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At least 649 records · Page 36Linked to original sources
PubMed1995

Localization of the gene (SYM1) for proximal symphalangism to human chromosome 17q21-q22.

Proximal symphalangism, or Cushing symphalangism (MIM 185800), is an autosomal dominant disorder characterized by ankylosis of the proximal interphalangeal joints. Conductive deafness and reduced flexibility of the ankles have also been observed in affected individuals. We have used polymorphic markers throughout the genome to perform genetic linkage analysis in subsequent generations of the family originally described by Harvey Cushing. We have established linkage for this disorder to markers on chromosome 17 (17q21-q22), with Zmax = 6.98 at theta = 0.05 with marker D17S790.

Abnormalities, Multiple↗
PubMed1985

Load cell analysis following silastic arthroplasty of the hallux.

The first metatarsophalangeal joint was replaced by a flexible silastic hinge prosthesis in 33 joints of 25 patients. Most patients were pleased with the operation but one third had some discomfort under the second and third metatarsal heads. We used a computer linked load cell matrix to analyse the forces under these feet during normal walking. After silastic arthroplasty there was a rise of 65% in peak load under the second and third metatarsal heads compared with that found in the opposite feet which had not undergone operation (P less than 0.001). This was associated with a fall in peak load under the hallux of 43% (P less than 0.03) compared to normal and a less significant fall averaging 23% in the peak pressure experienced under the first metatarsal head. There was a rise in peak heel loading and a reduction in the normal pronation which occurs during the stance phase of walking.

Hallux↗
PubMed1987

The hinged digit flap with dual W-plasties.

A U-shaped flap, hinged proximally and incised distally, adapts well on digits. When incising over joint skin, dual-running W-plasties are mandatory to prevent cicatricial bridging and functional compromise. In a series of 18 cases, no untoward difficulties have been noted.

Exostoses↗
PubMed1992

Articular manifestations of Scheie's syndrome.

A patient with the clinical and biochemical features of Scheie's syndrome is reported. Radiological investigation has shown severe progressive juxta-articular cystic lesions, which have not, to our knowledge, previously been described in Scheie's syndrome.

Finger Joint↗
PubMed1976

Sickle-cell dactylitis.

In order to define better the presentation, roentgenographic features, and clinical course of sickle-cell dactylitis, the records of nine children with sickle-cell anemia and acutely painful, swollen digits were reviewed. The average age of these children at the time of diagnosis was eighteen months, and in five instances the dactylitis occurred before the diagnosis of sickle-cell disease was established. The clinical signs, consisting of swelling, tenderness, fever, and leukocytosis, were self-limiting and resolved in five to thirty-one days. The roentgenographic features, characterized by periosteal new-bone formation or intramedullary densities, appeared in seven to fourteen days and resolved in two to three months. Incorrect diagnosis is frequent in this condition but can be avoided as familiarity with the syndrome increases.

Adult↗
PubMed1999

Bacillus Calmette-Guérin associated arthropathy mimicking undifferentiated spondyloarthropathy.

The development of an inflammatory arthritis mimicking an undifferentiated spondyloarthropathy (SpA) was seen in a patient being treated for a superficial bladder cancer with intravesical bacillus Calmette-Guérin (BCG). Physical findings included classic dactylitis of both feet. This is the fourth report identifying a patient with BCG induced articular findings suggestive of a SpA with dactylitis. Studies of BCG stimulated cytokine secretion from peripheral blood mononuclear cells showed the patient to have enhanced interleukin 6 (IL-6) levels and reduced interferon-gamma (IFN-gamma) levels. Spontaneous IL-6 secretion was markedly elevated for the patient, compared to the control subject, but IFN-gamma secretion was quite similar. No differences were apparent with IL-4.

Arthritis, Reactive↗
PubMedDate not supplied

Pan metatarsal head resection: retrospective analysis and literature review.

The authors present a retrospective study of pan metatarsal head resection. Overall outcome of pan metatarsal head resection with various modifications are analyzed. Subjective data are obtained ascertaining initial chief complaint, appearance, pain relief, and overall patient satisfaction. Additionally, an objective analysis was undertaken. It was found that over the first 4-year postoperative period, patient satisfaction was quite high. However, after this initial postoperative period, a majority of patients were very dissatisfied. This manuscript suggests recommendations pertaining to pan metatarsal head resection based on the results of this study.

Arthrodesis↗