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Kernel-based topographic map formation achieved with an information-theoretic approach.

A new information-theoretic learning algorithm is introduced for kernel-based topographic map formation. The kernels are allowed to overlap and move freely in the input space, and to have differing kernel ranges. We start with Linsker's infomax principle and observe that it cannot be readily extended to our case, exactly due to the presence of kernels. We then consider Bell and Sejnowski's generalization of Linsker's infomax principle, which suggests differential entropy maximization, and add a second component to be optimized, namely, mutual information minimization between the kernel outputs, in order to take into account the kernel overlap, and thus the topographic map's output redundancy. The result is joint entropy maximization of the kernel outputs, which we adopt as our learning criterion. We derive a learning algorithm and verify its performance both for a synthetic example, for which the optimal result can be derived analytically, and for a classic real-world example.

Algorithms↗

Neural correlates of memory organization deficits in schizophrenia. A single photon emission computed tomography study with 99mTc-ethyl-cysteinate dimer during a verbal learning task.

Regional cerebral blood flow (rCBF) during a verbal learning task was measured using 99mTc-ethyl-cysteinate dimer and single photon emission computed tomography in 10 patients with schizophrenia and nine normal controls. Verbal repetition was used as a control task. The schizophrenic patients showed failure to spontaneously utilize implicit category information to learn the word lists. In the normal controls, rCBF in the left inferior frontal and left anterior cingulate regions was significantly increased during the verbal learning task, compared with the verbal repetition task. In contrast, there was no significant frontal lobe activation by the verbal learning in the schizophrenic patients. The patients had lower rCBF during the verbal learning task than the controls in the bilateral inferior frontal, left anterior cingulate, right superior frontal, and bilateral middle frontal regions. Activation in the left inferior frontal region was significantly positively correlated with categorical clustering in the task in the controls, but no such correlation was found in the patients. These results indicate that memory organization deficits in schizophrenia may be related to dysfunction in the prefrontal areas, especially in the left inferior frontal region.

Adult↗

Initial results of a statewide extension program in calf and heifer management in Pennsylvania.

This study was designed to evaluate changes in calf and heifer management in a sample of Pennsylvania dairy farms in conjunction with a statewide extension program on dairy replacements. The extension program reached dairy farmers in addition to individuals in agribusiness, veterinarians, and others who have frequent contact with dairy farmers through a multiplicity of information channels. An extensive survey was conducted during the 1st yr of the project on 329 commercial dairy farms throughout Pennsylvania. The same farms were contacted 2.5 to 3 yr later for comparison. Most (84.7%) of the farmers in the original random sample learned new information about calf and heifer management during this time, and 77.3% reported that they received all or part of this new information from extension. Sources of information most often used by the farmers in this study were dairy magazines, extension newsletters, and meetings organized either through extension or agribusiness. Adoption by farmers of many of the targeted practices specific to calving management, preweaned calves, and health management increased over this period.

Animal Husbandry↗

Novel object presentation affects sleep-wake behavior in rats.

Sleep is suggested to be crucial for the processing and storage of new information. Several learning tasks have been shown to increase the amount of rapid eye movement sleep (REMS) with its typical theta activity (6-8 Hz) relative to total sleep time. Vice versa, REMS deprivation is able to affect memory consolidation following some, but not all learning tasks. Furthermore, recent studies have shown an increase of spindle activity (12-15 Hz) within the electroencephalogram (EEG) of nonREMS as well. The enhancement of both spindle and theta activity is suggested to serve as background activity for the synchronization of those neuronal pathways that were involved in the registration and, later on, participate in the long-term storage of new information in defined brain regions. In the present study, the presentation of a novel object to rats enhanced the amount of preREMS, an intermediate sleep stage with high spindle activity, within the first 2 h of the subsequent sleeping phase. Four hours later, the amount of REMS was increased as well. However, there were no changes in the EEG power spectra of nonREMS, preREMS and REMS. We therefore hypothesize that the increase of preREMS and REMS amounts and the related spindle and theta activity stand for the processing and storage of new information about the presented novel objects.

Action Potentials↗

Carrier testing in the fragile X syndrome: attitudes and opinions of obligate carriers.

This study surveyed obligate carriers of the fragile X syndrome fra(X) to ascertain opinions and attitudes regarding carrier testing. Female carriers of fra(X) syndrome were recruited during their visits to the Fragile X Clinic at Duke University Medical Center. Twenty-eight obligate carriers completed a 48 question structured interview and a visual analog scale (VAS). Strong trends in the responses were identified. Fra(X) syndrome was viewed as a very serious problem and the risk to offspring high. Subjects reported that prior knowledge of carrier status would have changed their reproductive plans. All felt that relatives should be informed about the inheritance of fra(X) syndrome; the mean age given for preferred age to inform their children of the inheritance of fra(X) syndrome was 12 years, and mean age given for optimal timing of carrier testing was 10 years. The women interviewed indicated that growing up with knowledge of their carrier status would have been preferable to learning this information as adults and they endorsed an aggressive approach to informing and testing their children. Further investigation is warranted to determine the psychological consequences of carrier testing for fra(X) syndrome in order to develop appropriate guidelines for testing and informing individuals at risk for fra(X) syndrome.

Adult↗

The information acquired during artificial grammar learning.

In an artificial grammar learning task, amnesic patients classified test items as well as normal subjects did. Item similarity did not affect grammaticality judgments when similar and nonsimilar test items were balanced for the frequency with which bigrams and trigrams (chunks) that appeared in the training set also appeared in the test items. Amnesic patients performed like normal subjects. The results suggest that concrete information about letter chunks can influence gramaticality judgments and that this information is acquired implicitly. The similarity of whole test items to training items does not appear to affect grammaticality judgments.

Aged↗

Diversity and complexity of HIV-1 drug resistance: a bioinformatics approach to predicting phenotype from genotype.

Drug resistance testing has been shown to be beneficial for clinical management of HIV type 1 infected patients. Whereas phenotypic assays directly measure drug resistance, the commonly used genotypic assays provide only indirect evidence of drug resistance, the major challenge being the interpretation of the sequence information. We analyzed the significance of sequence variations in the protease and reverse transcriptase genes for drug resistance and derived models that predict phenotypic resistance from genotypes. For 14 antiretroviral drugs, both genotypic and phenotypic resistance data from 471 clinical isolates were analyzed with a machine learning approach. Information profiles were obtained that quantify the statistical significance of each sequence position for drug resistance. For the different drugs, patterns of varying complexity were observed, including between one and nine sequence positions with substantial information content. Based on these information profiles, decision tree classifiers were generated to identify genotypic patterns characteristic of resistance or susceptibility to the different drugs. We obtained concise and easily interpretable models to predict drug resistance from sequence information. The prediction quality of the models was assessed in leave-one-out experiments in terms of the prediction error. We found prediction errors of 9.6-15.5% for all drugs except for zalcitabine, didanosine, and stavudine, with prediction errors between 25.4% and 32.0%. A prediction service is freely available at http://cartan.gmd.de/geno2pheno.html.

Computational Biology↗

Do blood donors read and understand screening educational materials?

BACKGROUND: Blood donors with high-risk behaviors may not self-defer because they failed to read or understand the screening educational materials. STUDY DESIGN AND METHODS: In 1993, a total of 34,726 allogeneic donors responded to an anonymous mail survey of 50,162 donors that inquired about demographics, donor status, amount of the donor educational materials read, new HIV knowledge gained, and donors' opinions on the length and difficulty of materials. RESULTS: Although 78 percent reported reading all materials, only 32 percent indicated reading carefully; 34 percent learned new information about HIV and 95 percent perceived the materials as easy to understand. First-time donors were more likely to read carefully (OR, 7.9) and gain more HIV knowledge from the materials (OR, 1.9) than repeat donors. Minority, less educated, screening test-reactive, and HIV test-seeking donors reported reading the materials more carefully and learning more about HIV than their respective counterparts. Donors with less education, those with reactive screening tests, those seeking HIV test results, and those not reporting a risk behavior were more likely to find the materials difficult to understand. CONCLUSION: Most donors reported skimming and not having difficulty understanding the educational materials. Some donors may be aware that they should not donate or are failing to assimilate the information in the materials. Methods to present information more clearly and concisely are clearly needed. However, some high-risk donors may still continue donating no matter how improved the educational materials are.

Acquired Immunodeficiency Syndrome↗

Interhemispheric transfer of learning in brain-damaged patients.

The purpose of the present study was to assess some of the mechanisms involved in the compensation of impaired cerebral functions in patients with unilateral brain lesions. Thirty patients with lesions of the left (dominant) hemisphere and 30 patients with lesions of the right (minor) hemispheres were studied. The subjects were blindfolded and submitted to some tests of manual performance, i.e. the relief maze test and identification of geometrical figures. The performances of each hand were determined, before and after ipsilateral and contra-lateral training. A post-training improvement index was also established. The hand related to the damaged hemisphere showed the worse performance. The post-training improvement was lower for the damaged hemisphere. The learning transfer test after contralateral training showed an improvement of the damaged hemisphere significantly greater than that of the healthy one. The authors conclude that in patients with unilateral brain lesions, the healthy hemisphere can compensate for some of the impaired higher cerebral functions by a transfer of information and learning to the damaged one.

Adult↗

Molecular biology of vertebrate learning: is c-fos a new beginning?

An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biological functions of the Fos protein, well known to be a component of a transcription factor, AP-1, (activator protein 1) a hypothesis suggesting a role of transcription factors in the integration of information during learning processes is proposed.

Animals↗

Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats.

The influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and perforant path LTP were assessed in pentobarbital-anesthetized rats. Water deprivation did not affect baseline cell excitability or low-frequency synaptic transmission in the dentate gyrus, but it increased the magnitude of perforant path LTP and elevated the proportion of theta rhythm in the EEG. In Experiment 2, rats were classically conditioned to fear a novel context through the use of aversive footshocks. Water deprivation facilitated the rate of contextual fear conditioning but did not alter the asymptote of learning. Experiment 3 demonstrated that the facilitation of contextual fear conditioning was not due to a change in unconditional shock sensitivity. These results suggest that water deprivation exerts an influence on contextual fear conditioning by modulating hippocampal LTP and theta rhythm and that these processes serve to encode contextual information during learning.

Animals↗

[Implicit memory and its contribution to the rehabilitation of an amnesic patient: case report].

Even severe amnesic patients usually are able to learn new information using implicit memory strategies. In the present study we describe our experience in the rehabilitation of an amnesic patient who had suffered cerebral anoxia. He was taught to use a computer text editor, enabling him to sheltered work. The training program lasted 14 weeks and was based on errorless learning and drilling practice techniques. The patient succeeded in all tasks, even though he could not remember accurately the training sessions. These results meet previous studies which point out that interaction between implicit and residual explicit memory can provide a basis new learning in amnesic patients. The domain-specific knowledge acquisition is demonstrating effectiveness in neuropsychological rehabilitation of brain injured patients.

Adult↗

Exploration of patients' needs for information on arrival at a geriatric and rehabilitation unit.

AIM: The aim of this study was to gather information about patients' needs prior to transferring from an acute care facility to a rehabilitation setting that could assist patients to engage actively in rehabilitation activities upon entering the unit. BACKGROUND: The provision of information is an important aspect of health care as it assists patients to become informed and actively participate in this care. Improved recovery has been associated with patients' adherence to care regimes. METHOD: Semi-structured interviews were undertaken with a convenient sample of nine patients shortly after admission/transfer to a rehabilitation unit and with four of these patients after discharge. The intent was to learn what information patients receive prior to admission to the rehabilitation unit, whether this information is useful and whether different information would be more useful to facilitate patients' engagement in the activities central to rehabilitation treatment. RESULTS: Interviews revealed that, generally, patients received very little information about what to expect on admission to the rehabilitation unit and patients' engagement was more dependent on perceptions about rehabilitation. Thematic analysis identified that, in general, rehabilitation was perceived as 'a ticket out' and 'a good thing'. In relation to provision of information of participants identified that 'doesn't matter that I don't know'; 'information is not always meaningful' and 'I will adjust in my own time'. RELEVANCE TO CLINICAL PRACTICE: Health professionals need to recognize that patients are often compliant with decisions made while they are inpatients of the current health care system. Even though patients may 'actively participate' in rehabilitation processes it is often still as a passive recipient of health care.

Activities of Daily Living↗

Avian clinical pathology.

Much of the information previously available concerning avian clinical pathology was drawn from data from domestic avian species, in particular, poultry. Clinical pathology of nondomestic avian species such as psittacines, however, has come a long way toward establishing normal reference values for caged birds. As a result, it is important for the avian clinician to learn which clinical tests can be used to detect and evaluate a single disease or disease processes by learning what information is gained from hematologic, biochemical, or cytologic samples acquired during a patient's clinical examination.

Anemia↗

Parenting behaviors in parents with anxiety disorders.

Anxiety disorders are familial, and although considerable evidence supports the role of genetic/biological parameters in their development, these alone do not entirely explain their etiology. In this study, the role of parenting behavior as a possible factor in the transmission of anxiety from parent to child was examined. Using interview, self-report, and direct behavioral observation, behaviors of parents with an anxiety disorder were compared to those of parents without an anxiety disorder on a number of dimensions, but particularly with respect to whether anxious parents actively inhibited their children from engaging in normal age appropriate activities. These behaviors were assessed during routine activities and in a structured non-conflictual play task. Although anxious parents did not overtly restrict their child's behavior in either type of activity, they reported higher levels of distress when their children were engaged in these activities. Similarly, the "emotional climate" in families with an anxious parent differed significantly from families without an anxious parent. The results are discussed in terms of how parenting behaviors might influence the development of maladaptive anxiety via social learning and information transfer, and their heuristic implications.

Adult↗

Effect of orientation in haptic reproduction of line length.

We investigated the accuracy of haptic reproduction of line length and whether accuracy is influenced by line orientation. 13 blindfolded subjects felt along different line lengths at various orientations in the horizontal plane, then reproduced the line lengths in the same orientation as that felt. Efforts were made to equate learning and reproductive scanning movements. Reproductions of line lengths were a nonveridical power function of their true lengths, but the power function exponents did not differ across spatial orientations. It was concluded that people can encode line lengths across spatial orientations by a common power function if care is taken to equate proprioceptive information across learning and reproduction.

Adult↗

Clinical brief: severe acute respiratory syndrome (SARS).

The World Health Organization (http:/www.who.int/en/) and Centers for Disease Control and Prevention (http://www.cdc.gov) websites are updated daily as new information is learned about the Severe Acute Respiratory Syndrome (SARS) phenomena. The transmission of SARS appears to occur predominantly through direct contact with infectious material. This includes dispersed respiratory droplets, making touching contaminated objects a potential concern. Occupational health nurses must educate themselves and their employees about SARS to allow for accurate and timely sharing of information.

Canada↗