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PubMed1996

Commissioning and periodic quality assurance of a clinical electronic portal imaging device.

PURPOSE: An electronic portal imaging device (EPID) was recently installed on our dual-energy linear accelerator. Commissioning and quality assurance techniques were developed for the EPID. METHODS AND MATERIALS: A commissioning procedure was developed consisting of five parts: (a) physical operation and safety; (b) image acquisition, resolution, and sensitivity calibration; (c) image storage, analysis, and handling; (d) reference image acquisition; and (e) clinical operations. RESULTS: The physical operation and safety tests relate to the motions of the unit, stability of the unit supports, safety interlocks, and interlock overrides. Imager contrast and spatial resolutions are monitored by imaging a contrast-detail phantom. The imager calibration procedure consists of a no-radiation image to compensate for signal offsets, as well as a "flat-field image." The flat-field image is taken with 5.0 cm of homogeneous phantom material placed at isocenter to provide some photon scatter and to approximate the presence of a patient. Daily quality assurance procedures consists of safety tests and the acquisition and inspection of images of the contrast-detail phantom. After 1 year, the frequency of the daily procedure was reduced to weekly. Quarterly QA procedures are conducted by the physicist and consist of the same procedures conducted in the weekly test. The annual QA procedure consists of a duplication of the commissioning procedure. CONCLUSION: The procedures discussed in this article were applied to an ionization-chamber device. They have been useful in identifying difficulties with the EPID operation, including the need for recalibrating and monitoring the accelerator output stability.

Calibration↗

PubMed1995

Clinical use of a digital simulator for rapid setup verification in high dose rate brachytherapy.

PURPOSE: Fractionated high dose rate (HDR) brachytherapy provides a number of technical advantages over conventional implant therapy in that (a) it can be carried out on an outpatient basis, (b) personnel exposure is reduced to insignificant levels, and (c) patient motion during irradiation is minimized, resulting in a more accurate delivery of the planned radiation dose distribution to the target and critical structures. The patient discomfort associated with the repeated applicator insertions and/or treatment setups can be alleviated to the extent that the setup time is held to a minimum. This work describes the use of a prototype digital simulator to obtain fast, high-quality digital images for rapid setup verification. METHODS AND MATERIALS: The digital imaging system of the prototype simulator consists of a charge-coupled device (CCD) camera, which views the x-ray image optically transmitted from a conventional phosphor screen. Treatment is carried out with a remote afterloading HDR unit immediately after setup verification with the patient on the simulator stretcher. The high-resolution digital images are processed and displayed in about 5 s, as opposed to a minimum of approximately 2 min for film. RESULTS: The imaging system has been evaluated for a variety of implant types, both intracavitary and interstitial. The digital radiographs provided permanent high-resolution images as required in most cases for precise applicator positioning. The gray scale manipulation capabilities were found to be useful for imaging in regions of different density, such as lung and soft tissue, in the same radiograph. The advantages of short image acquisition and display times were observed in all cases, but were most evident in the intraluminal procedures, which sometimes involved several pretreatment applicator adjustments at a time of considerable patient discomfort. CONCLUSION: Pretreatment imaging is necessary to fully exploit the technical advantages of HDR brachytherapy. High-quality digital radiography offers unique advantages in HDR setup and verification by providing fast high-resolution, undistorted images with software manipulation capabilities and permanent storage of images.

Brachytherapy↗

PubMed2000

Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization.

An encapsulation device, designed on the basis of the laminar jet break-up technique, is characterized for cell immobilization with different types of alginate. The principle of operation of the completely sterilizable encapsulator, together with techniques for the continuous production of beads from 250 microm to 1 mm in diameter, with a size distribution below 5%, at a flow rate of 1-15 mL/min, is described. A modification of the device, to incorporate an electrostatic potential between the alginate droplets and an internal electrode, results in enhanced monodispersity with no adverse effects on cell viability. The maximum cell loading capacity of the beads strongly depends on the nozzle diameter as well as the cells used. For the yeast Phaffia rhodozyma, it is possible to generate 700 microm alginate beads with an initial cell concentration of 1 x 10(8) cells/mL of alginate whereas only 1 x 10(6) cells/ml could be entrapped within 400 microm beads. The alginate beads have been characterized with respect to mechanical resistance and size distribution immediately after production and as a function of storage conditions. The beads remain stable in the presence of acetic acid, hydrochloric acid, water, basic water, and sodium ions. The latter stability applies when the ratio of sodium: calcium ions is less than 1/5. Complexing agents such as sodium citrate result in the rapid solubilization of the beads due to calcium removal. The presence of cells does not affect the mechanical resistance of the beads. Finally, the mechanical resistance of alginate beads can be doubled by treatment with 5-10 kDa chitosan, resulting in reduced leaching of cells.

Acetic Acid↗

PubMed2000

Picture archiving and communication systems.

Picture archiving and communication systems (PACS) are extremely versatile systems that facilitate the transfer of digital images and patient data throughout a healthcare enterprise. PACS are most commonly used in radiology departments to process images from diagnostic imaging modalities, such as digital radiography devices and magnetic resonance imaging (MRI) systems. In this article, we evaluate three such systems from three of the largest PACS suppliers--the Agfa IMPAX, GE PathSpeed, and Siemens Sienet. The ultimate goal of any PACS is to improve workflow within the enterprise. Our testing focused on whether, and to what degree, the systems could meet this goal. We found that all three PACS are fairly complete and able to support image distribution and improve workflow compared with film-based processes. However, we did identify significant differences--along with some noteworthy limitations--with respect to system design and operation, external integration capabilities, and supplier support and professional services. We have ranked the systems for each of these factors to help healthcare facilities identify the system that will best meet their needs. Also in this Evaluation, we present an overview of the technology, a Glossary of PACS terminology (see page 400), selection guidance, and discussions of PACS-related topics, including data compression options, the role of the DICOM standard, and concerns about data security in many of today's systems.

Automation↗

PubMed2006

Database testing of a subcutaneous monitor with wireless alarm.

UNLABELLED: We have tested the accuracy of detection of cardiac arrest in a cardiac event recorder that has the 4x4 cm sensor implanted, the recorder external, and the two connected by wireless. Storage and transmission is activated by the patient when symptoms are present or automatically when cardiac arrest is detected, in which case the recorder sounds a loud alarm to alert bystanders. It is the automatic mode that requires database testing of accuracy. MATERIALS: We obtained an appropriate database by mapping the chest in 60 ICD patients in sinus rhythm (SR) and induced ventricular fibrillation (VF), and deriving bipolar ECGs from adjacent electrodes located where the electrodes on the subQ sensor would be. (We then implanted the device in 2 dogs and demonstrated the equivalence of ECGs recorded on the skin to subcutaneous ECGs). A blinded selection of 10 of these 60 patients, together with 14 records from the MIT/BIH database, formed a testing set; the others were available for development and training of the detection algorithm. RESULTS: In all 60 patients, ECGs from closely-spaced electrodes properly located on the chest appeared suitable for automatic VF detection. Formal testing with the 24-patient database yielded sensitivity and specificity of 100% in detecting VF. CONCLUSION: It appears a 4 cm square subcutaneous sensor with electrodes at its corners can reliably monitor cardiac activity, accurately detect the occurrence of cardiac arrest, transmit the ECG to an external receiver, and produce an alarm when a life-threatening arrhythmia is detected.

Animals↗

PubMed1999

Thermafil retreatment using a new "System B" technique or a solvent.

The solid plastic carrier in the Thermafil obturation system must be removed to facilitate retreatment. The purpose of this study was to compare the efficacy and time required to retreat canals obturated with Thermafil with plastic carriers using a new technique based on the System B HeatSource or a solvent. Fifty-two extracted human mandibular premolars with single canals were instrumented and then obturated with Thermafil with plastic carriers. After 2 wk storage at 22 degrees C and 100% humidity, they were randomly divided into 2 groups of 26 teeth each. Group 1 teeth were retreated using chloroform and hand files, whereas teeth in group 2 were retreated with a new technique using the System B HeatSource. The end point of retreatment was defined as complete removal of the plastic carrier. The time required for retreatment was recorded. Then, the apical 5 mm segment of each root was sectioned horizontally at 1 mm intervals and each section digitally imaged. The total area of the canal and the area of the canal occupied by gutta-percha and sealer were measured using NIH image software. Data were analyzed using an unpaired t test. The mean time for retrieval of the plastic carrier was significantly less for the System B technique (1.8 min) than for the solvent technique (3.6 min) (p < 0.001). The difference between the two groups in the amount of filling material (carrier, gutta-percha, and sealer) removed was not significant (p > 0.05).

Bicuspid↗

PubMed2001

Suitability of cellulose molecular dialysis membrane for bioartificial pancreas: in vitro biocompatibility studies.

The success of immunoisolation devices for islet transplantation depends on the properties and biocompatibility of semipermeable immunobarrier membranes. In the present study, we have evaluated the in vitro biocompatibility of the cellulose membrane Spectra/Por 2 (MW no larger than 12- 14,000) for its possible application in islet immunoisolation. The membrane was found to be hydrophilic (octane contact angle: 153.2+/-0.66 degrees) and exhibited decreased protein adsorption. It showed mechanical stability after 1 month of storage in PBS (pH 7.4) with tensile strength, percent elongation, and Young's modulus of 88.88 MPa, 36.22, and 291.8 MPa, respectively. It allowed regulated transport of glucose and insulin in an in vitro diffusion assay. The high viability of NIH3T3 fibroblasts and the inability of lymphocytes to proliferate in vitro on exposure to the membrane leach-out products suggested its noncytotoxic and nonimmunogenic nature. Macrophages, when cultured on membranes, did not show increased expression of inflammatory surface marker such as CD11b/CD18, CD45, CD14, and B 7.2. Image analysis studies showed integrity and intact morphology of mouse islets cultured on and inside the membranes with high viability (91%, 89.7%). These islets also retained their functionality, as judged by insulin secretion. The present study provides sufficient documentation to consider cellulose molecular dialysis membrane Spectra/Por 2 (MW no larger than 12-14,000) as a potential candidate for immunoisolation of islets.

3T3 Cells↗

PubMed2006

Detection and classification of sensory information from acute spinal cord recordings.

One avenue of research for partial restoration of function following spinal cord injury is the use of neural prostheses, an example of which is functional electrical stimulation (FES) devices for motor functions. Neural prostheses may also be useful for the extraction of sensory information directly from the nervous system. We suggest the spinal cord as a possible site for the detection of peripheral sensory information from neural activity alone. Acute multichannel extracellular recordings were used to extract neural spike activity elicited from peripheral sensations from the spinal cords of rats. To test the recording method and classification potential, eight classes of sensory events were recorded consisting of electrical stimulation of seven locations on rat forepaws, and another class of data during which no stimulus was present. A dual-stage classification scheme using principal component analysis and k-Means clustering was devised to classify the sensory events during single trials. The eight tasks were correctly identified at a mean accuracy of 96%. Thus, we have shown the methodology to detect and classify peripheral sensory information from multichannel recordings of the spinal cord. These methods may be useful, for example, in a closed-loop FES for restoration of hand grasp.

Action Potentials↗

PubMed2005

A dual modality approach to quantitative quality control in emission tomography.

Routine quality control (QC) and optimization of image quality of reconstructed images in single photon emission computed tomography (SPECT) and positron emission tomography (PET) remains a relatively qualitative exercise. With the advent of combined SPECT/CT and PET/CT devices, and accurate post hoc co-registration algorithms, the potential exists to utilize high resolution structural information for QC evaluation in addition to their use for anatomical correlation in clinical studies. The aim of this work was to explore, in principle, the uses of x-ray CT data of QC phantoms used in SPECT and PET to develop more objective assessments of performance of the emission tomographic (ET) devices and reconstructed data. A CT reconstruction of a novel ET QC phantom was segmented into the various compartments it contained. Using software, the voxel values in the different compartments were then altered to correspond to the concentration of the radioactivity in the actual scan of the same phantom on the SPECT system. This produces a high resolution version of a 'perfect' ET scan. Image co-registration techniques were then used to spatially align the synthetic high resolution SPECT scan to the measured SPECT scan. Various parameters can then be objectively derived from the registered data, for example, image contrast, spatial resolution, spatial non-uniformity, etc. In this study, we have used this approach to estimate spatial resolution (full width at half maximum, FWHM) and recovered contrast in reconstructed images of a SPECT phantom. Two independent methods were used to measure spatial resolution, obtaining excellent agreement. In conclusion, the ability to produce high resolution synthetic phantoms in emission tomography QC affords an objective approach to assessing system performance and optimizing protocols which is readily automated and quantifiable.

Algorithms↗

PubMed2006

Effects of frequency-dependent attenuation and velocity dispersion on in vitro ultrasound velocity measurements in intact human femur specimens.

Numerous studies have shown that ultrasonic velocity measured in bone provides a good assessment of osteoporotic fracture risk. However, a lack of standardization of signal processing techniques used to compute the speed of sound (SOS) complicates the comparison between data obtained with different commercial devices. In this study, 38 intact femurs were tested using a through-transmission technique and SOS determined using different techniques. The resulting difference in measured SOS was determined as functions of the attenuation and the velocity dispersion. A numerical simulation was used to explain how attenuation and dispersion impact two different SOS measurements (group velocity, velocity based on the first zero crossing of the signal). A new method aimed at compensating for attenuation was devised and led to a significant reduction in the difference between SOS obtained with both signal processing techniques. A comparison between SOS and X-ray density measurements indicated that the best correlation was reached for SOS based on the first zero crossing apparently because it used a marker located in the early part of the signal and was less sensitive to multipath interference. The conclusion is that first zero crossing velocity may be preferred to group velocity for ultrasonic assessment at this potential fracture site.

Aged↗

PubMed2006

Diagnostic accuracy of two software modalities for detection of caries lesions in digital radiographs from four dental systems.

OBJECTIVE: To compare the caries diagnostic accuracy of two software modalities used in the assessment of digital radiographs obtained with four different dental systems, and to evaluate whether the software used for image assessment influenced the mutual comparison of those four dental systems relating to their caries diagnostic accuracy. METHODS: Under in vitro and standardized conditions 122 teeth (with 228 unrestored approximal and 99 occlusal surfaces) were radiographed in blocks of 3 test teeth and 2 non-test teeth using two storage phosphor plate systems: Digora (Soredex, Helsinki, Finland) and DenOptix (Gendex, Dentsply, Milan, Italy) and two charge coupled device (CCD)-based sensor systems: Dixi (Planmeca, Helsinki, Finland) and Sidexis (Sirona, Bensheim, Germany). The images were displayed and examined in two software modalities: their own dedicated software and a general software. Three observers examined all images for the presence of approximal enamel and dentine and occlusal dentine caries lesions using a 5-point confidence scale. The true presence of caries was validated by ground section histology. The diagnostic accuracy of the software modalities was expressed as ROC curve areas (A(z)) and differences between modalities were tested by paired t-test. Comparison of systems was analysed by post hoc t-test. RESULTS: Results of approximal and occlusal surfaces assessed together revealed nearly identical mean A(z) with the two software modalities on images obtained with the Digora (A(z)=0.71) and DenOptix (A(z)=0.72) systems. On Dixi images the mean A(z) was 0.75 using the system's own software and 0.73 using the general software. On Sidexis images the corresponding mean A(z)s were 0.79 and 0.75. None of those differences were significant. CONCLUSION: No significant difference in caries diagnostic accuracy was found between two software modalities used for examination of digital radiographs obtained with four different digital systems, and the software modality did not influence the mutual rank of the four systems relating to their diagnostic accuracy.

Data Display↗

PubMed2006

Memory in astrocytes: a hypothesis.

BACKGROUND: Recent work has indicated an increasingly complex role for astrocytes in the central nervous system. Astrocytes are now known to exchange information with neurons at synaptic junctions and to alter the information processing capabilities of the neurons. As an extension of this trend a hypothesis was proposed that astrocytes function to store information. To explore this idea the ion channels in biological membranes were compared to models known as cellular automata. These comparisons were made to test the hypothesis that ion channels in the membranes of astrocytes form a dynamic information storage device. RESULTS: Two dimensional cellular automata were found to behave similarly to ion channels in a membrane when they function at the boundary between order and chaos. The length of time information is stored in this class of cellular automata is exponentially related to the number of units. Therefore the length of time biological ion channels store information was plotted versus the estimated number of ion channels in the tissue. This analysis indicates that there is an exponential relationship between memory and the number of ion channels. Extrapolation of this relationship to the estimated number of ion channels in the astrocytes of a human brain indicates that memory can be stored in this system for an entire life span. Interestingly, this information is not affixed to any physical structure, but is stored as an organization of the activity of the ion channels. Further analysis of two dimensional cellular automata also demonstrates that these systems have both associative and temporal memory capabilities. CONCLUSION: It is concluded that astrocytes may serve as a dynamic information sink for neurons. The memory in the astrocytes is stored by organizing the activity of ion channels and is not associated with a physical location such as a synapse. In order for this form of memory to be of significant duration it is necessary that the ion channels in the astrocyte syncytium be electrically in contact with each other. This function may be served by astrocyte gap junctions and suggests that agents that selectively block these gap junctions should disrupt memory.

Astrocytes↗

PubMed2004

Catadioptric camera calibration using geometric invariants.

Central catadioptric cameras are imaging devices that use mirrors to enhance the field of view while preserving a single effective viewpoint. In this paper, we propose a novel method for the calibration of central catadioptric cameras using geometric invariants. Lines and spheres in space are all projected into conics in the catadioptric image plane. We prove that the projection of a line can provide three invariants whereas the projection of a sphere can only provide two. From these invariants, constraint equations for the intrinsic parameters of catadioptric camera are derived. Therefore, there are two kinds of variants of this novel method. The first one uses projections of lines and the second one uses projections of spheres. In general, the projections of two lines or three spheres are sufficient to achieve catadioptric camera calibration. One important conclusion in this paper is that the method based on projections of spheres is more robust and has higher accuracy than that based on projections of lines. The performances of our method are demonstrated by both the results of simulations and experiments with real images.

Algorithms↗

PubMed2004

3D RBI-EM reconstruction with spherically-symmetric basis function for SPECT rotating slat collimator.

A single photon emission computed tomography (SPECT) rotating slat collimator with strip detector acquires distance-weighted plane integral data, along with the attenuation factor and distance-dependent detector response. In order to image a 3D object, the slat collimator device has first to spin around its axis and then rotate around the object to produce 3D projection measurements. Compared to the slice-by-slice 2D reconstruction for the parallel-hole collimator and line integral data, a more complex 3D reconstruction is needed for the slat collimator and plane integral data. In this paper, we propose a 3D RBI-EM reconstruction algorithm with spherically-symmetric basis function, also called 'blobs', for the slat collimator. It has a closed and spherically symmetric analytical expression for the 3D Radon transform, which makes it easier to compute the plane integral than the voxel. It is completely localized in the spatial domain and nearly band-limited in the frequency domain. Its size and shape can be controlled by several parameters to have desired reconstructed image quality. A mathematical lesion phantom study has demonstrated that the blob reconstruction can achieve better contrast-noise trade-offs than the voxel reconstruction without greatly degrading the image resolution. A real lesion phantom study further confirmed this and showed that a slat collimator with CZT detector has better image quality than the conventional parallel-hole collimator with NaI detector. The improvement might be due to both the slat collimation and the better energy resolution of the CZT detector.

Algorithms↗

PubMed2004

An intelligent service-based network architecture for wearable robots.

We are developing a novel robot concept called the wearable robot. Wearable robots are mobile information devices capable of supporting remote communication and intelligent interaction between networked entities. In this paper, we explore the possible functions of such a robotic network and will present a distributed network architecture based on service components. In order to support the interaction and communication between the components in the wearable robot system, we have developed an intelligent network architecture. This service-based architecture involves three major mechanisms. The first mechanism involves the use of a task coordinator service such that the execution of the services can be managed using a priority queue. The second mechanism enables the system to automatically push the required service proxy to the client intelligently based on certain system-related conditions. In the third mechanism, we allow the system to automatically deliver services based on contextual information. Using a fuzzy-logic-based decision making system, the matching service can determine whether the service should be automatically delivered utilizing the information provided by the service, client, lookup service, and context sensors. An application scenario has been implemented to demonstrate the feasibility of this distributed service-based robot architecture. The architecture is implemented as extensions to the Jini network model.

Algorithms↗

PubMed2000

Radial stratification of ions as a function of mass to charge ratio in collisional cooling radio frequency multipoles used as ion guides or ion traps.

Collisional cooling in radio frequency (RF) ion guides has been used in mass spectrometry as an intermediate step during the transport of ions from high pressure regions of an ion source into high vacuum regions of a mass analyzer. Such collisional cooling devices are also increasingly used as 'linear', two-dimensional (2D) ion traps for ion storage and accumulation to achieve improved sensitivity and dynamic range. We have used the effective potential approach to study m/z dependent distribution of ions in the devices. Relationships obtained for the ideal 2D multipole demonstrate that after cooling the ion cloud forms concentric cylindrical layers, each of them composed of ions having the same m/z ratio; the higher the m/z, the larger is the radial position occupied by the ions. This behavior results from the fact that the effective RF focusing is stronger for ions of lower m/z, pushing these ions closer to the axis. Radial boundaries of the layers are more distinct for multiply charged ions, compared to singly charged ions having the same m/z and charge density. In the case of sufficiently high ion density and low ion kinetic energy, we show that each m/z layer is separated from its nearest neighbor by a radial gap of low ion density. The radial gaps of low ion population between the layers are formed due to the space charge repulsion. Conditions for establishing the m/z stratified structure include sufficiently high charge density and adequate collisional relaxation. These conditions are likely to occur in collisional RF multipoles operated as ion guides or 2D ion traps for external ion accumulation. When linear ion density increases, the maximum ion cloud radius also increases, and outer layers of high m/z ions approach the multipole rods and may be ejected. This 'overfilling' of the multipole capacity results in a strong discrimination against high m/z ions. A relationship is reported for the maximum linear ion density of a multipole that is not overfilled.

Algorithms↗

PubMed2005

Illumination-tolerant face verification of low-bit-rate JPEG2000 wavelet images with advanced correlation filters for handheld devices.

Face recognition on mobile devices, such as personal digital assistants and cell phones, is a big challenge owing to the limited computational resources available to run verifications on the devices themselves. One approach is to transmit the captured face images by use of the cell-phone connection and to run the verification on a remote station. However, owing to limitations in communication bandwidth, it may be necessary to transmit a compressed version of the image. We propose using the image compression standard JPEG2000, which is a wavelet-based compression engine used to compress the face images to low bit rates suitable for transmission over low-bandwidth communication channels. At the receiver end, the face images are reconstructed with a JPEG2000 decoder and are fed into the verification engine. We explore how advanced correlation filters, such as the minimum average correlation energy filter [Appl. Opt. 26, 3633 (1987)] and its variants, perform by using face images captured under different illumination conditions and encoded with different bit rates under the JPEG2000 wavelet-encoding standard. We evaluate the performance of these filters by using illumination variations from the Carnegie Mellon University's Pose, Illumination, and Expression (PIE) face database. We also demonstrate the tolerance of these filters to noisy versions of images with illumination variations.

Algorithms↗

PubMedDate not supplied

Line-scanning laser ophthalmoscope.

Scanning laser ophthalmoscopy (SLO) is a powerful imaging tool with specialized applications limited to research and ophthalmology clinics due in part to instrument size, cost, and complexity. Conversely, low-cost retinal imaging devices have limited capabilities in screening, detection, and diagnosis of diseases. To fill the niche between these two, a hand-held, nonmydriatic line-scanning laser ophthalmoscope (LSLO) is designed, constructed, and tested on normal human subjects. The LSLO has only one moving part and uses a novel optical approach to produce wide-field confocal fundus images. Imaging modes include multiwavelength illumination and live stereoscopic imaging with a split aperture. Image processing and display functions are controlled with two stacked prototype compact printed circuit boards. With near shot-noise limited performance, the digital LSLO camera requires low illumination power (<500 microW) at near-infrared wavelengths. The line-scanning principle of operation is examined in comparison to SLO and other imaging modes. The line-scanning approach produces high-contrast confocal images with nearly the same performance as a flying-spot SLO. The LSLO may significantly enhance SLO utility for routine use by ophthalmologists, optometrists, general practitioners, and also emergency medical personnel and technicians in the field for retinal disease detection and other diverse applications.

Computer-Aided Design↗