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At least 667 records · Page 37Linked to original sources
PubMed1994

[Bilateral conjunctivo-palpebral tumor in an immunocompetent man cause by human papilloma virus].

A 46-year-old white male patient in good general health presented with a bilateral conjunctival and eyelid tumor and a wart at the tip of the fourth right finger. Impression cytology showed dysplasic cells with loss of cohesion and up to 4 nucleoli per nucleus. The excisional biopsy of the conjunctiva revealed a dysplasic epithelial tissue that allowed the diagnosis of papilloma with parts of conjunctival intraepithelial neoplasia (CIN). Papilloma has been associated with Human Papillomavirus (HPV). The molecular hybridization analysis using PCR revealed that HPV was present in the eye tumor and in the wart, but the viral type was not the same. Treatment of the eye tumor with excision and low temperature cryocoagulation was successful.

Biopsy↗
PubMed1994

[Blue nevi of the conjunctiva].

PATIENT AND METHODS: A 54-year-old man presented with multifocal pigmentations of the left bulbar and palpebral conjunctiva. He had first noticed these changes 5 years ago without any evidence of progression. The pigmented lesions were located in the plica, caruncle, the lower fornix and the mucocutaneous junction of the lower lid. The right cornea showed a focal superficial scar paracentrally due to a herpes simplex keratitis in 1970. Visual acuity was 20/20, otherwise the eyes were unremarkable. Biopsies were performed in all areas. One year after surgery, there was no recurrence of the lesions. MICROSCOPY: Histopathologically, the conjunctival epithelium is essentially unremarkable. The substantia propria display mostly uniformly pigmented spindle-shaped melanocytic cells. Many cells contain coarsely clumped melanin granules. Other areas reveal poorly pigmented to unpigmented melanocytic cells, some of them with Schwannian features. Intranuclear vacuoles are commonly present. The tumor cells are often located in stromal areas displaying increased amounts of collagen. A few polyhydral melanophages are present within the lesion. DIAGNOSIS: Biopsy A (plica)--blue nevus with areas of cellular blue nevus. Biopsy B (caruncle)--cellular blue nevus. Biopsy C (lower fornix)--cellular blue nevus. Biopsy D (mucocutaneous junction of left lower lid)--Blue nevus.

Biopsy↗
PubMed1993

[1991 new developments regarding the conjunctiva].

Publications on the subject of conjunctiva in 1991 have been reviewed. Clinical relevant topics have been stressed. In the field of conjunctival affections caused by microorganisms a spectrum of bilateral squamous conjunctival tumors associated with human papillomavirus type 16 were first documented. Chlamydial antibodies cause proliferation of lymphocytes. The peripheral lymphocyte proliferative response to whole chlamydial elementary bodies seems to have a strong correlation between the responses to the Chlamydia trachomatis serotypes B and L1. In the field of impression cytology of the conjunctiva the topographical distribution of ocular surface cells was described. In patients with glaucoma using long-term topical medication, there seem to be significant degrees of conjunctival metaplasia associated with the number of glaucoma medications. These changes in the conjunctival surface may be related to the preservatives in the preparations (benzalkonium compounds). An ultrastructural defect in conjunctiva in recessive dystrophic epidermolysis bullosa may increase the susceptibility of the conjunctiva to minor mechanical trauma. Thus resulting in the bullous and cicatrical changes seen clinically.

Adrenergic beta-Antagonists↗
PubMed1993

[Radical conjunctivectomy in therapy of malignant melanoma of the conjunctiva].

BACKGROUND: In tumor excision of large malignant melanomas of the conjunctiva or in the excision of widespread precancerous melanosis the development of symblepharon is a threatening complication after conjunctivectomy, especially if the conjunctival fornix is afflicted. PATIENTS: Three patients with suspected nodular melanoma and surrounding precancerous melanosis of the conjunctiva were treated by extended excision of the conjunctiva. Instead of a conjunctival graft, spontaneous epithelization under the protection of an 'Illig' contact lens was achieved. After this, two patients with histologically proven malignant melanomas were treated by beta-ray radiation with 90-Strontium. RESULTS: Within four weeks after the excision a complete epithelization of the wound occurred and the functional as well as the cosmetic results were very satisfying. During the follow-up between 12 and 22 months no recurrence of the melanomas and no formation of symblepharon was observed. CONCLUSIONS: With regard to these results extended tumor excision without conjunctival graft seems to be a reasonable therapy for large nodular melanomas and widespread melanosis, while the application of an 'Illig' contact lens avoids the formation of symblepharon.

Adult↗
PubMed1992

[Treatment of eye tumors by accelerated proton beams. 7 years experience].

The therapeutic results of 1070 cases of intraocular tumors treated with an accelerated proton beam at the University Eye Clinic of Lausanne and at the Paul Scherrer Institute of Villigen are analysed. This total is composed of 981 cases of uveal melanomas treated by proton beam as first treatment modality, 42 cases of recurrent choroidal melanomas, 16 cases of conjunctival melanomas, 8 cases of choroidal hemangiomas, 18 cases of uveal metastases and of 5 other ocular tumors. The mortality rate at 5 years for tumors treated with an accelerated proton beam as first treatment modality was 13%, and the mortality rate of recurrent melanomas was 23%. The risk factor for life expectancy analysed with the Cox model pointed out that the largest tumor diameter, the width of the tumor, the presence of an extrocular extension and the age of the patient were the most significant parameters. The conclusions of this study are compared with those found in available literature.

Conjunctival Neoplasms↗
PubMed1990

[Lymphogenic dissemination of an epibulbar melanoma].

Conjunctival melanomas are considered to be malignant tumors, the prognosis of which depends on various factors such as the size and thickness of the tumor and the number of recurrences following excision. The authors report on a 47-year-old woman who, years after local excision of a recurrent limbal conjunctival melanoma, developed an epibulbar melanoma far from the site of the original scar. The authors attribute this recurrence to lymphogenic propagation.

Conjunctival Neoplasms↗
PubMed1990

[Melanoma of the conjunctiva and its treatment].

37 cases of conjunctival melanomas treated in the University Eye Clinic of Lausanne are analysed. This total is made of 20 men and 17 women aged between 19 and 81 years with a mean age of 54.7 years. Tumors were localized in the bulbar conjunctival in 27 cases, in the palpebral conjunctival in 2 cases and were diffuse in 8 cases. Cornea was infiltrated in 19 cases. In 21 cases, the first treatment was made in our service and 16 cases were recurrences following a treatment made elsewhere. The mortality rate to 5 years was 20%. In a multivariant analysis using the COX Model, the height of the tumor was the only significant parameter (p = 0.035) for life expectancy. Recurrence of the tumor (p = 0.060) and presence of a PAM (p = 0.652) were not significant parameters. Benefits of cryocoagulation and indications for a proton beam irradiation are discussed.

Adult↗
PubMed1990

[Malignant melanoma of the conjunctiva: histopathologic study].

The pathological features of 17 malignant melanomas of the conjunctiva, treated by local excision at the Clinique universitaire de Lausanne, were studied, and the most frequent difficulties encountered by the pathologist are presented. Cox's proportional hazards model confirmed that tumor thickness had a prognostic significance and showed that cell type was significant too.

Adult↗
PubMed1989

[Acquired ocular melanosis].

A case of ocular melanosis with a 24-year follow-up is presented. On the basis of the course and the results of histologic findings (conjunctival biopsy) it was classified as benign acquired melanosis with pronounced junctional activity. The constantly changing clinical appearance, ranging from a deep black conjunctiva to ultimately white tissue, is described and discussed.

Biopsy↗
PubMed1987

[S-100 protein in non-pigmented melanocytic and neuro-ectodermal tumors of the conjunctiva].

Using an immunoperoxidase method, S-100 protein was localized in 51 nonpigmented or slightly pigmented nevi, eight malignant melanomas, three neurofibromas, and one neurilemmoma of the conjunctiva. Clinico-immunohistochemical correlations are presented. Cells of these neuroectodermal tumors contain S-100 protein. Epithelial invaginations arising from the conjunctival surface and lying between melanocytes are S-100 protein-negative. This facilitates the differential diagnosis of particularly amelanotic lesions of the conjunctiva. Immunohistochemical identification of the S-100 protein represents an improvement in current histochemical differential diagnosis of these tumors.

Conjunctiva↗
PubMed1986

[Immunocytochemical detection of involucrin in precancerous and cancerous non-pigmented conjunctival tumors].

Involucrin is a precursor of the cross-linked envelope protein of the human stratum corneum. Its appearance in the upper layers of the epidermis reflects normal differentiation of keratinocytes. This study uses an immunoperoxidase technique for localization of involucrin in paraffin sections of normal conjunctiva, conjunctival dysplasia, carcinoma in situ, and invasive carcinoma. Clinicoimmunocytochemical correlations are presented. The results demonstrate that the distribution patterns of involucrin differ in precancerous and cancerous conjunctival lesions: normal limbal conjunctiva shows involucrin only in the three superficial cell layers; the fornix conjunctivae contains no involucrin. All 23 conjunctival dysplasias show an involvement also of deeper layers of the epithelium, sparing the basal layers. Three carcinomas in situ and one invasive squamous cell carcinoma, however, demonstrate an involvement of all layers of the epithelium. The involucrin staining pattern helps in histologic differential diagnosis of epithelial lesions of the conjunctiva.

Biopsy↗
PubMed1985

[Radiotherapy treatment of malignant melanoma of the corneoscleral zone].

Report on a case of malignant melanoma of the limbus and the neighboring cornea and conjunctiva. Excision of the tumor was not possible because of widely scattered cells in the cornea and conjunctiva. After evident progression of the tumor was observed, with signs of inflammation and prominence, radiotherapy was decided on. The melanotic area was irradiated with the strontium 90 applicator, with altogether 65 Gy. The central tumor region in the limbus was saturated with altogether 105 Gy. Four years later residual pigment cells were found in the limbus and the neighboring cornea and conjunctiva, without any signs of recurrence.

Aged↗
PubMed1985

[Kaposi's sarcoma and AIDS].

Kaposi's sarcoma occurs as a complication in numerous cases of AIDS, the much-discussed acquired immune deficiency syndrome. Considering the latter's near-epidemic incidence, the clinical and histological features of Kaposi's sarcoma are recalled to mind. Hitherto only sporadically recorded in non-African countries, the disease is now more frequently observed also in the USA and Central Europe. In textbooks of ophthalmology Kaposi's sarcoma has so far been grossly neglected. Therefore, on the basis of historical facts taken exclusively from original papers, Kaposi's sarcoma is reconsidered with special reference to ophthalmological aspects.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Treatment of primary acquired melanosis of the conjunctiva].

The progression to malignancy of primary acquired melanosis of the conjunctiva with cytologic atypia is often insidious and may not be recognized clinically. Because of the bad prognosis of such melanomas, destruction of the intraepithelial lesion has been recommended. We have been freezing proliferative melanosis with the aid of a cryoprobe. A double freeze-thaw cycle at -70 degrees to -80 degrees was sufficient to destroy the epithelium and eradicate atypical melanocytes without serious complications. Focal nodules, arising in acquired melanosis representing invasive melanomas, however, should be excised initially. Cryotherapy may then be applied to the base and surroundings of the tumor.

Adult↗
PubMed1985

[Treatment of recurrent conjunctival melanoma by lamellar resection and contact irradiation].

The author reports on a 43-year-old patient who, having been treated for a conjunctival melanoma by local resection, presented 6 years later with a recurrent melanoma of a superficial spreading type, having a nodular and a flat component. While lamellar corneal excision was performed on the nodular component, the flat portion was treated with beta-contact radiation. The results are described and the argument for this therapy discussed.

Combined Modality Therapy↗
PubMed1984

[Spontaneous changes in pigmentation in a conjunctival nevus].

The diagnosis and treatment of pigmented tumors of the conjunctiva require a great deal of experience. Some cases require particularly careful clinical supervision of the patient and possibly bioptic control. The differential diagnosis of melanocytic nevi and acquired melanosis is given with reference to an 8-year-old girl.

Child↗
PubMed1983

[Oncocytoma of the ocular adnexa].

The authors report on the clinical and pathological findings in 8 oncocytic lesions of the ocular adnexa. These tumors may involve the caruncle, the conjunctiva, the lacrimal gland and the lacrimal sac. They are often clinically mistaken for haemangiomas, nevi or cysts. In the present authors series the tumor involved the caruncle in 4 cases, the lacrimal gland in 3 and the conjunctiva in one. The clinical and histopathological findings are presented. The occurrence of a malignant oncocytoma (oxyphilic adenocarcinoma) in a 58-year-old man, an oncocytoma (oxyphilic adenoma) in 18-month-old girl and a cystic oncocytoma in a 76-year-old woman are particularly remarkable findings. They are compared, on the basis of a review of the literature, with 50 previously reported oncocytic lesions of the ocular adnexa, of which only 3 involved the lacrimal gland.

Adenocarcinoma↗