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PubMed1999

In vitro investigation of the liberation of fluoride ions from toothpaste compounds in a permeation model.

The most important requirement for effective topical fluoride prophylaxis from toothpaste containing fluoride is that the active fluoride agent must be chemically free, and the rapid spread of the dissolved fluoride ions over the tooth surface. Abrasive compounds in the toothpastes and the brief residence time at the site of action, the oral cavity and tooth surface must not prevent the liberation. Using a two-chamber diffusion cell and an ion-selective fluoride electrode, the content of fluoride ions in five different fluoride-containing toothpastes was determined by direct potentiometry as a function of time and the different abrasive compounds employed. The investigation has demonstrated that a reduction of the release rate of fluoride ions by nearly 50% is seen when calcium carbonate and calcium hydrogen phosphate dihydrate are used as abrasive compounds and combined with sodium fluoride.

Fluorides↗
PubMed1980

Monitoring and evaluation of results of community fluoride programs in Norway during the 1960's and 1970's.

The purpose of this paper was to report on the introduction, functioning and results of community fluoride programs in Norway during the 1960's and 1970's. Data on the treatment carried out in the School and Public Dental Services were available in official publications. Information on systematic community topical fluoride programs for priority groups was collected by postal questionnaire from all School and Public Dental Officers. Nine variables were described and used to construct a correlation matrix. During the 1970's, there has been an increase in rinsing and professional topical application at the expense of brushing programs. Though the participation-rate increased steadily among 7--15-year-olds and had reached 60% by 1970 and 90% by 1977. the mean number of surfaces filled did not show a consistent downward trend till 1972/73. The reduction in mean number of surfaces filled form 1972 to 1976 tended to be biggest in countries with a high mean number of surfaces filled in 1972 (r = 0.79). Regional variations in mean number of surfaces filled have decreased markedly during the 1970's. Possible explanations for this and problems concerning collection of data on preventive activities are discussed.

Adolescent↗
PubMed2003

Saturation of human saliva with respect to calcium salts.

It may be assumed that free ionic concentrations of calcium and phosphate in resting saliva tend to equilibrate with those in plaque fluid, and that salivary data can therefore be used to illustrate chemical conditions in both saliva and plaque. In the present study, salivary data collected from the literature or obtained in our laboratory were used to calculate degrees of super- and undersaturation with respect to apatites, brushite, beta-tricalcium phosphate, octacalcium phosphate, calcium carbonate and calcium fluoride in the pH range from 3 to 9. Concentrations of calcium, phosphate, fluoride, carbonate, and background ion strength of resting parotid saliva, resting submandibular saliva, and resting and stimulated whole saliva were entered into a computer program, and curves illustrating saturation in the pH range 3-9 constructed. It was found that oral fluids are supersaturated with respect to apatites above pH 5.3 and with respect to octacalcium phosphate and beta-tricalcium phosphate above pH 6. Parotid saliva was undersaturated with respect to brushite whilst submandibular saliva was supersaturated with respect to that salt in the pH range 6-8. Stimulated whole saliva with 25 mmol/l carbonate became supersaturated with respect to calcium carbonate only above pH 7.3, which may explain the absence of this salt in the human oral cavity. To maintain the saturation of oral fluids with respect to calcium fluoride, i.e. to ensure its survival in the mouth required 6 ppm fluoride in the aqueous phase. Therefore, this salt, the outcome of topical fluoride therapy, will inevitably dissolve in the oral fluids.

Adult↗
PubMed2003

Compressive strength, fluoride release and recharge of fluoride-releasing materials.

The compressive strength, fluoride releases and recharge profiles of 15 commercial fluoride-releasing restorative materials have been studied. The materials include glass ionomers (Fuji IX, Ketac Molar, Ketac Silver, and Miracle Mix), resin-modified glass ionomers (Fuji II LC Improved, Photac-Fil, and Vitremer), compomers (Compoglass, Dyract AP, F2000, and Hytac) and composite resins (Ariston pHc, Solitaire, Surefil and Tetric Ceram). A negative linear correlation was found between the compressive strength and fluoride release (r(2)=0.7741), i.e., restorative materials with high fluoride release have lower mechanical properties. The fluoride-releasing ability can be partially regenerated or recharged by using a topical fluoride agent. In general, materials with higher initial fluoride release have higher recharge capability (r(2)=0.7088). Five equations have been used in curve fitting to describe the cumulative fluoride release from different materials. The equation [F](c)=[F](I)(1-e(-bt))+betat best describes the cumulative fluoride release for most glass ionomers, resin-modified glass ionomers, and some high fluoride-releasing compomers and composites, whereas [F](c)=[F](I)/(t(1/2)+t)+alphat best describes the cumulative fluoride release for most compomers and composite resins. The clinic applications of different fluoride-releasing materials have also been discussed.

Cariostatic Agents↗
PubMed1990

Fluoride analysis in nanoliter- and microliter-size fluid samples.

A variety of techniques is described for measuring fluoride in volumes of from 0.005 to 5 microL, including: (1) micropipette procedures for transference and dilution of samples, (2) construction of miniature and micro fluoride-selective electrodes, and (3) methods for adapting standard electrodes for micro- and semi-micro volumes. These described techniques have a number of advantages, including speed of analysis, high accuracy, and adaptability to many types of fluid samples. Recent studies involving use of these procedures include the analysis of fluoride in: (1) plaque fluid samples from single sites before and after topical fluoride administration, (2) tooth mineral samples recovered by acid-etch or microdrill biopsy of enamel, and (3) fluid recovered from the interior of the tooth during simulation of the caries process.

Dental Enamel↗
PubMed1981

Effect of topically-applied solutions of iodine, sodium fluoride, or chlorhexidine on oral bacteria and caries in rats.

Antibacterial levels of iodine, chlorhexidine or sodium fluoride were topically applied to the molar teeth of rats. The effect of these agents on buccal and sulcal caries, as well as on certain oral bacterial populations was assayed. All three agents exerted a significant cariostatic effect which was site specific. Buccal caries incidence and reductions appeared correlated to S. mutans counts, while sulcal caries was better correlated to total cultivable counts. These studies suggested that the simultaneous application of iodine and NaF might exert an additive cariostatic effect.

Administration, Topical↗
PubMed1981

Fluoride rinsing: what dentists should know.

Self-application of fluoride by rinsing has gained popularity as a relatively easy method of providing frequent topical fluoride contact to the teeth. The two principal fluoride rinsing methods, low potency / high frequency and high potency / low frequency, are described.

Administration, Oral↗
PubMed1993

Child-rearing practices and nursing caries.

OBJECTIVE: To determine which child-rearing practices are associated with nursing caries. DESIGN: Cross-sectional study. SETTING: Hospital-based general pediatric clinic. PARTICIPANTS: Sequential sample of 110 healthy children aged 18 to 36 months. OUTCOME MEASURES: Feeding practices of children, limit-setting issues, and familial dental health were determined by maternal interview. Nursing caries were diagnosed by dental examination. RESULTS: Nursing caries were found in 22 (20%) of the children. Ninety percent of children with and without caries were bottle-feeding at 12 and 18 months of age. Ninety-one percent of children with caries and 84% without were still drinking a nighttime bottle at 18 months (P = .33). The mothers of children with caries were found to have fewer years of education, 8.9 vs 10.8 years (P = .02), and were more likely to have eight or more cavities, 55% vs 19% (P = .002). More infants in the caries group had been breast-fed, 72% vs 46% (P = .02), although length of breast-feeding was similar, 5.4 vs 6.7 months. Fewer children with caries drank fluoridated tap water, 27% vs 54% (P = .05), but there were no differences in topical fluoride use, dental hygiene practices, or visits to the dentist. CONCLUSIONS: These findings fail to substantiate a straightforward relationship between child-rearing practices and nursing caries and suggest that well-designed prospective studies are needed to clarify the etiology of early caries.

Adult↗
PubMed1988

Orthodontic appliances and enamel demineralization. Part 2. Prevention and treatment of lesions.

Clinical experiments were performed to investigate the effect of fluoride on carious lesion development and on lesions established during fixed orthodontic therapy. All presently available fluoride agents are developed from the concept of fluoridating the enamel in the form of fluorhydroxyapatite. Recent research has indicated, however, that calcium fluoride formation may be a major aspect of the mechanism of the cariostatic effect of topical fluoride. Therefore a fluoride solution with very low pH (1.9) that induced large amounts of calcium fluoride also was tested on lesion development underneath orthodontic bands. Daily fluoride mouth rinsing with a 0.2% solution sodium fluoride (NaF) retarded lesion development significantly, whereas the fluoride solution with low pH inhibited lesion formation completely. Fluoride applied as a mouth rinse to plaque-covered lesions underneath orthodontic bands retarded lesion progression. The remineralizing capacity of saliva was found to be rapid in the absence of any fluoride. Although white spot lesions may remineralize and even disappear, most of the emphasis should be directed against prevention of carious lesion development during treatment with fixed orthodontic appliances.

Adolescent↗
PubMed2001

Is the fluoride concentration limit of 1,500 ppm in cosmetics (EU guideline) still up-to-date?

The 1,500 ppm fluoride (F(-)) concentration limit set up for European cosmetic toothpaste needs to be considered in terms of effectiveness and toxicity. There is clear evidence for a dose-response relationship between F(-) concentration and caries-preventive effect (25-30% caries reduction achieved with a 1,000 ppm F(-) dentifrice). Clinical significance of higher F(-) concentration has not been totally proven. Low F(-) toothpastes (<500 ppm F(-)) have been marketed to reduce F(-) ingestion by young children in order to minimize the risk of dental fluorosis. Their effectiveness is, however, unclear. Fluoride intake and caries risk assessment should be performed by dental professionals and prescription of topical fluoride should be adjusted individually.

Cariostatic Agents↗
PubMed1991

Preventive oral health care for the infant, child, and adolescent.

Although we have the knowledge and technology necessary to prevent it, most children experience dental disease, and a few children continue to experience high rates of decay. The appropriateness and effectiveness of preventive measures vary throughout the life of a child, and recommendations should be tailored to the needs of the individual. Water fluoridation continues to be the most cost-effective preventive measure available. For patients who do not have access to fluoridated water, dietary supplementation offers similar benefits. A wide variety of professionally applied and home use topical fluoride products such as dentrifrices, gels, and rinses can also reduce the risk of dental caries, particularly on the smooth surfaces of the teeth. The most common site of decay in children is the fissures of the molar teeth. These areas can be protected by the professional application of plastic sealants. Dietary practices influence caries rates, and patients should be advised to limit the frequency of carbohydrate exposures rather than the total amount of carbohydrates consumed. Parents of infants should be advised to discontinue bottle feeding around the age of 12 months to avoid nursing caries. Although oral hygiene practices are not as effective in reducing caries rates as is generally believed, daily toothbrushing and flossing are unquestionably effective in preventing periodontal disease. In order to be maximally effective, preventive efforts should be initiated early in the life of the child. Although most children experience dental disease, a mouth free of caries and periodontal disease is a potentially attainable goal for all children when they use currently available techniques.

Adolescent↗
PubMed1990

Physical and chemical considerations of the role of firmly and loosely bound fluoride in caries prevention.

Historically, there has been considerable debate concerning the roles of loosely bound (calcium fluoride) and firmly bound (fluorapatite) fluoride for caries prevention. Research now shows that fluorapatite (FAP) is a finite reaction product of enamel/apatite fluoridation with or without CaF2 formation, suggesting that CaF2 always be considered as a supplement to, rather than a substitute for, FAP formation. In the presence of low levels of fluoride in the solution phase, the crystallization of hydroxyapatite is enhanced, while the corresponding dissolution is retarded. Fluoride in the bulk FAP or CaF2 solid phase, in contrast, has limited impact on crystal growth or dissolution kinetics. Both FAP and CaF2 can provide F to the solution phase to enhance remineralization and retard demineralization of enamel HAP crystallites. The FAP provides most of this F under low pH conditions, while CaF2 provides F at neutral or lower pH. The reactivity of fluoride on sound and carious enamel differs significantly. Carious enamel acquires more fluoride, acquires it more quickly, and itself acts as a source of retained fluoride in comparison with the more limited reactivity of sound enamel. Overall, the most important question concerning fluoride reactivity relates to its efficiency in enhancing remineralization or retarding demineralization processes. This is influenced not only by the reaction products, e.g., loosely or firmly bound fluoride, but also by the nature of the enamel substrate and frequency of application of the topical fluoridating agent. Inasmuch as the reactivity of bulk HAP is dominated by surface layers of FAP material, the debate over usefulness of various fluoride reaction products solely on a chemical level is no longer critical. Instead, all factors influencing the efficiency of a fluoridating regimen must be considered in the development of improved systems for caries prevention.

Apatites↗
PubMed1990

Tooth-bound fluoride and dental caries.

The cariostatic effects of tooth-bound fluoride reported in the recent literature are reviewed. Several treatment procedures which can increase the tooth-bound fluoride content are described. Based on this information, it is suggested that effectiveness of currently used topical fluoride treatments may be significantly increased by (1) including in the regimen a dicalcium-phosphate-dihydrate-forming treatment so that a portion of the labile fluoride is re-incorporated as tooth-bound fluoride, and (2) employing application methods which ensure the effective delivery of treatment agents to the fissures, and to approximal and cervical surfaces, where most caries occurs.

Animals↗
PubMedDate not supplied

Effects of daily fluoride exposures on fluoride release by glass ionomer-based restoratives.

It is well documented that glass ionomer cements absorb and release fluoride following single fluoride exposures. This study examined fluoride release among three glass ionomer-based restorative materials following multiple daily exposures to three topical fluoride regimens. Using a Delrin mold, 32 cylindrical specimens, each of a glass ionomer (Ketac-Fil), resin-modified glass ionomer (Photac-Fil) and polyacid-modified resin (Dyract AP) were created. Each specimen was subjected to one of four daily treatments (n = 8): (1) no fluoride treatment (control); (2) application of a fluoride dentifrice (1000 ppm) for one minute once daily; (3) application of the same dentifrice for one minute twice daily; (4) the same regimen as (3), plus immersion in a 0.05% sodium fluoride (NaF) mouth rinse (225 ppm) for one minute immediately following the second dentifrice application. Each specimen was suspended in a polyethylene test tube containing 1.0 ml demineralizing solution (pH 4.3) at 37 degrees C for six hours, then transferred to a new test tube containing 1.0 ml remineralizing solution (pH 7.0) at 37 degrees C for 18 hours. Fluoride treatments were completed at the time of transfer daily for seven days. Media solutions were buffered with equal volumes of TISAB II; fluoride levels were measured using a digital ion analyzer and fluoride electrode. Fluoride release decreased significantly from Day 1 to Day 3 for all materials regardless of fluoride treatment (Repeated Measures ANOVA, Tukey HSD, p < 0.05). All specimens released significantly more fluoride in demineralizing solution than in remineralizing solution. For Days 2-7, Treatment 4 produced greater fluoride release than both the control and Treatment 2 for all three materials (p < 0.05); For each material, the fluoride release produced by Treatments 3 and 4 was statistically similar on most days throughout the study. By Day 7, Photac-Fil demonstrated both the greatest total fluoride release and the greatest rechargability, followed by Ketac-Fil and Dyract AP. Although subsequent daily fluoride release never approached that of Day 1, increasing daily fluoride exposures enhanced fluoride release for all three restorative materials.

Absorption↗
PubMed2002

[A study on the effect of various fluorides on resistance to the erosion of beverage on enamel of primary teeth and remineralization of etched enamel].

OBJECTIVE: To study the effect of several fluorides on resistance to erosion of beverage on enamel and remineralization of etched enamel. METHODS: The enamel slabs were prepared from human retained primary teeth. After treated with 0.1%NaF solution, fluoride Protector and Bifluorid 12 respectively, they were immersed at intervals in beverage. The SMH were measured before and after experiments. Morphological changes of enamel surface were observed by SEM. RESULTS: The SMH of all enamel slabs descended obviously after exposed to beverage. The difference between control group and test groups was significant statistically. The variable degree etch caused by beverage were found by SEM. The SMH of etched enamel increased significantly after treated with fluoride, and the Bifluorid 12 showed the highest significant increase. CONCLUSION: The treatment of enamel with topical fluoride can enhance the resistance of enamel to acid etch of soft drinks and the remineralization of enamel following exposed to beverage. This study recommends the Bifluorid 12 is an efficacious fluoride in remineralization of etched enamel.

English Abstract↗