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Results for “Delayed-Action Preparations”

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At least 667 records · Page 37Linked to original sources
PubMed1978

Protein electrophoretic patterns of canine prostatic fluid. Effect of hormonal manipulation.

The effects of castration and estrogen administration on prostatic fluid proteins were compared in two groups of dogs. Prostatic fistulae were created in 10 animals and prostatic fluid secretions stimulated by electroejaculation. After a stabilization period, five animals were administered polyestradiol phosphate and the remaining five were castrated. After 3 months estrogen administration was discontinued and depo-testosterone was administered to the castrate animals. Fluids were collected at weekly intervals throughout the study and prostatic fluid proteins separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis. No difference between animal receiving estrogen and castrated animals was noted and administration of testosterone to castrate animals reestablished a normal protein pattern.

Animals↗
PubMed1978

[Iron absorption after gastrectomy following oral application of tardyferon].

Iron absorption was studied in 35 volunteers following oral application of Tardyferon during 21 days. In 25 patients a total gastrectomy and in 5 patients a subtotal gastrectomy have been performed, whereas 5 persons served as controls. The following parameters have been determined: Serum iron, iron binding capacity, hemoglobin, hematocrit, red blood cells and reticulocytes. The following results were obtained: Serum iron is markedly reduced in the patients with total gastrectomy during the first postoperative year, increases steadily and reaches normal values after the third postoperative year. Following oral application of Tardyferon an improved absorption is observed during the postoperative course. Because of the excellent absorption of Tardyferon it can be recommended for the oral application during the first two postoperative years.

Adult↗
PubMed1976

[Drug-drug interactions (author's transl)].

This short outline of drug-drug interactions does not claim to cover the entire field. The task of this paper is to illustrate the most important principles of drug-drug interactions by paradigms taken from the experience of the practitioner. One consequence of drug-drug interactions is the change in pharmacolinetic parameters important for the therapeutical effect of drugs in the organism. Very often the elucidation of the mechanisms of drug-drug interactions in man is impossible; therefore, for clinical pharmacologists experiments on animals remain the tool in order to gain more knowledge in this field.

Age Factors↗
PubMed1976

[Galenical possibilities and problems in protraction of drug effects (author's transl)].

In recent years, dosage forms with sustained release have obtained a significant importance. The technological possibilities for manufacturing are described as coating, embedding and matrix procedures. The range of auxiliary substances, which are responsible for the retardation of drug activity, reaches from lipophilic compounds as lipoids, fatty alcohols and compounds which are forming hydrogels as cellulose derivatives and natural polysaccharides to synthetic polymers derived from acrylic acid. The formulation of the dosage forms requires particular care in respect to the amount of initial and maintenance doses. On account of technological processes, for example during manufacturing of tablets, under certain circumstances the liberation rate is altered. In vitro test methods allow comparisons only then when the results can be counter-checked by in vitro experiments. The release of drug follows different mechanisms, which are described, entirely or in part, to be reactions following the time law of zero or first order. In special cases, a linear correlation is observed as a function of square root of time. The calculation of given special equations for events within the dosage form is feasible from blood-level values.

Biological Availability↗
PubMed1976

[The influence of neuroleptic drugs on urinary excretion of non-protein nitrogen (author's transl)].

During treatment with thioxanthenes or phenothiazines of schizophrenic patients non-protein nitrogen in urine was measured. The values were calculated in relation to the excretion of creatinine. a) Flupentixol or fluphenazine applied in optimal dosage, increased the excretion of urea and the amino acids asp, glu + gln, and gly. b) Moreover, if the drug induced a parkinsonoid (thioridazine) the excretion of ser and thr was increased, too. The usual desalting procedure by ion-exchanging resins before chromatography increases the contents of several amino acids, e.g. asp, asn, ala, gly, cys, ser, thr, indicating a breakdown of some instable products.

Amino Acids↗
PubMed1978

[Experience with the depot neuroleptic LyogenR-depot].

The authors report experience obtained with the use of Lyogen Depot in outpatient aftertreatment of schizophrenic psychoses. There has been observed a highly significant reduction in the number of relapses as compared with the time when this drug had not yet been available. A positive balance will be obtained especially in those cases in which it is possible for all patients to be systematically included in the dispensary treatment scheme.

Adult↗
PubMed1978

NMR studies of sustained release methadone tablets.

NMR studies for the identification of methadone in sustained release tablets is conducted. Up-field shifts of the N-methyl and phenyl groups of the compound were observed. These changes indicate an increased lipid solubility and therefore better absorptivity of the drug in the current form.

Delayed-Action Preparations↗