that a mixture of water-soluble polyhydroxy fullerenes (PHF) and titanium dioxide (anatase polymorph) enhances photocatalytic degradation of organic dye. The PHF molecules adsorbed to the surface of titanium dioxide due to electrostatic forces, with adsorption density being higher at lower pH values. The surface coverage of titanium dioxide nanoparticles by PHF molecules determined the extent of enhancement, with an optimum dosed weight ratio of PHF to titanium dioxide at 0.001. Hydroxylation and concomitant solubilization of fullerenes allow their unique electronic properties to be harnessed for photocatalysis.

Adsorption↗

Carbonate effects on hexavalent uranium removal from water by nanocrystalline titanium dioxide.

A novel nanocrystalline titanium dioxide was used to treat depleted uranium (DU)-contaminated water under neutral and alkaline conditions. The novel material had a total surface area of 329 m(2)/g, total surface site density of 11.0 sites/nm(2), total pore volume of 0.415 cm(3)/g and crystallite size of 6.0 nm. It was used in batch tests to remove U(VI) from synthetic solutions and contaminated water. However, the capacity of the nanocrystalline titanium dioxide to remove U(VI) from water decreased in the presence of inorganic carbonate at pH > 6.0. Adsorption isotherms, Fourier transform infrared (FTIR) spectroscopy, and surface charge measurements were used to investigate the causes of the reduced capacity. The surface charge and the FTIR measurements suggested that the adsorbed U(VI) species was not complexed with carbonate at neutral pH values. The decreased capacity of titanium dioxide to remove U(VI) from water in the presence of carbonate at neutral to alkaline pH values was attributed to the aqueous complexation of U(VI) by inorganic carbonate. The nanocrystalline titanium dioxide had four times the capacity of commercially available titanium dixoide (Degussa P-25) to adsorb U(VI) from water at pH 6 and total inorganic carbonate concentration of 0.01 M. Consequently, the novel material was used to treat DU-contaminated water at a Department of Defense (DOD) site.

Adsorption↗