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Drinking careers of older male alcoholics in treatment as compared to younger alcoholics and to older social drinkers.

OBJECTIVE: In order to answer the question whether older alcoholics form a distinct group among problem drinkers and within their age cohort, drinking histories of male, older (over 50 years of age) alcoholics in treatment (n = 52) are compared to those of younger alcoholics (n = 55), and to those of older social drinkers (n = 46). Within the older alcoholics category, comparisons are made by age of onset. Changes in consumption volume and onset and remission of heavy drinking, morning drinking and solitary drinking are related to events in other spheres of life. METHOD: In face-to-face interviews, respondents were asked to report drinking behavior in subsequent drinking phases, from the beginning of regular drinking to the present. Events that marked a transition to a new drinking phase, as well as the impact that these events had on the general well-being of the respondents, were assessed using a semistructured interview format. RESULTS: Compared to younger alcoholics, older alcoholics were older when they started drinking regularly, and they report later age at onset of heavy drinking. Older alcoholics and social drinkers were similar with respect to the first years of their drinking career. Older alcoholics with onset of heavy drinking before the age of 35 were similar to younger alcoholics, while older alcoholics with later onset of heavy drinking resembled social drinkers with respect to their earlier drinking history. Alcoholics with later onset more often reported onset in connection with events such as marital disruption. CONCLUSION: Among older alcoholics, a distinct group can be distinguished that may benefit from specific prevention and treatment measures.

Adult↗

Clinical approach to excessive daytime sleepiness.

Subjective sleepiness is defined as "an elemental feeling state" by which the subject, and only him/her knows whether he/she is alert or sleepy. Subjective sleepiness has little been used for the clinical evaluation of sleepiness. Objective sleepiness is defined as a consequence of the homeostatic need for sleep. In the absence of a measurable marker of the fulfillment of the function of sleep, the evaluation of objective sleepiness has to rely on a behavioral approach based on the postulate that the more you need sleep (i.e., the sleepier you are), the more likely you are to fall asleep. However, as for many other fundamental human behaviors (drinking, eating, sexual behavior), it is likely that the sleeping behavior serves other purposes than its primary objective, which distorts the relationship between the observed sleeping behavior and the actual need for sleep. The likelihood to fall asleep can be measured by the speed with which a sleep episode occurs under standardized laboratory conditions (multiple sleep latency test, maintenance of wakefulness test, OSLER test), or by the frequency of unwanted sleep episodes under the more naturalistic conditions of daily life (Epworth Sleepiness Scale). These various approaches have advantages and drawbacks, but none of them can be considered the "gold standard".

Chronic Disease↗

Etiological characteristics of abusive husbands.

This study compared abusive husbands with nonabusive, marital discordant husbands using six measures to ascertain certain etiological characteristics of abusers. Both groups completed the Jenkins Activity Survey for measuring type A behavior, the Short Michigan Alcoholism Screening Test, the Index of Self-Esteem, the Spence-Helmrich Attitudes Toward Women Scale, the Index of Marital Satisfaction, and a simple rating scale to access their perceptions of their wives' physical attractiveness. As predicted, abusers evidence significantly higher type A behaviors, higher problem drinking behaviors, more rigid attitudes toward women, lower marital satisfaction, and rated their wives as less attractive than did nonabusers. Inconsistent with the literature, however, no significant differences were discovered between the self-esteem of abusers and nonabusers.

Adult↗

The renin-angiotensin system and thirst: some unanswered questions.

Recent experiments dispute the significance of four findings that usually are cited to support the hypothesis that angiotensin is a natural dipsogen. First, although administration of exogenous renin consistently increases water intake, the plasma renin activities that are produced seem to be outside of the normal physiological range when the elicited drinking is substantial. Second, although plasma renin activities are elevated following caval ligation, colloid, or isoproterenol treatment, this activity of the renin-angiotensin system appears to account for only a small portion of the observed water intake. Third, although bilateral nephrectomy abolishes the water intake that otherwise occurs after caval ligation or isoproterenol treatment, the observed blood pressure appears to be so low as to preclude drinking behavior. Finally, although drinking can be stimulated in these hypotensive rats by various treatments, in each case a pressor response also is observed that might have restored the ability to drink. These new observations have provoked a reevaluation of the circumstances in which endogenous angiotensin stimulates thirst and the magnitude of its contribution then. At present, there is no persuasive evidence that the renin-angiotensin system normally plays a direct and substantial role in mediating the ingestion of water or saline.

Angiotensin II↗

Classifying risky-drinking college students: another look at the two-week drinker-type categorization.

OBJECTIVE: The present study examined the effectiveness of the 2-week period currently used in the categorization of heavy episodic drinking among college students. Two-week drinker-type labels included the following: nonbinge drinker, binge drinker, and frequent binge drinker. METHOD: Three samples of college student drinkers (104 volunteers, 283 adjudicated students, and 238 freshmen male students) completed the 3-month Timeline Followback assessment of drinking. Drinking behavior during the last 2 weeks of the month before the study was compared with drinking behavior during the first 2 weeks of the same month to compare behavior and resulting labels during both 2- week periods. RESULTS: Inconsistencies existed in drinker-type labels during the first 2 weeks of the month and the last 2 weeks of the month for all three samples. Between 40% and 50% of participants in the three samples were classified as a different drinker type across the month. Nonbinge drinkers experienced a wide range of alcohol-related problems, and much variation existed among the frequent-binge-drinker label. CONCLUSIONS: The results suggest that the current definition needs to be modified to accurately identify risky-drinking college students. Expanding the assessment window past 2 weeks of behavior, as well as developing different classification schemes, might categorize risky drinkers more accurately.

Adult↗

Changes in ingestive behavior, serum glucose and free fatty acids concentrations in rats following intracerebroventricular injection of spermine.

We examined the changes in ingestive behavior, serum glucose (Glc) and free fatty acids (FFA) concentrations in male rats following intracerebroventricular (i.c.v.) injection of spermine (SPM). In satiated rats, over a 53.3 nmol of SPM suppressed feeding and drinking behavior in a dose-dependent manner. The median suppressive dose was 90.8 nmol for feeding behavior and 68.3 nmol for drinking behavior. Spermidine also suppressed ingestive behavior but the potency was appreciable weak compared to that of SPM, and the occurrence of the maximal suppression was observed 2-3 days later than that of SPM. The most significant anorexia and adipsia induced by SPM appeared between 16 and 36 hr after i.c.v. administration. SPM (180 nmol) produced a biphasic increase in serum Glc concentration. The 1st peak was at 1 hr and the other peak was 24 hr after the dosing. The same dose of SPM elevated serum FFA concentrations gradually, and the maximal increase appeared 24 hr after the injection. As less than a 120 nmol dose of SPM did not alter serum Glc and FFA concentrations, there seems to be no causal relation between SPM-induced anorexia, and changes in serum Glc and FFA concentrations. Nevertheless, the findings that a very small dose of SPM produced anorexia and adipsia support the possibility that SPM may play some functional role in the brain.

Animals↗

The variable effects of stress on alcohol use from adolescence to early adulthood.

Despite evidence of a strong association between stress and level of drinking in adolescent populations, the role of stress in accounting for changes in drinking behavior throughout the adolescent years is unclear. This study uses a linear growth curve analysis to examine the determinants of within-individual changes in drinking frequency and binge drinking across five waves of data from a community sample of adolescents who were followed into young adulthood. Predictors of drinking include: stressful life events, parental and peer social support, and parental and peer relationship problems. Findings indicate significant effects of stressful life events and parental support and conflict on both the frequency and intensity of alcohol use. Although age-related changes in these variables coincide with changes in drinking behavior, they do not account for drinking variability over this period. Results from conditional models demonstrate that the impact of the stress is contingent on age, and that the strong associations between drinking and stress evidenced during the high school years weaken considerably as individuals move into their late teens and early twenties. Discussion centers on the complex motivations for and facilitators of drinking as young people mature and change environments over the adolescent years.

Adolescent↗

Event- and context-specific normative misperceptions and high-risk drinking: 21st birthday celebrations and football tailgating.

OBJECTIVE: Negative alcohol-related consequences often occur during specific events and in specific contexts (e.g., 21st birthday celebrations and tailgating parties). A lack of available event- and context-specific interventions suggests the need to better understand factors associated with heavy drinking in these contexts, with an eye toward developing specific interventions. The purpose of this research was to lay the foundation for developing personalized normative feedback interventions for 21st birthday celebratory drinking and tailgating drinking by evaluating whether students overestimate norms in these specific contexts, as they do more generally. METHOD: Perceived descriptive norms and alcohol consumption were assessed at event- and context-specific levels in two studies. Study 1 included 119 students turning 21 years old who reported their 21st birthday drinking behavior and estimated the typical number of drinks consumed by students celebrating their 21st birthday. Study 2 included 140 undergraduates drawn from a stratified random sample who reported their behavior regarding drinking and tailgating and their perceived norms for typical drinking and tailgating behavior. RESULTS: Results from Study 1 revealed that students overestimated peer drinking during 21 st birthday celebrations, and this overestimation was associated with heavier drinking on one's own 21st birthday. In Study 2, students underestimated the percentage of tailgaters who drank but overestimated typical consumption. Overestimation was consistently associated with heavier drinking during tailgating. CONCLUSIONS: Successful correction of general normative misperceptions has been shown to reduce drinking in other research. Documentation of normative misperceptions for specific events and contexts provided by these results represents an important step in developing event- and context-specific interventions utilizing specific normative feedback.

Adult↗

Effects of Kamikihi-To, a traditional Chinese medicine, on behavioral changes induced by methyl-beta-carboline-3-carboxylate in mice and rats.

The effects of Kamikihi-To (KMK), a traditional Chinese medicine, on behavioral changes induced by methyl-beta-carboline-3-carboxylate (beta-CCM) were evaluated in mice and rats. Beta-CCM, an anxiogenic benzodiazepine receptor inverse agonist (3.0 mg/kg, i.v. administered 1 min before the test), decreased the locomotor activity of mice in a novel environment. Furthermore, beta-CCM (0.1 mg/kg, i.v. administered 10 min before the test) facilitated the suppression of drinking behavior induced by punishment in the water lick conflict test in rats. KMK (1.0 and 2.0 g/kg, p.o. administered 1 hr before the test) antagonized the decreased locomotor activity in the beta-CCM-treated mice. KMK (2.0 g/kg, p.o.) also recovered the suppression of drinking behavior in the beta-CCM-treated rats. KMK (2.0 g/kg, p.o.) had no effect on beta-CCM-untreated mice and rats in these tests. These findings suggest that KMK has a protective effect against beta-CCM-induced behavioral changes.

Administration, Oral↗

American Indians, stress, and alcohol.

American Indian drinking behavior is often attributed to stress. The causal relationship of stress to Indian drinking and alcohol's role as a stressor is explored. It is likely that some drinking behavior is a response to psychosocial stressors, and that rapid ingestion or large quantity alcohol consumption may also precipitate the psychogenic stress response, thereby exacerbating stress in the individual. Using alcohol to reduce stress increases opportunities for injury and illness.

Alcohol Drinking↗

Is the apparent cardioprotective effect of recent alcohol consumption due to confounding by prodromal symptoms?

Previous research has reported a protective association between alcohol drinking and acute coronary heart disease in the 24-hour period after drinking. This study investigated whether this apparent protective association resulted from confounding due to the effect of prodromal symptoms on drinking behavior. In 1992, the authors conducted a case-control study that measured recent alcohol consumption and reasons for recent abstention from alcohol among patients with acute coronary heart disease identified from a community-based disease register and a representative control sample from the same community (Auckland, New Zealand). Cases were significantly more likely than controls to report recent abstention from drinking because they felt unwell. In unadjusted analyses, a protective association was observed between recent alcohol consumption and acute coronary heart disease; however, this association was weakened considerably after adjustment for the effect of prodromal symptoms on drinking behavior. The previously reported protective association between recent alcohol consumption and acute coronary heart disease appears to be largely due to the confounding effect of prodromal symptoms on drinking.

Alcohol Drinking↗

Circadian rhythm of body temperature persists after suprachiasmatic lesions in the squirrel monkey.

Squirrel monkeys (Saimiri sciureus) demonstrate prominent circadian (approx 24 h) rhythms in many behavioral and physiological variables including drinking and body temperature. Both of these rhythms can be entrained by a 24-h light-dark cycle (LD 12:12) but will free-run with an endogenous period in a constantly illuminated (LL:600 lx) environment free of time cues. After radio-frequency lesions were placed stereotaxically in the suprachiasmatic nuclei (SCN) of five monkeys, the circadian rhythm of drinking behavior was disrupted when the monkeys were maintained in LL. However, the circadian rhythm in core body temperature in these animals persisted in LL with a significant circadian spectral component following destruction of the SCN. The SCN thus appear to be of fundamental importance for regulating the circadian organization of drinking; however, an oscillator located elsewhere in the squirrel monkey is capable of generating the core body temperature rhythm.

Acclimatization↗

Automatic measurement of drinking in rats: effects of hypophysectomy.

A new apparatus for the continuous measurement of drinking in the rats was assembled. The principle of the device is as follows: a cartridge which makes water drops (0.05 ml) is inserted between a water tank and a drinking spout. When a rat drinks, water falls into the cartridge drop by drop and the number of drops is electrically counted. The total count of drops per day, as well as counts at definite intervals, can be atuomatically printed out. To test apparatus reliability and applicability, drinking behavior in hypophysectomized rats was investigated in the light and dark phases, alternating every 12 hr. Activity and feeding in these phases were also observed. In the sham-operated rats, the total daily water intake was 30-40 ml, which corresponded to 10-15% of the body weight, and 85-95% of the total daily drinking counts were recorded in the dark phase. In the hypophysectomized rats, a large amount of water was drunk immediately after the operation. However, the high rate of drinking rapidly returned to near the normal level within a few days. Drinking in the dark phase decreased to about 75% of the total daily, but synchronization with the light-dark cycle was still maintained. The daily patterns of activity and eating ran nearly parallel with the drinking behavior. These results indicate that our drinkometer could have extensive applications within many fields of research.

Animals↗

Empirical correlates of self-report drinking measures.

Self-report questionnaires assessing various drinking behaviors and constructs were administered to subjects in two separate empirical studies of longitudinal drinking patterns. The results suggest that self-report measures of both specific and general drinking behavior accurately differentiate drinkers who vary in frequency and intensity of alcohol consumption.

Adult↗

Influence of genetic background on alcohol drinking and behavioral phenotypes of 5-HT3 receptor over-expressing mice.

Behavioral effects of genetic manipulations are influenced by the background genetics of mouse strains used for the creation of transgenic mice. One strategy to address whether background genes may compromise interpretation of phenotype is the production of congenics. 5-HT3 receptor over-expressing mice have been behaviorally characterized on a B6SJL/F2 background (B6SJL/F2-OE mice), and were found to consume less ethanol failed to develop conditioned place preference to moderate doses of cocaine and demonstrate improved hippocampal-dependent learning. To assess the contribution of parental strain genetics to these behaviors, we bred the transgene onto two well-defined backgrounds that differ in ethanol consumption and contextual fear conditioning, C57Bl/6J (B6) and DBA/2J (D2) strains. The behavioral phenotype of B6SJL/F2-OE was recapitulated in C57Bl/6J-OE mice. However, the effect of transgene over-expression on behavior was only apparent for one aspect of the novelty test using DBA/2J-OE mice. Results underscore the need to consider the genetic environment conferred by strain selection on the effects of genetic manipulation in mice.

Alcohol Drinking↗

[Hypertensive syndrome and changes of water-salt metabolism in the OXYS rats with early ageing].

Peculiarities of drinking behavior and ion deposit capacity have been studied in Wistar and OXYS rats using chronic salt loading. Increased arterial blood pressure in OXYS as compared with Wistar rats has been registered already in the age of 1.5 months. The difference between the two lines persisted up to the age of 18 months. Differences in drinking behavior were also detected: saline consumption in Wistar rats was increased up to 99 ml/day, whereas the OXYS rats revealed a diminished salt appetite. It has been found that tissues of the OXYS rats were characterized by pronounced ion deposit capacity under standard diet conditions as well as after intensive sodium input.

Aging↗

Brief group alcohol interventions with college students: examining motivational components.

The utility of brief interventions with at-risk college drinkers would be enhanced if they could also be delivered in group settings without the need for risk prescreening. The current study therefore explored whether components of brief interventions could be effectively administered to mixed groups of drinking and non-drinking students. Specifically, the outcomes of two methods aimed toward increasing motivation for change were compared to controls. One intervention focused on enhancing actual-ideal drinking behavior discrepancy through a structured group discussion, while the other focused on enhancing self-norm drinking behavior discrepancy through the provision and discussion of didactic information. Among at-risk drinkers, significant reductions in heavy drinking episode frequency at four-week follow-up were found for the self-norm (S-N) group only, while reductions in alcohol problems were obtained in both the S-N and control groups. Results suggest that self-norm discrepancy enhancement strategies may be more effective than actual-ideal discrepancy strategies when used with a mixed drinking group.

Adolescent↗