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PubMed1982

Testosterone : testosterone estradiol binding globulin ratio in evaluating hirsute women.

Testosterone : testosterone estradiol binding globulin (TEBG) ratio is evaluated in 35 hirsute women (age 12 to 38 years), and 14 healthy nonhirsute normal controls (age 21 to 40 years). This is an attempt to emphasize the significance of TEBG in evaluating hirsute women. This is a significant negative linear correlation between the weight of the patients and TEBG concentrations (r = 0.414, P less than 0.05). There is negative linear correlation between TEBG and serum free testosterone concentration that reached significance only in the hirsute nonobese. T:TEBG ratio is significantly high in hirsute women compared to the controls. T:TEBG ratio shows a significant positive linear correlation with free testosterone concentration. In addition, T:TEBG ratio is a direct simple method of evaluating hirsute women. Demulen and Dexamethazone treatment produced a significant fall in T:TEBG ratio in hirsute women.

Adolescent↗
PubMed1984

[Planning of the treatment of atypical hyperplasia of the endometrium in patients with uterine myoma].

The results of a two-stage hormonal treatment of 62 cases of atypical hyperplasia of the endometrium were analysed. Within the first 6 months, patients received 24.0-28.0 g of hydroxyprogesterone capronate each. Six courses of steroid contraceptives such as non-ovlon and bisecurin were given during the second stage when regression of endometrial precancer had already been registered. The results proved hormonal therapy to be highly effective in managing atypical hyperplasia of the endometrium. Complete response was observed in 67.7% of patients. Coexistent uterine myoma affected the efficacy of treatment adversely: only 4 out of 14 patients with atypical hyperplasia of the endometrium with concomitant myoma were good responders. Hormonal treatment was ineffective mainly in cases of myoma of sizes exceeding 8 weeks of gestation and in pre- and postmenopausal patients. This makes the case for surgery.

17 alpha-Hydroxyprogesterone Caproate↗
PubMed1977

Proper management of hepatic adenoma associated with oral contraceptives.

Four patients with oral contraceptive associated hepatic adenoma have been studied and the literature reviewed. Clinically, these patients can be divided into ruptured and nonruptured hepatoma groups. In instances of ruptured hepatomas, resection only sufficient to control hemorrhage definitely is recommended. In instances of nonruptured hepatomas, major resection should only be attempted by skilled surgeons, and small multiple lesions should be observed. These management principles will deserve re-evaluation as more experience with these tumors accumulates. Until then, a conservative approach is indicated. This includes the avoidance of oral contraception until the biochemistry of these tumors is better clarified.

Adenoma↗
PubMed1982

The role of augmented Hageman factor (factor XII) titers in the cold-promoted activation of factor VII and spontaneous shortening of the prothrombin time in women using oral contraceptives.

Spontaneous shortening of the Thrombotest time and an increase in factor VII activity after cold storage of plasma in plastic vials have been described in the plasma of women using OCAs. The phenomenon if CPA is dependent on the presence of HF (factor XII) and is associated with increased plasma kallikrein activity and the disappearance of C1-INH activity. In the present study, spontaneous CPA and shortening of the prothrombin time were observed in 66% of women using OCAs. The prothrombin time was inversely related to factor VII activity and HF coagulant titer, whereas factor VII activity was strongly associated with the titer of HF. The addition of purified HF to normal plasma to a degree observed in OCA users promoted CPA generation and shortening of the prothrombin time. In contrast, reduction of the HF coagulant titer in the plasma of OCA users to a normal level prevented the rise in factor VII activity and shortening of the prothrombin time after cold storage. These data indicate that a high titer of HF, such as that observed in OCA users, is needed for the spontaneous CPA and add support to evidence linking the extrinsic and intrinsic pathways of clotting. The relationship of this in vitro phenomenon to the pathogenesis of thrombosis in women using OCAs is presently unclear. (J Lab Clin Med 99:363, 1982.)

Adult↗